JP2016014070A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016014070A5 JP2016014070A5 JP2015207655A JP2015207655A JP2016014070A5 JP 2016014070 A5 JP2016014070 A5 JP 2016014070A5 JP 2015207655 A JP2015207655 A JP 2015207655A JP 2015207655 A JP2015207655 A JP 2015207655A JP 2016014070 A5 JP2016014070 A5 JP 2016014070A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- oligonucleotide decoy
- pain
- cell
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 10
- 229920000272 Oligonucleotide Polymers 0.000 claims 7
- 208000002193 Pain Diseases 0.000 claims 4
- 210000004027 cells Anatomy 0.000 claims 4
- 210000002569 neurons Anatomy 0.000 claims 2
- 230000003040 nociceptive Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 102000004219 Brain-Derived Neurotrophic Factor Human genes 0.000 claims 1
- 108090000715 Brain-Derived Neurotrophic Factor Proteins 0.000 claims 1
- 102100003298 CDK5R1 Human genes 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 102100010392 GCH1 Human genes 0.000 claims 1
- 101700086161 GCH1 Proteins 0.000 claims 1
- 102100006612 GRM5 Human genes 0.000 claims 1
- 101700027086 GRM5 Proteins 0.000 claims 1
- 102000017679 HTR3A Human genes 0.000 claims 1
- 108060004362 HTR3A Proteins 0.000 claims 1
- 108010008858 Nitric Oxide Synthase Type I Proteins 0.000 claims 1
- 102000006538 Nitric Oxide Synthase Type I Human genes 0.000 claims 1
- 102100008104 PEMT Human genes 0.000 claims 1
- 101700037699 PEMT Proteins 0.000 claims 1
- 101700000601 PNMT Proteins 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 208000000399 Procedural Pain Diseases 0.000 claims 1
- 102100010563 SCN9A Human genes 0.000 claims 1
- 101700051996 SCN9A Proteins 0.000 claims 1
- 230000001154 acute Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 230000000051 modifying Effects 0.000 claims 1
- 108010064131 neuronal Cdk5 activator (p25-p35) Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001105 regulatory Effects 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000002103 transcriptional Effects 0.000 claims 1
Claims (13)
- 配列番号３３の配列からなる、オリゴヌクレオチドデコイ。
- 請求項１に記載のオリゴヌクレオチドデコイおよび薬学的に許容しうる担体を含む、医薬組成物。
- 請求項１に記載のオリゴヌクレオチドデコイおよび場合により前記オリゴヌクレオチドデコイを使用するための説明書を含む、キット。
- 請求項１に記載のオリゴヌクレオチドデコイの有効量を含む、侵害受容シグナル伝達に関与する細胞中に存在する遺伝子の転写を調節するための組成物。
- 前記細胞がニューロンである、請求項４に記載の組成物。
- 転写の調節が遺伝子発現を抑制、阻害、活性化、誘導または安定化する、請求項４に記載の組成物。
- 前記遺伝子がＢＤＫＲＤ２、ＨＴＲ３Ａ、ＳＣＮ９Ａ、ＢＤＮＦ、ＧＲＭ５、ＮＯＳ１、ＧＣＨ１、ＣＤＫ５Ｒ１、およびＰＮＭＴよりなる群から選択される、請求項４〜６のいずれかに記載の組成物。
- 請求項１に記載のオリゴヌクレオチドデコイの有効量を含む、細胞における侵害受容シグナル伝達を調節するための組成物。
- 前記細胞がニューロンである、請求項８に記載の組成物。
- 請求項１に記載のオリゴヌクレオチドデコイの治療有効量を含む、患者における疼痛を処置または予防するための組成物。
- 前記疼痛が急性から慢性の疼痛の何れかの疼痛である、請求項１０に記載の組成物。
- 前記疼痛が術後疼痛である、請求項１０に記載の組成物。
- 硬膜外／硬膜周囲または髄腔内に投与されることを特徴とする、請求項１０〜１２のいずれかに記載の組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91758307P | 2007-05-11 | 2007-05-11 | |
| US60/917,583 | 2007-05-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014149516A Division JP5890869B2 (ja) | 2007-05-11 | 2014-07-23 | 遺伝子発現と疼痛 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016064037A Division JP6306075B2 (ja) | 2007-05-11 | 2016-03-28 | 遺伝子発現と疼痛 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016014070A JP2016014070A (ja) | 2016-01-28 |
