JP2016528295A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016528295A5 JP2016528295A5 JP2016536456A JP2016536456A JP2016528295A5 JP 2016528295 A5 JP2016528295 A5 JP 2016528295A5 JP 2016536456 A JP2016536456 A JP 2016536456A JP 2016536456 A JP2016536456 A JP 2016536456A JP 2016528295 A5 JP2016528295 A5 JP 2016528295A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- fusion polypeptide
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 92
- 229920001184 polypeptide Polymers 0.000 claims description 91
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 91
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 76
- 230000004927 fusion Effects 0.000 claims description 49
- 150000001413 amino acids Chemical class 0.000 claims description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
- 201000010099 disease Diseases 0.000 claims description 14
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims description 12
- 108091033319 polynucleotide Proteins 0.000 claims description 10
- 102000040430 polynucleotide Human genes 0.000 claims description 10
- 239000002157 polynucleotide Substances 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 7
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 7
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims description 6
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 6
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 6
- 239000000710 homodimer Substances 0.000 claims description 6
- 208000011580 syndromic disease Diseases 0.000 claims description 6
- 201000001320 Atherosclerosis Diseases 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 230000003176 fibrotic effect Effects 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 231100000241 scar Toxicity 0.000 claims description 4
- 230000002784 sclerotic effect Effects 0.000 claims description 4
- 206010005949 Bone cancer Diseases 0.000 claims description 2
- 208000018084 Bone neoplasm Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 2
- 108091026890 Coding region Proteins 0.000 claims description 2
- 201000003066 Diffuse Scleroderma Diseases 0.000 claims description 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 2
- 206010019280 Heart failures Diseases 0.000 claims description 2
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims description 2
- 208000001826 Marfan syndrome Diseases 0.000 claims description 2
- 208000032056 Radiation Fibrosis Syndrome Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 102000007562 Serum Albumin Human genes 0.000 claims description 2
- 108010071390 Serum Albumin Proteins 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 2
- 201000008982 Thoracic Aortic Aneurysm Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 206010047141 Vasodilatation Diseases 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 208000007474 aortic aneurysm Diseases 0.000 claims description 2
- 230000036755 cellular response Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000009918 complex formation Effects 0.000 claims description 2
- 208000003457 familial thoracic 1 aortic aneurysm Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 230000013595 glycosylation Effects 0.000 claims description 2
- 238000006206 glycosylation reaction Methods 0.000 claims description 2
- 208000019622 heart disease Diseases 0.000 claims description 2
- 230000002008 hemorrhagic effect Effects 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims description 2
- 201000002313 intestinal cancer Diseases 0.000 claims description 2
