JP2015531769A5 - - Google Patents
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- JP2015531769A5 JP2015531769A5 JP2015528636A JP2015528636A JP2015531769A5 JP 2015531769 A5 JP2015531769 A5 JP 2015531769A5 JP 2015528636 A JP2015528636 A JP 2015528636A JP 2015528636 A JP2015528636 A JP 2015528636A JP 2015531769 A5 JP2015531769 A5 JP 2015531769A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- substituted
- optionally
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 89
- 125000000217 alkyl group Chemical group 0.000 claims 86
- 229910052739 hydrogen Inorganic materials 0.000 claims 35
- 239000001257 hydrogen Substances 0.000 claims 35
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 30
- 125000000623 heterocyclic group Chemical group 0.000 claims 26
- -1 R 13 and R 14 Chemical compound 0.000 claims 24
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 22
- 125000001072 heteroaryl group Chemical group 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000003107 substituted aryl group Chemical group 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 14
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 13
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 12
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 11
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 claims 10
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 7
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 150000002240 furans Chemical class 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002460 imidazoles Chemical class 0.000 claims 7
- 150000002916 oxazoles Chemical class 0.000 claims 7
- 150000003216 pyrazines Chemical class 0.000 claims 7
- 150000003222 pyridines Chemical class 0.000 claims 7
- 150000003230 pyrimidines Chemical class 0.000 claims 7
- 150000003233 pyrroles Chemical class 0.000 claims 7
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 7
- 229930192474 thiophene Natural products 0.000 claims 7
- 150000003577 thiophenes Chemical class 0.000 claims 7
- 125000004103 aminoalkyl group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 6
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 6
- CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical class C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 claims 5
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 claims 5
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 5
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical group CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims 5
- 239000012964 benzotriazole Substances 0.000 claims 5
- 125000003354 benzotriazolyl group Chemical class N1N=NC2=C1C=CC=C2* 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- AWJUIBRHMBBTKR-UHFFFAOYSA-N iso-quinoline Natural products C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 5
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 claims 5
- 150000002545 isoxazoles Chemical class 0.000 claims 5
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 claims 5
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 4
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims 4
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 4
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 4
- 150000002475 indoles Chemical class 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 150000003557 thiazoles Chemical class 0.000 claims 4
- 125000005354 acylalkyl group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 150000001556 benzimidazoles Chemical class 0.000 claims 3
- 150000008316 benzisoxazoles Chemical class 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- BBVIDBNAYOIXOE-UHFFFAOYSA-N 1,2,4-oxadiazole Chemical compound C=1N=CON=1 BBVIDBNAYOIXOE-UHFFFAOYSA-N 0.000 claims 2
- KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical class C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 claims 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 241000711920 Human orthopneumovirus Species 0.000 claims 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- QZSZPSDRJPPZDZ-OAQYLSRUSA-N (9bs)-9b-(4-chlorophenyl)-1-(pyridine-3-carbonyl)-2,3-dihydroimidazo[5,6]pyrrolo[1,2-a]pyridin-5-one Chemical compound C1=CC(Cl)=CC=C1[C@]1(C2=CN=CC=C2C2=O)N2CCN1C(=O)C1=CC=CN=C1 QZSZPSDRJPPZDZ-OAQYLSRUSA-N 0.000 claims 1
