WO2013103268A3 - Ｌ-아미노산을 생산할 수 있는 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법 - Google Patents

Ｌ-아미노산을 생산할 수 있는 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법 Download PDF

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WO2013103268A3
WO2013103268A3 PCT/KR2013/000072 KR2013000072W WO2013103268A3 WO 2013103268 A3 WO2013103268 A3 WO 2013103268A3 KR 2013000072 W KR2013000072 W KR 2013000072W WO 2013103268 A3 WO2013103268 A3 WO 2013103268A3
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amino acid
producing
same
produce
tryptophan
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PCT/KR2013/000072
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English (en)
French (fr)
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WO2013103268A2 (ko
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정기용
이석명
황영빈
이근철
이광호
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씨제이제일제당(주)
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Priority to JP2014551193A priority Critical patent/JP6326375B2/ja
Priority to BR112014016751-6A priority patent/BR112014016751B1/pt
Application filed by 씨제이제일제당(주) filed Critical 씨제이제일제당(주)
Priority to CN201380008312.0A priority patent/CN104185679A/zh
Priority to MX2020004988A priority patent/MX2020004988A/es
Priority to EP13733718.4A priority patent/EP2801611B1/en
Priority to DK13733718.4T priority patent/DK2801611T3/da
Priority to ES13733718T priority patent/ES2796799T3/es
Priority to MYPI2014001996A priority patent/MY188383A/en
Priority to CA2860616A priority patent/CA2860616C/en
Priority to MX2014008267A priority patent/MX2014008267A/es
Priority to RU2014132431/10A priority patent/RU2600875C2/ru
Priority to US14/370,500 priority patent/US10041099B2/en
Publication of WO2013103268A2 publication Critical patent/WO2013103268A2/ko
Publication of WO2013103268A3 publication Critical patent/WO2013103268A3/ko
Priority to PH12014501556A priority patent/PH12014501556A1/en
Priority to US15/465,881 priority patent/US10787692B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/59—Biological synthesis; Biological purification

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 L-쓰레오닌 또는 L-트립토판을 생산할 수 있는 미생물 및 이를 이용하여 L-쓰레오닌 또는 L-트립토판을 생산하는 방법에 관한 것이며, 보다 상세하게는 L-쓰레오닌 또는 L-트립토판을 생산하는데 세포 내에서 가장 많은 에너지원으로서 사용되는 ATP의 생산성을 증가시킴으로써 L-쓰레오닌 또는 L-트립토판의 생산효율이 향상된 재조합 대장균 및 이를 이용하여 L-쓰레오닌 또는 L-트립토판을 생산하는 방법에 관한 것이다. [대표도] 도 1
PCT/KR2013/000072 2012-01-06 2013-01-07 Ｌ-아미노산을 생산할 수 있는 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법 WO2013103268A2 (ko)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CA2860616A CA2860616C (en) 2012-01-06 2013-01-07 L-threonine and l-tryptophan producing bacterial strain and method of making same
MYPI2014001996A MY188383A (en) 2012-01-06 2013-01-07 Microorganism able to produce l-amino acid, and a method for producing l-amino acid by using the same
CN201380008312.0A CN104185679A (zh) 2012-01-06 2013-01-07 能够产生l-氨基酸的微生物及使用其产生l-氨基酸的方法
BR112014016751-6A BR112014016751B1 (pt) 2012-01-06 2013-01-07 Cepa de e. coli recombinante produtora de l-treonina ou ltriptofano e método para a produção de l-treonina ou l-triptofano
EP13733718.4A EP2801611B1 (en) 2012-01-06 2013-01-07 Microorganism able to produce l-amino acid, and method for producing l-amino acid by using same
DK13733718.4T DK2801611T3 (da) 2012-01-06 2013-01-07 Mikroorganisme, der kan producere l-aminosyre, og fremgangsmåde til fremstilling af l-aminosyre ved brug af samme
MX2014008267A MX2014008267A (es) 2012-01-06 2013-01-07 Microorganismo capaz de producir l-aminoacido, y metodo para producir l-aminoacido usando el mismo.
JP2014551193A JP6326375B2 (ja) 2012-01-06 2013-01-07 Ｌ−アミノ酸を産生する微生物及びこれを用いてｌ−アミノ酸を産生する方法
MX2020004988A MX2020004988A (es) 2012-01-06 2013-01-07 Microorganismo capaz de producir l-aminoacido, y un metodo para producir l-aminoacido usando el mismo.
ES13733718T ES2796799T3 (es) 2012-01-06 2013-01-07 Microorganismo capaz de producir l-aminoácido y método para producir L-aminoácido mediante el uso del mismo
RU2014132431/10A RU2600875C2 (ru) 2012-01-06 2013-01-07 Микроорганизм, способный продуцировать l- аминокислоту, и способ получения l-аминокислоты с применением этого микроорганизма
US14/370,500 US10041099B2 (en) 2012-01-06 2013-01-07 L-threonine and L-tryptophan producing bacteria strain and method of making same
PH12014501556A PH12014501556A1 (en) 2012-01-06 2014-07-04 Microorganism able to produce l-amino acid, and method for producing l-amino acid by using same
US15/465,881 US10787692B2 (en) 2012-01-06 2017-03-22 L-threonine and L-tryptophan producing bacteria strain and method of making same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020120001819A KR101327093B1 (ko) 2012-01-06 2012-01-06 Ｌ-아미노산을 생산할 수 있는 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
KR10-2012-0001819 2012-01-06

