ES2191007T3 - Receptor tipo iii de tgf-beta, cdna que lo codifica y sus usos. - Google Patents

Receptor tipo iii de tgf-beta, cdna que lo codifica y sus usos.

Info

Publication number
ES2191007T3
ES2191007T3 ES92924163T ES92924163T ES2191007T3 ES 2191007 T3 ES2191007 T3 ES 2191007T3 ES 92924163 T ES92924163 T ES 92924163T ES 92924163 T ES92924163 T ES 92924163T ES 2191007 T3 ES2191007 T3 ES 2191007T3
Authority
ES
Spain
Prior art keywords
tgf
beta
codifies
type iii
receiver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92924163T
Other languages
English (en)
Inventor
Herbert Y Lin
Xiao-Fan Wang
Robert A Weinberg
Harvey F Lodish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitehead Institute for Biomedical Research
Original Assignee
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25137484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2191007(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Whitehead Institute for Biomedical Research filed Critical Whitehead Institute for Biomedical Research
Application granted granted Critical
Publication of ES2191007T3 publication Critical patent/ES2191007T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PRESENTAN UN DNA QUE CODIFICA UN RECEPTOR DEL TGF-(BETA) DEL TIPO III DE ORIGEN MAMIFERO, UN DNA QUE CODIFICA UN RECEPTOR DE TGF-(BETA) DE TIPO II DE ORIGEN MAMIFERO, UN RECEPTOR DE TGF-(BETA) DE TIPO III, Y UN RECEPTOR DEL TGF-(BETA) DE TIPO II Y USOS DE LOS MISMOS.
ES92924163T 1991-10-31 1992-10-30 Receptor tipo iii de tgf-beta, cdna que lo codifica y sus usos. Expired - Lifetime ES2191007T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78606391A 1991-10-31 1991-10-31

Publications (1)

Publication Number Publication Date
ES2191007T3 true ES2191007T3 (es) 2003-09-01

Family

ID=25137484

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92924163T Expired - Lifetime ES2191007T3 (es) 1991-10-31 1992-10-30 Receptor tipo iii de tgf-beta, cdna que lo codifica y sus usos.

Country Status (9)