- 125000003473 lipid group Chemical group 0.000 claims description 2
- 230000004807 localization Effects 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 206010028537 myelofibrosis Diseases 0.000 claims description 2
- 210000005036 nerve Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 201000011461 pre-eclampsia Diseases 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 208000037803 restenosis Diseases 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 11
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 2
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 2
- 102000056172 Transforming growth factor beta-3 Human genes 0.000 claims 2
- 108090000097 Transforming growth factor beta-3 Proteins 0.000 claims 2
- 229940099456 transforming growth factor beta 1 Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 description 12
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 239000012634 fragment Substances 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 238000010494 dissociation reaction Methods 0.000 description 3
- 230000005593 dissociations Effects 0.000 description 3
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 102000046181 human GDF15 Human genes 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361868713P | 2013-08-22 | 2013-08-22 | |
| US61/868,713 | 2013-08-22 | ||
| US201361906270P | 2013-11-19 | 2013-11-19 | |
| US61/906,270 | 2013-11-19 | ||
| US201361906849P | 2013-11-20 | 2013-11-20 | |
| US61/906,849 | 2013-11-20 | ||
| PCT/US2014/052130 WO2015027082A1 (en) | 2013-08-22 | 2014-08-21 | Tgf-beta receptor type ii variants and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019149750A Division JP2019194270A (ja) | 2013-08-22 | 2019-08-19 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016528295A JP2016528295A (ja) | 2016-09-15 |
| JP2016528295A5 true JP2016528295A5 (https=) | 2017-09-28 |
Family
ID=52480573
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536456A Withdrawn JP2016528295A (ja) | 2013-08-22 | 2014-08-21 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
| JP2019149750A Withdrawn JP2019194270A (ja) | 2013-08-22 | 2019-08-19 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
| JP2021079785A Pending JP2021112212A (ja) | 2013-08-22 | 2021-05-10 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
| JP2023199004A Pending JP2024015040A (ja) | 2013-08-22 | 2023-11-24 | Ｔｇｆ－ベータ受容体ｉｉ型変異体およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019149750A Withdrawn JP2019194270A (ja) | 2013-08-22 | 2019-08-19 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
| JP2021079785A Pending JP2021112212A (ja) | 2013-08-22 | 2021-05-10 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
| JP2023199004A Pending JP2024015040A (ja) | 2013-08-22 | 2023-11-24 | Ｔｇｆ－ベータ受容体ｉｉ型変異体およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US20150056199A1 (https=) |
| EP (2) | EP3036262A4 (https=) |
| JP (4) | JP2016528295A (https=) |
| CN (2) | CN105658672A (https=) |
| AU (2) | AU2014308751B2 (https=) |
| CA (1) | CA2921805C (https=) |
| HK (2) | HK1225742A1 (https=) |
| WO (1) | WO2015027082A1 (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6267425B2 (ja) | 2009-11-17 | 2018-01-24 | アクセルロン ファーマ， インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するａｃｔｒｉｉｂタンパク質およびその改変体およびその使用 |
| CA2902026C (en) | 2013-03-13 | 2023-08-29 | Prothena Biosciences Limited | Tau immunotherapy |
| CA2921805C (en) | 2013-08-22 | 2023-03-07 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
| WO2015077540A2 (en) * | 2013-11-21 | 2015-05-28 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating pulmonary hypertension |
