MX339227B - Alimentacion alcalina. - Google Patents

Alimentacion alcalina.

Info

Publication number
MX339227B
MX339227B MX2013002144A MX2013002144A MX339227B MX 339227 B MX339227 B MX 339227B MX 2013002144 A MX2013002144 A MX 2013002144A MX 2013002144 A MX2013002144 A MX 2013002144A MX 339227 B MX339227 B MX 339227B
Authority
MX
Mexico
Prior art keywords
polypeptide
cultivating
cell
producing
amino acid
Prior art date
Application number
MX2013002144A
Other languages
English (en)
Other versions
MX2013002144A (es
Inventor
Christian Schantz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013002144A publication Critical patent/MX2013002144A/es
Publication of MX339227B publication Critical patent/MX339227B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un método para cultivar una célula bacteriana que comprende la adición de un aminoácido en solución alcalina utilizado para regulación de pH. También un aspecto es un método para producir un polipéptido que comprende las etapas de: a) proporcionar una célula bacteriana que comprende un ácido nucleico que codifica para el polipéptido, b) cultivar la célula proporcionada, c) ajustar el valor de pH durante el cultivo con una solución básica que comprende un aminoácido, d) recuperar el polipéptido de la célula para el medio de cultivo y de esta manera producir el polipéptido.
MX2013002144A 2010-08-30 2011-08-25 Alimentacion alcalina. MX339227B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10008997 2010-08-30
PCT/EP2011/064598 WO2012028522A1 (en) 2010-08-30 2011-08-25 Alkaline feed

Publications (2)

Publication Number Publication Date
MX2013002144A MX2013002144A (es) 2013-04-03
MX339227B true MX339227B (es) 2016-05-17

Family

ID=43088050

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013002144A MX339227B (es) 2010-08-30 2011-08-25 Alimentacion alcalina.

Country Status (11)

Country Link
US (2) US8951756B2 (es)
EP (1) EP2611900B1 (es)
JP (2) JP5798193B2 (es)
KR (1) KR101584414B1 (es)
CN (1) CN103068967B (es)
BR (1) BR112013004396A2 (es)
CA (1) CA2807428A1 (es)
ES (1) ES2558751T3 (es)
MX (1) MX339227B (es)
RU (1) RU2631001C2 (es)
WO (1) WO2012028522A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2631001C2 (ru) * 2010-08-30 2017-09-15 Ф.Хоффманн-Ля Рош Аг Способ получения полипептида
RU2014108240A (ru) 2011-08-25 2015-09-27 Ф. Хоффманн-Ля Рош Аг Укороченный тетранектин-аполипопротеин а-i гибридный белок, содержащая его липидная частица и их применения
RU2014108241A (ru) 2011-08-25 2015-09-27 Ф.Хоффманн-Ля Рош Аг Способ катион- и анионобменной хроматографии
CA2860782A1 (en) * 2012-01-19 2013-07-25 Patrick Tso Method of treating diabetes using non-glycosylated apolipoprotein a-iv
ES2688044T3 (es) 2013-02-22 2018-10-30 F. Hoffmann-La Roche Ag Uso de una cepa procariota con supresión de auxotrofias para aminoácidos para la producción recombinante de un polipéptido
EP3184547A1 (en) 2015-10-29 2017-06-28 F. Hoffmann-La Roche AG Anti-tpbg antibodies and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60118196A (ja) * 1983-11-30 1985-06-25 Takeda Chem Ind Ltd インタ−フェロンの製造法
DD295867A5 (de) 1988-07-28 1991-11-14 Zi F. Mikrobiologie U. Exper. Therapie, Verfahren zur steuerung des wachstums von aerob-submersen mikroorganismen-kulturen
DE4001518A1 (de) 1990-01-19 1991-07-25 Biotechnolog Forschung Gmbh Verfahren zur hochzelldichte-fermentation von escherichia coli in einem ruehrkesselfermentor
SE9203753D0 (sv) * 1992-12-11 1992-12-11 Kabi Pharmacia Ab Expression system for producing apolipoprotein ai-m
AR005035A1 (es) * 1995-12-11 1999-04-07 Merck Patent Ges Mit Beschränkter Haftung Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas.
GB9602825D0 (en) 1996-02-12 1996-04-10 Therexsys Ltd Method of plasmid dna production and purification
US6291245B1 (en) * 1998-07-15 2001-09-18 Roche Diagnostics Gmbh Host-vector system
AU2002213843B2 (en) * 2000-11-10 2008-02-07 F. Hoffmann-La Roche Ltd. Apolipoprotein analogues
KR20050044706A (ko) * 2001-12-05 2005-05-12 디에스엠 아이피 어셋츠 비.브이. 방향족 아미노산 대사산물 또는 이의 유도체의 생산 방법
CA2443365C (en) 2002-11-19 2010-01-12 F. Hoffmann-La Roche Ag Methods for the recombinant production of antifusogenic peptides
RU2631001C2 (ru) * 2010-08-30 2017-09-15 Ф.Хоффманн-Ля Рош Аг Способ получения полипептида

Also Published As

Publication number Publication date
KR20130100301A (ko) 2013-09-10
EP2611900B1 (en) 2015-11-25
BR112013004396A2 (pt) 2016-05-17
US8951756B2 (en) 2015-02-10
EP2611900A1 (en) 2013-07-10
US20150132802A1 (en) 2015-05-14
HK1181811A1 (zh) 2013-11-15
US20130323783A1 (en) 2013-12-05
CN103068967A (zh) 2013-04-24
MX2013002144A (es) 2013-04-03
RU2631001C2 (ru) 2017-09-15
JP2013537432A (ja) 2013-10-03
CN103068967B (zh) 2016-05-04
US9845347B2 (en) 2017-12-19
ES2558751T3 (es) 2016-02-08
CA2807428A1 (en) 2012-03-08
KR101584414B1 (ko) 2016-01-13
JP2016005461A (ja) 2016-01-14
JP5798193B2 (ja) 2015-10-21
WO2012028522A1 (en) 2012-03-08
RU2013112563A (ru) 2014-10-10

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