- MTPVBMVUENFFLL-HXUWFJFHSA-N 1-(2-fluorophenyl)-3-[(3s)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea Chemical compound FC1=CC=CC=C1NC(=O)N[C@@H]1C(=O)NC2=CC=CC=C2C(C=2C=CC=CC=2)=N1 MTPVBMVUENFFLL-HXUWFJFHSA-N 0.000 claims 1
- BLQDKNLGVMVKCA-UHFFFAOYSA-N 1-piperidin-1-ylpyrrolidin-2-one Chemical compound O=C1CCCN1N1CCCCC1 BLQDKNLGVMVKCA-UHFFFAOYSA-N 0.000 claims 1
- BLUJRJMLDHEMRX-UHFFFAOYSA-N 2-[[2-hydroxy-5-[(5-methyltetrazol-1-yl)iminomethyl]phenyl]-(4-hydroxyphenyl)methyl]-4-[(5-methyltetrazol-1-yl)iminomethyl]phenol Chemical compound Cc1nnnn1N=Cc1ccc(O)c(c1)C(c1ccc(O)cc1)c1cc(C=Nn2nnnc2C)ccc1O BLUJRJMLDHEMRX-UHFFFAOYSA-N 0.000 claims 1
- DKORMNNYNRPTBJ-UHFFFAOYSA-N 2-[[6-[[2-(3-hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol Chemical compound CC1=CC=C(CCCO)C(NCC=2C=C3N(CC=4C(=CC=C(C)N=4)O)C(NCCCN4CCOCC4)=NC3=CC=2)=C1 DKORMNNYNRPTBJ-UHFFFAOYSA-N 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229960000402 palivizumab Drugs 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 150000003217 pyrazoles Chemical class 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- UNNCHYARSNZOPF-UHFFFAOYSA-L way-154641 Chemical compound [Na+].[Na+].NC(=O)CN(CC(N)=O)S(=O)(=O)C1=CC=CC(NC=2N=C(NC=3C=C(C(C=4C(=CC(NC=5N=C(NC=6C=C(C=CC=6)S(=O)(=O)N(CC(N)=O)CC(N)=O)N=C(NC=6C=C(C=CC=6)S(=O)(=O)N(CC(N)=O)CC(N)=O)N=5)=CC=4)S([O-])(=O)=O)=CC=3)S([O-])(=O)=O)N=C(NC=3C=C(C=CC=3)S(=O)(=O)N(CC(N)=O)CC(N)=O)N=2)=C1 UNNCHYARSNZOPF-UHFFFAOYSA-L 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261692595P | 2012-08-23 | 2012-08-23 | |
| US61/692,595 | 2012-08-23 | ||
| US201261702646P | 2012-09-18 | 2012-09-18 | |
| US61/702,646 | 2012-09-18 | ||
| PCT/US2013/056052 WO2014031784A1 (en) | 2012-08-23 | 2013-08-21 | Compounds for the treatment of paramoxyvirus viral infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531769A JP2015531769A (ja) | 2015-11-05 |
| JP2015531769A5 true JP2015531769A5 (https=) | 2016-10-20 |
| JP6243908B2 JP6243908B2 (ja) | 2017-12-06 |
Family
ID=50150369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528636A Expired - Fee Related JP6243908B2 (ja) | 2012-08-23 | 2013-08-21 | パラミクソウイルス感染症を治療するための化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9724351B2 (https=) |
| EP (1) | EP2888240B1 (https=) |
| JP (1) | JP6243908B2 (https=) |
| KR (1) | KR20150046259A (https=) |
| CN (1) | CN104736530A (https=) |
| AU (1) | AU2013305759C1 (https=) |
| BR (1) | BR112015003376A8 (https=) |
| CA (1) | CA2882088C (https=) |
| EA (1) | EA201590197A1 (https=) |
| ES (1) | ES2779748T3 (https=) |
| HK (1) | HK1211589A1 (https=) |
| IL (1) | IL237275A0 (https=) |
| MX (1) | MX2015002231A (https=) |
| NZ (1) | NZ704666A (https=) |
| PH (1) | PH12015500355B1 (https=) |
| SG (1) | SG11201501036RA (https=) |
| WO (1) | WO2014031784A1 (https=) |
| ZA (1) | ZA201501018B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EA201590197A1 (ru) * | 2012-08-23 | 2015-07-30 | Алиос Биофарма, Инк. | Соединения для лечения парамиксовирусных вирусных инфекций |
| BR112015014457A2 (pt) | 2012-12-21 | 2017-11-21 | Alios Biopharma Inc | composto ou sal farmaceuticamente aceitável do mesmo e composição farmacêutica e respectivos usos e processos para melhorar ou tratar infecção de hcv, para inibir a atividade da ns5b polimerase do vírus da hepatite c e a replicação de vírus da hepatite c |
| CN105102448B (zh) | 2013-02-28 | 2018-03-06 | 百时美施贵宝公司 | 作为rock1和rock2抑制剂的苯基吡唑衍生物 |
| AR094929A1 (es) * | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| AU2014308991B2 (en) | 2013-08-21 | 2019-02-14 | Janssen Biopharma, Inc. | Antiviral compounds |
| EA029661B1 (ru) | 2013-09-06 | 2018-04-30 | Ауриген Дискавери Текнолоджиз Лимитед | Производные 1,3,4-оксадиазола и 1,3,4-тиадиазола в качестве иммуномодуляторов |
| PE20170673A1 (es) * | 2014-08-05 | 2017-05-22 | Alios Biopharma Inc | Terapia de combinacion para tratar una paramixovirus |
| PT3204352T (pt) * | 2014-10-06 | 2020-09-23 | Cortexyme Inc | Inibidores de lisina-gingipaína |
| US10308871B2 (en) | 2015-02-19 | 2019-06-04 | Jnc Corporation | Liquid crystal compound having benzothiophene, liquid crystal composition and liquid crystal display device |
| MA41614A (fr) * | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| DK3324977T3 (da) | 2015-07-22 | 2022-10-17 | Enanta Pharm Inc | Benzodiazepinderivater som rsv-inhibitorer |
