JP2015526387A5 - - Google Patents
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- JP2015526387A5 JP2015526387A5 JP2015515243A JP2015515243A JP2015526387A5 JP 2015526387 A5 JP2015526387 A5 JP 2015526387A5 JP 2015515243 A JP2015515243 A JP 2015515243A JP 2015515243 A JP2015515243 A JP 2015515243A JP 2015526387 A5 JP2015526387 A5 JP 2015526387A5
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- JP
- Japan
- Prior art keywords
- seq
- amino acid
- antibody
- antibody comprises
- monoclonal antibody
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261654232P | 2012-06-01 | 2012-06-01 | |
| US61/654,232 | 2012-06-01 | ||
| PCT/US2013/043633 WO2013181543A1 (en) | 2012-06-01 | 2013-05-31 | High-affinity monoclonal antibodies to glypican-3 and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000195A Division JP2019062910A (ja) | 2012-06-01 | 2019-01-04 | グリピカン−３に対する高親和性モノクローナル抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015526387A JP2015526387A (ja) | 2015-09-10 |
| JP2015526387A5 true JP2015526387A5 (enExample) | 2016-06-02 |
| JP6494507B2 JP6494507B2 (ja) | 2019-04-03 |
Family
ID=48699931
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015515243A Active JP6494507B2 (ja) | 2012-06-01 | 2013-05-31 | グリピカン−３に対する高親和性モノクローナル抗体およびその使用 |
| JP2019000195A Pending JP2019062910A (ja) | 2012-06-01 | 2019-01-04 | グリピカン−３に対する高親和性モノクローナル抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000195A Pending JP2019062910A (ja) | 2012-06-01 | 2019-01-04 | グリピカン−３に対する高親和性モノクローナル抗体およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9409994B2 (enExample) |
| JP (2) | JP6494507B2 (enExample) |
| KR (1) | KR102159773B1 (enExample) |
| CN (1) | CN104520331B (enExample) |
| SG (1) | SG11201407972RA (enExample) |
| WO (1) | WO2013181543A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101198698B (zh) | 2005-03-31 | 2014-03-19 | 中外制药株式会社 | 通过调节多肽缔合制备多肽的方法 |
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| TWI638833B (zh) | 2010-11-30 | 2018-10-21 | 中外製藥股份有限公司 | 細胞傷害誘導治療劑 |
| EP4282419A1 (en) | 2012-12-20 | 2023-11-29 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| TWI693073B (zh) | 2012-12-21 | 2020-05-11 | 日商中外製藥股份有限公司 | 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑 |
| CN105764922B (zh) | 2013-09-27 | 2020-07-17 | 中外制药株式会社 | 多肽异源多聚体的制备方法 |
| CN105849562B (zh) * | 2013-12-24 | 2019-08-16 | 中外制药株式会社 | 可溶性gpc3蛋白质的测定方法 |
| TWI735410B (zh) | 2014-05-08 | 2021-08-11 | 日商中外製藥股份有限公司 | 對ｇｐｃ３標的治療劑療法為有效之患者投予的ｇｐｃ３標的治療劑 |
| MA40764A (fr) * | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
| KR102739664B1 (ko) * | 2015-04-20 | 2024-12-05 | 미노믹 인터내셔널 리미티드 | 치료용 항체 및 이의 용도 |
| WO2017002934A1 (ja) | 2015-07-01 | 2017-01-05 | 中外製薬株式会社 | Ｇｐｃ３標的治療剤が有効である患者に投与されるｇｐｃ３標的治療剤 |
| KR101796688B1 (ko) | 2015-10-29 | 2017-12-01 | 재단법인 목암생명과학연구소 | 신규 항-글리피칸 3 항체 및 이를 포함하는 약학적 조성물 |
| EP3428648B1 (en) * | 2016-03-10 | 2020-12-02 | National Cancer Center | Method for assisting prediction of recurrence risk in hepatocellular carcinoma patient, and use of a kit |
