JP2016500659A5 - - Google Patents
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- JP2016500659A5 JP2016500659A5 JP2015534675A JP2015534675A JP2016500659A5 JP 2016500659 A5 JP2016500659 A5 JP 2016500659A5 JP 2015534675 A JP2015534675 A JP 2015534675A JP 2015534675 A JP2015534675 A JP 2015534675A JP 2016500659 A5 JP2016500659 A5 JP 2016500659A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- uroplakin
- tissue
- item
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims description 109
- 239000000203 mixture Substances 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 55
- 210000004027 cell Anatomy 0.000 claims description 43
- 210000001519 tissue Anatomy 0.000 claims description 43
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 39
- 102000013532 Uroplakin II Human genes 0.000 claims description 30
- 108010065940 Uroplakin II Proteins 0.000 claims description 30
- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 26
- 108091007433 antigens Proteins 0.000 claims description 26
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 24
- 150000007523 nucleic acids Chemical group 0.000 claims description 24
- 238000001514 detection method Methods 0.000 claims description 19
- 239000012472 biological sample Substances 0.000 claims description 18
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 17
- 101000601664 Homo sapiens Paired box protein Pax-8 Proteins 0.000 claims description 16
- 102100037502 Paired box protein Pax-8 Human genes 0.000 claims description 16
- 238000003364 immunohistochemistry Methods 0.000 claims description 16
- 210000004408 hybridoma Anatomy 0.000 claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- 229920001184 polypeptide Polymers 0.000 claims description 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- 101001066288 Gallus gallus GATA-binding factor 3 Proteins 0.000 claims description 12
- 102100028092 Homeobox protein Nkx-3.1 Human genes 0.000 claims description 12
- 101000578249 Homo sapiens Homeobox protein Nkx-3.1 Proteins 0.000 claims description 12
- 102000009764 Uroplakin III Human genes 0.000 claims description 12
- 108010009737 Uroplakin III Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 8
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims description 8
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- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 6
- 241000287828 Gallus gallus Species 0.000 claims description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 6
- 235000013330 chicken meat Nutrition 0.000 claims description 6
- 210000005084 renal tissue Anatomy 0.000 claims description 6
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- 210000005068 bladder tissue Anatomy 0.000 claims description 5
- QRXMUCSWCMTJGU-UHFFFAOYSA-L (5-bromo-4-chloro-1h-indol-3-yl) phosphate Chemical compound C1=C(Br)C(Cl)=C2C(OP([O-])(=O)[O-])=CNC2=C1 QRXMUCSWCMTJGU-UHFFFAOYSA-L 0.000 claims description 4
- HSTOKWSFWGCZMH-UHFFFAOYSA-N 3,3'-diaminobenzidine Chemical compound C1=C(N)C(N)=CC=C1C1=CC=C(N)C(N)=C1 HSTOKWSFWGCZMH-UHFFFAOYSA-N 0.000 claims description 4
- OXEUETBFKVCRNP-UHFFFAOYSA-N 9-ethyl-3-carbazolamine Chemical compound NC1=CC=C2N(CC)C3=CC=CC=C3C2=C1 OXEUETBFKVCRNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000002965 ELISA Methods 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 4
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims description 4
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 4
- WLDHEUZGFKACJH-UHFFFAOYSA-K amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1N=NC1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-UHFFFAOYSA-K 0.000 claims description 4
- 102000005936 beta-Galactosidase Human genes 0.000 claims description 4
- 108010005774 beta-Galactosidase Proteins 0.000 claims description 4
- 239000000975 dye Substances 0.000 claims description 4
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- 238000003365 immunocytochemistry Methods 0.000 claims description 4
- 239000006249 magnetic particle Substances 0.000 claims description 4
- 230000002285 radioactive effect Effects 0.000 claims description 4
- 239000003053 toxin Substances 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- DHJFFLKPAYHPHU-BYNIDDHOSA-N 5-bromo-4-chloro-3-indolyl beta-D-glucuronide Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 DHJFFLKPAYHPHU-BYNIDDHOSA-N 0.000 claims description 3
- 101710087047 Cytoskeleton-associated protein 4 Proteins 0.000 claims description 3
- 241000283086 Equidae Species 0.000 claims description 3
- 241000699670 Mus sp. Species 0.000 claims description 3
- 102100027881 Tumor protein 63 Human genes 0.000 claims description 3
- 101710140697 Tumor protein 63 Proteins 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