| EP3795563B1 (en) | 2016-03-31 | 2024-07-17 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| ES2992410T3 (es) | 2016-09-16 | 2024-12-12 | Lighthouse Pharmaceuticals Inc | Inhibidores cetónicos de la lisina gingipaína |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| BR112020006334A2 (pt) | 2017-09-29 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | combinação de agentes farmacêuticos como inibidores de rsv |
| US11576981B2 (en) | 2017-12-06 | 2023-02-14 | Ontario Institute For Cancer Research (Oicr) | Acyl hydrazone linkers, methods and uses thereof |
| WO2019119141A1 (en) * | 2017-12-22 | 2019-06-27 | Ontario Institute For Cancer Research (Oicr) | Heterocyclic acyl hydrazone linkers, methods and uses thereof |
| EA202091889A1 (ru) | 2018-02-08 | 2020-10-29 | Энио Фарма | Конденсированные производные тиофена и их применение |
| CN108929273A (zh) * | 2018-06-27 | 2018-12-04 | 合肥医工医药有限公司 | 一种咪唑乙基香草酸醚钠盐的制备方法 |
| BR112021018335A2 (pt) | 2019-03-18 | 2021-11-23 | Enanta Pharm Inc | Derivados de benzodiazepina como inibidores de rsv |
| AU2020357452B2 (en) | 2019-10-04 | 2026-01-29 | Enanta Pharmaceuticals, Inc | Antiviral heterocyclic compounds |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| CN111004211B (zh) * | 2019-12-29 | 2021-04-02 | 苏州诚和医药化学有限公司 | 一种依匹哌唑中间体4-溴苯并［b］噻吩的合成方法 |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| CA3200111C (en) | 2020-10-28 | 2025-02-18 | Shionogi & Co., Ltd. | AMIDE DERIVATIVE WITH ANTIVIRAL ACTIVITY |
| US12612412B2 (en) | 2021-02-26 | 2026-04-28 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| WO2022182861A1 (en) | 2021-02-26 | 2022-09-01 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| AU2022315530A1 (en) | 2021-07-20 | 2024-01-18 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their preparation, and uses |
| WO2023052593A1 (en) | 2021-10-01 | 2023-04-06 | Janssen Sciences Ireland Unlimited Company | Rsv inhibiting spiro bearing derivatives |
| WO2023144127A1 (en) | 2022-01-31 | 2023-08-03 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon administration, and uses |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| WO2023211997A1 (en) | 2022-04-27 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| WO2023232976A1 (en) | 2022-06-03 | 2023-12-07 | Ags Therapeutics Sas | Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses |
| WO2023237732A1 (en) | 2022-06-10 | 2023-12-14 | Janssen Sciences Ireland Unlimited Company | Rsv inhibiting triazolo bearing derivatives |
| WO2023237730A1 (en) | 2022-06-10 | 2023-12-14 | Janssen Sciences Ireland Unlimited Company | Rsv inhibiting triazolo and spiro bearing derivatives |
| EP4538258A4 (en) * | 2022-06-13 | 2025-07-30 | Hefei Inst Of Pharmaceutical Industry Co Ltd | IMIDAZOLIDINYL VANILLIC ACID ETHER DERIVATIVE AND ITS USE |
| WO2024088808A1 (en) | 2022-10-24 | 2024-05-02 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof |
| CN116082254B (zh) * | 2022-12-28 | 2025-04-11 | 浙江永太科技股份有限公司 | 一种1-烷基-1,2,4-三氮唑-3-甲醇的制备方法 |
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-
2013
- 2013-08-21 EA EA201590197A patent/EA201590197A1/ru unknown
- 2013-08-21 CN CN201380054579.3A patent/CN104736530A/zh active Pending
- 2013-08-21 BR BR112015003376A patent/BR112015003376A8/pt not_active IP Right Cessation
- 2013-08-21 EP EP13830584.2A patent/EP2888240B1/en active Active
- 2013-08-21 KR KR1020157007347A patent/KR20150046259A/ko not_active Withdrawn
- 2013-08-21 ES ES13830584T patent/ES2779748T3/es active Active
- 2013-08-21 HK HK15112568.0A patent/HK1211589A1/xx unknown
- 2013-08-21 JP JP2015528636A patent/JP6243908B2/ja not_active Expired - Fee Related
- 2013-08-21 US US14/422,920 patent/US9724351B2/en not_active Expired - Fee Related
- 2013-08-21 MX MX2015002231A patent/MX2015002231A/es unknown
- 2013-08-21 CA CA2882088A patent/CA2882088C/en active Active
- 2013-08-21 AU AU2013305759A patent/AU2013305759C1/en not_active Ceased
- 2013-08-21 SG SG11201501036RA patent/SG11201501036RA/en unknown
- 2013-08-21 NZ NZ704666A patent/NZ704666A/en not_active IP Right Cessation
- 2013-08-21 WO PCT/US2013/056052 patent/WO2014031784A1/en not_active Ceased
-
2015
- 2015-02-12 ZA ZA2015/01018A patent/ZA201501018B/en unknown
- 2015-02-17 IL IL237275A patent/IL237275A0/en unknown
- 2015-02-18 PH PH12015500355A patent/PH12015500355B1/en unknown
-
2017
- 2017-06-20 US US15/627,757 patent/US11014935B2/en not_active Expired - Fee Related
-
2021
- 2021-04-12 US US17/228,573 patent/US20220396581A1/en not_active Abandoned
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