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/370,500 A-371-Of-International US10041099B2 (en) 2012-01-06 2013-01-07 L-threonine and L-tryptophan producing bacteria strain and method of making same
US15/465,881 Continuation US10787692B2 (en) 2012-01-06 2017-03-22 L-threonine and L-tryptophan producing bacteria strain and method of making same

Publications (2)

Publication Number Publication Date
WO2013103268A2 WO2013103268A2 (ko) 2013-07-11
WO2013103268A3 true WO2013103268A3 (ko) 2013-09-19

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PCT/KR2013/000072 WO2013103268A2 (ko) 2012-01-06 2013-01-07 Ｌ-아미노산을 생산할 수 있는 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법

Country Status (15)

Country Link
US (2) US10041099B2 (ko)
EP (1) EP2801611B1 (ko)
JP (2) JP6326375B2 (ko)
KR (1) KR101327093B1 (ko)
CN (4) CN105695381B (ko)
BR (1) BR112014016751B1 (ko)
CA (1) CA2860616C (ko)
DK (1) DK2801611T3 (ko)
ES (1) ES2796799T3 (ko)
HU (1) HUE049168T2 (ko)
MX (2) MX2014008267A (ko)
MY (1) MY188383A (ko)
PH (1) PH12014501556A1 (ko)
RU (1) RU2600875C2 (ko)
WO (1) WO2013103268A2 (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101327093B1 (ko) 2012-01-06 2013-11-07 씨제이제일제당 (주) Ｌ-아미노산을 생산할 수 있는 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
KR101599800B1 (ko) 2014-03-21 2016-03-04 씨제이제일제당 주식회사 Ｌ-아미노산의 생산능이 향상된 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
KR101599802B1 (ko) * 2014-05-23 2016-03-04 씨제이제일제당 주식회사 세포내 에너지 수준이 향상된 미생물 및 이를 이용하여 l-아미노산을 생산하는 방법
KR101704199B1 (ko) * 2015-05-14 2017-02-08 씨제이제일제당 (주) L-트립토판 생산능을 갖는 에스케리키아속 미생물 및 이를 이용한 l-트립토판의 제조 방법
CN105861380B (zh) * 2016-05-17 2017-05-10 河南巨龙生物工程股份有限公司 一株大肠埃希氏菌JLTrp及其在发酵生产L‑色氨酸中的应用
WO2017197887A1 (zh) * 2016-05-17 2017-11-23 河南巨龙生物工程股份有限公司 大肠埃希氏菌JLTrp及其在生产L-色氨酸中的应用
KR101996767B1 (ko) * 2018-11-29 2019-07-04 씨제이제일제당 (주) cAMP 수용 단백질 변이체 및 이를 이용한 L-아미노산 제조방법
KR101991207B1 (ko) * 2018-11-29 2019-06-19 씨제이제일제당 (주) cAMP 수용 단백질 변이체 및 이를 이용한 L-아미노산 제조방법
KR102134418B1 (ko) * 2019-06-17 2020-07-16 씨제이제일제당 주식회사 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법
TW202205966A (zh) 2020-06-26 2022-02-16 南韓商Ｃｊ第一製糖股份有限公司 由發酵液製備胺基酸顆粒之方法
KR102284726B1 (ko) * 2021-01-25 2021-08-02 씨제이제일제당 주식회사 신규한 타우토머레이즈 pptA 변이체 및 이를 이용한 L-트립토판 생산 방법
CN114585734B (zh) * 2021-01-25 2022-11-04 Cj第一制糖株式会社 新型水解酶变体及使用其生产l-色氨酸的方法
CN114616335B (zh) * 2021-01-25 2022-11-04 Cj第一制糖株式会社 新型H+/Cl-交换转运体变体及使用其生产L-色氨酸的方法
TW202333581A (zh) 2021-12-24 2023-09-01 南韓商Ｃｊ第一製糖股份有限公司 由發酵液製備含胺基酸製品之方法

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