WO2016163799A3 - 2-메톡시-4-(3-(4-메톡시페닐)프로프-1-엔-1-일)페놀을 유효성분으로 하는 암의 치료용 약제학적 조성물 - Google Patents

2-메톡시-4-(3-(4-메톡시페닐)프로프-1-엔-1-일)페놀을 유효성분으로 하는 암의 치료용 약제학적 조성물 Download PDF

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Publication number
WO2016163799A3
WO2016163799A3 PCT/KR2016/003696 KR2016003696W WO2016163799A3 WO 2016163799 A3 WO2016163799 A3 WO 2016163799A3 KR 2016003696 W KR2016003696 W KR 2016003696W WO 2016163799 A3 WO2016163799 A3 WO 2016163799A3
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WO
WIPO (PCT)
Prior art keywords
present
compound
methoxyphenyl
methoxy
phenol
Prior art date
Application number
PCT/KR2016/003696
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English (en)
French (fr)
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WO2016163799A2 (ko
Inventor
홍진태
이희범
함영완
김춘식
정현상
Original Assignee
충북대학교 산학협력단
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Publication date
Application filed by 충북대학교 산학협력단 filed Critical 충북대학교 산학협력단
Priority to US15/564,027 priority Critical patent/US10166203B2/en
Priority to CN201680021186.6A priority patent/CN107530300A/zh
Publication of WO2016163799A2 publication Critical patent/WO2016163799A2/ko
Publication of WO2016163799A3 publication Critical patent/WO2016163799A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 신규 화합물 2-메톡시-4-(3-(4-메톡시페닐)프로필-1-엔-1-일)페놀의 항암 용도에 관한 것이다. 본 발명의 화합물은 인 비트로 및 이종이식 동물모델에서 암세포와 종양의 성장을 효과적으로 억제한다. 본 발명의 화합물은 암세포에서 전사인자 STAT3의 DNA 결합 활성을 억제하고, 암세포의 세포사멸(apoptosis)를 유도하며, 세포주기 조절 단백질의 발현을 감소시킴으로써 항암 활성을 나타낸다. 본 발명의 화합물은 강력한 항암제의 활성성분으로 개발될 수 있다.
PCT/KR2016/003696 2015-04-10 2016-04-08 2-메톡시-4-(3-(4-메톡시페닐)프로프-1-엔-1-일)페놀을 유효성분으로 하는 암의 치료용 약제학적 조성물 WO2016163799A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US15/564,027 US10166203B2 (en) 2015-04-10 2016-04-08 Pharmaceutical composition for treating cancer including 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol as active ingredient
CN201680021186.6A CN107530300A (zh) 2015-04-10 2016-04-08 将2‑甲氧基‑4‑(3‑(4‑甲氧基苯基)丙‑1‑烯‑1‑基)苯酚作为有效成分的癌的治疗用药剂学组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0050578 2015-04-10
KR1020150050578A KR101671020B1 (ko) 2015-04-10 2015-04-10 2-메톡시-4-(3-(4-메톡시페닐)프로프-1-엔-1-일)페놀을 유효성분으로 하는 암의 치료용 약제학적 조성물

Publications (2)

Publication Number Publication Date
WO2016163799A2 WO2016163799A2 (ko) 2016-10-13
WO2016163799A3 true WO2016163799A3 (ko) 2016-12-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/003696 WO2016163799A2 (ko) 2015-04-10 2016-04-08 2-메톡시-4-(3-(4-메톡시페닐)프로프-1-엔-1-일)페놀을 유효성분으로 하는 암의 치료용 약제학적 조성물

Country Status (4)

Country Link
US (1) US10166203B2 (ko)
KR (1) KR101671020B1 (ko)
CN (1) CN107530300A (ko)
WO (1) WO2016163799A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101687751B1 (ko) * 2015-04-09 2016-12-19 주식회사 중헌제약 2-메톡시-4-(3-(4-메톡시페닐)프로필-1-엔-1-일)페놀을 유효성분으로 함유하는 염증성 질환 또는 관절염 치료 또는 예방용 약학적 조성물
US11493519B2 (en) 2019-02-08 2022-11-08 Dewpoint Therapeutics, Inc. Methods of characterizing condensate-associated characteristics of compounds and uses thereof
CA3140651A1 (en) * 2019-05-15 2020-11-19 Whitehead Institute For Biomedical Research Methods of characterizing and utilizing agent-condensate interactions
CN110563563B (zh) * 2019-08-30 2021-06-25 四川大学 一种查耳酮类化合物及其制备方法和用途
JP2022548695A (ja) 2019-09-18 2022-11-21 デューポイント セラピューティクス， インコーポレイテッド 凝縮体関連特異性のスクリーニング方法及びその使用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260290A1 (en) * 2004-05-20 2005-11-24 Rutgers, The State University Of New Jersey Botanical anti-inflammatory compositions and methods
US7598294B2 (en) * 2001-10-03 2009-10-06 Spear Therapeutics Limited 3,4-methylenedioxy-substituted chalcones as therapeutic agents
KR20110087930A (ko) * 2010-01-27 2011-08-03 영남대학교 산학협력단 잔토휴몰 또는 이의 유도체를 함유하는 방사선 항암치료 감수성 증진용 조성물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7598294B2 (en) * 2001-10-03 2009-10-06 Spear Therapeutics Limited 3,4-methylenedioxy-substituted chalcones as therapeutic agents
US20050260290A1 (en) * 2004-05-20 2005-11-24 Rutgers, The State University Of New Jersey Botanical anti-inflammatory compositions and methods
KR20110087930A (ko) * 2010-01-27 2011-08-03 영남대학교 산학협력단 잔토휴몰 또는 이의 유도체를 함유하는 방사선 항암치료 감수성 증진용 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HIYOSHI, H. ET AL.: "2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses Tumor Progression and Metastatic Potential of Breast Cancer Cells by Inducing Ubiquit in Ligase CHIP", SCIENTIFIC REPORTS, vol. 4, no. 7095, 2014, pages 1 - 10, XP055332089 *
PATHAK, V. ET AL.: "Syntheses of 2-methoxyestradiol and Eugenol Template based Diarylpropenes as Non-steroidal Anticancer Agents", RSC ADVANCES, vol. 4, no. 66, 2014, pages 35171 - 35185, XP055332088 *

Also Published As

Publication number Publication date
WO2016163799A2 (ko) 2016-10-13
US20180133168A1 (en) 2018-05-17
US10166203B2 (en) 2019-01-01
KR101671020B1 (ko) 2016-11-02
CN107530300A (zh) 2018-01-02
KR20160121685A (ko) 2016-10-20

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