JP2015533788A5 - - Google Patents

Download PDF

Info

Publication number
JP2015533788A5
JP2015533788A5 JP2015530124A JP2015530124A JP2015533788A5 JP 2015533788 A5 JP2015533788 A5 JP 2015533788A5 JP 2015530124 A JP2015530124 A JP 2015530124A JP 2015530124 A JP2015530124 A JP 2015530124A JP 2015533788 A5 JP2015533788 A5 JP 2015533788A5
Authority
JP
Japan
Prior art keywords
seq
antibody
antigen
binding fragment
folr1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015530124A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015533788A (ja
JP6293147B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/057682 external-priority patent/WO2014036495A2/en
Publication of JP2015533788A publication Critical patent/JP2015533788A/ja
Publication of JP2015533788A5 publication Critical patent/JP2015533788A5/ja
Application granted granted Critical
Publication of JP6293147B2 publication Critical patent/JP6293147B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015530124A 2012-08-31 2013-08-30 葉酸受容体1の検出のための診断分析およびキット Active JP6293147B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261695791P 2012-08-31 2012-08-31
US61/695,791 2012-08-31
US201361756254P 2013-01-24 2013-01-24
US61/756,254 2013-01-24
PCT/US2013/057682 WO2014036495A2 (en) 2012-08-31 2013-08-30 Diagnostic assays and kits for detection of folate receptor 1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017247587A Division JP6480558B2 (ja) 2012-08-31 2017-12-25 葉酸受容体1の検出のための診断分析およびキット

Publications (3)

Publication Number Publication Date
JP2015533788A JP2015533788A (ja) 2015-11-26
JP2015533788A5 true JP2015533788A5 (enExample) 2016-10-20
JP6293147B2 JP6293147B2 (ja) 2018-03-14

Family

ID=50184673

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2015530124A Active JP6293147B2 (ja) 2012-08-31 2013-08-30 葉酸受容体1の検出のための診断分析およびキット
JP2017247587A Active JP6480558B2 (ja) 2012-08-31 2017-12-25 葉酸受容体1の検出のための診断分析およびキット
JP2018052302A Withdrawn JP2018088942A (ja) 2012-08-31 2018-03-20 葉酸受容体1の検出のための診断分析およびキット
JP2019203933A Pending JP2020018325A (ja) 2012-08-31 2019-11-11 葉酸受容体1の検出のための診断分析およびキット
JP2021200640A Active JP7289346B2 (ja) 2012-08-31 2021-12-10 葉酸受容体1の検出のための診断分析およびキット
JP2023088416A Pending JP2023111942A (ja) 2012-08-31 2023-05-30 葉酸受容体1の検出のための診断分析およびキット

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2017247587A Active JP6480558B2 (ja) 2012-08-31 2017-12-25 葉酸受容体1の検出のための診断分析およびキット
JP2018052302A Withdrawn JP2018088942A (ja) 2012-08-31 2018-03-20 葉酸受容体1の検出のための診断分析およびキット
JP2019203933A Pending JP2020018325A (ja) 2012-08-31 2019-11-11 葉酸受容体1の検出のための診断分析およびキット
JP2021200640A Active JP7289346B2 (ja) 2012-08-31 2021-12-10 葉酸受容体1の検出のための診断分析およびキット
JP2023088416A Pending JP2023111942A (ja) 2012-08-31 2023-05-30 葉酸受容体1の検出のための診断分析およびキット

Country Status (27)

