AR098827A1 - ISOFORMA DEL RECEPTOR II DE TGF-b, POLINUCLEÓTIDOS QUE LA CODIFICAN VECTORES, CÉLULAS TRANSFORMADAS, PÉPTIDOS Y DE FUSIÓN, MÉTODO Y USOS - Google Patents

ISOFORMA DEL RECEPTOR II DE TGF-b, POLINUCLEÓTIDOS QUE LA CODIFICAN VECTORES, CÉLULAS TRANSFORMADAS, PÉPTIDOS Y DE FUSIÓN, MÉTODO Y USOS

Info

Publication number
AR098827A1
AR098827A1 ARP140104755A ARP140104755A AR098827A1 AR 098827 A1 AR098827 A1 AR 098827A1 AR P140104755 A ARP140104755 A AR P140104755A AR P140104755 A ARP140104755 A AR P140104755A AR 098827 A1 AR098827 A1 AR 098827A1
Authority
AR
Argentina
Prior art keywords
isoform
tgf
polynucleotides
peptides
fusion
Prior art date
Application number
ARP140104755A
Other languages
English (en)
Inventor
Alfredo Dewey Ricardo
Jorge Velasco Zamora Benito
Carrea Alejandra
Melina Rodrguez Tania
Nancy Chisari Andrea
Javier Perone Marcelo
Original Assignee
Consejo Nac De Investig Científicas Y Técnicas (Conicet)
Fundación Articular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361917974P priority Critical
Application filed by Consejo Nac De Investig Científicas Y Técnicas (Conicet), Fundación Articular filed Critical Consejo Nac De Investig Científicas Y Técnicas (Conicet)
Publication of AR098827A1 publication Critical patent/AR098827A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse Transcribing RNA Viruses
    • C12N2740/00011Reverse Transcribing RNA Viruses
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16041Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Abstract

Una isoforma del receptor II de TGF b que comprende una secuencia de alrededor de 80 aminoácidos y carece del dominio transmembrana; en donde la isoforma es agonista de TGFb-1. La isoforma comprende a la secuencia de aminoácidos SEQ ID Nº 12. La isoforma puede tener la secuencia de aminoácidos SEQ ID Nº 2 o secuencias que tienen al menos un 85% de identidad de secuencia con la secuencia SEQ ID Nº 2. Reivindicación 5: El polinucleótido de acuerdo con la reivindicación 4, caracterizado porque comprende una secuencia de nucleótidos que tiene al menos un 90% de identidad con la secuencia de nucleótidos SEQ ID Nº 1. Reivindicación 20: Un método de tratamiento de enfermedades asociadas a la desregulación de TGF-b, caracterizado porque comprende administrar a un mamífero que lo necesite el anticuerpo de la reivindicación 17.
ARP140104755A 2013-12-19 2014-12-18 ISOFORMA DEL RECEPTOR II DE TGF-b, POLINUCLEÓTIDOS QUE LA CODIFICAN VECTORES, CÉLULAS TRANSFORMADAS, PÉPTIDOS Y DE FUSIÓN, MÉTODO Y USOS AR098827A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US201361917974P true 2013-12-19 2013-12-19

Publications (1)

Publication Number Publication Date
AR098827A1 true AR098827A1 (es) 2016-06-15

Family

ID=53403721

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140104755A AR098827A1 (es) 2013-12-19 2014-12-18 ISOFORMA DEL RECEPTOR II DE TGF-b, POLINUCLEÓTIDOS QUE LA CODIFICAN VECTORES, CÉLULAS TRANSFORMADAS, PÉPTIDOS Y DE FUSIÓN, MÉTODO Y USOS

Country Status (5)

Country Link
US (1) US10233227B2 (es)
EP (1) EP3082846B1 (es)
AR (1) AR098827A1 (es)
ES (1) ES2749615T3 (es)
WO (1) WO2015095628A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR107780A1 (es) * 2016-11-14 2018-06-06 Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet Método para determinar la actividad de enfermedades autoinmunes y kit
CN110372800A (zh) * 2019-08-27 2019-10-25 南京安吉生物科技有限公司 具有多功能活性的融合多肽及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008011A (en) 1991-10-31 1999-12-28 Whitehead Institute For Biomedical Research TGF-β type II receptor cDNAs
DE69232986T2 (de) 1991-10-31 2003-12-11 Whitehead Biomedical Inst TGF-BETA TYP III REZEPTOR, DAFüR KODIERENDE CDNS UND DEREN VERWENDUNG
WO1994009815A1 (en) 1992-10-29 1994-05-11 Celtrix Pharmaceuticals, Inc. USES OF TGF-β RECEPTOR FRAGMENT AS A THERAPEUTIC AGENT
US6395494B1 (en) * 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
CA2286933A1 (en) 1997-04-18 1998-10-29 Biogen, Inc. Type ii tgf-beta receptor/immunoglobulin constant region fusion proteins
JP2001206899A (ja) * 1999-11-18 2001-07-31 Japan Tobacco Inc TGF−βII型受容体に対するヒトモノクローナル抗体及びその医薬用途
US20030028905A1 (en) * 2001-07-31 2003-02-06 Petra Knaus Mutant forms of the TGF-beta type II receptor which bind all TGF-beta isoforms
AU2002357362A1 (en) * 2001-12-21 2003-07-30 The Regents Of The University Of California USE OF SOLUBLE TYPE II TGF-Beta RECEPTOR TO SUPPRESS PANCREATIC CANCER GROWTH AND METASTASIS
WO2008157367A1 (en) 2007-06-15 2008-12-24 Genzyme Corporation Fusion proteins containing two tgf-beta binding domains of tgf-beta type ii receptor
CN102850458B (zh) * 2011-06-28 2014-10-01 华博生物医药技术(上海)有限公司 新型重组双功能融合蛋白及其制法和用途

Also Published As

Publication number Publication date
WO2015095628A8 (en) 2016-09-29
EP3082846A4 (en) 2017-09-20
US10233227B2 (en) 2019-03-19
EP3082846B1 (en) 2019-07-17
US20160318989A1 (en) 2016-11-03
EP3082846A1 (en) 2016-10-26
WO2015095628A1 (en) 2015-06-25
ES2749615T3 (es) 2020-03-23

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