JP2016500659A5 - - Google Patents
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- JP2016500659A5 JP2016500659A5 JP2015534675A JP2015534675A JP2016500659A5 JP 2016500659 A5 JP2016500659 A5 JP 2016500659A5 JP 2015534675 A JP2015534675 A JP 2015534675A JP 2015534675 A JP2015534675 A JP 2015534675A JP 2016500659 A5 JP2016500659 A5 JP 2016500659A5
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- Prior art keywords
- antibody
- uroplakin
- tissue
- item
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims description 109
- 239000000203 mixture Substances 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 55
- 210000004027 cell Anatomy 0.000 claims description 43
- 210000001519 tissue Anatomy 0.000 claims description 43
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 39
- 102000013532 Uroplakin II Human genes 0.000 claims description 30
- 108010065940 Uroplakin II Proteins 0.000 claims description 30
- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 26
- 108091007433 antigens Proteins 0.000 claims description 26
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 24
- 150000007523 nucleic acids Chemical group 0.000 claims description 24
- 238000001514 detection method Methods 0.000 claims description 19
- 239000012472 biological sample Substances 0.000 claims description 18
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 17
- 101000601664 Homo sapiens Paired box protein Pax-8 Proteins 0.000 claims description 16
- 102100037502 Paired box protein Pax-8 Human genes 0.000 claims description 16
- 238000003364 immunohistochemistry Methods 0.000 claims description 16
- 210000004408 hybridoma Anatomy 0.000 claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- 229920001184 polypeptide Polymers 0.000 claims description 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- 101001066288 Gallus gallus GATA-binding factor 3 Proteins 0.000 claims description 12
- 102100028092 Homeobox protein Nkx-3.1 Human genes 0.000 claims description 12
- 101000578249 Homo sapiens Homeobox protein Nkx-3.1 Proteins 0.000 claims description 12
- 102000009764 Uroplakin III Human genes 0.000 claims description 12
- 108010009737 Uroplakin III Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 8
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims description 8
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- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 6
- 241000287828 Gallus gallus Species 0.000 claims description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 6
- 235000013330 chicken meat Nutrition 0.000 claims description 6
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- QRXMUCSWCMTJGU-UHFFFAOYSA-L (5-bromo-4-chloro-1h-indol-3-yl) phosphate Chemical compound C1=C(Br)C(Cl)=C2C(OP([O-])(=O)[O-])=CNC2=C1 QRXMUCSWCMTJGU-UHFFFAOYSA-L 0.000 claims description 4
- HSTOKWSFWGCZMH-UHFFFAOYSA-N 3,3'-diaminobenzidine Chemical compound C1=C(N)C(N)=CC=C1C1=CC=C(N)C(N)=C1 HSTOKWSFWGCZMH-UHFFFAOYSA-N 0.000 claims description 4
- OXEUETBFKVCRNP-UHFFFAOYSA-N 9-ethyl-3-carbazolamine Chemical compound NC1=CC=C2N(CC)C3=CC=CC=C3C2=C1 OXEUETBFKVCRNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000002965 ELISA Methods 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 4
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims description 4
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 4
- WLDHEUZGFKACJH-UHFFFAOYSA-K amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1N=NC1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-UHFFFAOYSA-K 0.000 claims description 4
- 102000005936 beta-Galactosidase Human genes 0.000 claims description 4
- 108010005774 beta-Galactosidase Proteins 0.000 claims description 4
