JP2016528295A5 - - Google Patents
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- JP2016528295A5 JP2016528295A5 JP2016536456A JP2016536456A JP2016528295A5 JP 2016528295 A5 JP2016528295 A5 JP 2016528295A5 JP 2016536456 A JP2016536456 A JP 2016536456A JP 2016536456 A JP2016536456 A JP 2016536456A JP 2016528295 A5 JP2016528295 A5 JP 2016528295A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 92
- 229920001184 polypeptide Polymers 0.000 claims description 91
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 91
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 76
- 230000004927 fusion Effects 0.000 claims description 49
- 150000001413 amino acids Chemical class 0.000 claims description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
- 201000010099 disease Diseases 0.000 claims description 14
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims description 12
- 108091033319 polynucleotide Proteins 0.000 claims description 10
- 102000040430 polynucleotide Human genes 0.000 claims description 10
- 239000002157 polynucleotide Substances 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 7
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 7
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims description 6
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 6
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 6
- 239000000710 homodimer Substances 0.000 claims description 6
- 208000011580 syndromic disease Diseases 0.000 claims description 6
- 201000001320 Atherosclerosis Diseases 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 230000003176 fibrotic effect Effects 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 231100000241 scar Toxicity 0.000 claims description 4
- 230000002784 sclerotic effect Effects 0.000 claims description 4
- 206010005949 Bone cancer Diseases 0.000 claims description 2
- 208000018084 Bone neoplasm Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 2
- 108091026890 Coding region Proteins 0.000 claims description 2
- 201000003066 Diffuse Scleroderma Diseases 0.000 claims description 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 2
- 206010019280 Heart failures Diseases 0.000 claims description 2
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims description 2
- 208000001826 Marfan syndrome Diseases 0.000 claims description 2
- 208000032056 Radiation Fibrosis Syndrome Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 102000007562 Serum Albumin Human genes 0.000 claims description 2
- 108010071390 Serum Albumin Proteins 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 2
- 201000008982 Thoracic Aortic Aneurysm Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 206010047141 Vasodilatation Diseases 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 208000007474 aortic aneurysm Diseases 0.000 claims description 2
- 230000036755 cellular response Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000009918 complex formation Effects 0.000 claims description 2
- 208000003457 familial thoracic 1 aortic aneurysm Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 230000013595 glycosylation Effects 0.000 claims description 2
- 238000006206 glycosylation reaction Methods 0.000 claims description 2
- 208000019622 heart disease Diseases 0.000 claims description 2
- 230000002008 hemorrhagic effect Effects 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims description 2
- 201000002313 intestinal cancer Diseases 0.000 claims description 2
- 125000003473 lipid group Chemical group 0.000 claims description 2
- 230000004807 localization Effects 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 206010028537 myelofibrosis Diseases 0.000 claims description 2
- 210000005036 nerve Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 201000011461 pre-eclampsia Diseases 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 208000037803 restenosis Diseases 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 11
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 2
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 2
- 102000056172 Transforming growth factor beta-3 Human genes 0.000 claims 2
- 108090000097 Transforming growth factor beta-3 Proteins 0.000 claims 2
- 229940099456 transforming growth factor beta 1 Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 description 12
