|
CA2647846C
(en)
|
2006-03-31 |
2016-06-21 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
PL2202245T3
(pl)
|
2007-09-26 |
2017-02-28 |
Chugai Seiyaku Kabushiki Kaisha |
Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr
|
|
KR102269708B1
(ko)
|
2008-04-11 |
2021-06-25 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
WO2012016227A2
(en)
|
2010-07-29 |
2012-02-02 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
|
EP4231014A3
(en)
|
2010-11-30 |
2024-08-14 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
EP2889376A4
(en)
|
2012-08-24 |
2016-11-02 |
Chugai Pharmaceutical Co Ltd |
ANTIBODIES Fc SPECIFIC TO FCTRII OF MOUSE
|
|
SG10201709559PA
(en)
|
2012-08-24 |
2017-12-28 |
Chugai Pharmaceutical Co Ltd |
Fcγriib-specific fc region variant
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
HRP20191865T1
(hr)
|
2013-01-14 |
2020-01-10 |
Xencor, Inc. |
Novi heterodimerni proteini
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
CA2897987A1
(en)
|
2013-01-15 |
2014-07-24 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
WO2014145159A2
(en)
*
|
2013-03-15 |
2014-09-18 |
Permeon Biologics, Inc. |
Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
DK2970486T3
(en)
|
2013-03-15 |
2018-08-06 |
Xencor Inc |
MODULATION OF T-CELLS WITH BISPECIFIC ANTIBODIES AND FC-FUSIONS
|
|
EP3424952A1
(en)
|
2013-03-15 |
2019-01-09 |
Amgen, Inc |
Heterodimeric bispecific antibodies
|
|
LT2951203T
(lt)
|
2013-03-15 |
2019-09-10 |
Xencor, Inc. |
Heterodimeriniai baltymai
|
|
CN105246914B
(zh)
|
2013-04-02 |
2021-08-27 |
中外制药株式会社 |
Fc区变体
|
|
CA2922979A1
(en)
|
2013-09-03 |
2015-03-12 |
Novimmune S.A. |
Readily isolated bispecific binding molecules with native format having mutated constant regions
|
|
EP3176185A1
(en)
*
|
2013-11-04 |
2017-06-07 |
Glenmark Pharmaceuticals S.A. |
Production of t cell retargeting hetero-dimeric immunoglobulins
|
|
SG11201607983YA
(en)
|
2014-03-28 |
2016-10-28 |
Xencor Inc |
Bispecific antibodies that bind to cd38 and cd3
|
|
CU20170041A7
(es)
|
2014-09-26 |
2017-09-06 |
Macrogenics Inc |
Diacuerpos monovalentes biespecíficos que son capaces de unir cd19 y cd3
|
|
CN107250158B
(zh)
*
|
2014-11-19 |
2022-03-25 |
基因泰克公司 |
抗转铁蛋白受体/抗bace1多特异性抗体和使用方法
|
|
EP3845565A3
(en)
|
2014-11-19 |
2021-09-08 |
Genentech, Inc. |
Antibodies against bace1 and use thereof for neural disease immunotherapy
|
|
WO2016086186A2
(en)
*
|
2014-11-26 |
2016-06-02 |
Xencor, Inc. |
Heterodimeric antibodies including binding to cd8
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
RS62332B1
(sr)
|
2014-11-26 |
2021-10-29 |
Xencor Inc |
Heterodimerna antitela koja vezuju cd3 i cd20
|
|
CN107406512A
(zh)
|
2014-11-26 |
2017-11-28 |
Xencor公司 |
结合cd3和cd38的异二聚体抗体
|
|
IL278014B2
(en)
|
2014-12-19 |
2023-10-01 |
Chugai Pharmaceutical Co Ltd |
Anti-myostatin antibodies, polypeptides containing variable FC regions and methods of use
|
|
US10428155B2
(en)
|
2014-12-22 |
2019-10-01 |
Xencor, Inc. |
Trispecific antibodies
|
|
CN107108729A
(zh)
|
2015-02-05 |
2017-08-29 |
中外制药株式会社 |
包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il‑8‑结合抗体,及其应用
|
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
|
MX390190B
(es)
*
|
2015-05-08 |
2025-03-20 |
Xencor Inc |
Anticuerpos heterodimericos que se unen a cd3 y a antigenos tumorales.