Country Link
US (6) US9200073B2 (enExample)
EP (2) EP2890717B1 (enExample)
JP (6) JP6293147B2 (enExample)
KR (4) KR20240005129A (enExample)
CN (2) CN104755498B (enExample)
AU (4) AU2013308497B2 (enExample)
BR (1) BR112015004229B1 (enExample)
CA (2) CA3137438A1 (enExample)
CY (1) CY1122907T1 (enExample)
DK (1) DK2890717T3 (enExample)
ES (1) ES2788151T3 (enExample)
HR (1) HRP20200482T1 (enExample)
HU (1) HUE049693T2 (enExample)
IL (4) IL299620A (enExample)
LT (1) LT2890717T (enExample)
ME (1) ME03799B (enExample)
MX (2) MX362514B (enExample)
NZ (2) NZ630433A (enExample)
PL (1) PL2890717T3 (enExample)
PT (1) PT2890717T (enExample)
RS (1) RS60217B1 (enExample)
RU (1) RU2668824C2 (enExample)
SG (2) SG10201804260QA (enExample)
SI (1) SI2890717T1 (enExample)
SM (1) SMT202000158T1 (enExample)
WO (1) WO2014036495A2 (enExample)
ZA (1) ZA201707245B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT201700139T1 (it) 2010-02-24 2017-05-08 Immunogen Inc Immunoconiugati contro il recettore 1 del folato e relativi usi
CN114441757A (zh) 2011-04-01 2022-05-06 伊缪诺金公司 用于增加folr1癌症治疗的功效的方法
MX362514B (es) 2012-08-31 2019-01-22 Immunogen Inc Kits y ensayos de diagnostico para la deteccion del receptor 1 de folato.
WO2014205342A2 (en) * 2013-06-20 2014-12-24 Morphotek, Inc. Methods for treatment of ovarian cancer
SG11201601037YA (en) 2013-08-30 2016-03-30 Immunogen Inc Antibodies and assays for detection of folate receptor 1
SG10201907042PA (en) * 2013-10-08 2019-09-27 Immunogen Inc Anti-folr1 immunoconjugate dosing regimens
US20150297744A1 (en) * 2014-03-28 2015-10-22 Immunogen, Inc. Anti-FOLR1 Immunoconjugate Dosing Regimens
WO2015186823A1 (ja) * 2014-06-06 2015-12-10 協和発酵キリン株式会社 Folr1標的薬および葉酸代謝拮抗剤によるがん患者のための治療方法並びに医薬
DK3221356T3 (da) * 2014-11-20 2020-11-02 Hoffmann La Roche T-celleaktiverende, bispecifikke, antigenbindende molekyler mod folr1 og cd3
JP6880006B2 (ja) 2015-09-17 2021-06-02 イミュノジェン, インコーポレイテッド 抗folr1免疫複合体を含む治療組み合わせ
CN105548059B (zh) * 2016-01-29 2018-08-24 福建医科大学 叶酸-牛血清白蛋白-铂铋纳米复合材料
US10940112B2 (en) 2016-05-04 2021-03-09 L.E.A.F. Holdings Group Llc Targeted liposomal gemcitabine compositions and methods thereof
US10822410B2 (en) 2016-11-23 2020-11-03 Eisai R&D Management Co., Ltd. Anti-folate receptor alpha antibodies and uses thereof
CN108982430B (zh) * 2017-05-31 2020-09-29 北京大学 标记细菌菌群样品的试剂盒、方法及应用
JP7604226B2 (ja) * 2017-09-05 2024-12-23 イミュノジェン, インコーポレイテッド 患者の試料中のヒト葉酸受容体1を検出するための方法
WO2019177854A1 (en) * 2018-03-13 2019-09-19 Phanes Therapeutics, Inc. Anti-folate receptor 1 antibodies and uses thereof
CN113728007B (zh) * 2019-04-12 2025-01-24 凡恩世制药(北京)有限公司 人源化抗叶酸受体1嵌合抗原受体及其用途
KR20220004687A (ko) 2019-04-29 2022-01-11 이뮤노젠 아이엔씨 이중파라토프 fr-알파 항체 및 면역접합체
CN112794911B (zh) * 2021-04-14 2021-08-03 上海偌妥生物科技有限公司 人源化抗叶酸受体1抗体及其应用
US20240226312A1 (en) * 2021-06-04 2024-07-11 Immunogen, Inc. Treatment of cancer in patients with soluble fr-alpha
CN114163520B (zh) * 2021-11-23 2024-01-30 南京京达生物技术有限公司 一种血源性人IgM抗体纯化介质制备方法
EP4455164A1 (en) 2021-12-24 2024-10-30 Bio-Thera Solutions, Ltd. ANTI-FRalpha ANTIBODY, AND ANTIBODY-DRUG CONJUGATE AND USE THEREOF
CN119019546B (zh) * 2022-07-05 2025-09-05 东莞市朋志生物科技有限公司 抗乙型流感病毒抗体、检测乙型流感病毒的试剂和试剂盒
WO2025094146A1 (en) 2023-11-02 2025-05-08 Immunogen Switzerland Gmbh Vasconstrictors for reducing ocular toxicity of antibody-maytansinoid conjugates
CN117700557B (zh) * 2024-02-05 2024-04-30 卡秋(江苏)生物科技有限公司 一种特异性结合叶酸受体α的抗体或抗原结合片段
CN117700556B (zh) * 2024-02-05 2024-04-12 苏州百道医疗科技有限公司 一种抗FRα小鼠单克隆抗体及其应用

