|
US4741900A
(en)
|
1982-11-16 |
1988-05-03 |
Cytogen Corporation |
Antibody-metal ion complexes
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
DE3668186D1
(de)
|
1985-04-01 |
1990-02-15 |
Celltech Ltd |
Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert.
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
JPS63501765A
(ja)
|
1985-11-01 |
1988-07-21 |
インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド |
抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
CA1323293C
(en)
|
1987-12-11 |
1993-10-19 |
Keith C. Backman |
Assay using template-dependent nucleic acid probe reorganization
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP1541682A3
(en)
|
1988-09-02 |
2005-07-06 |
Dyax Corp. |
Generation and selection of recombinant varied binding proteins
|
|
FI903489A0
(fi)
|
1988-11-11 |
1990-07-10 |
Medical Res Council |
Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US6291158B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
|
GB9106048D0
(en)
|
1991-03-21 |
1991-05-08 |
Smithkline Beecham Biolog |
Vaccines
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
DE69123848T2
(de)
|
1990-10-22 |
1997-07-10 |
Abbott Lab |
Stabile sauerstoff-freie reagenzienlösung für diagnostik
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
ATE414768T1
(de)
|
1991-04-10 |
2008-12-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
CA2110799A1
(en)
|
1991-06-14 |
1992-12-23 |
Arnold H. Horwitz |
Microbially-produced antibody fragments and their conjugates
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
DK0616640T3
(da)
|
1991-12-02 |
2004-12-20 |
Medical Res Council |
Fremstilling af anti-selv antistoffer fra repertoirer af antistofsegmenter og fremvist på fag
|
|
ATE463573T1
(de)
|
1991-12-02 |
2010-04-15 |
Medimmune Ltd |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
DE69308573T2
(de)
|
1992-08-17 |
1997-08-07 |
Genentech Inc |
Bispezifische immunoadhesine
|
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
DE69333969T2
(de)
|
1992-10-30 |
2006-09-14 |
The General Hospital Corp., Boston |
Wechselwirkendes Fallensystem zur Isolierung von Proteinen
|
|
US5807683A
(en)
|
1992-11-19 |
1998-09-15 |
Combichem, Inc. |
Combinatorial libraries and methods for their use
|
|
DK0698097T3
(da)
|
1993-04-29 |
2001-10-08 |
Unilever Nv |
Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
|
|
WO1995015982A2
(en)
|
1993-12-08 |
1995-06-15 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
SE9400088D0
(sv)
|
1994-01-14 |
1994-01-14 |
Kabi Pharmacia Ab |
Bacterial receptor structures
|
|
DE69531148T2
(de)
|
1994-01-31 |
2004-04-29 |
Trustees Of Boston University, Boston |
Bibliotheken aus polyklonalen antikörpern
|
|
WO1995026204A1
(en)
|
1994-03-25 |
1995-10-05 |
Isis Pharmaceuticals, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
|
US5738996A
(en)
|
1994-06-15 |
1998-04-14 |
Pence, Inc. |
Combinational library composition and method
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
US5616502A
(en)
|
1995-05-19 |
1997-04-01 |
Molecular Probes, Inc. |
Non-specific protein staining using merocyanine dyes
|
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
|
GB9608510D0
(en)
|
1996-04-25 |
1996-07-03 |
Medical Res Council |
Calcium dependent binding ligands