- 239000000975 dye Substances 0.000 claims description 4
- 239000007850 fluorescent dye Substances 0.000 claims description 4
- 238000003365 immunocytochemistry Methods 0.000 claims description 4
- 239000006249 magnetic particle Substances 0.000 claims description 4
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- 239000003053 toxin Substances 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- DHJFFLKPAYHPHU-BYNIDDHOSA-N 5-bromo-4-chloro-3-indolyl beta-D-glucuronide Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 DHJFFLKPAYHPHU-BYNIDDHOSA-N 0.000 claims description 3
- 101710087047 Cytoskeleton-associated protein 4 Proteins 0.000 claims description 3
- 241000283086 Equidae Species 0.000 claims description 3
- 241000699670 Mus sp. Species 0.000 claims description 3
- 102100027881 Tumor protein 63 Human genes 0.000 claims description 3
- 101710140697 Tumor protein 63 Proteins 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
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- 238000012137 double-staining Methods 0.000 claims description 3
- 230000002357 endometrial effect Effects 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 claims description 3
- 210000001165 lymph node Anatomy 0.000 claims description 3
- 230000001613 neoplastic effect Effects 0.000 claims description 3
- 210000002741 palatine tonsil Anatomy 0.000 claims description 3
- 210000004923 pancreatic tissue Anatomy 0.000 claims description 3
- 210000002307 prostate Anatomy 0.000 claims description 3
- 210000002784 stomach Anatomy 0.000 claims description 3
- 210000001685 thyroid gland Anatomy 0.000 claims description 3
- 210000002700 urine Anatomy 0.000 claims description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims description 2
- 230000002611 ovarian Effects 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 claims 1
- 230000000762 glandular Effects 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 3
- 102100038851 Uroplakin-2 Human genes 0.000 description 3
- 101710173761 Uroplakin-2 Proteins 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010191 image analysis Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 241001529936 Murinae Species 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 102100038854 Uroplakin-3a Human genes 0.000 description 1
- 108050004295 Uroplakin-3a Proteins 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 206010044412 transitional cell carcinoma Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261706312P | 2012-09-27 | 2012-09-27 | |
| US61/706,312 | 2012-09-27 | ||
| PCT/US2013/062043 WO2014052672A1 (en) | 2012-09-27 | 2013-09-26 | Anti-uroplakin ii antibodies systems and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016500659A JP2016500659A (ja) | 2016-01-14 |
| JP2016500659A5 true JP2016500659A5 (enExample) | 2016-11-17 |
| JP6324970B2 JP6324970B2 (ja) | 2018-05-23 |
Family
ID=50388980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534675A Active JP6324970B2 (ja) | 2012-09-27 | 2013-09-26 | 抗ウロプラキンｉｉ抗体システムおよび方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9429577B2 (enExample) |
| EP (1) | EP2900265B1 (enExample) |
| JP (1) | JP6324970B2 (enExample) |
| DK (1) | DK2900265T3 (enExample) |
| ES (1) | ES2682345T3 (enExample) |
| WO (1) | WO2014052672A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012154983A2 (en) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systems and methods for anti-pax8 antibodies |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| DK2900265T3 (en) | 2012-09-27 | 2018-08-20 | Biocare Medical Llc | Anti-Uroplakin II Antibodies, Systems and Methods |
