|
US4741900A
(en)
|
1982-11-16 |
1988-05-03 |
Cytogen Corporation |
Antibody-metal ion complexes
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
DE3668186D1
(de)
|
1985-04-01 |
1990-02-15 |
Celltech Ltd |
Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert.
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
JPS63501765A
(ja)
|
1985-11-01 |
1988-07-21 |
インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド |
抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
CA1323293C
(en)
|
1987-12-11 |
1993-10-19 |
Keith C. Backman |
Assay using template-dependent nucleic acid probe reorganization
|
|
EP1026240A3
(en)
|
1988-09-02 |
2004-04-07 |
Dyax Corp. |
Generation and selection of recombinant varied binding proteins
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US6291158B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
DK0546073T3
(da)
|
1990-08-29 |
1998-02-02 |
Genpharm Int |
Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
GB9106048D0
(en)
|
1991-03-21 |
1991-05-08 |
Smithkline Beecham Biolog |
Vaccines
|
|
ATE146821T1
(de)
|
1990-10-22 |
1997-01-15 |
Abbott Lab |
Stabile sauerstoff-freie reagenzienlösung für diagnostik
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
ATE269401T1
(de)
|
1991-04-10 |
2004-07-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
JPH07503124A
(ja)
|
1991-06-14 |
1995-04-06 |
ゾーマ・コーポレーション |
微生物によって生産される抗体断片とそれらの複合体
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
DE69233408T2
(de)
|
1991-12-02 |
2005-09-22 |
Cambridge Antibody Technology Ltd., Melbourn |
Herstellung von Antikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken.
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
CA2140280A1
(en)
|
1992-08-17 |
1994-03-03 |
Avi J. Ashkenazi |
Bispecific immunoadhesins
|
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
EP0672131B1
(en)
|
1992-10-30 |
2003-12-17 |
The General Hospital Corporation |
A novel cell cycle control protein
|
|
US5807683A
(en)
|
1992-11-19 |
1998-09-15 |
Combichem, Inc. |
Combinatorial libraries and methods for their use
|
|
DE69427974T2
(de)
|
1993-04-29 |
2001-12-06 |
Unilever N.V., Rotterdam |
Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae
|
|
JPH09506262A
(ja)
|
1993-12-08 |
1997-06-24 |
ジェンザイム・コーポレイション |
特異的抗体の製造方法
|
|
SE9400088D0
(sv)
|
1994-01-14 |
1994-01-14 |
Kabi Pharmacia Ab |
Bacterial receptor structures
|
|
ATE300610T1
(de)
|
1994-01-31 |
2005-08-15 |
Univ Boston |
Bibliotheken aus polyklonalen antikörpern
|
|
WO1995026204A1
(en)
|
1994-03-25 |
1995-10-05 |
Isis Pharmaceuticals, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
|
US5738996A
(en)
|
1994-06-15 |
1998-04-14 |
Pence, Inc. |
Combinational library composition and method
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
US5616502A
(en)
|
1995-05-19 |
1997-04-01 |
Molecular Probes, Inc. |
Non-specific protein staining using merocyanine dyes
|
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
|
GB9608510D0
(en)
|
1996-04-25 |
1996-07-03 |
Medical Res Council |
Calcium dependent binding ligands
|
|
JP2000512490A
(ja)
|
1996-05-29 |
2000-09-26 |
デレク ナイジェル ジョン ハート |
樹状細胞のレセプター
|
|
EP0929575A4
(en)
*
|
1996-08-23 |
2004-09-08 |
Human Genome Sciences Inc |
NEW HUMAN GROWTH FACTORS.