Country Link
US (7) US6010872A (es)
EP (2) EP0610427B1 (es)
JP (2) JP4124815B2 (es)
AU (1) AU671606B2 (es)
CA (1) CA2122491A1 (es)
DE (1) DE69232986T2 (es)
ES (1) ES2191007T3 (es)
HK (1) HK1040744A1 (es)
WO (1) WO1993009228A1 (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5843775A (en) * 1992-09-03 1998-12-01 Regeneron Pharmaceuticals, Inc. Human dorsal tissue affecting factor (noggin) and nucleic acids encoding same
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
CA2146973C (en) * 1992-10-29 2008-09-02 Patricia R. Segarini Uses of tgf-.beta. receptor fragment as a therapeutic agent
WO1994026303A1 (en) * 1993-05-13 1994-11-24 Neorx Corporation Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
WO1995006656A1 (en) * 1993-09-03 1995-03-09 The Regents Of The University Of California Neural tissue affecting factor and compositions
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
DE69434651T2 (de) 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US6306622B1 (en) 1994-11-04 2001-10-23 The Procter & Gamble Co. cDNA encoding a BMP type II receptor
US6210899B1 (en) 1994-11-04 2001-04-03 The Procter & Gamble Company Use of a BMP protein receptor complex for screening bone metabolism actives and cells co-transfected with a type II BMP receptor and type I BMP receptor
US5824655A (en) * 1995-02-15 1998-10-20 The University Of Utah Anti-transforming growth factor-β gene therapy
US5866323A (en) 1995-04-07 1999-02-02 Case Western Reserve University Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
US5780436A (en) * 1995-05-01 1998-07-14 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US5661127A (en) * 1995-05-01 1997-08-26 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US6638912B2 (en) 1995-05-01 2003-10-28 The Regents Of The University Of California Peptide compositions mimicking TGF-β activity
GB2304045A (en) † 1995-08-04 1997-03-12 Univ Manchester Betaglycan compositions for promoting the healing of wounds and fibrotic diseases
WO1998046588A2 (en) 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
ATE271886T1 (de) 1999-10-15 2004-08-15 Inst Genetics Llc Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
JP2001206899A (ja) 1999-11-18 2001-07-31 Japan Tobacco Inc ＴＧＦ−βＩＩ型受容体に対するヒトモノクローナル抗体及びその医薬用途
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
EP1478354A4 (en) * 2002-01-22 2008-09-24 Genzyme Corp USE OF TGF-BETA ANTAGONISTS IN THE TREATMENT OR PREVENTION OF CHRONIC RELEASE OF TRANSPLANT
US20070184052A1 (en) * 2003-05-09 2007-08-09 Lin Herbert Y Soluble tgf-b type III receptor fusion proteins
US8058077B2 (en) * 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
JP4543189B2 (ja) * 2004-03-10 2010-09-15 学校法人日本医科大学 ＴＧＦβ１レセプターＩＩ型に対するＲＮＡｉとして作用するＲＮＡ配列
CA2561686C (en) 2004-03-31 2014-12-02 Genentech, Inc. Humanized anti-tgf-beta antibodies
JP4706193B2 (ja) * 2004-05-27 2011-06-22 国立大学法人 長崎大学 マルファン症候群の分析のためのプローブの使用、スクリーニング方法およびキット
JP5481028B2 (ja) * 2004-10-13 2014-04-23 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション ウイルス関連リンパ増殖性障害を処置または予防するための方法
JP2007043918A (ja) * 2005-08-08 2007-02-22 Medeinetto:Kk 腫瘍成長因子β受容体発現細胞株
WO2007050793A2 (en) 2005-10-25 2007-05-03 The Johns Hopkins University Methods and compositions for the treatment of marfan syndrome and associated disorders
EP2230252A1 (en) 2006-03-13 2010-09-22 The Johns Hopkins University Augmentation of endothelial thromboresistance
EP2918288B1 (en) 2006-10-03 2017-08-16 Genzyme Corporation Use of TGF beta antagonists to treat infants at risk of developing bronchopulmonary dysplasia
WO2009152610A1 (en) * 2008-06-20 2009-12-23 The Royal Institution For The Advancement Of Learning/Mcgill University Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof
JO3096B1 (ar) * 2008-11-07 2017-03-15 Imclone Llc الأجسام المضادة لمستقبل ii مضاد tgfb
JP2011045339A (ja) * 2009-08-28 2011-03-10 Univ Of Tokyo ＴＧＦ−βＩＩ型受容体に結合する核酸およびその使用
TR201816180T4 (tr) 2010-03-12 2018-11-21 Genzyme Corp Meme kanserini tedavi etmek için kombinasyonlu tedavi.
CA2823154A1 (en) 2010-12-27 2012-07-05 Lsip, Llc Ips cells and method for generating same
US20140308275A1 (en) 2011-07-27 2014-10-16 Inserm (Institut National De La Sante Et De La Recherche Medicale Methods for diagnosing and treating myhre syndrome
BR112014009789A2 (pt) 2011-10-26 2017-04-25 Seattle Children's Res Inst cisteamina no tratamento da doença fibrótica
EP2799537B1 (en) 2011-12-28 2021-09-22 Kyoto Prefectural Public University Corporation Normalization of culture of corneal endothelial cells
PL2971048T4 (pl) 2013-03-11 2019-05-31 Genzyme Corp Zmodyfikowane przeciwciała anty-TGF-beta i fragmenty wiążące antygen
AU2014308751B2 (en) 2013-08-22 2020-03-05 Acceleron Pharma, Inc. TGF-beta receptor type II variants and uses thereof
WO2015064768A1 (ja) 2013-10-31 2015-05-07 京都府公立大学法人 角膜内皮の小胞体細胞死関連疾患治療薬
AR098827A1 (es) 2013-12-19 2016-06-15 Consejo Nac De Investig Científicas Y Técnicas (Conicet) ISOFORMA DEL RECEPTOR II DE TGF-b, POLINUCLEÓTIDOS QUE LA CODIFICAN VECTORES, CÉLULAS TRANSFORMADAS, PÉPTIDOS Y DE FUSIÓN, MÉTODO Y USOS
US10882903B2 (en) 2015-05-18 2021-01-05 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and compositions for treating an alphavirus infection
CN116327952A (zh) 2015-08-04 2023-06-27 阿塞勒隆制药公司 用于治疗骨髓增生性病症的方法
BR112019023071A2 (pt) 2017-05-04 2020-06-09 Acceleron Pharma Inc proteínas de fusão do receptor tgf-beta do tipo ii e uso das mesmas
AU2018264455B2 (en) 2017-05-12 2024-12-12 Jiangsu Hengrui Medicine Co., Ltd. Fusion protein containing TGF-beta receptor and medicinal uses thereof
WO2019173324A1 (en) 2018-03-06 2019-09-12 The Trustees Of The University Of Pennsylvania Prostate-specific membrane antigen cars and methods of use thereof
TWI809130B (zh) 2018-06-22 2023-07-21 美商凱特製藥公司 嵌合跨膜蛋白及其用途
TWI829799B (zh) 2018-11-09 2024-01-21 大陸商江蘇恆瑞醫藥股份有限公司 一種TGF-β受體融合蛋白醫藥組成物及其用途
US20220177978A1 (en) 2019-04-02 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
US12109235B2 (en) 2019-06-21 2024-10-08 Kite Pharma, Inc. TGF-beta receptors and methods of use
JP7766672B2 (ja) 2020-07-24 2025-11-10 ▲邁▼威（上海）生物科技股▲フン▼有限公司 ＴＧＦ－β ＲＩＩ突然変異体及びその融合タンパク質
CN117730100A (zh) 2021-06-08 2024-03-19 凯德药业股份有限公司 Gpc3结合分子