|
|
EP1015489B1
(en)
|
1996-05-29 |
2006-07-05 |
Derek Nigel John Hart |
Dendritic cell receptor
|
|
US6171816B1
(en)
*
|
1996-08-23 |
2001-01-09 |
Human Genome Sciences, Inc. |
Human XAG-1 polynucleotides and polypeptides
|
|
JP2002508652A
(ja)
*
|
1996-08-23 |
2002-03-19 |
ヒューマン ジノーム サイエンシーズ，インコーポレイテッド |
新規なヒト増殖因子
|
|
GB9624927D0
(en)
|
1996-11-29 |
1997-01-15 |
Oxford Glycosciences Uk Ltd |
Gels and their use
|
|
US6057098A
(en)
|
1997-04-04 |
2000-05-02 |
Biosite Diagnostics, Inc. |
Polyvalent display libraries
|
|
GB9710582D0
(en)
|
1997-05-22 |
1997-07-16 |
Oxford Glycosciences Uk Ltd |
A method for de novo peptide sequence determination
|
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
ES2434961T5
(es)
|
1998-04-20 |
2018-01-18 |
Roche Glycart Ag |
Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
|
|
EP1176195B1
(en)
|
1999-04-09 |
2013-05-22 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
AU3087801A
(en)
|
2000-02-04 |
2001-08-14 |
Molecular Dynamics Inc |
Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells
|
|
WO2001062914A1
(en)
*
|
2000-02-25 |
2001-08-30 |
Oxford Glycosciences (Uk) Ltd. |
Bcmp 84, a protein associated to breast cancer
|
|
GB0004576D0
(en)
*
|
2000-02-25 |
2000-04-19 |
Oxford Glycosciences Uk Ltd |
Proteins
|
|
US6900016B1
(en)
|
2000-09-08 |
2005-05-31 |
Applera Corporation |
Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof
|
|
CN102311986B
(zh)
|
2000-10-06 |
2015-08-19 |
协和发酵麒麟株式会社 |
产生抗体组合物的细胞
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
ES2404689T3
(es)
|
2001-04-05 |
2013-05-28 |
The Johns Hopkins University |
Vacunas quiméricas que comprenden el dominio lumenal de LAMP-1 o LAMP-2
|
|
AU2002347428A1
(en)
|
2001-06-18 |
2003-01-02 |
Eos Biotechnology Inc. |
Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
|
|
CA2447851C
(en)
|
2001-06-28 |
2012-08-28 |
Domantis Limited |
Dual-specific ligand and its use
|
|
WO2003042661A2
(en)
|
2001-11-13 |
2003-05-22 |
Protein Design Labs, Inc. |
Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
|
|
EP1497454A2
(en)
*
|
2001-11-13 |
2005-01-19 |
Protein Design Labs, Inc. |
Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
|
|
AU2002348268A1
(en)
*
|
2001-12-03 |
2003-06-17 |
Bristol-Myers Squibb Company |
Polynucleotides and polypeptides associated with the development of osteoarthritis
|
|
US20030215835A1
(en)
*
|
2002-01-15 |
2003-11-20 |
Zairen Sun |
Differentially-regulated prostate cancer genes
|
|
US20040110226A1
(en)
|
2002-03-01 |
2004-06-10 |
Xencor |
Antibody optimization
|
|
CA2478063A1
(en)
|
2002-03-07 |
2003-10-02 |
Ludwig Institute For Cancer Research |
Lymphatic and blood endothelial cell genes
|
|
CN102911987B
(zh)
|
2002-04-09 |
2015-09-30 |
协和发酵麒麟株式会社 |
基因组被修饰的细胞
|
|
EP1517921B1
(en)
|
2002-06-28 |
2006-06-07 |
Domantis Limited |
Dual specific ligands with increased serum half-life
|
|
AU2003256240A1
(en)
|
2002-08-29 |
2004-03-19 |
National University Of Singapore |
Recombinant nucleic acid useful for inducing protective immune response against allergens
|
|
JP2006515165A
(ja)
|
2002-09-16 |
2006-05-25 |
ジェネンテック・インコーポレーテッド |
免疫関連疾患の治療のための新規組成物と方法
|
|
AU2002951409A0
(en)
*
|
2002-09-16 |
2002-09-26 |
North Western Adelaide Health Services |