| WO2014100220A2 (en) | 2012-12-18 | 2014-06-26 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| DK2962113T3 (da) | 2013-02-28 | 2019-07-01 | Biocare Medical Llc | Systemer og fremgangsmåder med anti-p40-antistoffer |
| ES2765423T3 (es) | 2013-10-03 | 2020-06-09 | Biocare Medical Llc | Sistemas y procedimientos de anticuerpos anti-SOX10 |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| CN108727496A (zh) * | 2018-06-21 | 2018-11-02 | 南京基诺米医疗科技有限公司 | 鼠抗人p63蛋白单克隆抗体制备及其免疫组化用途 |
| JP7156653B2 (ja) * | 2018-08-30 | 2022-10-19 | イノベイティブ セルラー セラピューティクス ホールディングス，エルティディ | 固形腫瘍を治療するためのキメラ抗原受容体細胞 |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
| US12043654B2 (en) | 2020-06-02 | 2024-07-23 | Innovative Cellular Therapeutics Holdings, Ltd. | Anti-GCC antibody and CAR thereof for treating digestive system cancer |
| CN113295866A (zh) * | 2021-04-26 | 2021-08-24 | 深圳市龙华区中心医院 | Upⅱ抗原和upⅱ抗体联合在制备检测膀胱癌的产品中的应用 |
| WO2025188810A1 (en) * | 2024-03-08 | 2025-09-12 | Agilent Technologies, Inc. | Anti-human pax8 antibody for in vitro diagnostic use by immunohistochemistry |
| CN118930648B (zh) * | 2024-08-22 | 2025-02-28 | 武汉爱博泰克生物科技有限公司 | 抗人pax8蛋白的兔单克隆抗体、抗体偶联物及其应用 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4145406A (en) | 1977-04-11 | 1979-03-20 | Miles Laboratories, Inc. | Specific binding - adsorbent assay method and test means |
| US4254082A (en) | 1978-06-12 | 1981-03-03 | Miles Laboratories, Inc. | Specific binding-adsorbent assay test means |
| CA1247538A (en) | 1982-05-21 | 1988-12-28 | Mark C. Glassy | Human-human hybridomas for solid tumors |
| US4687732A (en) | 1983-06-10 | 1987-08-18 | Yale University | Visualization polymers and their application to diagnostic medicine |
| US4690890A (en) | 1984-04-04 | 1987-09-01 | Cetus Corporation | Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay |
| JPS60248618A (ja) | 1984-05-24 | 1985-12-09 | Nippon Zoki Pharmaceut Co Ltd | ジペプチドを含有する潰瘍治療剤 |
| US4792521A (en) | 1985-08-15 | 1988-12-20 | Immunomedics, Inc. | Non-enzymatic immunohistochemical staining system and reagents |
| US4863875A (en) | 1985-08-26 | 1989-09-05 | Gia Research Company, L.P. | Dye labelled antibodies as reagents for use in immunoassay systems |
| GB8607101D0 (en) | 1986-03-21 | 1986-04-30 | Serono Diagnostics Ltd | Immunoassay |
| JPS6447952A (en) | 1987-05-06 | 1989-02-22 | Saibaafuruua Inc | Immunoassay, reagent used therefor and making thereof |
| US5620845A (en) | 1988-06-06 | 1997-04-15 | Ampcor, Inc. | Immunoassay diagnostic kit |
| US5252487A (en) | 1989-05-19 | 1993-10-12 | Cell Analysis Systems, Inc. | Method and apparatus for determining the amount of oncogene protein product in a cell sample |
| US6008057A (en) | 1989-08-25 | 1999-12-28 | Roche Diagnostics Corporation | Immunoassay system |
| US5719063A (en) | 1989-08-25 | 1998-02-17 | Boehringer Mannheim Corporation | Multiplex immunoassay system |
| CA2073511A1 (en) | 1990-11-14 | 1992-05-29 | Matthew R. Callstrom | Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5280108A (en) | 1991-09-27 | 1994-01-18 | United States Of America | Antibodies to p40 |
| EP1005870B1 (en) | 1992-11-13 | 2009-01-21 | Biogen Idec Inc. | Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5482698A (en) | 1993-04-22 | 1996-01-09 | Immunomedics, Inc. | Detection and therapy of lesions with biotin/avidin polymer conjugates |
| US5487975A (en) | 1993-11-15 | 1996-01-30 | Ventana Medical Systems, Inc. | Biotin/avidin formulation |
| JPH09509054A (ja) | 1994-02-01 | 1997-09-16 | アメリカ合衆国 | 抗体部分および非抗体部分を含む融合タンパク質 |
| US5869274A (en) | 1995-08-09 | 1999-02-09 | Zymed Laboratories, Inc. | Immuno-histochemical method that reduces background staining |
| US5891658A (en) | 1996-06-27 | 1999-04-06 | FCI--FiberChem, Inc. | Single-step, solid-state competitive immunoassay |