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 239000012634 fragment Substances 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 238000010494 dissociation reaction Methods 0.000 description 3
- 230000005593 dissociations Effects 0.000 description 3
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 102000046181 human GDF15 Human genes 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361868713P | 2013-08-22 | 2013-08-22 | |
| US61/868,713 | 2013-08-22 | ||
| US201361906270P | 2013-11-19 | 2013-11-19 | |
| US61/906,270 | 2013-11-19 | ||
| US201361906849P | 2013-11-20 | 2013-11-20 | |
| US61/906,849 | 2013-11-20 | ||
| PCT/US2014/052130 WO2015027082A1 (en) | 2013-08-22 | 2014-08-21 | Tgf-beta receptor type ii variants and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019149750A Division JP2019194270A (ja) | 2013-08-22 | 2019-08-19 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016528295A JP2016528295A (ja) | 2016-09-15 |
| JP2016528295A5 true JP2016528295A5 (enExample) | 2017-09-28 |
Family
ID=52480573
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536456A Withdrawn JP2016528295A (ja) | 2013-08-22 | 2014-08-21 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
| JP2019149750A Withdrawn JP2019194270A (ja) | 2013-08-22 | 2019-08-19 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
| JP2021079785A Active JP7881284B2 (ja) | 2013-08-22 | 2021-05-10 | Ｔｇｆ－ベータ受容体ｉｉ型変異体およびその使用 |
| JP2023199004A Pending JP2024015040A (ja) | 2013-08-22 | 2023-11-24 | Ｔｇｆ－ベータ受容体ｉｉ型変異体およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019149750A Withdrawn JP2019194270A (ja) | 2013-08-22 | 2019-08-19 | Ｔｇｆ−ベータ受容体ｉｉ型変異体およびその使用 |
| JP2021079785A Active JP7881284B2 (ja) | 2013-08-22 | 2021-05-10 | Ｔｇｆ－ベータ受容体ｉｉ型変異体およびその使用 |
| JP2023199004A Pending JP2024015040A (ja) | 2013-08-22 | 2023-11-24 | Ｔｇｆ－ベータ受容体ｉｉ型変異体およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US20150056199A1 (enExample) |
| EP (3) | EP3036262A4 (enExample) |
| JP (4) | JP2016528295A (enExample) |
| CN (2) | CN105658672A (enExample) |
| AU (2) | AU2014308751B2 (enExample) |
| CA (1) | CA2921805C (enExample) |
| ES (1) | ES3070098T3 (enExample) |
| HK (2) | HK1225742A1 (enExample) |
| WO (1) | WO2015027082A1 (enExample) |
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| CN120919282A (zh) | 2013-11-21 | 2025-11-11 | 布里格姆及妇女医院股份有限公司 | 用于治疗肺高压的组合物和方法 |
| CN106794233B (zh) * | 2014-08-01 | 2021-11-12 | 布里格姆及妇女医院股份有限公司 | 与肺动脉高压的治疗有关的组合物和方法 |
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| CN113683708A (zh) | 2015-04-06 | 2021-11-23 | 阿塞勒隆制药公司 | 单臂i型和ii型受体融合蛋白和其用途 |
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2014
- 2014-08-21 HK HK16113935.3A patent/HK1225742A1/zh unknown
- 2014-08-21 WO PCT/US2014/052130 patent/WO2015027082A1/en not_active Ceased
- 2014-08-21 ES ES20153745T patent/ES3070098T3/es active Active
- 2014-08-21 CN CN201480057870.0A patent/CN105658672A/zh active Pending
- 2014-08-21 EP EP14837885.4A patent/EP3036262A4/en not_active Withdrawn
- 2014-08-21 AU AU2014308751A patent/AU2014308751B2/en active Active
- 2014-08-21 CA CA2921805A patent/CA2921805C/en active Active
- 2014-08-21 EP EP26152357.5A patent/EP4775215A2/en active Pending
- 2014-08-21 US US14/465,182 patent/US20150056199A1/en not_active Abandoned
- 2014-08-21 JP JP2016536456A patent/JP2016528295A/ja not_active Withdrawn
- 2014-08-21 HK HK16113925.5A patent/HK1225740A1/zh unknown
- 2014-08-21 EP EP20153745.3A patent/EP3705498B1/en active Active
- 2014-08-21 CN CN202310399163.0A patent/CN116655801A/zh active Pending
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2016
- 2016-02-16 US US15/044,883 patent/US9809637B2/en active Active
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2017
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- 2019-08-19 JP JP2019149750A patent/JP2019194270A/ja not_active Withdrawn
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2020
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- 2020-05-28 AU AU2020203514A patent/AU2020203514B2/en active Active
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2021
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- 2021-05-10 JP JP2021079785A patent/JP7881284B2/ja active Active
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2023
- 2023-11-24 JP JP2023199004A patent/JP2024015040A/ja active Pending
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