Methods for regulating cancer
|
|
EP1558647B1
(en)
|
2002-11-08 |
2015-06-10 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
US20060281672A1
(en)
|
2002-12-06 |
2006-12-14 |
Hart Derek N J |
Dec-205 (ly 75)/dcl-1 intergenic splice variants associated with hodgkin's disease, and uses thereof
|
|
EP1578801A2
(en)
|
2002-12-27 |
2005-09-28 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
|
JP4889493B2
(ja)
|
2003-05-14 |
2012-03-07 |
ドマンティス リミテッド |
ポリペプチドレパートリーから可逆的にアンフォールドするポリペプチドを回収するための方法
|
|
US20080181906A1
(en)
|
2003-05-19 |
2008-07-31 |
Haynes Barton F |
Polyvalent Immunogen
|
|
SI1639011T1
(sl)
|
2003-06-30 |
2009-04-30 |
Domantis Ltd |
Pegilirana protitelesa z enojno domeno (dAb)
|
|
WO2005019258A2
(en)
|
2003-08-11 |
2005-03-03 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
CA2552658A1
(en)
|
2004-01-07 |
2005-07-28 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
|
|
WO2006093524A2
(en)
*
|
2004-07-16 |
2006-09-08 |
The General Hospital Corporation |
Antigen-carbohydrate conjugates
|
|
US20060204512A1
(en)
*
|
2004-09-23 |
2006-09-14 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
|
AU2005325801A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
EP1695981A1
(de)
|
2005-02-25 |
2006-08-30 |
Forschungsverbund Berlin e.V. |
Verfahren zum Redox-Potential-abhängigen Nachweis von Targetmolekülen durch wechselwirkende Polypeptide
|
|
US7608413B1
(en)
*
|
2005-03-25 |
2009-10-27 |
Celera Corporation |
Kidney disease targets and uses thereof
|
|
WO2007039818A2
(en)
|
2005-05-09 |
2007-04-12 |
Glycart Biotechnology Ag |
Antigen binding molecules having modified fc regions and altered binding to fc receptors
|
|
WO2007030531A2
(en)
|
2005-09-06 |
2007-03-15 |
Molecular Image Inc. |
Reagents for testing and molecular imaging of liver cancer
|
|
US7842466B1
(en)
*
|
2005-09-16 |
2010-11-30 |
Celera Corporation |
Colon disease targets and uses thereof
|
|
AU2006317242A1
(en)
|
2005-11-28 |
2007-05-31 |
Genmab A/S |
Recombinant monovalent antibodies and methods for production thereof
|
|
GB0611116D0
(en)
*
|
2006-06-06 |
2006-07-19 |
Oxford Genome Sciences Uk Ltd |
Proteins
|
|
US20100120627A1
(en)
|
2006-08-02 |
2010-05-13 |
Abdelmajid Belouchi |
Genemap of the human genes associated with psoriasis
|
|
WO2008021290A2
(en)
|
2006-08-09 |
2008-02-21 |
Homestead Clinical Corporation |
Organ-specific proteins and methods of their use
|
|
WO2008104803A2
(en)
|
2007-02-26 |
2008-09-04 |
Oxford Genome Sciences (Uk) Limited |
Proteins
|
|
EP2224954B1
(en)
|
2007-11-07 |
2014-01-08 |
Celldex Therapeutics, Inc. |
Antibodies that bind human dendritic and epithelial cell 205 (dec-205)
|
|
US8168586B1
(en)
|
2007-11-21 |
2012-05-01 |
Celera Corporation |
Cancer targets and uses thereof
|
|
DE102008006841B4
(de)
|
2008-01-30 |
2013-07-11 |
Wolfram Kangler |
Verfahren und Vorrichtung zum Betrieb einer Brennkraftmaschine mit einem flüssigen Kraftstoffgemisch
|
|
EP2159291A1
(en)
|
2008-09-01 |
2010-03-03 |
Agendia B.V. |
Means and method for determining tumor cell percentage in a sample
|
|
WO2011011677A2
(en)
|
2009-07-23 |
2011-01-27 |
Aderans Research Institute, Inc. |
Potency markers
|
|
US9002545B2
(en)
|
2011-01-07 |
2015-04-07 |
Wabtec Holding Corp. |
Data improvement system and method
|