ES2586418T3 - Vacuna de proteína de fusión - Google Patents

Vacuna de proteína de fusión Download PDF

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Publication number
ES2586418T3
ES2586418T3 ES08724181.6T ES08724181T ES2586418T3 ES 2586418 T3 ES2586418 T3 ES 2586418T3 ES 08724181 T ES08724181 T ES 08724181T ES 2586418 T3 ES2586418 T3 ES 2586418T3
Authority
ES
Spain
Prior art keywords
amino acid
fusion protein
acid sequence
protein vaccine
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08724181.6T
Other languages
English (en)
Inventor
Gunnar Lindahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minervax Aps
Original Assignee
Minervax Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minervax Aps filed Critical Minervax Aps
Application granted granted Critical
Publication of ES2586418T3 publication Critical patent/ES2586418T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Una proteína de fusión que comprende al menos dos secuencias de aminoácidos, donde dichas dos secuencias de aminoácidos consisten en una primera secuencia de aminoácidos que tiene al menos el 90% de identidad de secuencia con una secuencia de aminoácidos tal como se muestra en la SEQ ID NO: 2, fusionada con una segunda secuencia de aminoácidos que tiene al menos el 90% de identidad de secuencia con una secuencia de aminoácidos tal como se muestra en la SEQ ID NO: 4, donde dicha proteína de fusión es capaz de conferir inmunidad protectora contra el estreptococo del grupo B.

Description

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Claims (1)

  1. imagen1
ES08724181.6T 2007-04-16 2008-04-14 Vacuna de proteína de fusión Active ES2586418T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0700919 2007-04-16
SE0700919 2007-04-16
US94047307P 2007-05-29 2007-05-29
US940473P 2007-05-29
PCT/SE2008/000270 WO2008127179A1 (en) 2007-04-16 2008-04-14 Fusion protein vaccine

Publications (1)

Publication Number Publication Date
ES2586418T3 true ES2586418T3 (es) 2016-10-14

Family

ID=39864173

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08724181.6T Active ES2586418T3 (es) 2007-04-16 2008-04-14 Vacuna de proteína de fusión

Country Status (15)

Country Link
US (1) US8313748B2 (es)
EP (1) EP2144924B1 (es)
CN (1) CN101855238B (es)
CA (1) CA2684494C (es)
CY (1) CY1117896T1 (es)
DK (1) DK2144924T3 (es)
ES (1) ES2586418T3 (es)
HR (1) HRP20160995T1 (es)
HU (1) HUE028253T2 (es)
LT (1) LT2144924T (es)
PL (1) PL2144924T3 (es)
PT (1) PT2144924T (es)
RU (1) RU2487890C2 (es)
SI (1) SI2144924T1 (es)
WO (1) WO2008127179A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014018904A1 (en) * 2012-07-26 2014-01-30 Genocea Biosciences, Inc. Fused antigen vaccines and compositions against streptococcus pneumoniae
ES2848048T3 (es) 2012-10-03 2021-08-05 Glaxosmithkline Biologicals Sa Composiciones inmunogénicas
CN103694323B (zh) * 2013-12-09 2017-01-18 成都欧林生物科技股份有限公司 金黄色葡萄球菌MntC重组蛋白及其制备方法和应用
EP3365003A1 (en) 2015-10-21 2018-08-29 Minervax APS Immunogenic fusion protein
US10888610B2 (en) * 2015-12-30 2021-01-12 Minerv Ax Aps Immunogenic complex for eliciting protective immunity against group b streptococcus
CA3066020A1 (en) 2017-06-16 2018-12-20 Glaxosmithkline Biologicals Sa Method of treatment
CN114728051A (zh) 2019-11-22 2022-07-08 葛兰素史克生物有限公司 细菌糖糖缀合物疫苗的剂量和施用
WO2021250626A2 (en) 2020-06-12 2021-12-16 Glaxosmithkline Biologicals Sa Dock tag system
WO2021250625A2 (en) 2020-06-12 2021-12-16 Glaxosmithkline Biologicals Sa Gbs ferritin nanoparticles
EP4066854A1 (en) 2021-03-29 2022-10-05 MinervaX Immunogenic fusion protein
CN114437235B (zh) * 2022-01-04 2024-02-09 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 马链球菌马亚种8种蛋白的重组融合蛋白及其制备方法和应用
CN116478953B (zh) * 2023-06-14 2023-09-12 四川大学华西医院 鲍曼不动杆菌DlaT重组蛋白、制备方法及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225579A (en) * 1979-02-27 1980-09-30 Israel Kleinberg Means and method for improving defenses against caries
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
WO1994001031A1 (fr) 1992-07-02 1994-01-20 Paul Charvet Appareil de cuisson dans l'huile a chauffage au gaz
ATE214601T1 (de) * 1992-09-16 2002-04-15 Univ Tennessee Res Corp Rekombinantes vielwertiges m-protein-vakzin
IL107458A0 (en) 1992-11-02 1994-02-27 Gen Hospital Corp Conjugate vaccine against group b streptococcus
DE69432658T2 (de) * 1993-03-19 2004-04-08 Gunnar Lindahl Rib-protein, ein oberflächenprotein welches immunität gegen viele streptococcus-stämme der gruppe b verleiht, reinigungsverfahren für das rib-protein, testsatz und pharmazeutische zusammenstellung (arznei)
US6355255B1 (en) * 1998-12-07 2002-03-12 Regents Of The University Of Minnesota Streptococcal C5a peptidase vaccine
US6426074B1 (en) 1997-03-19 2002-07-30 The Brigham And Women's Hospital Inc. Group B Streptococcus vaccine
GB9808932D0 (en) * 1998-04-27 1998-06-24 Chiron Spa Polyepitope carrier protein
EP1601689B1 (en) * 2003-03-13 2007-11-28 GlaxoSmithKline Biologicals S.A. Purification process for bacterial cytolysin
CA2537742C (en) * 2003-09-15 2014-07-22 Chiron Corporation Immunogenic compositions for streptococcus agalactiae

Also Published As

Publication number Publication date
PL2144924T3 (pl) 2017-06-30
RU2009142976A (ru) 2011-05-27
WO2008127179A8 (en) 2009-07-23
HUE028253T2 (en) 2017-02-28
RU2487890C2 (ru) 2013-07-20
EP2144924A1 (en) 2010-01-20
SI2144924T1 (sl) 2016-12-30
WO2008127179A1 (en) 2008-10-23
CY1117896T1 (el) 2017-05-17
CN101855238A (zh) 2010-10-06
CA2684494A1 (en) 2008-10-23
HRP20160995T1 (hr) 2016-10-21
DK2144924T3 (en) 2016-08-22
PT2144924T (pt) 2016-08-17
LT2144924T (lt) 2016-10-10
EP2144924A4 (en) 2010-08-25
CA2684494C (en) 2016-07-05
CN101855238B (zh) 2014-09-17
US20100062015A1 (en) 2010-03-11
US8313748B2 (en) 2012-11-20
EP2144924B1 (en) 2016-05-11

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