|
|
US11623957B2
(en)
|
2015-12-07 |
2023-04-11 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and PSMA
|
|
ES2901794T3
(es)
|
2015-12-09 |
2022-03-23 |
Hoffmann La Roche |
Anticuerpo anti-CD20 de tipo II para reducir la formación de anticuerpos antifármaco
|
|
EP3394098A4
(en)
|
2015-12-25 |
2019-11-13 |
Chugai Seiyaku Kabushiki Kaisha |
ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE
|
|
WO2017210443A1
(en)
|
2016-06-01 |
2017-12-07 |
Xencor, Inc. |
Bispecific antibodies that bind cd123 and cd3
|
|
WO2017210485A1
(en)
|
2016-06-01 |
2017-12-07 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3 for use in the treatment of lymphoma
|
|
EP3252078A1
(en)
|
2016-06-02 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
|
|
AU2018276419A1
(en)
|
2016-06-02 |
2019-10-17 |
F. Hoffmann-La Roche Ag |
Type II anti-CD20 antibody and anti-CD20/CD3 bispecific antibody for treatment of cancer
|
|
IL263542B2
(en)
|
2016-06-14 |
2024-10-01 |
Xencor Inc |
Bispecific antibodies inhibit immunological checkpoint
|
|
CN116063545A
(zh)
|
2016-06-28 |
2023-05-05 |
Xencor股份有限公司 |
结合生长抑素受体2的异源二聚抗体
|
|
TWI831965B
(zh)
|
2016-08-05 |
2024-02-11 |
日商中外製藥股份有限公司 |
Il-8相關疾病之治療用或預防用組成物
|
|
CN110267990B
(zh)
*
|
2016-08-30 |
2023-11-07 |
Xencor股份有限公司 |
结合共刺激性和检查点受体的双特异性免疫调节抗体
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
WO2018045110A1
(en)
|
2016-08-30 |
2018-03-08 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
MA46534A
(fr)
|
2016-10-14 |
2019-08-21 |
Xencor Inc |
Protéines de fusion fc hétérodimères il15/il15r
|
|
WO2018119114A1
(en)
|
2016-12-22 |
2018-06-28 |
Cue Biopharma, Inc. |
T-cell modulatory multimeric polypeptides and methods of use thereof
|
|
US11851471B2
(en)
|
2017-01-09 |
2023-12-26 |
Cue Biopharma, Inc. |
T-cell modulatory multimeric polypeptides and methods of use thereof
|
|
US11111305B2
(en)
|
2017-01-09 |
2021-09-07 |
Torch Therapeutics |
Method of using a bispecific antibody to conditionally inhibit a receptor signaling complex
|
|
CA3221995C
(en)
|
2017-02-08 |
2024-05-28 |
Dragonfly Therapeutics, Inc. |
Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
|
|
SG11201907646YA
(en)
*
|
2017-02-20 |
2019-09-27 |
Dragonfly Therapeutics Inc |
Proteins binding her2, nkg2d and cd16
|
|
SG11201907638QA
(en)
*
|
2017-02-20 |
2019-09-27 |
Dragonfly Therapeutics Inc |
Proteins binding cd33, nkg2d and cd16
|
|
EP3596118B1
(en)
|
2017-03-15 |
2024-08-21 |
Cue Biopharma, Inc. |
Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer
|
|
BR112019020940A2
(pt)
|
2017-04-11 |
2020-05-05 |
Inhibrx, Inc. |