| CA2263890C (en) | 1996-08-23 | 2013-05-14 | Ludwig Institute For Cancer Research | Recombinant vascular endothelial cell growth factor d (vegf-d) |
| US7196164B2 (en) | 1997-07-08 | 2007-03-27 | Human Genome Sciences, Inc. | Secreted protein HHTLF25 |
| WO1999015901A1 (en) | 1997-09-22 | 1999-04-01 | Chiron Corporation | Buffers for stabilizing antigens |
| US7294459B1 (en) | 1997-10-15 | 2007-11-13 | President And Fellows Of Harvard College | Cell regulatory genes, encoded products, and uses related thereto |
| US6277968B1 (en) * | 1997-11-13 | 2001-08-21 | New York University | Human uroplakin II gene and methods for detecting and classifying bladder cancer via human uroplakin genes |
| WO1999050287A2 (en) | 1998-03-27 | 1999-10-07 | The Johns Hopkins University | P40 protein acts as an oncogene |
| JP3524401B2 (ja) | 1998-09-16 | 2004-05-10 | 株式会社ニチレイ | 酵素抗体複合体およびその製造方法 |
| ATE277642T1 (de) | 1999-05-14 | 2004-10-15 | Univ California | Makromolekular träger auf basis von dextran fur arzneimittel und diagnosticum abgabe |
| WO2001052789A2 (en) | 2000-01-20 | 2001-07-26 | The Brigham And Women's Hospital, Inc. | PAX8-PPARη NUCLEIC ACID MOLECULES AND POLYPEPTIDES AND USES THEREOF |
| US20030017491A1 (en) | 2000-09-14 | 2003-01-23 | Zuo-Rong Shi | Chromogenic in situ hybridization methods, kits, and compositions |
| DE10063179A1 (de) | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur spezifischen Detektion von Tumorzellen und ihren Vorstufen in Gebärmutterhalsabstrichen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20020173053A1 (en) | 2001-04-27 | 2002-11-21 | Bassam Damaj | Multiple simultaneous antigen detection by immunohistochemistry |
| US20040076955A1 (en) * | 2001-07-03 | 2004-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer |
| US6580056B1 (en) | 2001-09-21 | 2003-06-17 | Biocare Medical | Biological specimen heating device and quality control method for immunohistochemistry heat retrieval procedures |
| EP1480520A4 (en) | 2002-02-12 | 2006-02-15 | Raven Biotechnologies Inc | EPITHELIAL CELLS FROM THE HUMAN FOLDS BUBBLE |
| MXPA04008870A (es) | 2002-03-13 | 2005-06-17 | Biogen Idec Inc | Anticuerpos anti-avb6. |
| US7850912B2 (en) | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
| EP1613273B1 (en) | 2003-04-11 | 2012-06-13 | MedImmune, LLC | Recombinant il-9 antibodies and uses thereof |
| CA2527878A1 (en) | 2003-05-30 | 2005-01-27 | Alexion Pharmaceuticals, Inc. | Antibodies and fusion proteins that include engineered constant regions |
| JP2005122810A (ja) | 2003-10-16 | 2005-05-12 | Hitachi Ltd | 光ディスク装置 |
| AU2004295699A1 (en) | 2003-12-01 | 2005-06-16 | Dako Denmark A/S | Methods and compositions for immuno-histochemical detection |
| WO2005076005A2 (en) | 2004-01-30 | 2005-08-18 | Medizinische Universität Wien | A method for classifying a tumor cell sample based upon differential expression of at least two genes |
| US20050186642A1 (en) | 2004-02-24 | 2005-08-25 | Biocare Medical, Inc. | Immunoassay reagents and methods of use thereof |
| US7502666B2 (en) | 2004-05-14 | 2009-03-10 | Mts Medication Technologies, Inc. | Systems and methods for storing and dispensing medication |
| JP4576168B2 (ja) * | 2004-06-29 | 2010-11-04 | Ｔｓｓバイオテック株式会社 | 膀胱尿管逆流症または間質性膀胱炎の検査方法 |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| ES2351057T3 (es) | 2005-07-08 | 2011-01-31 | Pfizer Limited | Anticuerpos contra madcam. |
| US8114588B2 (en) * | 2005-07-15 | 2012-02-14 | Tss Biotech Inc. | Method for detecting vesicoureteral reflux or interstitial cystitis |