|
|
US6171816B1
(en)
*
|
1996-08-23 |
2001-01-09 |
Human Genome Sciences, Inc. |
Human XAG-1 polynucleotides and polypeptides
|
|
GB9624927D0
(en)
|
1996-11-29 |
1997-01-15 |
Oxford Glycosciences Uk Ltd |
Gels and their use
|
|
US6057098A
(en)
|
1997-04-04 |
2000-05-02 |
Biosite Diagnostics, Inc. |
Polyvalent display libraries
|
|
GB9710582D0
(en)
|
1997-05-22 |
1997-07-16 |
Oxford Glycosciences Uk Ltd |
A method for de novo peptide sequence determination
|
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
AU3657899A
(en)
|
1998-04-20 |
1999-11-08 |
James E. Bailey |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
|
|
EP2275540B1
(en)
|
1999-04-09 |
2016-03-23 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
EP1290217A2
(en)
|
2000-02-04 |
2003-03-12 |
Aeomica, Inc. |
Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
|
|
JP2003524017A
(ja)
*
|
2000-02-25 |
2003-08-12 |
オックスフォード グリコサイエンセス（ユーケー） リミテッド |
タンパク質
|
|
GB0004576D0
(en)
*
|
2000-02-25 |
2000-04-19 |
Oxford Glycosciences Uk Ltd |
Proteins
|
|
US6900016B1
(en)
*
|
2000-09-08 |
2005-05-31 |
Applera Corporation |
Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof
|
|
CA2424602C
(en)
|
2000-10-06 |
2012-09-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Antibody composition-producing cell
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US7754208B2
(en)
*
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
EP1385538B1
(en)
*
|
2001-04-05 |
2013-01-30 |
The Johns Hopkins University |
Chimeric Vaccines comprising the lumenal domain of LAMP-1 or LAMP-2
|
|
JP2005508144A
(ja)
*
|
2001-06-18 |
2005-03-31 |
イオス バイオテクノロジー，インコーポレイティド |
卵巣癌の診断方法、卵巣癌のモジュレーターをスクリーニングする組成物及び方法
|
|
WO2004058821A2
(en)
|
2002-12-27 |
2004-07-15 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
|
AU2002319402B2
(en)
|
2001-06-28 |
2008-09-11 |
Domantis Limited |
Dual-specific ligand and its use
|
|
WO2003042661A2
(en)
|
2001-11-13 |
2003-05-22 |
Protein Design Labs, Inc. |
Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
|
|
AU2002357734A1
(en)
*
|
2001-11-13 |
2003-05-26 |
Protein Design Labs, Inc. |
Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
|
|
AU2002348268A1
(en)
*
|
2001-12-03 |
2003-06-17 |
Bristol-Myers Squibb Company |
Polynucleotides and polypeptides associated with the development of osteoarthritis
|
|
US20030215835A1
(en)
*
|
2002-01-15 |
2003-11-20 |
Zairen Sun |
Differentially-regulated prostate cancer genes
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
JP2005536186A
(ja)
|
2002-03-07 |
2005-12-02 |
ルードビッヒ、インスティテュート、フォー、キャンサー、リサーチ |
リンパ管および血管内皮細胞遺伝子
|
|
PL373256A1
(en)
|
2002-04-09 |
2005-08-22 |
Kyowa Hakko Kogyo Co, Ltd. |
Cells with modified genome
|
|
EP1600459A3
(en)
|
2002-06-28 |
2005-12-07 |
Domantis Limited |
Ligand
|
|
AU2003256240A1
(en)
|
2002-08-29 |
2004-03-19 |
National University Of Singapore |
Recombinant nucleic acid useful for inducing protective immune response against allergens
|
|
US20070010434A1
(en)
|
2002-09-16 |
2007-01-11 |
Genetech, Inc. |
Novel compositions and methods for the treatment of immune related diseases
|
|
AU2002951409A0
(en)
*
|
2002-09-16 |
2002-09-26 |
North Western Adelaide Health Services |
Methods for regulating cancer
|
|
EP1558650A2
(en)
|
2002-11-08 |
2005-08-03 |
Ablynx N.V. |
Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders
|
|
AU2002953223A0
(en)
*
|
2002-12-06 |
2003-01-02 |
The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland |
Novel therapeutic molecules and uses thereof
|
|
JP4889493B2
(ja)
|
2003-05-14 |
2012-03-07 |
ドマンティス リミテッド |
ポリペプチドレパートリーから可逆的にアンフォールドするポリペプチドを回収するための方法
|
|
WO2005016952A2
(en)
|
2003-05-19 |
2005-02-24 |
Duke University |
Polyvalent immunogen
|
|
EP1639011B1
(en)
|
2003-06-30 |
2008-11-12 |
Domantis Limited |
Pegylated single domain antibodies (dAb)
|
|
WO2005019258A2
(en)
|
2003-08-11 |
2005-03-03 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
JP2007537717A
(ja)
|
2004-01-07 |
2007-12-27 |
ブリストル−マイヤーズ スクイブ カンパニー |
上皮増殖因子受容体モデュレーターに対する感受性を決定するためのバイオマーカーおよび方法
|
|
US8273357B2
(en)
*
|
2004-07-16 |
2012-09-25 |
Massachusetts Institute Of Technology |
Antigen-carbohydrate conjugates
|
|
EP1799713B1
(en)
*
|
2004-09-23 |
2014-11-05 |
VasGene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
|
WO2006079372A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
EP1695981A1
(de)
*
|
2005-02-25 |
2006-08-30 |
Forschungsverbund Berlin e.V. |
Verfahren zum Redox-Potential-abhängigen Nachweis von Targetmolekülen durch wechselwirkende Polypeptide
|
|
US7608413B1
(en)
*
|
2005-03-25 |
2009-10-27 |
Celera Corporation |
Kidney disease targets and uses thereof
|
|
BRPI0611445A2
(pt)
|
2005-05-09 |
2010-09-08 |
Glycart Biotechnology Ag |
molécula de ligação a antìgeno glicomanipulada, polinucleotìdeo, polipeptìdeo, vetor, célula hospedeira, método para produção, uso e composição farmacêutica
|
|
WO2007030571A2
(en)
|
2005-09-06 |
2007-03-15 |
Molecular Image Inc. |
Identification of targets and development of reagents for testing and molecular imaging of human disease
|
|
US7842466B1
(en)
*
|
2005-09-16 |
2010-11-30 |
Celera Corporation |
Colon disease targets and uses thereof
|
|
BRPI0619056A2
(pt)
|
2005-11-28 |
2011-09-20 |
Genmab As |
anticorpo monovalente, método para preparar e produzir um antcorpo monovalente, construção de ácido nucleico, célula hospedeira, imunoconjugado, uso de um anticorpo monovalente, e, composição farmacêutica
|
|
GB0611116D0
(en)
*
|
2006-06-06 |
2006-07-19 |
Oxford Genome Sciences Uk Ltd |
Proteins
|
|
EP2052088A2
(en)
|
2006-08-02 |
2009-04-29 |
Genizon Biosciences |
Genemap of the human genes associated with psoriasis
|
|
CA2660286A1
(en)
|
2006-08-09 |
2008-02-21 |
Homestead Clinical Corporation |
Organ-specific proteins and methods of their use
|
|
WO2008104803A2
(en)
|
2007-02-26 |
2008-09-04 |
Oxford Genome Sciences (Uk) Limited |
Proteins
|
|
EP2224954B1
(en)
*
|
2007-11-07 |
2014-01-08 |
Celldex Therapeutics, Inc. |
Antibodies that bind human dendritic and epithelial cell 205 (dec-205)
|
|
US8168586B1
(en)
*
|
2007-11-21 |
2012-05-01 |
Celera Corporation |
Cancer targets and uses thereof
|
|
DE102008006841B4
(de)
|
2008-01-30 |
2013-07-11 |
Wolfram Kangler |
Verfahren und Vorrichtung zum Betrieb einer Brennkraftmaschine mit einem flüssigen Kraftstoffgemisch
|
|
EP2159291A1
(en)
|
2008-09-01 |
2010-03-03 |
Agendia B.V. |
Means and method for determining tumor cell percentage in a sample
|
|
US20120128642A1
(en)
|
2009-07-23 |
2012-05-24 |
Jeffrey Keeler Teumer |
Potency markers
|
|
US9002545B2
(en)
|
2011-01-07 |
2015-04-07 |
Wabtec Holding Corp. |
Data improvement system and method
|