construções polipeptídicas multipecíficas que têm ligação a cd3 restrita e métodos de usar as mesmas
|
|
US20200179511A1
(en)
|
2017-04-28 |
2020-06-11 |
Novartis Ag |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
EP3409322A1
(en)
|
2017-06-01 |
2018-12-05 |
F. Hoffmann-La Roche AG |
Treatment method
|
|
WO2018223004A1
(en)
|
2017-06-01 |
2018-12-06 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3
|
|
CA3065929A1
(en)
|
2017-06-01 |
2018-12-06 |
Michael Wayne SAVILLE |
Bispecific antibodies that bind cd123 and cd3
|
|
UY37758A
(es)
|
2017-06-12 |
2019-01-31 |
Novartis Ag |
Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
|
|
WO2019006472A1
(en)
|
2017-06-30 |
2019-01-03 |
Xencor, Inc. |
TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS
|
|
EP3668893A4
(en)
*
|
2017-08-16 |
2021-08-04 |
Dragonfly Therapeutics, Inc. |
PROTEINS BINDING TO NKG2D, CD16 AND EGFR, HLA-E, CCR4, OR PD-L1
|
|
CA3072919A1
(en)
*
|
2017-08-23 |
2019-02-28 |
Dragonfly Therapeutics, Inc. |
Proteins binding nkg2d, cd16 and a tumor-associated antigen
|
|
US11987609B2
(en)
|
2017-09-25 |
2024-05-21 |
Dingfu Biotarget Co., Ltd. |
Proteinaceous heterodimer and use thereof
|
|
CN112272563A
(zh)
|
2017-11-08 |
2021-01-26 |
Xencor股份有限公司 |
使用新颖抗pd-1序列的双特异性和单特异性抗体
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
IL275426B2
(en)
|
2017-12-19 |
2025-03-01 |
Xencor Inc |
Engineered il-2 fc fusion proteins
|
|
KR20200118824A
(ko)
|
2018-02-08 |
2020-10-16 |
드래곤플라이 쎄라퓨틱스, 인크. |
자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법
|
|
PT3749346T
(pt)
|
2018-02-08 |
2024-09-05 |
Dragonfly Therapeutics Inc |
Combinações de domínios variáveis de anticorpos dirigidas ao receptor nkg2d
|
|
CA3089906A1
(en)
|
2018-02-08 |
2019-08-15 |
Amgen Inc. |
Low ph pharmaceutical antibody formulation
|
|
CA3091424A1
(en)
*
|
2018-02-20 |
2019-08-29 |
Dragonfly Therapeutics, Inc. |
Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
|
|
JP7508368B2
(ja)
|
2018-03-15 |
2024-07-01 |
中外製薬株式会社 |
ジカウイルスに対して交差反応性を有する抗デングウイルス抗体および使用方法
|
|
AU2019247415A1
(en)
|
2018-04-04 |
2020-10-22 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
|
KR20200142525A
(ko)
*
|
2018-04-05 |
2020-12-22 |
노파르티스 아게 |
암에 대한 삼중특이성 결합 분자 및 이의 용도
|
|
IL323061A
(en)
|
2018-04-11 |
2025-10-01 |
Inhibrx Biosciences Inc |
Multispecific polypeptide constructs with forced CD3 binding and related methods and uses
|
|
EP3781598A1
(en)
|
2018-04-18 |
2021-02-24 |
Xencor, Inc. |
Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
|
|
KR20210010862A
(ko)
|
2018-04-18 |
2021-01-28 |
젠코어 인코포레이티드 |
IL-15/IL-15Rα Fc-융합 단백질 및 PD-1 항원 결합 도메인을 함유하는 PD-1 표적화 이종이량체 융합 단백질 및 이의 용도