| CN106794233B (zh) | 2014-08-01 | 2021-11-12 | 布里格姆及妇女医院股份有限公司 | 与肺动脉高压的治疗有关的组合物和方法 |
| US10603359B2 (en) | 2014-10-30 | 2020-03-31 | Acceleron Pharma Inc. | Methods and compositions using GDF15 polypeptides for increasing red blood cells |
| US10227392B2 (en) | 2015-04-06 | 2019-03-12 | Acceleron Pharma Inc. | ALK7:ActRIIB heteromultimers and uses thereof |
| CN107849114B (zh) * | 2015-04-06 | 2021-08-20 | 阿塞勒隆制药公司 | 单臂i型和ii型受体融合蛋白和其用途 |
| KR101706462B1 (ko) * | 2015-07-09 | 2017-02-14 | 부산대학교 산학협력단 | Nag-1 억제제를 유효성분으로 포함하는 난소암 환자의 항암제 내성 억제용 약학조성물 |
| HK1256638A1 (zh) * | 2015-08-04 | 2019-09-27 | Acceleron Pharma Inc. | 用於治疗骨髓增生性病症的方法 |
| US20200231652A1 (en) | 2015-08-31 | 2020-07-23 | National Research Council Of Canada | Tgf-b-receptor ectodomain fusion molecules and uses thereof |
| US20170299608A1 (en) * | 2016-03-04 | 2017-10-19 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for modulating body weight |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| PE20190208A1 (es) | 2016-05-02 | 2019-02-07 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
| EP3452507B1 (en) | 2016-05-02 | 2022-10-19 | Prothena Biosciences Limited | Tau immunotherapy |
| CN109414471A (zh) | 2016-05-24 | 2019-03-01 | 诺和诺德股份有限公司 | Mic-1化合物及其用途 |
| CN118307682A (zh) | 2016-09-27 | 2024-07-09 | 埃皮辛特瑞柯斯公司 | 免疫调节性融合蛋白 |
| JP7280182B2 (ja) | 2016-10-05 | 2023-05-23 | アクセルロン ファーマ インコーポレイテッド | バリアントＡｃｔＲＩＩＢタンパク質およびその使用 |
| JOP20190100A1 (ar) * | 2016-11-19 | 2019-05-01 | Potenza Therapeutics Inc | بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها |
| AU2018212403A1 (en) * | 2017-01-25 | 2019-08-22 | Tessa Therapeutics Ltd. | TGF-ß decoy receptor |
| CN118255902A (zh) | 2017-03-02 | 2024-06-28 | 加拿大国家研究委员会 | TGF-β受体胞外域融合分子及其用途 |
| CN110881274B (zh) | 2017-05-02 | 2024-11-15 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| LT3628049T (lt) * | 2017-05-04 | 2023-08-25 | Acceleron Pharma Inc. | Tgf-beta ii tipo receptoriaus sulieti baltymai ir jų panaudojimo būdai |
| AU2018264455B2 (en) * | 2017-05-12 | 2024-12-12 | Jiangsu Hengrui Medicine Co., Ltd. | Fusion protein containing TGF-beta receptor and medicinal uses thereof |
| TWI710377B (zh) | 2017-05-23 | 2020-11-21 | 丹麥商諾佛 儂迪克股份有限公司 | Ｍｉｃ－１化合物及其用途 |
| JP2020536518A (ja) | 2017-09-27 | 2020-12-17 | エピセントアールエックス，インコーポレイテッド | 免疫調節融合タンパク質 |
| JP7348899B2 (ja) | 2017-12-08 | 2023-09-21 | マレンゴ・セラピューティクス，インコーポレーテッド | 多重特異性分子及びその使用 |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| EP3749682B1 (en) * | 2018-02-09 | 2025-09-24 | Acceleron Pharma Inc. | Treating heterotopic ossification |
| TWI823906B (zh) | 2018-03-09 | 2023-12-01 | 美商艾吉納斯公司 | 抗-cd73 抗體及其使用方法 |
| WO2019178364A2 (en) | 2018-03-14 | 2019-09-19 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| CA3099325A1 (en) | 2018-05-03 | 2019-11-07 | Acceleron Pharma Inc. | Novel binders of tgf.beta.-superfamily ligands and uses thereof |
| TWI809130B (zh) | 2018-06-22 | 2023-07-21 | 美商凱特製藥公司 | 嵌合跨膜蛋白及其用途 |
| EP3818083A2 (en) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| WO2020014285A2 (en) | 2018-07-09 | 2020-01-16 | Intrexon Corporation | Fusion constructs and methods of using thereof |
| CN109097461B (zh) * | 2018-09-06 | 2021-07-30 | 北京中关村生命科学园生物医药科技孵化有限公司 | 一种心肌病相关基因检测试剂及其应用 |
| JP7465272B2 (ja) | 2018-09-27 | 2024-04-10 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｃｓｆ１ｒ／ｃｃｒ２多特異性抗体 |
| US12559539B2 (en) * | 2018-11-09 | 2026-02-24 | Jiangsu Hengrui Medicine Co., Ltd. | TGF-beta receptor fusion protein pharmaceutical composition and use thereof |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用 |
