JP2020510409A5 - - Google Patents
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- Publication number
- JP2020510409A5 JP2020510409A5 JP2019527561A JP2019527561A JP2020510409A5 JP 2020510409 A5 JP2020510409 A5 JP 2020510409A5 JP 2019527561 A JP2019527561 A JP 2019527561A JP 2019527561 A JP2019527561 A JP 2019527561A JP 2020510409 A5 JP2020510409 A5 JP 2020510409A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- amino acid
- antibody
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012634 fragment Substances 0.000 claims 66
- 239000000427 antigen Substances 0.000 claims 64
- 102000036639 antigens Human genes 0.000 claims 64
- 108091007433 antigens Proteins 0.000 claims 64
- 125000003275 alpha amino acid group Chemical group 0.000 claims 58
- 102100035139 Folate receptor alpha Human genes 0.000 claims 36
- 239000000523 sample Substances 0.000 claims 27
- 239000002773 nucleotide Substances 0.000 claims 17
- 125000003729 nucleotide group Chemical group 0.000 claims 17
- 239000012472 biological sample Substances 0.000 claims 13
- 102000006815 folate receptor Human genes 0.000 claims 12
- 108020005243 folate receptor Proteins 0.000 claims 12
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000007787 solid Substances 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 7
- 108010090804 Streptavidin Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 6
- 238000004020 luminiscence type Methods 0.000 claims 6
- 229960002685 biotin Drugs 0.000 claims 5
- 235000020958 biotin Nutrition 0.000 claims 5
- 239000011616 biotin Substances 0.000 claims 5
- 238000002965 ELISA Methods 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 238000000684 flow cytometry Methods 0.000 claims 3
- 238000003018 immunoassay Methods 0.000 claims 3
- 238000010166 immunofluorescence Methods 0.000 claims 3
- 238000003364 immunohistochemistry Methods 0.000 claims 3
- 238000001114 immunoprecipitation Methods 0.000 claims 3
- 238000003127 radioimmunoassay Methods 0.000 claims 3
- 238000001262 western blot Methods 0.000 claims 3
- 206010003445 Ascites Diseases 0.000 claims 2
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 2
- 238000001574 biopsy Methods 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000003040 circulating cell Anatomy 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 102000010451 Folate receptor alpha Human genes 0.000 claims 1
- 108050001931 Folate receptor alpha Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662425752P | 2016-11-23 | 2016-11-23 | |
| US62/425,752 | 2016-11-23 | ||
| PCT/US2017/063014 WO2018098277A1 (en) | 2016-11-23 | 2017-11-22 | Anti-folate receptor alpha antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510409A JP2020510409A (ja) | 2020-04-09 |
| JP2020510409A5 true JP2020510409A5 (enExample) | 2021-01-14 |
| JP7072571B2 JP7072571B2 (ja) | 2022-05-20 |
Family
ID=60703077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019527561A Active JP7072571B2 (ja) | 2016-11-23 | 2017-11-22 | 抗葉酸受容体アルファ抗体およびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10822410B2 (enExample) |
| EP (1) | EP3544999A1 (enExample) |
| JP (1) | JP7072571B2 (enExample) |
| WO (1) | WO2018098277A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11873335B2 (en) | 2018-03-13 | 2024-01-16 | Phanes Therapeutics, Inc. | Anti-folate receptor 1 antibodies and uses thereof |
| US12018069B2 (en) | 2018-06-28 | 2024-06-25 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for imaging amyloid deposits |
| TWI865456B (zh) * | 2018-07-09 | 2024-12-11 | 大陸商沐特圖公司 | 葉酸受體阿法特異性抗體 |
| WO2020092474A1 (en) * | 2018-10-31 | 2020-05-07 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for imaging amyloid deposits |
| TW202116332A (zh) * | 2019-06-23 | 2021-05-01 | 大陸商廣東天科雅生物醫藥科技有限公司 | 抗alpp car-t細胞療法 |
| JP2023511560A (ja) * | 2020-01-22 | 2023-03-20 | ミリタウア エルエルシー | 妊娠中の葉酸受容体自己免疫疾患及び自閉症を減少させるための葉酸受容体タンパク質を除去することによる家畜乳の再定義 |
| CA3195114A1 (en) * | 2020-10-09 | 2022-04-14 | Martin Klatt | Compositions targeting ndc80/mhc complexes and uses thereof |
| CN117209603B (zh) * | 2021-12-02 | 2024-02-27 | 北京东方百泰生物科技股份有限公司 | 一种抗tslp的单克隆抗体、其抗原结合片段及其应用 |
| CN117700557B (zh) * | 2024-02-05 | 2024-04-30 | 卡秋(江苏)生物科技有限公司 | 一种特异性结合叶酸受体α的抗体或抗原结合片段 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1716179A2 (en) | 2004-02-12 | 2006-11-02 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| EP1864133B1 (en) | 2005-03-30 | 2010-03-10 | Purdue Research Foundation | Method for breastcancer prognosis using cellular folate vitamin receptor quantification |
| US7754698B2 (en) | 2007-01-09 | 2010-07-13 | Isis Pharmaceuticals, Inc. | Modulation of FR-alpha expression |
| WO2009132081A2 (en) | 2008-04-24 | 2009-10-29 | The Research Foundation Of State University Of New York | Monoclonal antibody-based targeting of folate receptors |
| CA2816991C (en) * | 2010-11-05 | 2020-06-09 | Morphotek Inc. | Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers |
| EP3330291B1 (en) * | 2011-07-15 | 2020-09-02 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
| DK2890717T3 (da) * | 2012-08-31 | 2020-05-11 | Immunogen Inc | Diagnostiske assays og kits til detektering af folatreceptor 1 |
| MX2017013390A (es) * | 2015-04-17 | 2018-06-13 | Morphotek Inc | Método para el tratamiento de cáncer pulmonar. |
-
2017
- 2017-11-22 US US15/821,296 patent/US10822410B2/en active Active
- 2017-11-22 EP EP17817451.2A patent/EP3544999A1/en not_active Withdrawn
- 2017-11-22 JP JP2019527561A patent/JP7072571B2/ja active Active
- 2017-11-22 WO PCT/US2017/063014 patent/WO2018098277A1/en not_active Ceased
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