|
|
WO2019204646A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains
|
|
MA52289A
(fr)
|
2018-04-18 |
2021-02-24 |
Xencor Inc |
Protéines de fusion fc hétérodimères il-15/il-15ra et leurs utilisations
|
|
AU2019260717A1
(en)
|
2018-04-27 |
2020-11-12 |
Novartis Ag |
Dosing of a bispecific antibody that bind CD123 and CD3
|
|
EA202091977A1
(ru)
*
|
2018-05-28 |
2021-02-09 |
Драгонфлай Терапьютикс, Инк. |
Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
|
|
AU2019276656A1
(en)
|
2018-06-01 |
2021-01-07 |
Novartis Ag |
Dosing of a bispecific antibody that bind CD123 and CD3
|
|
KR20210016448A
(ko)
|
2018-06-01 |
2021-02-15 |
컴퓨젠 엘티디. |
항-pvrig/항-tigit 이중특이적 항체 및 사용 방법
|
|
BR112020024351A2
(pt)
|
2018-06-01 |
2021-02-23 |
Novartis Ag |
moléculas de ligação contra bcma e usos das mesmas
|
|
JP7439372B2
(ja)
*
|
2018-06-21 |
2024-02-28 |
シャタック ラボ,インコーポレイテッド |
ヘテロ二量体タンパク質及びその使用
|
|
TW202019965A
(zh)
|
2018-07-16 |
2020-06-01 |
美商安進公司 |
治療多發性骨髓瘤之方法
|
|
WO2020023553A1
(en)
|
2018-07-24 |
2020-01-30 |
Inhibrx, Inc. |
Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same
|
|
CA3108646A1
(en)
|
2018-08-08 |
2020-02-13 |
Dragonfly Therapeutics, Inc. |
Proteins binding nkg2d, cd16 and a tumor-associated antigen
|
|
EA202091888A1
(ru)
*
|
2018-08-08 |
2020-10-23 |
Драгонфлай Терапьютикс, Инк. |
Вариабельные домены антител, нацеленные на рецептор nkg2d
|
|
AU2019318083A1
(en)
|
2018-08-08 |
2021-02-25 |
Dragonfly Therapeutics, Inc. |
Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use
|
|
JP7612571B2
(ja)
|
2018-10-03 |
2025-01-14 |
ゼンコア インコーポレイテッド |
Il-12ヘテロ二量体fc-融合タンパク質
|
|
CN113166263A
(zh)
|
2018-10-11 |
2021-07-23 |
印希比股份有限公司 |
Dll3单域抗体及其治疗性组合物
|
|
WO2020076970A1
(en)
|
2018-10-11 |
2020-04-16 |
Inhibrx, Inc. |
B7h3 single domain antibodies and therapeutic compositions thereof
|
|
CA3114693A1
(en)
|
2018-10-11 |
2020-04-16 |
Inhibrx, Inc. |
5t4 single domain antibodies and therapeutic compositions thereof
|
|
CR20210239A
(es)
|
2018-10-12 |
2021-12-15 |
Xencor Inc |
Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas
|
|
KR20210099027A
(ko)
|
2018-11-30 |
2021-08-11 |
지앙수 헨그루이 메디슨 컴퍼니 리미티드 |
항-cd40 항체, 이의 항원-결합 단편 및 약학적 용도
|
|
WO2020114479A1
(zh)
*
|
2018-12-07 |
2020-06-11 |
江苏恒瑞医药股份有限公司 |
多特异性蛋白分子
|
|
WO2020132646A1
(en)
|
2018-12-20 |
2020-06-25 |
Xencor, Inc. |
Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains
|
|
CN113811549A
(zh)
|
2019-02-21 |
2021-12-17 |
Xencor股份有限公司 |
非靶向和靶向性il-10 fc融合蛋白
|
|
BR112021016955A2
(pt)
|
2019-03-01 |
2021-11-23 |
Xencor Inc |