| AU2020224681A1 (en) | 2019-02-21 | 2021-09-16 | Marengo Therapeutics, Inc. | Antibody molecules that bind to NKp30 and uses thereof |
| EP3927745A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders |
| EP3935083A4 (en) | 2019-03-03 | 2022-11-30 | Prothena Biosciences Limited | Antibodies recognizing tau |
| WO2020257823A2 (en) | 2019-06-21 | 2020-12-24 | Kite Pharma, Inc. | TGF-β RECEPTORS AND METHODS OF USE |
| US10851157B2 (en) | 2019-07-01 | 2020-12-01 | Gensun Biopharma, Inc. | Antagonists targeting the TGF-β pathway |
| CN114173806A (zh) | 2019-07-26 | 2022-03-11 | 密歇根州立大学董事会 | 预防或治疗骨骼肌脂肪变性的方法 |
| US11802145B2 (en) | 2019-10-21 | 2023-10-31 | Nanjing Leads Biolabs Co., Ltd. | Recombinant protein targeting PD-1 and TGFß |
| CN114728072A (zh) | 2019-10-23 | 2022-07-08 | 库尔生物制药有限公司 | TGF-β多肽 |
| WO2021092079A1 (en) * | 2019-11-05 | 2021-05-14 | Acceleron Pharma Inc. | Treatments for systemic sclerosis |
| WO2021104434A1 (en) * | 2019-11-27 | 2021-06-03 | Shanghai Epimab Biotherapeutics Co., Ltd. | TGFβ/PD-L1 BISPECIFIC BINDING PROTEINS |
| WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| GB2612450A (en) | 2020-04-24 | 2023-05-03 | Marengo Therapeutics Inc | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| PH12022552826A1 (en) * | 2020-04-28 | 2024-03-11 | Sinocelltech Ltd | Tgfãr2 extracellular domain truncated molecule, fusion protein of tgfãr2 extracellular domain truncated molecule and anti-egfr antibody, and anti-tumor use of fusion protein |
| CN113754777A (zh) * | 2020-06-02 | 2021-12-07 | 三生国健药业（上海）股份有限公司 | 一种抗PD-L1/TGF-β融合蛋白 |
| EP4178680A4 (en) | 2020-07-10 | 2024-07-31 | Precigen, Inc. | FUSION CONSTRUCTS AND THEIR METHODS OF USE |
| US11028174B1 (en) | 2020-07-28 | 2021-06-08 | Lepu Biopharma Co., Ltd. | Bifunctional molecules targeting PD-L1 and TGF-β |
| CA3190755A1 (en) | 2020-08-26 | 2022-03-03 | Andreas Loew | Multifunctional molecules that bind to calreticulin and uses thereof |
| KR20230074487A (ko) | 2020-08-26 | 2023-05-30 | 마렝고 테라퓨틱스, 인크. | Trbc1 또는 trbc2를 검출하는 방법 |
| AU2021331076A1 (en) | 2020-08-26 | 2023-04-06 | Marengo Therapeutics, Inc. | Antibody molecules that bind to NKp30 and uses thereof |
| CN112215941B (zh) * | 2020-09-04 | 2021-06-25 | 北京科技大学 | 一种基于微分几何的主动脉扭曲的评估方法及系统 |
| WO2022068894A1 (zh) * | 2020-09-30 | 2022-04-07 | 上海齐鲁制药研究中心有限公司 | 同时靶向pd-l1和vegf的双功能分子及其医药用途 |
| WO2022105751A1 (zh) * | 2020-11-19 | 2022-05-27 | 信达生物制药(苏州)有限公司 | TGFβRII融合蛋白以及其用途 |
| WO2022125548A1 (en) * | 2020-12-08 | 2022-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Growth and differentiation factor 15 for treatment of proliferative vitreoretinopathy therapy |
| WO2022261061A1 (en) | 2021-06-08 | 2022-12-15 | Kite Pharma, Inc. | Gpc3 binding molecules |
| US20240277807A1 (en) * | 2021-06-11 | 2024-08-22 | Acceleron Pharma Inc. | Actrii proteins and uses thereof |
| WO2023030408A1 (zh) * | 2021-09-02 | 2023-03-09 | 广东菲鹏制药股份有限公司 | TGFβRII突变体及其应用 |
| KR20240150761A (ko) | 2022-01-28 | 2024-10-16 | 35파마 인크. | 액티빈 수용체 유형 iib 변이체 및 이의 용도 |
| JP2024096518A (ja) * | 2023-01-03 | 2024-07-16 | エフビーデー バイオロジクス リミテッド | 操作されたｔｇｆｂｒｉｉバリアント及びその使用方法 |
| KR20260019369A (ko) | 2023-05-31 | 2026-02-10 | 에프비디 바이올로직스 리미티드 | Cd47/pd-l1-표적화 단백질 복합체 및 그의 사용 방법 |
| US20260092096A1 (en) | 2024-05-14 | 2026-04-02 | 35Pharma Inc. | Activin receptor type iib variants and uses thereof |
Family Cites Families (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8529014D0 (en) | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
