HRP20200482T1 - Dijagnostičke analize i setovi za detekciju folat receptora 1 - Google Patents

Dijagnostičke analize i setovi za detekciju folat receptora 1 Download PDF

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HRP20200482T1
HRP20200482T1 HRP20200482TT HRP20200482T HRP20200482T1 HR P20200482 T1 HRP20200482 T1 HR P20200482T1 HR P20200482T T HRP20200482T T HR P20200482TT HR P20200482 T HRP20200482 T HR P20200482T HR P20200482 T1 HRP20200482 T1 HR P20200482T1
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antigen
antibody
binding fragment
polypeptide
seq
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HRP20200482TT
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English (en)
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Nathan E. TESTA
Christina N. Carrigan
Olga Ab
Daniel Tavares
Beni B. Wolf
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Immunogen, Inc.
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Publication of HRP20200482T1 publication Critical patent/HRP20200482T1/hr

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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

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  • Immunology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Claims (13)

1. Antitijelo ili antigen-vezujući fragment istog koje se specifično veže za FOLR1, pri čemu spomenuto antitijelo ili antigen-vezujući fragment istog sadrži VH-CDR1, VH-CDR2, VH-CDR3, VL-CDR1, VL-CDR2 i VL-CDR3 sekvence amino kiselina iz: SEQ ID NOs: 1, 2, i 3 te SEQ ID NOs: 13, 14 i 15.
2. Antitijelo ili antigen-vezujući fragment istog prema zahtjevu 1, pri čemu spomenuto antitijelo ili antigen-vezujući fragment istog sadrži sekvence amino kiselina iz: SEQ ID NO: 25 i SEQ ID NO: 29.
3. Antitijelo ili antigen-vezujući fragment istog prema zahtjevu 1 ili 2, pri čemu spomenuto antitijelo ili antigen-vezujući fragment istog je murin, ne-humani, humanizirani, kimerni ili obnovljene površine.
4. Polipeptid koji specifično veže FOLR1, pri čemu spomenuti polipeptid sadrži sekvence iz: SEQ ID NOs: 1, 2, i 3 te SEQ ID NOs: 13, 14 i 15.
5. Molekula nukleinske kiseline koja šifrira antitijelo, antigen-vezujući fragment istog, ili polipeptid prema bilo kojem od zahtjeva 1-4.
6. Postupak detektiranja FOLR1 proteina u uzorku koji sadrži kontaktiranje spomenutog uzorka s antitijelom, antigen-vezujućim fragmentom istog, ili polipeptidom prema bilo kojem od zahtjeva 1-4.
7. Postupak prema zahtjevu 6, pri čemu je FOLR1 protein detektiran radioimunološkom analizom, Western blot analizom, imunofluorescencijskom analizom, enzimskom analizom, imunoprecipitacijskom analizom, kemiluminescencijskom analizom, citometrijom ili imunohistokemijskom analizom.
8. Postupak prema zahtjevu 7, pri čemu se FOLR1 protein detektira citometrijom, enzimskom imunoanalizom, ili imunohistokemijskom analizom, pri čemu citometrija je protočna citometrija, te pri čemu enzimska imunoanaliza je imunosorbentska analiza vezanih enzima (ELISA).
9. Postupak prema zahtjevu 6 ili 7, pri čemu spomenuti FOLR1 protein je ogoljeni FOLR1 protein.
10. Izolirana stanica koja proizvodi antitijelo, antigen-vezujući fragment istog, ili polipeptid prema bilo kojem od zahtjeva 1-4.
11. Postupak proizvodnje antitijela, antigen-vezujućeg fragmenta istog, ili polipeptida prema bilo kojem od zahtjeva 1-4, koji sadrži (a) kultiviranje stanice prema zahtjevu 10; i (b) izoliranje spomenutog antitijela, antigen-vezujućeg fragmenta istog, ili polipeptida iz spomenute kultivirane stanice.
12. Set za imunološku analizu za detekciju FOLR1 proteina u uzorku, set sadrži: (a) prvi reagens, pri čemu prvi reagens je antitijelo ili antigen-vezujući fragment istog prema bilo kojem od zahtjeva 1-3 ili polipeptid prema zahtjevu 4, te (b) drugi reagens, pri čemu drugi reagens je detekcijski reagens.
13. Antitijelo ili antigen-vezujući fragment istog prema bilo kojem od zahtjeva 1 do 3 ili polipeptid prema zahtjevu 4 za uporabu u postupku dijagnosticiranja raka.
HRP20200482TT 2012-08-31 2020-03-24 Dijagnostičke analize i setovi za detekciju folat receptora 1 HRP20200482T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261695791P 2012-08-31 2012-08-31
US201361756254P 2013-01-24 2013-01-24
PCT/US2013/057682 WO2014036495A2 (en) 2012-08-31 2013-08-30 Diagnostic assays and kits for detection of folate receptor 1
EP13833526.0A EP2890717B1 (en) 2012-08-31 2013-08-30 Diagnostic assays and kits for detection of folate receptor 1

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HRP20200482T1 true HRP20200482T1 (hr) 2020-06-26

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US (6) US9200073B2 (hr)
EP (2) EP2890717B1 (hr)
JP (6) JP6293147B2 (hr)
KR (4) KR20150046316A (hr)
CN (2) CN110294805B (hr)
AU (4) AU2013308497B2 (hr)
BR (1) BR112015004229B1 (hr)
CA (2) CA3137438A1 (hr)
CY (1) CY1122907T1 (hr)
DK (1) DK2890717T3 (hr)
ES (1) ES2788151T3 (hr)
HK (1) HK1210188A1 (hr)
HR (1) HRP20200482T1 (hr)
HU (1) HUE049693T2 (hr)
IL (4) IL299620A (hr)
LT (1) LT2890717T (hr)
ME (1) ME03799B (hr)
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RU (1) RU2668824C2 (hr)
SG (2) SG11201500938XA (hr)
SI (1) SI2890717T1 (hr)
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