Family Cites Families (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2046920B1 (enExample) 1969-06-19 1974-05-03 Citizen Watch Co Ltd
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US4588585A (en) 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE3546806C2 (enExample) 1985-03-30 1991-03-28 Marc Genf/Geneve Ch Ballivet
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
DE3600905A1 (de) 1986-01-15 1987-07-16 Ant Nachrichtentech Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
US5681718A (en) 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
JP3040121B2 (ja) 1988-01-12 2000-05-08 ジェネンテク,インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
GB8826530D0 (en) 1988-11-12 1988-12-14 Ped Capacitors Ltd Electrical capacitors
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US20030229208A1 (en) 1988-12-28 2003-12-11 Protein Design Labs, Inc. Humanized immunoglobulins
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
CA2016841C (en) 1989-05-16 1999-09-21 William D. Huse A method for producing polymers having a preselected activity
CA2057923A1 (en) 1989-05-16 1990-11-17 William D. Huse Co-expression of heteromeric receptors
CA2016842A1 (en) 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
AU8505191A (en) 1990-08-24 1992-03-17 Ixsys, Inc. Methods of synthesizing oligonucleotides with random codons
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JP2938569B2 (ja) 1990-08-29 1999-08-23 ジェンファーム インターナショナル,インコーポレイティド 異種免疫グロブリンを作る方法及びトランスジェニックマウス
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
WO1992011272A1 (en) 1990-12-20 1992-07-09 Ixsys, Inc. Optimization of binding proteins
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
WO1993011794A1 (en) 1991-12-13 1993-06-24 Xoma Corporation Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
AU3737893A (en) 1992-03-05 1993-10-05 Board Of Regents, The University Of Texas System Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells
US20030148406A1 (en) 1992-03-17 2003-08-07 David John King Multivalent antigen-binding proteins
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
AU6132994A (en) 1993-02-02 1994-08-29 Scripps Research Institute, The Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
WO1994029351A2 (en) 1993-06-16 1994-12-22 Celltech Limited Antibodies
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
DE69637481T2 (de) 1995-04-27 2009-04-09 Amgen Fremont Inc. Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
US7264963B1 (en) 1995-08-18 2007-09-04 Morphosys Ag Protein(poly)peptide libraries
ES2176484T3 (es) 1995-08-18 2002-12-01 Morphosys Ag Bancos de proteinas/(poli)peptidos.
JP2002514895A (ja) 1995-09-28 2002-05-21 アレクション、ファーマスーティカルズ、インコーポレーテッド ブタ細胞相互作用タンパク質
US6331431B1 (en) 1995-11-28 2001-12-18 Ixsys, Inc. Vacuum device and method for isolating periplasmic fraction from cells
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
ES2301183T3 (es) 1996-12-03 2008-06-16 Amgen Fremont Inc. Anticuerpo completamente humano que se une al receptor del egfr.
US6596850B1 (en) 1998-01-30 2003-07-22 Ixsys, Incorporated Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same
WO1999006834A2 (en) 1997-08-04 1999-02-11 Ixsys, Incorporated Methods for identifying ligand specific binding molecules
CA2354862A1 (en) 1998-10-19 2000-04-27 Yeda Research And Development Co. Ltd. Treatment of systemic lupus erythematosus by down-regulating the autoimmune response to autoantigens
US20040031072A1 (en) 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
ATE482275T1 (de) 1999-07-02 2010-10-15 Morphosys Ag Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden
IT1307309B1 (it) 1999-12-30 2001-10-30 Enea Ente Nuove Tec Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono.
AU5697001A (en) 2000-03-31 2001-10-15 Purdue Research Foundation Method of treatment using ligand-immunogen conjugates
DE10037759A1 (de) 2000-08-03 2002-07-04 Gruenenthal Gmbh Screeningverfahren
EP1998266A3 (en) 2001-02-19 2009-02-11 Merck Patent GmbH Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity
US20030087250A1 (en) 2001-03-14 2003-05-08 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
RU2316349C2 (ru) 2001-05-02 2008-02-10 Пердью Рисерч Фаундейшн Лечение и диагностика заболеваний, опосредованных макрофагами
US7314974B2 (en) 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