| AU597574B2 (en) | 1986-03-07 | 1990-06-07 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| ZA914750B (en) | 1990-06-20 | 1992-03-25 | Bristol Myers Squibb Co | Methods of modulating blood pressure using tgf-beta and antagonists thereof |
| GB9106678D0 (en) | 1991-03-28 | 1991-05-15 | Ferguson Mark W J | Wound healing |
| US6008011A (en) | 1991-10-31 | 1999-12-28 | Whitehead Institute For Biomedical Research | TGF-β type II receptor cDNAs |
| JP4124815B2 (ja) | 1991-10-31 | 2008-07-23 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | ＴＧＦ−β型受容体ｃＤＮＡおよびその用途 |
| US5543143A (en) | 1992-03-06 | 1996-08-06 | Corixa Corporation | Method for activating macrophages/monocytes |
| CA2146973C (en) * | 1992-10-29 | 2008-09-02 | Patricia R. Segarini | Uses of tgf-.beta. receptor fragment as a therapeutic agent |
| US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| DE69434934D1 (de) | 1993-10-14 | 2007-04-12 | Harvard College | Verfahren zur induzierung und zur erhaltung neuronalen zellen |
| US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
| US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| US5866323A (en) | 1995-04-07 | 1999-02-02 | Case Western Reserve University | Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors |
| DE69636866D1 (en) | 1995-04-11 | 2007-03-15 | Gen Hospital Corp | Reverse "two-hybrid"-systeme |
| US6423501B2 (en) | 1996-12-13 | 2002-07-23 | Beth Israel Deaconess Medical Center | Calcium-independent negative regulation by CD81 of receptor signaling |
| JP2001515360A (ja) | 1997-04-18 | 2001-09-18 | バイオジェン，インコーポレイテッド | ▲ＩＩ▼型ＴＧＦ−βレセプター／免疫グロブリン定常領域融合タンパク質 |
| WO1998047531A2 (en) | 1997-04-21 | 1998-10-29 | Arch Development Corporation | Fc receptor non-binding anti-cd3 monoclonal antibodies deliver a partial tcr signal and induce clonal anergy |
| US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
| ZA988461B (en) | 1997-09-18 | 1999-03-30 | Idec Pharma Corp | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis |
| ES2292236T3 (es) | 1998-04-02 | 2008-03-01 | Genentech, Inc. | Variantes de anticuerpos y sus fragmentos. |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| CA2330939A1 (en) | 1998-06-16 | 1999-12-23 | Biogen, Inc. | Variant type ii tgf-beta receptor fusion proteins and methods |
| ES2146552B1 (es) | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
| WO2001066140A1 (en) | 2000-03-09 | 2001-09-13 | Genzyme Corporation | Use of tgf-beta antagonists to treat or to prevent loss of renal function |
| AU2001249446A1 (en) | 2000-03-24 | 2001-10-08 | Dzgenes, L.L.C. | Diagnostic polymorphisms of tgf-beta-rii promoter |
| US20030028905A1 (en) | 2001-07-31 | 2003-02-06 | Petra Knaus | Mutant forms of the TGF-beta type II receptor which bind all TGF-beta isoforms |
| AU2003209308A1 (en) | 2002-01-22 | 2003-09-02 | Genzyme Corporation | Use of tgf-beta antagonists to treat or to prevent chronic transplant rejection |
| US7919084B2 (en) | 2002-06-17 | 2011-04-05 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
| CA2513086A1 (en) | 2002-12-19 | 2004-07-08 | Scios Inc. | Treatment of obesity and associated conditions with tgf-.beta. inhibitors |
| EP1620128A1 (en) | 2003-04-30 | 2006-02-01 | Genzyme Corporation | Tgf-beta antagonists combined with renin-angiotensin-aldosteron-system antagonists for treating renal insufficiency |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| US20060229266A1 (en) | 2003-08-13 | 2006-10-12 | Kumar Nalin M | Silencing of tgf-beta receptor type II expression by sirna |