| CA3016424A1 (en) * | 2016-03-14 | 2017-09-21 | Chugai Seiyaku Kabushiki Kaisha | Cell injury inducing therapeutic drug for use in cancer therapy |
| US12144850B2 (en) | 2016-04-08 | 2024-11-19 | Purdue Research Foundation | Methods and compositions for car T cell therapy |
| WO2017196847A1 (en) * | 2016-05-10 | 2017-11-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Variable new antigen receptor (vnar) antibodies and antibody conjugates targeting tumor and viral antigens |
| US20170326249A1 (en) | 2016-05-10 | 2017-11-16 | Bristol-Myers Squibb Company | Antibody-drug conjugate of an anti-glypican-3 antibody and a tubulysin analog, preparation and uses |
| CN107556387A (zh) * | 2016-06-30 | 2018-01-09 | 中国科学院深圳先进技术研究院 | 抗gpc3和cd3特异性双靶向抗体、含该双靶向抗体表达盒的微环dna及应用 |
| AU2017301826A1 (en) | 2016-07-26 | 2019-03-14 | Tessa Therapeutics Ltd. | Chimeric antigen receptor |
| KR102564097B1 (ko) | 2017-01-10 | 2023-08-04 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 항 gpc3 항체 |
| AU2018219226B2 (en) | 2017-02-07 | 2024-12-19 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| ES3010559T3 (en) | 2017-02-28 | 2025-04-03 | Endocyte Inc | Compositions and methods for car t cell therapy |
| IL270138B2 (en) * | 2017-04-26 | 2025-08-01 | Eureka Therapeutics Inc | Structures that specifically recognize glypican 3 and their uses |
| CN108250266A (zh) * | 2017-09-05 | 2018-07-06 | 首都医科大学附属北京佑安医院 | 一种hla-a11限制性gpc3源性多肽及包含它的疫苗 |
| CN111683962B (zh) * | 2017-11-10 | 2025-05-16 | 美国政府(由卫生和人类服务部的部长所代表) | 靶向肿瘤抗原的嵌合抗原受体 |
| CN109988240B (zh) * | 2017-12-29 | 2022-06-28 | 安源医药科技（上海）有限公司 | 抗gpc-3抗体及其用途 |
| US11311576B2 (en) | 2018-01-22 | 2022-04-26 | Seattle Children's Hospital | Methods of use for CAR T cells |
| WO2019156795A1 (en) | 2018-02-06 | 2019-08-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors |
| CA3091674A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| CN110577600B (zh) * | 2018-06-07 | 2021-05-04 | 中国科学院上海药物研究所 | 靶向gpc3的抗体-药物偶联物及其制备方法和用途 |
| TWI809130B (zh) | 2018-06-22 | 2023-07-21 | 美商凱特製藥公司 | 嵌合跨膜蛋白及其用途 |
| CN109021108B (zh) * | 2018-08-27 | 2019-06-25 | 南京医科大学 | 抗gpc3全人源化抗体、其嵌合抗原受体细胞及应用 |
| CA3117212A1 (en) | 2018-10-23 | 2020-04-30 | Dragonfly Therapeutics, Inc. | Heterodimeric fc-fused proteins |
| CA3125033A1 (en) | 2019-01-22 | 2020-07-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High affinity monoclonal antibodies targeting glypican-1 and methods of use |
| EP3941942A4 (en) * | 2019-03-21 | 2023-04-26 | Agency For Science, Technology And Research | COMPOSITION |
| US12466891B2 (en) | 2019-05-15 | 2025-11-11 | Kyowa Kirin Co., Ltd. | Bispecific antibody binding to CD40 and GPC3 |
| WO2020242926A1 (en) * | 2019-05-24 | 2020-12-03 | Memorial Sloan Kettering Cancer Center | Anti-glypican-3 antibodies and uses thereof |
| US12109235B2 (en) | 2019-06-21 | 2024-10-08 | Kite Pharma, Inc. | TGF-beta receptors and methods of use |
| CN116063528A (zh) * | 2019-08-16 | 2023-05-05 | 原启生物科技(上海)有限责任公司 | 一种分离的抗原结合蛋白及其用途 |