Composição, composição de ácido nucleico, composição de vetor de expressão, vetor de expressão, célula hospedeira, métodos de produção de um domínio de ligação de membro de família 3 de pirofosfatase/fosfodiesterase de ectonucleotídeo e de tratamento de um câncer, anticorpo anti-enpp3, e, anticorpo heterodimérico
|
|
WO2020205516A1
(en)
|
2019-03-29 |
2020-10-08 |
Xencor, Inc. |
Dosing of a bispecific antibody that binds pd1 and ctla4
|
|
NZ782091A
(en)
*
|
2019-05-09 |
2025-08-29 |
Merus Nv |
Variant domains for multimerizing proteins and separation thereof
|
|
EP3969119A1
(en)
|
2019-05-17 |
2022-03-23 |
Xencor, Inc. |
Il-7-fc-fusi0n proteins
|
|
CA3136241A1
(en)
|
2019-05-20 |
2020-11-26 |
Ulrich Moebius |
Il-2/il-15r.beta.y agonist dosing regimens for treating cancer or infectious diseases
|
|
JP7664183B2
(ja)
|
2019-05-21 |
2025-04-17 |
ノバルティス アーゲー |
Bcmaに対する三重特異性結合分子及びその使用
|
|
WO2020236797A1
(en)
|
2019-05-21 |
2020-11-26 |
Novartis Ag |
Variant cd58 domains and uses thereof
|
|
KR102878895B1
(ko)
|
2019-05-21 |
2025-10-31 |
노파르티스 아게 |
Cd19 결합 분자 및 이의 용도
|
|
AU2020282736B2
(en)
*
|
2019-05-29 |
2025-10-30 |
Cue Biopharma, Inc. |
Multimeric T-cell modulatory polypeptides and methods of use thereof
|
|
JP2022534513A
(ja)
*
|
2019-05-31 |
2022-08-01 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
がん細胞遊走を阻害するためのIL-6Rα/IL-8R二重特異性結合剤
|
|
EP3976644A4
(en)
|
2019-05-31 |
2022-12-14 |
The Johns Hopkins University |
BI-SPECIFIC LIAISONS
|
|
US20220235133A1
(en)
*
|
2019-06-24 |
2022-07-28 |
Nanjing GenScript Biotech Co., Ltd. |
Monoclonal antibody-cytokine fusion protein dimer and application thereof
|
|
EP4010376A2
(en)
|
2019-08-06 |
2022-06-15 |
Xencor, Inc. |
Heterodimeric igg-like bispecific antibodies
|
|
AU2020358979A1
(en)
|
2019-10-03 |
2022-04-21 |
Xencor, Inc. |
Targeted IL-12 heterodimeric Fc-fusion proteins
|
|
TW202128757A
(zh)
|
2019-10-11 |
2021-08-01 |
美商建南德克公司 |
具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
|
|
TW202136287A
(zh)
|
2019-12-17 |
2021-10-01 |
法商Ose免疫治療公司 |
包含il-7變體之雙官能分子
|
|
KR20220145833A
(ko)
*
|
2020-01-23 |
2022-10-31 |
아다젠 아게 |
Fc 돌연변이를 갖는 이형이량체 단백질
|
|
KR20220148175A
(ko)
|
2020-01-29 |
2022-11-04 |
인히브릭스, 인크. |
Cd28 단일 도메인 항체 및 이의 다가 및 다중특이적 구조체
|
|
TW202146452A
(zh)
|
2020-02-28 |
2021-12-16 |
瑞士商諾華公司 |
結合cd123和cd3之雙特異性抗體的給藥
|
|
US11365239B2
(en)
|
2020-03-20 |
2022-06-21 |
Tsb Therapeutics (Beijing) Co., Ltd. |
Anti-SARS-COV-2 antibodies and uses thereof
|
|
CN116249549A
(zh)
|
2020-03-27 |
2023-06-09 |
诺华股份有限公司 |
用于治疗增殖性疾病和自身免疫病症的双特异性组合疗法
|
|
MX2022013944A
(es)
|
2020-05-06 |
2022-11-30 |
Dragonfly Therapeutics Inc |
Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a).