| CA2536293A1 (en) | 2003-08-22 | 2005-03-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods of treating copd and pulmonary hypertension |
| WO2005113585A2 (en) | 2004-05-20 | 2005-12-01 | Acceleron Pharma Inc. | Modified tgf-beta superfamily polypeptides |
| EP1750746A1 (en) * | 2004-06-04 | 2007-02-14 | Regeneron Pharmaceuticals, Inc. | Methods of using il-1 antagonists to treat autoinflammatory disease |
| US7786261B2 (en) | 2004-09-02 | 2010-08-31 | National Research Council Of Canada | Coiled-coil fusion proteins comprising cell receptor domains |
| CN101084007A (zh) | 2004-09-22 | 2007-12-05 | 金齐姆公司 | TGF－β拮抗剂限制免疫抑制剂肾毒性的用途 |
| US7795389B2 (en) | 2004-09-28 | 2010-09-14 | The Board Of Regents Of The University Of Texas System | Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins |
| JP5481028B2 (ja) | 2004-10-13 | 2014-04-23 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | ウイルス関連リンパ増殖性障害を処置または予防するための方法 |
| WO2006086469A2 (en) | 2005-02-08 | 2006-08-17 | Genzyme Corporation | Antibodies to tgfbeta |
| JP5342834B2 (ja) | 2008-09-05 | 2013-11-13 | 日東電工株式会社 | 骨髄線維症処置剤 |
| ITMI20060181A1 (it) | 2006-02-03 | 2007-08-04 | Univ Padova | Modulatori del tgf-b e loro uso |
| US8454952B2 (en) | 2006-03-13 | 2013-06-04 | The Johns Hopkins University | Augmentation of endothelial thromboresistance |
| EP2029625A2 (en) | 2006-06-05 | 2009-03-04 | Novartis AG | Use of tgf-beta antagonists in treatment of parathyroid-related disorders |
| DK2083863T3 (da) | 2006-10-03 | 2015-06-22 | Genzyme Corp | Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi |
| ES2449753T3 (es) | 2007-03-19 | 2014-03-21 | National Research Council Of Canada | Proteínas de fusión que comprenden dos dominios de unión tgf-beta |
| EP2171062A1 (en) * | 2007-06-15 | 2010-04-07 | Genzyme Corporation | Fusion proteins containing two tgf-beta binding domains of tgf-beta type ii receptor |
| CA2697077C (en) | 2007-08-22 | 2012-10-16 | Irm Llc | 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors |
| WO2009092087A2 (en) | 2008-01-18 | 2009-07-23 | The Brigham And Women's Hospital, Inc. | Selective differentiation, identification, and modulation of human th17 cells |
| TWI672151B (zh) * | 2008-05-02 | 2019-09-21 | 艾西利羅製藥公司 | 調節血管新生與周圍細胞組成的方法與組合物 |
| WO2009143309A2 (en) | 2008-05-21 | 2009-11-26 | Trustees Of Dartmouth College | Female reproductive tract and anal prophylaxes |
| WO2009152610A1 (en) | 2008-06-20 | 2009-12-23 | The Royal Institution For The Advancement Of Learning/Mcgill University | Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof |
| AU2009262970A1 (en) * | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
| NZ590667A (en) * | 2008-07-02 | 2013-01-25 | Emergent Product Dev Seattle | Tgf-b antagonist multi-target binding proteins |
| EP2326670A4 (en) * | 2008-09-17 | 2014-04-16 | Nat Res Council Canada | HETERO MULTIVALENT BINDING AGENT FOR ELEMENTS OF THE TGF-BETA SUPERFAMILY |
| WO2010048273A2 (en) | 2008-10-21 | 2010-04-29 | President And Fellows Of Harvard College | Methods and compounds for treatment of neurodegenerative disorders |
| US8138142B2 (en) | 2009-01-13 | 2012-03-20 | Acceleron Pharma Inc. | Methods for increasing adiponectin in a patient in need thereof |
| CN102548617B (zh) * | 2009-03-30 | 2017-11-07 | 阿塞勒隆制药公司 | Bmp‑alk3拮抗剂和促进骨生长的用途 |
| WO2010129515A1 (en) | 2009-05-08 | 2010-11-11 | The United Satates Of America As Represented By The Secretary, Department Of Health & Human Services | Modulation of the tgf-beta and pi3k/akt pathways in the diagnosis and treatment of squamous cell carcinoma |