| GB201918103D0 (en) * | 2019-12-10 | 2020-01-22 | Oblique Therapeutics Ab | Epitopes and antibodies |
| CN115087466A (zh) * | 2019-12-12 | 2022-09-20 | 森迪生物科学公司 | 用于细胞的调控装甲的方法和组合物 |
| KR20220163940A (ko) | 2020-02-04 | 2022-12-12 | 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 | 항-디니트로페놀 키메라 항원 수용체 |
| EP4110912A4 (en) * | 2020-02-27 | 2024-07-10 | Legend Biotech Ireland Limited | ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS TARGETING GLYPICAN-3 (GPC3) AND METHODS OF USE THEREOF |
| CN111662385B (zh) * | 2020-04-08 | 2022-11-22 | 重庆金迈博生物科技有限公司 | 全人源抗人gpc3单克隆抗体及其用途 |
| CN111187351B (zh) * | 2020-04-14 | 2020-08-04 | 浙江恒驭生物科技有限公司 | 一种肝癌检测试剂盒 |
| EP4138778A1 (en) | 2020-04-22 | 2023-03-01 | Dragonfly Therapeutics, Inc. | Formulation, dosage regimen, and manufacturing process for heterodimeric fc-fused proteins |
| CN111349178B (zh) * | 2020-05-25 | 2020-09-29 | 北京达熙生物科技有限公司 | 一种靶向gpc3的嵌合抗原受体(car)及其抗癌的用途 |
| CN120383678A (zh) * | 2020-10-23 | 2025-07-29 | 华中农业大学 | 识别磷脂酰肌醇蛋白聚糖3多个不同表位的抗体及其应用 |
| CN114478779B (zh) * | 2020-10-26 | 2024-10-11 | 华中农业大学 | 人源化的磷脂酰肌醇蛋白聚糖3的单克隆抗体及其应用 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| CN114685668B (zh) * | 2020-12-28 | 2023-10-13 | 石药集团巨石生物制药有限公司 | 一种人gpc3单克隆抗体及其缀合物 |
| US20260116991A1 (en) * | 2021-02-03 | 2026-04-30 | Hainan Simcere Zaiming Pharmaceutical Co., Ltd. | Monoclonal antibody for specifically recognizing glypican-3, and application thereof |
| CN113072643B (zh) * | 2021-03-22 | 2021-10-15 | 南京医科大学 | 抗Glypican-3耐酸性全人源抗体、其免疫毒素、其嵌合抗原受体细胞及应用 |
| CN117730100A (zh) * | 2021-06-08 | 2024-03-19 | 凯德药业股份有限公司 | Gpc3结合分子 |
| WO2023283361A1 (en) * | 2021-07-07 | 2023-01-12 | Triumvira Immunologics Usa, Inc. | Gpc3 t cell-antigen couplers and uses thereof |
| CN115298222B (zh) * | 2021-09-24 | 2023-07-07 | 浙江时迈药业有限公司 | 针对gpc3的抗体及其用途 |
| WO2023056474A1 (en) * | 2021-09-30 | 2023-04-06 | University Of Washington | Mouse anti-human monoclonal antibody against glypican-3 |
| JP2025531401A (ja) * | 2022-09-22 | 2025-09-19 | レプ バイオファーマ カンパニー，リミティド | Ｇｐｃ３抗体薬物複合体及びその使用 |
| CN120225568A (zh) * | 2022-12-27 | 2025-06-27 | 广州瑞风生物科技有限公司 | 一种融合蛋白及其应用 |
| CN117304343B (zh) * | 2023-10-11 | 2024-05-07 | 北京景达生物科技有限公司 | Gpc3靶向的car-nk细胞的制备及其应用 |
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| WO2012145469A1 (en) | 2011-04-19 | 2012-10-26 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Human monoclonal antibodies specific for glypican-3 and use thereof |
-
2013
- 2013-05-31 US US14/403,896 patent/US9409994B2/en active Active
- 2013-05-31 WO PCT/US2013/043633 patent/WO2013181543A1/en not_active Ceased
- 2013-05-31 CN CN201380039993.7A patent/CN104520331B/zh active Active
- 2013-05-31 JP JP2015515243A patent/JP6494507B2/ja active Active
- 2013-05-31 SG SG11201407972RA patent/SG11201407972RA/en unknown
- 2013-05-31 KR KR1020147037046A patent/KR102159773B1/ko active Active
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2019
- 2019-01-04 JP JP2019000195A patent/JP2019062910A/ja active Pending