| JP4736037B2 (ja) | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| PT1954718E (pt) | 2005-11-30 | 2014-12-16 | Abbvie Inc | Anticorpos anti-globulómeros aβ, suas porções de ligação ao antigénio, correspondentes hibridomas, ácidos nucleicos, vectores, células hospedeiras, métodos de produção dos ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos para uso dos ditos anticorpos |
| RU2461572C2 (ru) | 2006-06-07 | 2012-09-20 | Биоэллаенс К.В. | Антитела, распознающие содержащий углеводы эпитоп на cd-43 и сеа, экспрессируемых на злокачественных клетках, и способы их применения |
| EP2548576B1 (en) | 2006-08-14 | 2016-11-30 | Chugai Seiyaku Kabushiki Kaisha | Diagnosis of cancer using anti-desmoglein-3 antibodies |
| CN101855241B (zh) | 2006-12-08 | 2013-11-06 | 莱克康制药公司 | 针对angptl3的单克隆抗体 |
| WO2008127642A1 (en) | 2007-04-11 | 2008-10-23 | Enteron Limited Partnership | Myelin specific ige unencumbered by corresponding blocking antibodies as a causative factor in multiple sclerosis |
| JP5117765B2 (ja) | 2007-05-28 | 2013-01-16 | 国立大学法人 東京大学 | 抗ｒｏｂｏ１抗体を含むｐｅｔ用腫瘍診断剤 |
| TWI547503B (zh) | 2007-09-26 | 2016-09-01 | 建南德克公司 | 抗α5β1抗體、編碼其之核酸、包含其之組合物及其製造及使用方法 |
| CN102137874B (zh) * | 2008-08-29 | 2015-02-18 | 西福根有限公司 | 抗表皮生长因子受体的重组抗体组合物 |
| US8927697B2 (en) | 2008-09-12 | 2015-01-06 | Isis Innovation Limited | PD-1 specific antibodies and uses thereof |
| US7846762B2 (en) | 2008-09-22 | 2010-12-07 | Applied Materials, Inc. | Integrated emitter formation and passivation |
| WO2010124689A1 (en) * | 2009-05-01 | 2010-11-04 | Dako Denmark A/S | New antibody cocktail |
| WO2010131185A1 (en) | 2009-05-12 | 2010-11-18 | Pfizer Inc. | Blocking anti-dkk-1 antibodies and their uses |
| US20120245051A1 (en) | 2009-10-13 | 2012-09-27 | Rimm David L | Objective, quantitative method to predict histological subtype in non-small cell lung cancer |
| US20120321557A1 (en) | 2010-02-26 | 2012-12-20 | Forerunner Pharma Research Co., Ltd. | Anti-icam3 antibody and use thereof |
| EP2402370A1 (en) | 2010-06-29 | 2012-01-04 | Pierre Fabre Médicament | Novel antibody for the diagnosis and/or prognosis of cancer |
| BR112013005116A2 (pt) * | 2010-09-03 | 2019-09-24 | Stem Centrx Inc | moduladores e métodos de uso |
| ES2699950T3 (es) | 2010-10-06 | 2019-02-13 | Biocare Medical Llc | Procedimiento y sistema para el procesamiento eficaz de muestras biológicas |
| US20120154983A1 (en) | 2010-10-08 | 2012-06-21 | The Regents Of The University Of California | Method of Fabrication of Carbon Nanofibers on Nickel Foam |
| WO2012154983A2 (en) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systems and methods for anti-pax8 antibodies |
| US9156915B2 (en) | 2012-04-26 | 2015-10-13 | Thomas Jefferson University | Anti-GCC antibody molecules |
| DK2900265T3 (en) | 2012-09-27 | 2018-08-20 | Biocare Medical Llc | Anti-Uroplakin II Antibodies, Systems and Methods |
| WO2014100220A2 (en) | 2012-12-18 | 2014-06-26 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| DK2962113T3 (da) | 2013-02-28 | 2019-07-01 | Biocare Medical Llc | Systemer og fremgangsmåder med anti-p40-antistoffer |
| ES2765423T3 (es) | 2013-10-03 | 2020-06-09 | Biocare Medical Llc | Sistemas y procedimientos de anticuerpos anti-SOX10 |
-
2013
- 2013-09-26 DK DK13841542.7T patent/DK2900265T3/en active
- 2013-09-26 JP JP2015534675A patent/JP6324970B2/ja active Active
- 2013-09-26 WO PCT/US2013/062043 patent/WO2014052672A1/en not_active Ceased
- 2013-09-26 US US14/432,132 patent/US9429577B2/en active Active
- 2013-09-26 ES ES13841542.7T patent/ES2682345T3/es active Active
- 2013-09-26 EP EP13841542.7A patent/EP2900265B1/en active Active
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2016
- 2016-08-02 US US15/226,794 patent/US9823251B2/en active Active
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