| WO2011088148A1 (en) | 2010-01-12 | 2011-07-21 | Isis Pharmaceuticals, Inc. | Modulation of transforming growth factor-beta 1 expression |
| CA3083324A1 (en) | 2010-03-05 | 2011-09-09 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| CN101852804B (zh) * | 2010-03-29 | 2013-06-12 | 中国医学科学院病原生物学研究所 | Gdf15蛋白的抗体的新用途 |
| US8080568B1 (en) | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
| MY165160A (en) | 2010-09-01 | 2018-02-28 | Genzyme Corp | TREATMENT OF MYOCARDIAL INFARCTION USING TGF-ß ANTAGONISTS |
| US20130287688A1 (en) | 2010-11-18 | 2013-10-31 | Xtuit Pharmaceuticals, Inc. | Novel compositions and uses of anti-hypertension agents for cancer therapy |
| US8800906B2 (en) | 2010-12-27 | 2014-08-12 | The Board Of Trustees Of The Leland Stanford Junior University | Use of transforming growth factor-beta neutralizing antibodies and fusion proteins thereof in treating pain |
| JP6062375B2 (ja) | 2011-01-06 | 2017-01-18 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | Ｔｇｆ−ベータ受容体ｉｉに結合するリガンド |
| DK2699590T3 (en) | 2011-04-20 | 2019-05-06 | Acceleron Pharma Inc | ENDOGLIN POLYPEPTIDES AND APPLICATIONS THEREOF |
| CN102850458B (zh) * | 2011-06-28 | 2014-10-01 | 华博生物医药技术（上海）有限公司 | 新型重组双功能融合蛋白及其制法和用途 |
| WO2013012648A1 (en) * | 2011-07-15 | 2013-01-24 | Emory University | Gdf15 in diagnostic and therapeutic applications |
| EP2739645B1 (en) | 2011-08-01 | 2018-12-19 | Tufts Medical Center, Inc. | Endoglin-specific antibody for use in a method of treating heart failure and related conditions |
| WO2013059879A1 (en) | 2011-10-26 | 2013-05-02 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
| CN110563850A (zh) | 2012-04-30 | 2019-12-13 | 比奥孔有限公司 | 靶向/免疫调节性融合蛋白及其制造方法 |
| US20150080320A1 (en) | 2012-05-16 | 2015-03-19 | Aadigen, Llc | Multi-target modulation for treating fibrosis and inflammatory conditions |
| PT2971048T (pt) | 2013-03-11 | 2019-02-06 | Genzyme Corp | Anticorpos anti-tgf-beta manipulados e fragmentos de ligação a antigénios |
| CA3081073C (en) | 2013-03-12 | 2023-09-12 | Biocon Ltd. | Fusion immunomodulatory proteins and methods for making same |
| CA2909701C (en) | 2013-04-17 | 2022-12-06 | Baylor College Of Medicine | Immunosuppressive tgf-.beta. signal converter |
| CA2921805C (en) | 2013-08-22 | 2023-03-07 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
| WO2015077540A2 (en) | 2013-11-21 | 2015-05-28 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating pulmonary hypertension |
| US9676863B2 (en) | 2014-02-10 | 2017-06-13 | Merck Patent Gmbh | Targeted TGFβ inhibitors |
| CA2949083C (en) | 2014-05-18 | 2023-10-10 | Children's Medical Center Corporation | Methods and compositions relating to exosomes |
| CN106413740A (zh) | 2014-06-13 | 2017-02-15 | 诺华股份有限公司 | 用于降低gdf‑15的serelaxin应用 |
| CN106794233B (zh) | 2014-08-01 | 2021-11-12 | 布里格姆及妇女医院股份有限公司 | 与肺动脉高压的治疗有关的组合物和方法 |
| US10227392B2 (en) | 2015-04-06 | 2019-03-12 | Acceleron Pharma Inc. | ALK7:ActRIIB heteromultimers and uses thereof |
| HK1256638A1 (zh) | 2015-08-04 | 2019-09-27 | Acceleron Pharma Inc. | 用於治疗骨髓增生性病症的方法 |
| US20200231652A1 (en) | 2015-08-31 | 2020-07-23 | National Research Council Of Canada | Tgf-b-receptor ectodomain fusion molecules and uses thereof |
| WO2017134592A1 (en) | 2016-02-03 | 2017-08-10 | Biocon Limited | Anti-cd20/immunomodulatory fusion proteins and methods for making same |
| EP3497130B1 (en) | 2016-08-12 | 2021-10-27 | Merck Patent GmbH | Combination therapy for cancer |
| CN118307682A (zh) | 2016-09-27 | 2024-07-09 | 埃皮辛特瑞柯斯公司 | 免疫调节性融合蛋白 |
| WO2018129331A1 (en) | 2017-01-07 | 2018-07-12 | Merck Patent Gmbh | Dosing regimens and dosage forms for targeted tgf-b inhibition |