|
|
CA3182697A1
(en)
|
2020-05-11 |
2021-11-18 |
Janssen Biotech, Inc. |
Methods for treating multiple myeloma
|
|
AU2021272895A1
(en)
|
2020-05-12 |
2022-09-22 |
Cue Biopharma, Inc. |
Multimeric T-cell modulatory polypeptides and methods of use thereof
|
|
EP4149632A1
(en)
|
2020-05-14 |
2023-03-22 |
Xencor, Inc. |
Heterodimeric antibodies that bind msln and cd3
|
|
US11919956B2
(en)
|
2020-05-14 |
2024-03-05 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
|
|
KR20230015996A
(ko)
*
|
2020-06-30 |
2023-01-31 |
하버 바이오메드 (상하이) 컴퍼니 리미티드 |
H2l2 및 hcab 구조를 갖는 결합 단백질
|
|
KR20220014531A
(ko)
*
|
2020-07-29 |
2022-02-07 |
(주)메디톡스 |
헤테로이량체 Fc 융합 단백질, 및 관련 조성물, 용도 및 방법
|
|
US11919958B2
(en)
|
2020-08-19 |
2024-03-05 |
Xencor, Inc. |
Anti-CD28 compositions
|
|
EP4211149A4
(en)
|
2020-09-09 |
2024-10-09 |
Cue Biopharma, Inc. |
MULTIMERIC POLYPEPTIDES MODULATING MHC CLASS II T CELLS FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF
|
|
WO2022061240A1
(en)
*
|
2020-09-21 |
2022-03-24 |
The Board Of Trustees Of The Leland Stanford Junior University |
Heteromultimeric proteins for reducing ige-dependent allergic effector cell activation
|
|
US11926667B2
(en)
|
2020-10-13 |
2024-03-12 |
Janssen Biotech, Inc. |
Bioengineered T cell mediated immunity, materials and other methods for modulating cluster of differentiation IV and/or VIII
|
|
US20220135684A1
(en)
|
2020-10-14 |
2022-05-05 |
Xencor, Inc. |
Bispecific antibodies that bind pd-l1 and cd28
|
|
WO2022087418A1
(en)
|
2020-10-23 |
2022-04-28 |
Xencor, Inc. |
Anti-cd20 antibodies and therapeutic uses thereof
|
|
KR20230096049A
(ko)
|
2020-10-26 |
2023-06-29 |
싸이튠 파마 |
편평 세포 암종 치료용 IL-2/IL-15Rβγ 작용제
|
|
WO2022090202A1
(en)
|
2020-10-26 |
2022-05-05 |
Cytune Pharma |
IL-2/IL-15RBβү AGONIST FOR TREATING NON-MELANOMA SKIN CANCER
|
|
CA3199839A1
(en)
|
2020-11-06 |
2022-05-12 |
Novartis Ag |
Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
|
|
US20240025993A1
(en)
|
2020-11-06 |
2024-01-25 |
Novartis Ag |
Cd19 binding molecules and uses thereof
|
|
US20220144956A1
(en)
|
2020-11-06 |
2022-05-12 |
Xencor, Inc. |
HETERODIMERIC ANTIBODIES THAT BIND TGFbetaRII
|
|
JP2023547499A
(ja)
*
|
2020-11-06 |
2023-11-10 |
ノバルティス アーゲー |
抗体Fc変異体
|
|
CA3197104A1
(en)
*
|
2020-11-11 |
2022-05-19 |
Hq Han |
Bifunctional antagonists of activin/tgf-beta and rankl and uses thereof
|
|
MX2023007301A
(es)
|
2020-12-17 |
2023-07-04 |
Ose Immunotherapeutics |
Moleculas bifuncionales anti-pd1/il-7.
|
|
US20220227867A1
(en)
|
2020-12-24 |
2022-07-21 |
Xencor, Inc. |
ICOS TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND ICOS ANTIGEN BINDING DOMAINS
|
|
JP2024508894A
(ja)
|
2021-03-03 |
2024-02-28 |
ドラゴンフライ セラピューティクス, インコーポレイテッド |
Nkg2d、cd16、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法
|
|
KR20230156079A
(ko)
|
2021-03-09 |
2023-11-13 |
젠코어 인코포레이티드 |
Cd3과 cldn6에 결합하는 이종이량체 항체
|
|
EP4305065A1
(en)
|
2021-03-10 |
2024-01-17 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and gpc3
|
|
JP2024515263A
(ja)
|
2021-04-09 |
2024-04-08 |
オーエスイー・イミュノセラピューティクス |