WO2003074704A1 (fr) 2002-03-01 2003-09-12 Japan Envirochemicals, Ltd. Proteines capables de se lier aux hormones sexuelles feminines et procede de preparation
EP2090591A3 (en) 2002-04-22 2009-10-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
AU2003295411A1 (en) 2002-11-07 2004-06-03 Celltech R & D Human monoclonal antibodies to heparanase
KR20050059332A (ko) 2002-11-07 2005-06-17 이뮤노젠 아이엔씨 항-씨디33 항체와 이를 이용한 급성 골수성 백혈병의치료방법
EP1481993A1 (en) 2003-05-28 2004-12-01 Xerion Pharmaceuticals AG Modulation of the poliovirus receptor function
US20050255114A1 (en) 2003-04-07 2005-11-17 Nuvelo, Inc. Methods and diagnosis for the treatment of preeclampsia
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
KR101412271B1 (ko) 2003-05-09 2014-06-25 듀크 유니버시티 Cd20-특이적 항체 및 이를 이용한 방법
MX342007B (es) 2003-05-14 2016-09-09 Immunogen Inc Composicion de farmaco conjugado.
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
MXPA05014153A (es) 2003-07-02 2006-07-03 Genentech Inc Composiciones y metodoso para el diagnostico y tratamiento de tumor.
WO2005054469A1 (en) 2003-12-05 2005-06-16 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Anti-sars monoclonal antibodies
WO2005080431A2 (en) * 2004-02-12 2005-09-01 Morphotek, Inc. Monoclonal antibodies that specifically bind to folate receptor alpha
US20080187954A1 (en) 2004-03-10 2008-08-07 Lonza Ltd. Method For Producing Antibodies
EP2259063B1 (en) 2004-04-27 2012-05-23 Galapagos N.V. Compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts
AU2005279347A1 (en) 2004-08-30 2006-03-09 Lonza Biologics Plc. Affinity- plus ion exchange- chromatography for purifying antibodies
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
US7780963B2 (en) 2004-10-25 2010-08-24 Merck & Co., Inc. Anti-ADDL antibodies and uses thereof
EP2562259B1 (en) 2004-12-21 2016-07-06 Monsanto Technology LLC Transgenic plants with enhanced agronomic traits
US20080181888A1 (en) 2004-12-31 2008-07-31 Ambrose Christine M Polypeptides That Bind Br3 and Uses Thereof
EP1850866A4 (en) 2005-01-27 2009-07-08 Univ California MONOCLONAL THERAPEUTIC ANTIBODIES FOR THE NEUTRALIZATION OF BOTULIN NEUROTOXINES
CA2602777C (en) 2005-03-25 2018-12-11 Tolerrx, Inc. Gitr binding molecules and uses therefor
US7608413B1 (en) 2005-03-25 2009-10-27 Celera Corporation Kidney disease targets and uses thereof
WO2006105141A1 (en) 2005-03-30 2006-10-05 Purdue Research Foundation Method for cancer prognosis using cellular folate vitamin receptor quantification
JP2009521206A (ja) * 2005-04-22 2009-06-04 モルフォテック、インク. 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体
EP1888639A1 (en) 2005-05-12 2008-02-20 Oncotherapy Science, Inc. Methods for damaging cells using effector function of anti-dsc2 antibody
AU2006249087B2 (en) 2005-05-20 2012-05-17 Lonza Biologics Plc High-level expression of recombinant antibody in a mammalian host cell
JP2009508467A (ja) 2005-05-24 2009-03-05 アベスタゲン リミテッド B細胞リンパ腫の治療のためのcd20に対するモノクローナル抗体を生成する方法
WO2007006041A2 (en) 2005-07-05 2007-01-11 Purdue Research Foundation Imaging and therapeutic method using monocytes
US7521195B1 (en) 2005-07-21 2009-04-21 Celera Corporation Lung disease targets and uses thereof
US8124076B2 (en) 2005-08-18 2012-02-28 Ramot At Tel Aviv University Ltd. Single chain antibodies against β-amyloid peptide
ES2543341T3 (es) 2005-09-13 2015-08-18 National Research Council Of Canada Métodos y composiciones para modular la actividad de células tumorales
US20070099251A1 (en) 2005-10-17 2007-05-03 Institute For Systems Biology Tissue-and serum-derived glycoproteins and methods of their use
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
EP3441403A1 (en) 2005-12-20 2019-02-13 SBI Biotech Co., Ltd. Anti-ilt7 antibody
US8486412B2 (en) 2006-06-01 2013-07-16 Mayo Foundation For Medical Education And Research Immunity to folate receptors
WO2007147265A1 (en) 2006-06-23 2007-12-27 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
US7910702B2 (en) 2006-07-28 2011-03-22 The Governors Of The University Of Alberta Recombinant antibodies to sclerotinia antigens
CA2660286A1 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
US20090182955A1 (en) 2006-09-08 2009-07-16 Rao Cherukuri Application configuration across client devices of a local system
EP1900752A1 (en) 2006-09-15 2008-03-19 DOMPE' pha.r.ma s.p.a. Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
WO2008047723A1 (fr) 2006-10-12 2008-04-24 Forerunner Pharma Research Co., Ltd. Diagnostic et traitement du cancer à l'aide d'un anticorps anti-ereg