| JP2016014070A5 true JP2016014070A5 (ja) | 2016-05-19 |
| JP6082796B2 JP6082796B2 (ja) | 2017-02-15 |
Family
ID=40002879
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507728A Expired - Fee Related JP5646320B2 (ja) | 2007-05-11 | 2008-05-12 | 遺伝子発現と疼痛 |
| JP2014149516A Expired - Fee Related JP5890869B2 (ja) | 2007-05-11 | 2014-07-23 | 遺伝子発現と疼痛 |
| JP2015207655A Expired - Fee Related JP6082796B2 (ja) | 2007-05-11 | 2015-10-22 | 遺伝子発現と疼痛 |
| JP2016064037A Expired - Fee Related JP6306075B2 (ja) | 2007-05-11 | 2016-03-28 | 遺伝子発現と疼痛 |
| JP2017106521A Pending JP2017148074A (ja) | 2007-05-11 | 2017-05-30 | 遺伝子発現と疼痛 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507728A Expired - Fee Related JP5646320B2 (ja) | 2007-05-11 | 2008-05-12 | 遺伝子発現と疼痛 |
| JP2014149516A Expired - Fee Related JP5890869B2 (ja) | 2007-05-11 | 2014-07-23 | 遺伝子発現と疼痛 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016064037A Expired - Fee Related JP6306075B2 (ja) | 2007-05-11 | 2016-03-28 | 遺伝子発現と疼痛 |
| JP2017106521A Pending JP2017148074A (ja) | 2007-05-11 | 2017-05-30 | 遺伝子発現と疼痛 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US7943591B2 (ja) |
| EP (3) | EP2158316B1 (ja) |
| JP (5) | JP5646320B2 (ja) |
| AU (1) | AU2008251320B2 (ja) |
| CA (1) | CA2723672C (ja) |
| DK (1) | DK2158316T3 (ja) |
| ES (2) | ES2542511T3 (ja) |
| HK (1) | HK1205530A1 (ja) |
| HR (1) | HRP20150759T1 (ja) |
| HU (1) | HUE025701T2 (ja) |
| PL (1) | PL2158316T3 (ja) |
| PT (1) | PT2158316E (ja) |
| SI (1) | SI2158316T1 (ja) |
| WO (1) | WO2008141308A2 (ja) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7943591B2 (en) | 2007-05-11 | 2011-05-17 | Adynxx, Inc. | Gene expression and pain |
| KR101881596B1 (ko) | 2008-12-02 | 2018-07-24 | 웨이브 라이프 사이언시스 재팬 인코포레이티드 | 인 원자 변형된 핵산의 합성 방법 |
| CN102596204B (zh) | 2009-07-06 | 2016-11-23 | 波涛生命科学有限公司 | 新的核酸前药及其使用方法 |
| US8609617B2 (en) | 2009-09-04 | 2013-12-17 | University Of Miami | KLF family members regulate intrinsic axon regeneration ability |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| ES2626488T3 (es) | 2011-07-19 | 2017-07-25 | Wave Life Sciences Pte. Ltd. | Procedimientos para la síntesis de ácidos nucleicos funcionalizados |
| WO2013040417A1 (en) | 2011-09-16 | 2013-03-21 | The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Medical Center | Amphiphilic cationic polymers for the delivery of therapeutic agents |
| US9139829B2 (en) * | 2012-02-28 | 2015-09-22 | Medical Diagnostic Laboratories, Llc | SiRNA targeting ETS1 and ELK1 and method of using same in the inhibition of CIP2A gene in cancer treatment |
| EP2846839B1 (en) | 2012-05-10 | 2019-02-20 | Adynxx, Inc. | Formulations for the delivery of active ingredients |
| EP2873674B1 (en) | 2012-07-13 | 2020-05-06 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| SG11201500232UA (en) | 2012-07-13 | 2015-04-29 | Wave Life Sciences Pte Ltd | Chiral control |
| AU2013288048A1 (en) | 2012-07-13 | 2015-01-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| GB201310853D0 (en) * | 2013-06-18 | 2013-07-31 | Ucb Pharma Sa | Method |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| CN106068325B (zh) | 2014-01-16 | 2021-07-09 | 波涛生命科学有限公司 | 手性设计 |