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- 210000001072 colon Anatomy 0.000 claims description 3
- 238000012137 double-staining Methods 0.000 claims description 3
- 230000002357 endometrial effect Effects 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 claims description 3
- 210000001165 lymph node Anatomy 0.000 claims description 3
- 230000001613 neoplastic effect Effects 0.000 claims description 3
- 210000002741 palatine tonsil Anatomy 0.000 claims description 3
- 210000004923 pancreatic tissue Anatomy 0.000 claims description 3
- 210000002307 prostate Anatomy 0.000 claims description 3
- 210000002784 stomach Anatomy 0.000 claims description 3
- 210000001685 thyroid gland Anatomy 0.000 claims description 3
- 210000002700 urine Anatomy 0.000 claims description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims description 2
- 230000002611 ovarian Effects 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 claims 1
- 230000000762 glandular Effects 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 3
- 102100038851 Uroplakin-2 Human genes 0.000 description 3
- 101710173761 Uroplakin-2 Proteins 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010191 image analysis Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 241001529936 Murinae Species 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 102100038854 Uroplakin-3a Human genes 0.000 description 1
- 108050004295 Uroplakin-3a Proteins 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 206010044412 transitional cell carcinoma Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261706312P | 2012-09-27 | 2012-09-27 | |
| US61/706,312 | 2012-09-27 | ||
| PCT/US2013/062043 WO2014052672A1 (en) | 2012-09-27 | 2013-09-26 | Anti-uroplakin ii antibodies systems and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016500659A JP2016500659A (ja) | 2016-01-14 |
| JP2016500659A5 true JP2016500659A5 (enExample) | 2016-11-17 |
| JP6324970B2 JP6324970B2 (ja) | 2018-05-23 |
Family
ID=50388980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534675A Active JP6324970B2 (ja) | 2012-09-27 | 2013-09-26 | 抗ウロプラキンｉｉ抗体システムおよび方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9429577B2 (enExample) |
| EP (1) | EP2900265B1 (enExample) |
| JP (1) | JP6324970B2 (enExample) |
| DK (1) | DK2900265T3 (enExample) |
| ES (1) | ES2682345T3 (enExample) |
| WO (1) | WO2014052672A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012154983A2 (en) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systems and methods for anti-pax8 antibodies |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| DK2900265T3 (en) | 2012-09-27 | 2018-08-20 | Biocare Medical Llc | Anti-Uroplakin II Antibodies, Systems and Methods |
| US10429390B2 (en) | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| DK2962113T3 (da) | 2013-02-28 | 2019-07-01 | Biocare Medical Llc | Systemer og fremgangsmåder med anti-p40-antistoffer |
| WO2015051320A2 (en) | 2013-10-03 | 2015-04-09 | Biocare Medical, Llc | Anti-sox10 antibody systems and methods |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| CN108727496A (zh) * | 2018-06-21 | 2018-11-02 | 南京基诺米医疗科技有限公司 | 鼠抗人p63蛋白单克隆抗体制备及其免疫组化用途 |
| CA3110096A1 (en) * | 2018-08-30 | 2020-03-05 | Innovative Cellular Therapeutics CO., LTD. | Chimeric antigen receptor cells for treating solid tumor |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
| US12043654B2 (en) | 2020-06-02 | 2024-07-23 | Innovative Cellular Therapeutics Holdings, Ltd. | Anti-GCC antibody and CAR thereof for treating digestive system cancer |
| CN113295866A (zh) * | 2021-04-26 | 2021-08-24 | 深圳市龙华区中心医院 | Upⅱ抗原和upⅱ抗体联合在制备检测膀胱癌的产品中的应用 |
| CN118930648B (zh) * | 2024-08-22 | 2025-02-28 | 武汉爱博泰克生物科技有限公司 | 抗人pax8蛋白的兔单克隆抗体、抗体偶联物及其应用 |
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| DK2900265T3 (en) | 2012-09-27 | 2018-08-20 | Biocare Medical Llc | Anti-Uroplakin II Antibodies, Systems and Methods |
| US10429390B2 (en) | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| DK2962113T3 (da) | 2013-02-28 | 2019-07-01 | Biocare Medical Llc | Systemer og fremgangsmåder med anti-p40-antistoffer |
| WO2015051320A2 (en) | 2013-10-03 | 2015-04-09 | Biocare Medical, Llc | Anti-sox10 antibody systems and methods |
-
2013
- 2013-09-26 DK DK13841542.7T patent/DK2900265T3/en active
- 2013-09-26 WO PCT/US2013/062043 patent/WO2014052672A1/en not_active Ceased
- 2013-09-26 US US14/432,132 patent/US9429577B2/en active Active
- 2013-09-26 ES ES13841542.7T patent/ES2682345T3/es active Active
- 2013-09-26 JP JP2015534675A patent/JP6324970B2/ja active Active
- 2013-09-26 EP EP13841542.7A patent/EP2900265B1/en active Active
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2016
- 2016-08-02 US US15/226,794 patent/US9823251B2/en active Active
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