CA2672581A1 (en) 2006-12-14 2008-06-19 Forerunner Pharma Research Co., Ltd. Anti-claudin 3 monoclonal antibody and treatment and diagnosis of cancer using the same
KR101378302B1 (ko) 2006-12-20 2014-03-28 엠엠알글로벌, 인코포레이티드 항체 및 이들의 제조 및 사용 방법
US20080227704A1 (en) 2006-12-21 2008-09-18 Kamens Joanne S CXCL13 binding proteins
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US9216228B2 (en) 2007-02-16 2015-12-22 KTB Tumorforschungsgesellschaft MBM Receptor and antigen targeted prodrug
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
WO2008145136A1 (en) 2007-05-30 2008-12-04 Aarhus Universitet Stat3 inactivation by inhibition of the folate receptor pathway
US9138484B2 (en) 2007-06-25 2015-09-22 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
CN101139613B (zh) 2007-08-01 2011-06-08 姜荣锡 抗肿瘤二元多肽及其应用与制备方法
PT2227549E (pt) 2007-12-21 2015-10-08 Novartis Ag Sistema de seleção para cultura de células eucarióticas com base num gene de recetor de folato ligado à membrana
CA2711557A1 (en) 2008-01-11 2009-07-16 The University Of Tokyo Anti-cldn6 antibody
WO2009092014A1 (en) 2008-01-18 2009-07-23 Gagnon Peter S Enhanced purification of antibodies and antibody fragments by apatite chromatography
JP5470817B2 (ja) 2008-03-10 2014-04-16 日産自動車株式会社 電池用電極およびこれを用いた電池、並びにその製造方法
MX2010011621A (es) 2008-04-21 2011-01-14 Swapsol Corp Conversion de sulfuro de hidrogeno a hidrogeno.
WO2009132081A2 (en) 2008-04-24 2009-10-29 The Research Foundation Of State University Of New York Monoclonal antibody-based targeting of folate receptors
CN104524592B (zh) 2008-04-30 2018-06-05 伊缪诺金公司 交联剂和它们的用途
CN102083461B (zh) 2008-04-30 2014-09-17 伊缪诺金公司 有效的偶联物和亲水性连接体
US8383351B2 (en) 2008-06-11 2013-02-26 Oxford Brookes University Antibody to inhibin/ activin β-B subunit
US20100069298A1 (en) * 2008-09-16 2010-03-18 Robert Penny Methods for Detecting Overexpression of SPARC and Therapeutic and Diagnostic Methods Relating to Same
AU2009293140A1 (en) 2008-09-17 2010-03-25 Endocyte, Inc. Folate receptor binding conjugates of antifolates
WO2010033913A1 (en) 2008-09-22 2010-03-25 Icb International, Inc. Antibodies, analogs and uses thereof
CN101440130B (zh) 2008-11-21 2011-07-27 中国人民解放军第四军医大学 一种抗人IL-13Rα2单克隆抗体的重链和轻链的可变区
EP2995953B1 (en) 2009-03-24 2017-11-29 Biocept, Inc. Devices and methods of cell capture and analysis
WO2011010652A1 (ja) * 2009-07-23 2011-01-27 株式会社資生堂 油中水型乳化化粧料
JP5769316B2 (ja) * 2009-08-06 2015-08-26 イムナス・ファーマ株式会社 Aβオリゴマーに特異的に結合する抗体およびその利用
WO2011100398A1 (en) 2010-02-10 2011-08-18 Immunogen, Inc. Cd20 antibodies and uses thereof
SMT201700139T1 (it) * 2010-02-24 2017-05-08 Immunogen Inc Immunoconiugati contro il recettore 1 del folato e relativi usi
EP2629798A4 (en) * 2010-10-20 2014-05-28 Morphotek Inc GLYCOFORMS OF ANTI-RECEPTOR ANTIBODY-ALPHA FOLATE (ANTI-FRA)
JP6224456B2 (ja) * 2010-11-05 2017-11-01 モルフォテック、インク. 葉酸受容体アルファ発現癌の診断および予後マーカーとしての葉酸受容体アルファ
EA201991268A3 (ru) 2011-03-29 2020-01-31 Иммуноджен, Инк. Получение конъюгатов "майтансиноид-антитело" одностадийным способом
CA2831562A1 (en) 2011-03-29 2012-10-04 Immunogen, Inc. Process for manufacturing conjugates of improved homogeneity
CN114441757A (zh) 2011-04-01 2022-05-06 伊缪诺金公司 用于增加folr1癌症治疗的功效的方法
US20120282282A1 (en) 2011-04-04 2012-11-08 Immunogen, Inc. Methods for Decreasing Ocular Toxicity of Antibody Drug Conjugates
JP6220333B2 (ja) * 2011-07-15 2017-10-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗葉酸受容体アルファ抗体およびその使用
MX362514B (es) 2012-08-31 2019-01-22 Immunogen Inc Kits y ensayos de diagnostico para la deteccion del receptor 1 de folato.
EP2930240B1 (en) 2012-12-07 2018-08-01 Kyowa Hakko Kirin Co., Ltd. Anti-folr1 antibody
JP6136279B2 (ja) 2013-01-15 2017-05-31 株式会社ジェイテクト 転がり軸受装置
TWI503850B (zh) 2013-03-22 2015-10-11 Polytronics Technology Corp 過電流保護元件
KR20240068778A (ko) 2013-05-14 2024-05-17 이뮤노젠 아이엔씨 항-folr1 면역접합체 투약 섭생
SG11201601037YA (en) 2013-08-30 2016-03-30 Immunogen Inc Antibodies and assays for detection of folate receptor 1
TWI510996B (zh) 2013-10-03 2015-12-01 Acer Inc 控制觸控面板的方法以及使用該方法的可攜式電腦
SG10201907042PA (en) 2013-10-08 2019-09-27 Immunogen Inc Anti-folr1 immunoconjugate dosing regimens
US20150297744A1 (en) 2014-03-28 2015-10-22 Immunogen, Inc. Anti-FOLR1 Immunoconjugate Dosing Regimens
JP6880006B2 (ja) 2015-09-17 2021-06-02 イミュノジェン, インコーポレイテッド 抗folr1免疫複合体を含む治療組み合わせ
US9816280B1 (en) 2016-11-02 2017-11-14 Matthew Reitnauer Portable floor