| PT3180434T (pt) | 2014-08-15 | 2019-10-29 | Adynxx Inc | Chamarizes oligonucleotídicos para o tratamento da dor |
| US11453880B2 (en) | 2015-09-09 | 2022-09-27 | Anges, Inc. | Chimeric decoy |
| WO2017151644A1 (en) * | 2016-02-29 | 2017-09-08 | Adynxx, Inc. | Compositions and methods for pain amelioration via modification of gene expression |
| WO2024044770A1 (en) * | 2022-08-26 | 2024-02-29 | Core Biotherapeutics, Inc. | Oligonucleotides for the treatment of breast cancer |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150090A (en) * | 1986-01-09 | 2000-11-21 | Massachusetts Institute Of Technology | Nuclear factors associated with transcriptional regulation |
| US5206152A (en) * | 1988-04-08 | 1993-04-27 | Arch Development Corporation | Cloning and expression of early growth regulatory protein genes |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5272056A (en) | 1991-01-03 | 1993-12-21 | The Research Foundation Of State University Of New York | Modification of DNA and oligonucleotides using metal complexes of polyaza ligands |
| CA2106386A1 (en) * | 1991-04-18 | 1992-10-19 | Barbara C. F. Chu | Oligodeoxynucleotides and oligonucleotides useful as decoys for proteins which selectively bind to defined dna sequences |
| FR2675803B1 (fr) | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
| CA2168245A1 (en) * | 1993-07-29 | 1995-02-09 | C. Anthony Hunt | Polynucleotide decoys that inhibit mhc-ii expression and uses thereof |
| EP0732929B1 (en) * | 1993-10-29 | 2008-05-14 | The Brigham And Women's Hospital, Inc. | Therapeutic use of cis-element decoys in vivo |
| ATE295367T1 (de) | 1994-11-17 | 2005-05-15 | Taiho Pharmaceutical Co Ltd | Doppelsträngiges oligonukleotid und karzinostatisches mittel das dieses als aktiven inhaltsstoff enthält |
| AU5369396A (en) | 1995-03-23 | 1996-10-08 | Research Foundation Of The State University Of New York, The | Rest protein and dna |
| DK0824588T3 (da) * | 1995-05-11 | 2004-08-16 | Applied Research Systems | Inhibitor af IL-6 aktivitet |
| PT824918E (pt) * | 1995-05-12 | 2007-06-22 | Anges Mg Inc | Tratamento e prevenção para doenças causadas pelo nf-kb |
| GB9515356D0 (en) | 1995-07-26 | 1995-09-20 | Medical Res Council | Improvements in or relating to delivery of nucleic acid |
| US6265389B1 (en) | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
| DE69738454D1 (de) * | 1996-05-20 | 2008-02-21 | Us Gov Health & Human Serv | Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden |
| US6022863A (en) * | 1996-05-21 | 2000-02-08 | Yale University | Regulation of gene expression |
| JP4215219B2 (ja) * | 1997-07-04 | 2009-01-28 | アンジェスＭｇ株式会社 | 脳保護剤 |
| JP3667047B2 (ja) | 1997-09-12 | 2005-07-06 | キヤノン株式会社 | 人工核酸およびその製造方法、デオキシリボフラノース化合物、リボフラノース化合物およびこれらの製造方法 |
| US6376471B1 (en) | 1997-10-10 | 2002-04-23 | Johns Hopkins University | Gene delivery compositions and methods |
| US6060310A (en) | 1997-11-24 | 2000-05-09 | The United States Of America As Represented By The Department Of Health And Human Services | Transcription factor decoy and tumor growth inhibitor |
| JP2002508386A (ja) | 1997-12-16 | 2002-03-19 | ザ・ユニバーシティー・オブ・サスカチワン・テクノロジーズ・インコーポレーテッド | 導電性金属含有核酸 |
| IL139936A0 (en) | 1998-06-02 | 2002-02-10 | Glaxo Group Ltd | Gene therapy method |