改善された特性を有する二機能性分子のための新規足場構造
|
|
US20240182572A1
(en)
|
2021-04-09 |
2024-06-06 |
Ose Immunotherapeutics |
Scaffold for bifunctional molecules comprising pd-1 or cd28 and sirp binding domains
|
|
JP7651145B2
(ja)
*
|
2021-04-20 |
2025-03-26 |
コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーション |
向上した癌細胞死滅効能を有する非対称抗体
|
|
CN115925967A
(zh)
|
2021-04-22 |
2023-04-07 |
广东菲鹏制药股份有限公司 |
双特异性多功能融合多肽
|
|
AU2021443318A1
(en)
|
2021-04-30 |
2023-09-07 |
F. Hoffmann-La Roche Ag |
Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
|
|
WO2022228706A1
(en)
|
2021-04-30 |
2022-11-03 |
F. Hoffmann-La Roche Ag |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody
|
|
US20240247062A1
(en)
|
2021-06-15 |
2024-07-25 |
Xencor, Inc. |
Heterodimeric antibodies that bind claudin18.2 and cd3
|
|
IL308134A
(en)
|
2021-06-22 |
2023-12-01 |
Novartis Ag |
BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT OF HIDRADENITIS SUPPURATIVA
|
|
EP4359428A2
(en)
*
|
2021-06-23 |
2024-05-01 |
Cytune Pharma |
Interleukin-15 based immunocytokines
|
|
IL309662A
(en)
|
2021-07-02 |
2024-02-01 |
Univ Yale |
Compositions and methods for treating cancers
|
|
US20230146665A1
(en)
|
2021-07-27 |
2023-05-11 |
Xencor, Inc. |
Il-18-fc fusion proteins
|
|
CA3225815A1
(en)
|
2021-08-13 |
2023-02-16 |
Cytune Pharma |
Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer
|
|
KR20240055016A
(ko)
*
|
2021-08-25 |
2024-04-26 |
바이오그래프 55, 인크. |
면역억제성 b 세포와 연관된 암을 치료하는 방법
|
|
US20240352156A1
(en)
*
|
2021-08-25 |
2024-10-24 |
Biograph 55, Inc. |
Antibodies targeting immunosuppressive b cells
|
|
WO2023034864A1
(en)
|
2021-08-31 |
2023-03-09 |
Yale University |
Compositions and methods for treating cancers
|
|
EP4408889A1
(en)
|
2021-09-27 |
2024-08-07 |
Xencor, Inc. |
B-cell maturation antigen (bcma) binding domain compositions
|
|
AU2022380722A1
(en)
|
2021-11-03 |
2024-06-20 |
Janssen Biotech, Inc. |
Methods of treating cancers and enhancing efficacy of bcmaxcd3 bispecific antibodies
|
|
WO2023081915A1
(en)
|
2021-11-08 |
2023-05-11 |
Xencor, Inc. |
Il-8 as a predictive biomarker and methods of use thereof for the treatment of cancer
|
|
WO2023110918A1
(en)
|
2021-12-14 |
2023-06-22 |
Cdr-Life Ag |
Dual mhc-targeting t cell engager
|
|
IL314993A
(en)
|
2022-02-23 |
2024-10-01 |
Xencor Inc |
Anti-cd28 x anti-psma antibodies
|
|
KR20240164782A
(ko)
|
2022-03-23 |
2024-11-20 |
에프. 호프만-라 로슈 아게 |
항-cd20/항-cd3 이중특이적 항체와 화학요법의 병용 치료
|
|
US20240025968A1
(en)
|
2022-04-07 |
2024-01-25 |
Xencor, Inc. |
LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS
|
|
CA3255366A1
(en)
|
2022-04-13 |
2023-10-19 |
F. Hoffmann-La Roche Ag |
Pharmaceutical compositions based on bispecific anti-CD20/anti-CD3 antibodies and methods of use
|
|
US20230383012A1
(en)
|
2022-04-13 |
2023-11-30 |
Xencor, Inc. |
Antibodies that bind pd-l1, pd-l2, and/or cd28
|
|
AR129136A1
(es)
|
2022-04-26 |
2024-07-17 |
Novartis Ag |
Anticuerpos multiespecíficos que se dirigen a il-13 e il-18
|
|
US20250171562A1
(en)
|
2022-07-01 |
2025-05-29 |
ALK-Abelló |
