JP2010510809A5 - - Google Patents

Info

Publication number

JP2010510809A5

JP2010510809A5 JP2009539435A JP2009539435A JP2010510809A5 JP 2010510809 A5 JP2010510809 A5 JP 2010510809A5 JP 2009539435 A JP2009539435 A JP 2009539435A JP 2009539435 A JP2009539435 A JP 2009539435A JP 2010510809 A5 JP2010510809 A5 JP 2010510809A5

Authority

JP

Japan

Prior art keywords

antibody

group

ovr110

antigen

binding fragment

Prior art date

2007-11-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000427 antigen Substances 0.000 claims 16
• 108091007433 antigens Proteins 0.000 claims 16
• 102000036639 antigens Human genes 0.000 claims 16
• 239000012634 fragment Substances 0.000 claims 16
• 239000000203 mixture Substances 0.000 claims 11
• 206010028980 Neoplasm Diseases 0.000 claims 9
• 125000003275 alpha amino acid group Chemical group 0.000 claims 8
• 210000000822 natural killer cell Anatomy 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 210000003719 b-lymphocyte Anatomy 0.000 claims 4
• 230000004663 cell proliferation Effects 0.000 claims 4
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
• 230000028993 immune response Effects 0.000 claims 4
• 229940127121 immunoconjugate Drugs 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 230000009545 invasion Effects 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 230000001629 suppression Effects 0.000 claims 3
• 230000003844 B-cell-activation Effects 0.000 claims 2
• 206010005003 Bladder cancer Diseases 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 2
• 230000006051 NK cell activation Effects 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
• 206010038389 Renal cancer Diseases 0.000 claims 2
• 230000006044 T cell activation Effects 0.000 claims 2
• 230000006052 T cell proliferation Effects 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 230000004709 cell invasion Effects 0.000 claims 2
• 239000002254 cytotoxic agent Substances 0.000 claims 2
• 231100000599 cytotoxic agent Toxicity 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 201000010982 kidney cancer Diseases 0.000 claims 2
• 201000005202 lung cancer Diseases 0.000 claims 2
• 208000020816 lung neoplasm Diseases 0.000 claims 2
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• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
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• 201000002528 pancreatic cancer Diseases 0.000 claims 2
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
• 239000003053 toxin Substances 0.000 claims 2
• 231100000765 toxin Toxicity 0.000 claims 2
• 108700012359 toxins Proteins 0.000 claims 2
• 210000004881 tumor cell Anatomy 0.000 claims 2
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• 201000005112 urinary bladder cancer Diseases 0.000 claims 2
• 206010003445 Ascites Diseases 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 108010039491 Ricin Proteins 0.000 claims 1
• 108010084592 Saporins Proteins 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 230000033228 biological regulation Effects 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
• 229930195731 calicheamicin Natural products 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
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• 230000001293 nucleolytic effect Effects 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 239000003330 peritoneal dialysis fluid Substances 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1