| US6818626B1 (en) | 1998-07-17 | 2004-11-16 | Mirus Corporation | Chelating systems for use in the delivery of compounds to cells |
| US6423493B1 (en) * | 1998-10-26 | 2002-07-23 | Board Of Regents The University Of Texas System | Combinatorial selection of oligonucleotide aptamers |
| US6008048A (en) * | 1998-12-04 | 1999-12-28 | Isis Pharmaceuticals Inc. | Antisense inhibition of EGR-1 expression |
| US7160869B2 (en) | 1998-12-16 | 2007-01-09 | University Of Saskatchewan | Biologically active metal-containing nucleic acids |
| JP3674686B2 (ja) | 1998-12-23 | 2005-07-20 | ジェネンテック・インコーポレーテッド | リン酸カルシウム及び核酸を含むトランスフェクタコン |
| US6395029B1 (en) | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
| US6333408B1 (en) * | 1999-03-08 | 2001-12-25 | Kureha Chemical Industry Co., Ltd. | Oligonucleotides inhibitors of PAI-1 MRNA |
| FR2790955B1 (fr) * | 1999-03-19 | 2003-01-17 | Assist Publ Hopitaux De Paris | Utilisation d'oligonucleotides stabilises comme principe actif antitumoral |
| US6599741B1 (en) * | 1999-09-14 | 2003-07-29 | Avontec Gmbh | Modulating transcription of genes in vascular cells |
| US6927027B2 (en) | 1999-12-21 | 2005-08-09 | Ingeneus Corporation | Nucleic acid multiplex formation |
| US6969704B1 (en) * | 2000-08-25 | 2005-11-29 | The Trustees Of Columbia University In The City Of New York | Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject |
| DE10049549A1 (de) | 2000-10-06 | 2002-05-02 | Markus Hecker | Modulation der Transkription pro-inflammatorischer Genprodukte |
| WO2002030355A2 (en) | 2000-10-11 | 2002-04-18 | Laura Kragie | Composition and method of alleviating adverse side effects and/or enhancing efficacy of agents that inhibit aromatase |
| JPWO2002041922A1 (ja) | 2000-11-24 | 2004-03-25 | 丸山 弘樹 | 生体に導入された遺伝子の発現産物の活性を制御する方法 |
| US20020137715A1 (en) | 2001-01-03 | 2002-09-26 | Alain Mauviel | Blocking Sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis |
| AU2002241952A1 (en) * | 2001-01-22 | 2002-07-30 | Genta Incorporated | Cell-proliferative disorder treatments using cre decoy oligomers, bcl-2 antisense and hybrid oligomers |
| US9012417B2 (en) | 2001-02-20 | 2015-04-21 | Anges Mg, Inc. | Topical administration of NF-kappaB decoy to treat atopic dermatitis |
| US20070122401A1 (en) | 2001-03-06 | 2007-05-31 | Andrews William H | Methods and compositions for modulating telomerase reverse transcriptase (tert) expression |
| US20030166555A1 (en) * | 2001-04-02 | 2003-09-04 | Alberini Cristina M. | Methods and compositions for regulating memory consolidation |
| EP1298141A1 (en) | 2001-09-27 | 2003-04-02 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Interleukin-4 (IL-4) promoter sequences specifically interacting with IRF-1 and IRF-2 |
| DE10148828B4 (de) * | 2001-10-04 | 2005-05-19 | Avontec Gmbh | Modulation der Expression STAT-1-abhängiger Gene |
| US6663880B1 (en) | 2001-11-30 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Permeabilizing reagents to increase drug delivery and a method of local delivery |
| CN1697647A (zh) | 2002-02-01 | 2005-11-16 | 奥默罗斯公司 | 用于抑制疼痛,炎症和软骨退化的溶液及方法 |
| CN1240439C (zh) | 2002-03-28 | 2006-02-08 | 南京凯基生物科技发展有限公司 | 肿瘤基因开关药物 |