Displacers of ige-fceri
|
|
CN119907811A
(zh)
|
2022-08-02 |
2025-04-29 |
Ose免疫疗法公司 |
针对cd28的多功能分子
|
|
KR20250067130A
(ko)
|
2022-09-14 |
2025-05-14 |
씨디알-라이프 아게 |
Mage-a4 펩티드 이중 t 세포 연결체
|
|
WO2024088987A1
(en)
|
2022-10-26 |
2024-05-02 |
F. Hoffmann-La Roche Ag |
Combination therapy for the treatment of cancer
|
|
WO2024102645A1
(en)
|
2022-11-07 |
2024-05-16 |
Xencor, Inc. |
Combination treatment with a bispecific antibody that binds ctla4 and pd1 for prostate cancer
|
|
WO2024102693A2
(en)
|
2022-11-07 |
2024-05-16 |
Xencor, Inc. |
Il-18-fc fusion proteins
|
|
WO2024102948A1
(en)
|
2022-11-11 |
2024-05-16 |
Celgene Corporation |
Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods
|
|
TW202440636A
(zh)
|
2023-03-21 |
2024-10-16 |
美商傳記55有限公司 |
Cd19/cd38多特異性抗體
|
|
WO2024215989A1
(en)
|
2023-04-14 |
2024-10-17 |
Sotio Biotech Inc. |
ENGINEERED IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-2/IL-15 RECEPTOR βγ AGONISTS
|
|
WO2025038668A1
(en)
|
2023-08-14 |
2025-02-20 |
Voro Therapeutics, Inc. |
Therapeutic binding agents that conditionally promote myeloid cell activity against target cells and uses thereof
|
|
US20250122299A1
(en)
|
2023-08-28 |
2025-04-17 |
Xencor, Inc. |
ANTI-CD20 x ANTI-CD28 COMBINATION THERAPIES
|
|
WO2025068957A1
(en)
|
2023-09-29 |
2025-04-03 |
Novartis Ag |
Bispecific antibodies for use in lowering the risk of cardiovascular disease events in subjects known to be a carrier of clonal expansion of hematopoietic cell lines with somatic mutations
|
|
WO2025075057A1
(ja)
*
|
2023-10-02 |
2025-04-10 |
国立大学法人 熊本大学 |
ポリペプチドの会合体形成抑制方法
|
|
WO2025085447A1
(en)
|
2023-10-17 |
2025-04-24 |
Xencor, Inc. |
Pd-1 targeted il18-fc fusion proteins
|
|
WO2025157132A1
(en)
|
2024-01-23 |
2025-07-31 |
Wuxi Biologics (Shanghai) Co., Ltd. |
Multispecific antibodies targeting cd3, cd19 and cd20 and uses thereof
|
|
WO2025183172A1
(ja)
*
|
2024-02-28 |
2025-09-04 |
旭化成株式会社 |
等電点が改変されたドメインを有する抗体
|
|
WO2025210181A1
(en)
|
2024-04-04 |
2025-10-09 |
Cdr-Life Ag |
Antigen binding proteins targeting an hla-restricted kk-lc-1 peptide
|
|
WO2025215160A1
(en)
|
2024-04-11 |
2025-10-16 |
Cdr-Life Ag |
Antigen binding proteins targeting an hla-restricted prame peptide
|
|
WO2025240670A2
(en)
|
2024-05-15 |
2025-11-20 |
Abalytics Oncology, Inc. |
Anti-pd-1 antibodies and related binding molecules and methods and uses thereof
|
|
WO2025242835A1
(en)
|
2024-05-22 |
2025-11-27 |
Ose Immunotherapeutics |
Molecules comprising masking linkers and uses thereof for the treatment of cancer
|
|
WO2025242836A1
(en)
|
2024-05-22 |
2025-11-27 |
Ose Immunotherapeutics |
Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders
|
|
WO2025245508A1
(en)
|
2024-05-24 |
2025-11-27 |
Xencor, Inc. |
Anti-tnf-like ligand 1a (tl1a) antibodies
|
|
WO2025255405A1
(en)
|
2024-06-06 |
2025-12-11 |
Bristol-Myers Squibb Company |
Anti-fap antibodies and uses thereof
|
|
WO2025255349A1
(en)
|
2024-06-06 |
2025-12-11 |
Bristol-Myers Squibb Company |
Multispecific anti-cd40 / anti-fap antibodies and uses thereof
|