JP2011502517A5 - - Google Patents

Info

Publication number

JP2011502517A5

JP2011502517A5 JP2010533279A JP2010533279A JP2011502517A5 JP 2011502517 A5 JP2011502517 A5 JP 2011502517A5 JP 2010533279 A JP2010533279 A JP 2010533279A JP 2010533279 A JP2010533279 A JP 2010533279A JP 2011502517 A5 JP2011502517 A5 JP 2011502517A5

Authority

JP

Japan

Prior art keywords

seq

antibody

acid sequence

amino acid

antigen

Prior art date

2008-11-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 20
• 102000036639 antigens Human genes 0.000 claims 15
• 108091007433 antigens Proteins 0.000 claims 15
• 239000000427 antigen Substances 0.000 claims 11
• 206010009944 Colon cancer Diseases 0.000 claims 9
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 9
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 9
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 9
• 201000002528 pancreatic cancer Diseases 0.000 claims 9
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 9
• 239000012634 fragment Substances 0.000 claims 7
• 238000000034 method Methods 0.000 claims 7
• 150000007523 nucleic acids Chemical class 0.000 claims 7
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• 239000003153 chemical reaction reagent Substances 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 201000009030 Carcinoma Diseases 0.000 claims 2
• 108090000790 Enzymes Proteins 0.000 claims 2
• 102000004190 Enzymes Human genes 0.000 claims 2
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 2
• 108010039491 Ricin Proteins 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 231100000433 cytotoxic Toxicity 0.000 claims 2
• 230000001472 cytotoxic effect Effects 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229940088598 enzyme Drugs 0.000 claims 2
• 229960000485 methotrexate Drugs 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 claims 1
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
• 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 claims 1
• 108010032595 Antibody Binding Sites Proteins 0.000 claims 1
• 230000006820 DNA synthesis Effects 0.000 claims 1
• 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
• 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
• 108010064785 Phospholipases Proteins 0.000 claims 1
• 102000015439 Phospholipases Human genes 0.000 claims 1
• 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims 1
• 230000006819 RNA synthesis Effects 0.000 claims 1
• 229940009456 adriamycin Drugs 0.000 claims 1
• 230000003302 anti-idiotype Effects 0.000 claims 1
• 230000000259 anti-tumor effect Effects 0.000 claims 1
• 230000001588 bifunctional effect Effects 0.000 claims 1
• 229940044683 chemotherapy drug Drugs 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 229960000975 daunorubicin Drugs 0.000 claims 1
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 229940125532 enzyme inhibitor Drugs 0.000 claims 1
• 239000002532 enzyme inhibitor Substances 0.000 claims 1
• 239000003018 immunosuppressive agent Substances 0.000 claims 1
• 229940125721 immunosuppressive agent Drugs 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 239000002184 metal Substances 0.000 claims 1
• 229960004857 mitomycin Drugs 0.000 claims 1
• 230000001575 pathological effect Effects 0.000 claims 1
• 108700028325 pokeweed antiviral Proteins 0.000 claims 1
• 238000001243 protein synthesis Methods 0.000 claims 1
• 230000002285 radioactive effect Effects 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 230000014616 translation Effects 0.000 claims 1
• UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 claims 1
• 229960004355 vindesine Drugs 0.000 claims 1