| WO2003091432A1 (en) | 2002-04-26 | 2003-11-06 | Anges Mg, Inc. | Circular dumbbell decoy oligodeoxynucleotides (cdodn) containing dna bindings sites of transcription |
| DE10242319A1 (de) * | 2002-09-12 | 2004-03-25 | Avontec Gmbh | Funkionelle Korrektur der-786C/T-Varianz des humanen eNOS-Gens |
| DE10257421A1 (de) * | 2002-12-09 | 2004-07-08 | Grünenthal GmbH | Regulatorische Elemente im 5'-Bereich des VR1-Gens |
| KR20140148502A (ko) | 2002-12-09 | 2014-12-31 | 아브락시스 바이오사이언스, 엘엘씨 | 약리학적 물질의 조성물 및 그 전달방법 |
| WO2005004702A2 (en) | 2003-06-30 | 2005-01-20 | Massachusetts Institute Of Technology | Egr genes as targets for the diagnosis and treatment of schizophrenia |
| US20080233644A1 (en) * | 2003-09-12 | 2008-09-25 | Helen Fillmore | Chimeric Transcription Factor Decoy Oligonucleotides |
| JP2005336081A (ja) | 2004-05-26 | 2005-12-08 | Anges Mg Inc | Ｎｒ２ｂ−ｎｍｄａ受容体の再発現抑制剤 |
| US7482158B2 (en) * | 2004-07-01 | 2009-01-27 | Mathison Brian H | Composite polynucleic acid therapeutics |
| US20060293264A1 (en) * | 2004-07-22 | 2006-12-28 | Grandis Jennifer R | STAT3 decoy oligonucleotides and uses therefor |
| AU2005286640A1 (en) * | 2004-09-21 | 2006-03-30 | Anesiva, Inc. | Delivery of polynucleotides |
| CA2580126C (en) | 2004-09-28 | 2014-08-26 | Quark Biotech, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| WO2006043722A1 (ja) * | 2004-10-22 | 2006-04-27 | Anges Mg, Inc. | キメラ（ダブル）デコイ |
| US7585848B2 (en) * | 2005-01-11 | 2009-09-08 | Rush University Medical Center | Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc |
| WO2006096498A2 (en) * | 2005-03-04 | 2006-09-14 | Dana-Farber Cancer Institute, Inc. | Regulation of runx1 for treatment of pain |
| US7680060B2 (en) * | 2005-03-08 | 2010-03-16 | Cisco Technology, Inc. | Transferring state information in a network |
| EP1877556B1 (en) * | 2005-03-25 | 2011-09-14 | Medtronic, Inc. | Use of anti-tnf or anti-il1 rnai to suppress pro- inflammatory cytokine actions locally to treat pain |
| EP2086573B1 (en) | 2006-10-09 | 2020-11-25 | Neurofluidics, Inc. | Cerebrospinal fluid purification system |
| JP5744513B2 (ja) | 2007-04-17 | 2015-07-08 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 肺送達のための核酸微小粒子 |
| US7943591B2 (en) * | 2007-05-11 | 2011-05-17 | Adynxx, Inc. | Gene expression and pain |
| EA026660B1 (ru) | 2010-08-20 | 2017-05-31 | Репликор Инк. | Введение олигонуклеотидов в виде хелатных комплексов |
| US20140275211A1 (en) | 2011-06-21 | 2014-09-18 | Alnylam Pharmaceuticals, Inc. | Assays and methods for determining activity of a therapeutic agent in a subject |
| CN103781484A (zh) | 2011-07-20 | 2014-05-07 | 赫思公司 | 治疗疼痛的方法 |
| EP2846839B1 (en) | 2012-05-10 | 2019-02-20 | Adynxx, Inc. | Formulations for the delivery of active ingredients |
| RS62030B1 (sr) | 2012-05-18 | 2021-07-30 | Replicor Inc | Kompozicije oligonukleotidni helatni kompleks-polipeptid i postupci |
| PT3180434T (pt) | 2014-08-15 | 2019-10-29 | Adynxx Inc | Chamarizes oligonucleotídicos para o tratamento da dor |
| WO2017151644A1 (en) | 2016-02-29 | 2017-09-08 | Adynxx, Inc. | Compositions and methods for pain amelioration via modification of gene expression |
-
2008
- 2008-05-12 US US12/119,435 patent/US7943591B2/en not_active Expired - Fee Related
