MX2019005420A - Preparacion de acido (r)-3-hidroxibutirico o sus sales mediante fermentacion de una etapa. - Google Patents

Preparacion de acido (r)-3-hidroxibutirico o sus sales mediante fermentacion de una etapa.

Info

Publication number
MX2019005420A
MX2019005420A MX2019005420A MX2019005420A MX2019005420A MX 2019005420 A MX2019005420 A MX 2019005420A MX 2019005420 A MX2019005420 A MX 2019005420A MX 2019005420 A MX2019005420 A MX 2019005420A MX 2019005420 A MX2019005420 A MX 2019005420A
Authority
MX
Mexico
Prior art keywords
hydroxybutyric acid
salts
preparation
step fermentation
fermentation
Prior art date
Application number
MX2019005420A
Other languages
English (en)
Inventor
Liao Kylin
Fan Wenchao
Original Assignee
Nnb Nutrition Usa Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nnb Nutrition Usa Llc filed Critical Nnb Nutrition Usa Llc
Publication of MX2019005420A publication Critical patent/MX2019005420A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/124—Acids containing four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se relaciona a un proceso para preparar ácido (R)-3-hidroxibutírico o una sal del mismo mediante fermentación de una etapa con un microorganismo no patogénico. La fermentación de ácido (R)-3-hidroxibutírico se realizó al suministrar con ciertas fuentes de carbono y nitrógeno. Estos microorganismos incluyen una cepa de Bacteria HR057 de Ácido Glutámico o un tipo de Corynebacterium Glutamicum genéticamente diseñada.
MX2019005420A 2017-04-04 2018-04-03 Preparacion de acido (r)-3-hidroxibutirico o sus sales mediante fermentacion de una etapa. MX2019005420A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762481476P 2017-04-04 2017-04-04
PCT/US2018/025879 WO2018187324A1 (en) 2017-04-04 2018-04-03 Preparation of (r)-3-hydroxybutyric acid or its salts by one-step fermentation

Publications (1)

Publication Number Publication Date
MX2019005420A true MX2019005420A (es) 2019-11-18

Family

ID=63672435

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019005420A MX2019005420A (es) 2017-04-04 2018-04-03 Preparacion de acido (r)-3-hidroxibutirico o sus sales mediante fermentacion de una etapa.

Country Status (9)

Country Link
US (3) US10428357B2 (es)
EP (1) EP3507272A1 (es)
JP (1) JP7156594B2 (es)
KR (1) KR102480436B1 (es)
CN (1) CN110035991B (es)
AU (1) AU2018250146B2 (es)
CA (1) CA3039255C (es)
MX (1) MX2019005420A (es)
WO (1) WO2018187324A1 (es)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
US11241403B2 (en) 2016-03-11 2022-02-08 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt compositions and methods of use
US11103470B2 (en) 2017-11-22 2021-08-31 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US11202769B2 (en) 2017-11-22 2021-12-21 Axcess Global Sciences, Llc Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
US10925843B2 (en) 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
US11944598B2 (en) 2017-12-19 2024-04-02 Axcess Global Sciences, Llc Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer
US11806324B2 (en) 2018-04-18 2023-11-07 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
CN110862316A (zh) * 2018-08-27 2020-03-06 浙江华睿生物技术有限公司 一种（r）-3-羟基丁酸的晶型及其应用
CN109369372A (zh) * 2018-11-28 2019-02-22 上海欣海国际贸易有限公司 一种制备3-羟基丁酸盐的方法
CN111944853A (zh) * 2019-05-17 2020-11-17 南京纽邦生物科技有限公司 一种微生物发酵生产(r)-3-羟基丁酸的方法
US11950616B2 (en) 2019-06-21 2024-04-09 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
CN111534561A (zh) * 2020-05-19 2020-08-14 南京纽邦生物科技有限公司 一种(r)-3-羟基丁酸的制备方法
EP4200274A2 (en) * 2020-08-18 2023-06-28 Axcess Global Sciences, LLC Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
WO2022217582A1 (en) * 2021-04-16 2022-10-20 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Low-lead and low-arsenic beta-hydroxybutyrate salts and methods for producing the same
CN114436807B (zh) * 2022-01-24 2023-12-22 珠海麦得发生物科技股份有限公司 一种(r)-3-羟基丁酸盐的制备方法
US11969430B1 (en) 2023-03-10 2024-04-30 Axcess Global Sciences, Llc Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance

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US6696561B1 (en) 1909-07-09 2004-02-24 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport
JPS58158190A (ja) * 1982-03-16 1983-09-20 Kanegafuchi Chem Ind Co Ltd Ｄ（−）−β−ヒドロキシ酪酸の製造法
JPS6474999A (en) * 1987-09-16 1989-03-20 Nissei Kagaku Kogyo Kk Production of optically active (r)-(-)-beta-hydroxylactic acid
JP2761063B2 (ja) * 1989-12-12 1998-06-04 ダイセル化学工業株式会社 光学活性３―ヒドロキシ酪酸の製造法
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PL364087A1 (en) * 2001-02-21 2004-12-13 Basf Aktiengesellschaft Method for the production of d-pantothenic acid and/or salts thereof as adjunct for animal feedstuffs
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CN107083406B (zh) 2017-05-27 2021-02-02 浙江华睿生物技术有限公司 (r)-3-羟基丁酸的生产方法

Also Published As

Publication number Publication date
CA3039255A1 (en) 2018-10-11
US20180282767A1 (en) 2018-10-04
AU2018250146B2 (en) 2020-11-05
CA3039255C (en) 2022-11-29
CN110035991A (zh) 2019-07-19
US20190376098A1 (en) 2019-12-12
AU2018250146A1 (en) 2019-04-18
EP3507272A4 (en) 2019-07-10
US20220162653A1 (en) 2022-05-26
JP2019536478A (ja) 2019-12-19
US10428357B2 (en) 2019-10-01
KR102480436B1 (ko) 2022-12-21
WO2018187324A1 (en) 2018-10-11
US11198890B2 (en) 2021-12-14
KR20190137060A (ko) 2019-12-10
CN110035991B (zh) 2022-06-17
EP3507272A1 (en) 2019-07-10
JP7156594B2 (ja) 2022-10-19

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