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2002011A1 (en) * 1988-11-14 1990-05-14 Anthony F. Purchio Normal human growth regulatory receptor for tgf-beta
CA2146973C (en) * 1992-10-29 2008-09-02 Patricia R. Segarini Uses of tgf-.beta. receptor fragment as a therapeutic agent

Also Published As

Publication number Publication date
DE69232986D1 (de) 2003-05-08
AU671606B2 (en) 1996-09-05
WO1993009228A1 (en) 1993-05-13
JP2006055164A (ja) 2006-03-02
US20080234216A1 (en) 2008-09-25
US20060247198A1 (en) 2006-11-02
EP0610427B1 (en) 2003-04-02
JP4185512B2 (ja) 2008-11-26
US6201108B1 (en) 2001-03-13
US20050260579A1 (en) 2005-11-24
AU3057892A (en) 1993-06-07
EP1149908A1 (en) 2001-10-31
US6046157A (en) 2000-04-04
HK1040744A1 (en) 2002-06-21
EP0610427A1 (en) 1994-08-17
JP4124815B2 (ja) 2008-07-23
US6086867A (en) 2000-07-11
DE69232986T2 (de) 2003-12-11
US6010872A (en) 2000-01-04
CA2122491A1 (en) 1993-05-13
JPH07501212A (ja) 1995-02-09

Similar Documents

Publication Publication Date Title
ES2022873B3 (es) Termoplasticos de ingenieria que contienen grupos de benzociclobuteno unidos.
BR8702533A (pt) Mecanismo prendedor de manga corredica
NO874489L (no) Bicykliske forbindelser.
ES2111031T3 (es) Uso de preparaciones que contienen anticuerpos para la inmunosupresion.
FI885733L (fi) Stabiliserat zirkonium dess framstaellning och anvaendning i keramiska kompositioner.
DE3789206D1 (de) Pendelrückkopplungs-Detektor.
DK0467026T3 (da) Middel til farvning af hår og anvendelse af midlet
ES511428A0 (es) Un receptor optico.
ES522683A0 (es) Detector de humos basado en el principado de la extincion de radiacion.
DE3776159D1 (de) Feuerdetektor.
NL183733C (nl) Verbindingsmof.
ES2076595T3 (es) Derivados de amidinofenilalanina, procedimiento para su preparacion, su empleo y agentes que los contienen.
DE3788585D1 (de) Flüssige Brennstoffzusammensetzungen.
DE3782773D1 (de) Fluessige brennstoffzusammensetzungen.
NO873816D0 (no) Tricykliske forbindelser.
DE3773321D1 (de) Fasswaage.
MX9303444A (es) Polinucleotidos aislados que codifican para una familia de receptores del sistema nervioso central humano.
DE3784246D1 (de) Lichtempfindliche haertbare zusammensetzungen.
MX9101435A (es) Sistema de comunicacion submarina con uso del medio ambiente fisico
DE3774914D1 (de) Schnellkupplung fuer fallschirm.
DE3779991D1 (de) Dioxopiperidin-derivate enthaltende anxiolytische zusammensetzungen.
MX9101436A (es) Sistema de comunicacion submarina con uso del medio ambiente fisico
DE68903162D1 (de) Reaktionsgefaess.
DE3789942D1 (de) Projektionsröhre.
NO162444C (no) Hurtigmonterbar knappanordning.