- 2008-05-12 JP JP2010507728A patent/JP5646320B2/ja not_active Expired - Fee Related
- 2008-05-12 PL PL08755344T patent/PL2158316T3/pl unknown
- 2008-05-12 EP EP08755344.2A patent/EP2158316B1/en not_active Not-in-force
- 2008-05-12 CA CA2723672A patent/CA2723672C/en active Active
- 2008-05-12 ES ES08755344.2T patent/ES2542511T3/es active Active
- 2008-05-12 EP EP14179247.3A patent/EP2818550B1/en not_active Not-in-force
- 2008-05-12 ES ES14179247.3T patent/ES2619314T3/es active Active
- 2008-05-12 EP EP16199871.1A patent/EP3199635B1/en not_active Not-in-force
- 2008-05-12 SI SI200831461T patent/SI2158316T1/sl unknown
- 2008-05-12 HU HUE08755344A patent/HUE025701T2/en unknown
- 2008-05-12 PT PT87553442T patent/PT2158316E/pt unknown
- 2008-05-12 WO PCT/US2008/063471 patent/WO2008141308A2/en active Application Filing
- 2008-05-12 DK DK08755344.2T patent/DK2158316T3/en active
- 2008-05-12 AU AU2008251320A patent/AU2008251320B2/en not_active Ceased
-
2011
- 2011-03-15 US US13/048,793 patent/US8093225B2/en not_active Expired - Fee Related
- 2011-12-09 US US13/316,321 patent/US8741864B2/en active Active - Reinstated
-
2014
- 2014-04-22 US US14/258,927 patent/US9290762B2/en not_active Expired - Fee Related
- 2014-07-23 JP JP2014149516A patent/JP5890869B2/ja not_active Expired - Fee Related
-
2015
- 2015-06-26 HK HK15106124.9A patent/HK1205530A1/xx not_active IP Right Cessation
- 2015-07-10 HR HRP20150759TT patent/HRP20150759T1/hr unknown
- 2015-10-22 JP JP2015207655A patent/JP6082796B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-09 US US15/019,791 patent/US10041069B2/en active Active
- 2016-03-28 JP JP2016064037A patent/JP6306075B2/ja not_active Expired - Fee Related
-
2017
- 2017-05-30 JP JP2017106521A patent/JP2017148074A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016014070A5 (ja) | ||
| WO2016205410A3 (en) | Defined multi-conjugate oligonucleotides | |
| WO2015106128A3 (en) | Rnai agents modified at the 4'-c-position | |
| JP2016518337A5 (ja) | ||
| JP2010526541A5 (ja) | ||
| WO2017078499A3 (ko) | 단백질 타이로신 탈인산화효소 억제제를 포함하는 신경염증성 질환의 예방 또는 치료용 조성물 | |
| JP2015517488A5 (ja) | ||
| JP2016528301A5 (ja) | ||
| MX2021011563A (es) | Derivados de 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmaceuticas que los incluyen. | |
| RU2016150116A (ru) | Ингибитор пролиферации раковых стволовых клеток | |
| JP2016523260A5 (ja) | ||
| JP2016531894A5 (ja) | ||
| JP2016199578A5 (ja) | ||
| EA201692392A1 (ru) | Новая лекарственная форма мелоксикама | |
| JP2016512817A5 (ja) | ||
| JP2017529834A5 (ja) | ||
| WO2016105516A8 (en) | Methods of using smad7 antisense oligonucleotides | |
| JP2018522891A5 (ja) | ||
| EP3594346A4 (en) | ANTISENSE OLIGONUCLEOTIDE AND COMPOSITION FOR THE PREVENTION OR TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE IA | |
| WO2016163799A3 (ko) | 2-메톡시-4-(3-(4-메톡시페닐)프로프-1-엔-1-일)페놀을 유효성분으로 하는 암의 치료용 약제학적 조성물 | |
| RU2014148977A (ru) | Обработка популяции рыб луфенуроном | |
| WO2015195684A3 (en) | Small molecule anti-scarring agents | |
| HRP20191434T1 (hr) | Liječenje eritromelalgije | |
| RU2016108808A (ru) | Терапевтическое применение vegf-c и ccbe1 | |
| IL274363B2 (en) | Use of a specific siRNA against protein S for the treatment of hemophilia |