| CN118255902A (zh) | 2017-03-02 | 2024-06-28 | 加拿大国家研究委员会 | TGF-β受体胞外域融合分子及其用途 |
| LT3628049T (lt) | 2017-05-04 | 2023-08-25 | Acceleron Pharma Inc. | Tgf-beta ii tipo receptoriaus sulieti baltymai ir jų panaudojimo būdai |
| EP3749682B1 (en) | 2018-02-09 | 2025-09-24 | Acceleron Pharma Inc. | Treating heterotopic ossification |
-
2014
- 2014-08-21 CA CA2921805A patent/CA2921805C/en active Active
- 2014-08-21 JP JP2016536456A patent/JP2016528295A/ja not_active Withdrawn
- 2014-08-21 CN CN201480057870.0A patent/CN105658672A/zh active Pending
- 2014-08-21 AU AU2014308751A patent/AU2014308751B2/en active Active
- 2014-08-21 WO PCT/US2014/052130 patent/WO2015027082A1/en not_active Ceased
- 2014-08-21 EP EP14837885.4A patent/EP3036262A4/en not_active Withdrawn
- 2014-08-21 HK HK16113935.3A patent/HK1225742A1/zh unknown
- 2014-08-21 HK HK16113925.5A patent/HK1225740A1/zh unknown
- 2014-08-21 EP EP20153745.3A patent/EP3705498B1/en active Active
- 2014-08-21 CN CN202310399163.0A patent/CN116655801A/zh active Pending
- 2014-08-21 US US14/465,182 patent/US20150056199A1/en not_active Abandoned
-
2016
- 2016-02-16 US US15/044,883 patent/US9809637B2/en active Active
-
2017
- 2017-09-25 US US15/714,015 patent/US10316076B2/en active Active
-
2019
- 2019-04-24 US US16/393,277 patent/US10981973B2/en active Active
- 2019-08-19 JP JP2019149750A patent/JP2019194270A/ja not_active Withdrawn
-
2020
- 2020-01-30 US US16/777,546 patent/US11008377B2/en active Active
- 2020-05-28 AU AU2020203514A patent/AU2020203514B2/en active Active
-
2021
- 2021-04-13 US US17/229,132 patent/US20210230252A1/en not_active Abandoned
- 2021-05-10 JP JP2021079785A patent/JP2021112212A/ja active Pending
-
2023
- 2023-11-24 JP JP2023199004A patent/JP2024015040A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016528295A5 (https=) | ||
| CN110573532B (zh) | TGF-β 受体胞外域融合分子及其用途 | |
| KR102668200B1 (ko) | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 | |
| US9493530B2 (en) | FGF21 mutants comprising a mutation at position 98, 171 and/or 180 | |
| EP3144320B1 (en) | Fc fusion proteins comprising novel linkers or arrangements | |
| Baldwin | Comparison of transferrin sequences from different species | |
| CN111100197B (zh) | 用于治疗或预防疾病的因子1蛋白、因子2蛋白及其抑制剂 | |
| EP2585098B1 (en) | Fzd8 extracellular domains and fzd8 extracellular domain fusion molecules for use in treating obesity and obesity-related disorders | |
| US10618949B2 (en) | Method and compositions for producing disulfide-linked trimeric TNF family of cytokines and their use | |
| JP2018519803A (ja) | 抗がん性融合ポリペプチド | |
| JP2008500373A5 (https=) | ||
| JP2006512894A5 (https=) | ||
| CN106687478A (zh) | 新的抗人Tie‑2抗体 | |
| EP3355908A1 (en) | Treatment of bile acid disorders | |
| JP2021522795A5 (https=) | ||
| JP2021522793A5 (https=) | ||
| ITFI20090006A1 (it) | Processo per la produzione di proteine di fusione polivalenti e polispecifiche utilizzando come struttura portante l'uteroglobina e prodotti cosi' ottenuti. | |
| US11377490B2 (en) | Method for treating cancer using disulfide-linked trimeric 4-1BBL | |
| EP2597102A1 (en) | A novel fusion protein comprising an antibody light chain and a polypeptide binding to IL-17 | |
| JPWO2021229076A5 (https=) | ||
| ES2956439T3 (es) | Proteína de fusión | |
| JP2023538902A (ja) | 操作されたリガンドを使用する材料及び方法 | |
| JPWO2019213446A5 (https=) | ||
| JPWO2019213442A5 (https=) | ||
| HK40029335A (en) | Factor 1 protein, factor 2 protein and inhibitors thereof for use in treating or preventing diseases |