Similar Documents

Publication Publication Date Title
JP2015533788A5 (enExample)
JP6858181B2 (ja) 免疫チェックポイントブロッカーを用いる治療の臨床アウトカムを予測するための診断マーカーとしてのgdf−15
JP6715770B2 (ja) モノクローナル抗tk1抗体
JP2018042573A5 (enExample)
JP7022191B2 (ja) 前立腺がんの分析のための組成物及び方法
RU2015104579A (ru) Диагностические анализы и наборы для детекции фолатного рецептора 1
JP2018138058A (ja) 間葉及び上皮間葉形質転換循環腫瘍細胞のための特異的検出ツール
JP2017518366A5 (enExample)
AU2015265870A1 (en) PD-L1 antibodies and uses thereof
JP2016536330A5 (enExample)
JP2017524725A5 (enExample)
JP6129956B2 (ja) 抗c−Met抗体
KR102366820B1 (ko) 진단을 위한 세포 표면 전립선암 항원
RU2016144178A (ru) Антитело против muc1 или его антигенсвязывающий фрагмент и его применение
RU2641968C2 (ru) Композиции и способы анализа рака предстательной железы
WO2014068300A1 (en) Anti-s100a4 antibody molecules and their uses
CA3076997C (en) Anti-ckap4 monoclonal antibody
JP2018532699A5 (enExample)
ES2967740T3 (es) GDF-15 como marcador de diagnóstico de melanoma
JP6977105B2 (ja) Igf−1r抗体および癌の診断のためのその使用
ES2846836T3 (es) Método para predecir la sensibilidad a una terapia combinada con lenvatinib y everolimus
KR20250165646A (ko) Nr1에 대한 자가항체의 검출
KR102350259B1 (ko) Igf-1r 항체 및 암의 진단을 위한 그의 용도
US20250060369A1 (en) Compositions and methods for predicting therapeutic outcome
JP6195716B2 (ja) 抗癌剤耐性診断マーカー