JP6324970B2 - 抗ウロプラキンｉｉ抗体システムおよび方法 - Google Patents

抗ウロプラキンｉｉ抗体システムおよび方法 Download PDF

Info

Publication number
JP6324970B2
JP6324970B2 JP2015534675A JP2015534675A JP6324970B2 JP 6324970 B2 JP6324970 B2 JP 6324970B2 JP 2015534675 A JP2015534675 A JP 2015534675A JP 2015534675 A JP2015534675 A JP 2015534675A JP 6324970 B2 JP6324970 B2 JP 6324970B2
Authority
JP
Japan
Prior art keywords
antibody
upii
tissue
staining
uroplakin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015534675A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016500659A (ja
JP2016500659A5 (enExample
Inventor
ウェイミン チ，
ウェイミン チ，
デイビッド タチャ，
デイビッド タチャ，
Original Assignee
バイオケア メディカル， エルエルシー
バイオケア メディカル， エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオケア メディカル， エルエルシー, バイオケア メディカル， エルエルシー filed Critical バイオケア メディカル， エルエルシー
Publication of JP2016500659A publication Critical patent/JP2016500659A/ja
Publication of JP2016500659A5 publication Critical patent/JP2016500659A5/ja
Application granted granted Critical
Publication of JP6324970B2 publication Critical patent/JP6324970B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3038—Kidney, bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015534675A 2012-09-27 2013-09-26 抗ウロプラキンｉｉ抗体システムおよび方法 Active JP6324970B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261706312P 2012-09-27 2012-09-27
US61/706,312 2012-09-27
PCT/US2013/062043 WO2014052672A1 (en) 2012-09-27 2013-09-26 Anti-uroplakin ii antibodies systems and methods

Publications (3)

Publication Number Publication Date
JP2016500659A JP2016500659A (ja) 2016-01-14
JP2016500659A5 JP2016500659A5 (enExample) 2016-11-17
JP6324970B2 true JP6324970B2 (ja) 2018-05-23

Family

ID=50388980

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015534675A Active JP6324970B2 (ja) 2012-09-27 2013-09-26 抗ウロプラキンｉｉ抗体システムおよび方法

Country Status (6)

Country Link
US (2) US9429577B2 (enExample)
EP (1) EP2900265B1 (enExample)
JP (1) JP6324970B2 (enExample)
DK (1) DK2900265T3 (enExample)
ES (1) ES2682345T3 (enExample)
WO (1) WO2014052672A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012154983A2 (en) 2011-05-10 2012-11-15 Biocare Medical, Llc Systems and methods for anti-pax8 antibodies
US10316103B1 (en) 2012-03-30 2019-06-11 Biocare Medical, Llc Systems and methods for anti-Uroplakin III antibodies
DK2900265T3 (en) 2012-09-27 2018-08-20 Biocare Medical Llc Anti-Uroplakin II Antibodies, Systems and Methods
US10429390B2 (en) 2012-12-18 2019-10-01 Biocare Medical, Llc Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer
DK2962113T3 (da) 2013-02-28 2019-07-01 Biocare Medical Llc Systemer og fremgangsmåder med anti-p40-antistoffer
WO2015051320A2 (en) 2013-10-03 2015-04-09 Biocare Medical, Llc Anti-sox10 antibody systems and methods
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
CN108727496A (zh) * 2018-06-21 2018-11-02 南京基诺米医疗科技有限公司 鼠抗人p63蛋白单克隆抗体制备及其免疫组化用途
CA3110096A1 (en) * 2018-08-30 2020-03-05 Innovative Cellular Therapeutics CO., LTD. Chimeric antigen receptor cells for treating solid tumor
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
US12076343B2 (en) 2020-02-19 2024-09-03 Innovative Cellular Therapeutics Holdings, Ltd. Engineered safety in cell therapy
US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer
CN113295866A (zh) * 2021-04-26 2021-08-24 深圳市龙华区中心医院 Upⅱ抗原和upⅱ抗体联合在制备检测膀胱癌的产品中的应用
CN118930648B (zh) * 2024-08-22 2025-02-28 武汉爱博泰克生物科技有限公司 抗人pax8蛋白的兔单克隆抗体、抗体偶联物及其应用

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4145406A (en) 1977-04-11 1979-03-20 Miles Laboratories, Inc. Specific binding - adsorbent assay method and test means
US4254082A (en) 1978-06-12 1981-03-03 Miles Laboratories, Inc. Specific binding-adsorbent assay test means
CA1247538A (en) 1982-05-21 1988-12-28 Mark C. Glassy Human-human hybridomas for solid tumors
US4687732A (en) 1983-06-10 1987-08-18 Yale University Visualization polymers and their application to diagnostic medicine
US4690890A (en) 1984-04-04 1987-09-01 Cetus Corporation Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay
JPS60248618A (ja) 1984-05-24 1985-12-09 Nippon Zoki Pharmaceut Co Ltd ジペプチドを含有する潰瘍治療剤
US4792521A (en) 1985-08-15 1988-12-20 Immunomedics, Inc. Non-enzymatic immunohistochemical staining system and reagents
US4863875A (en) 1985-08-26 1989-09-05 Gia Research Company, L.P. Dye labelled antibodies as reagents for use in immunoassay systems
GB8607101D0 (en) 1986-03-21 1986-04-30 Serono Diagnostics Ltd Immunoassay
US5089423A (en) 1987-05-06 1992-02-18 Cyberfluor Inc. Immunoassay methods and reagents and methods for producing the latter
US5620845A (en) 1988-06-06 1997-04-15 Ampcor, Inc. Immunoassay diagnostic kit
US5252487A (en) 1989-05-19 1993-10-12 Cell Analysis Systems, Inc. Method and apparatus for determining the amount of oncogene protein product in a cell sample
US6008057A (en) 1989-08-25 1999-12-28 Roche Diagnostics Corporation Immunoassay system
US5719063A (en) 1989-08-25 1998-02-17 Boehringer Mannheim Corporation Multiplex immunoassay system
US5492821A (en) 1990-11-14 1996-02-20 Cargill, Inc. Stabilized polyacrylic saccharide protein conjugates
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5280108A (en) 1991-09-27 1994-01-18 United States Of America Antibodies to p40
EP0669836B1 (en) 1992-11-13 1996-07-03 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
US5482698A (en) 1993-04-22 1996-01-09 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin polymer conjugates
US5487975A (en) 1993-11-15 1996-01-30 Ventana Medical Systems, Inc. Biotin/avidin formulation
AU689214B2 (en) 1994-02-01 1998-03-26 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Fusion proteins that include antibody and nonantibody portions
US5869274A (en) 1995-08-09 1999-02-09 Zymed Laboratories, Inc. Immuno-histochemical method that reduces background staining
US5891658A (en) 1996-06-27 1999-04-06 FCI--FiberChem, Inc. Single-step, solid-state competitive immunoassay
ES2327440T3 (es) 1996-08-23 2009-10-29 Vegenics Limited Factor recombinante de crecimiento de las celulas endoteliales vasculares-d (vegf-d).
US7196164B2 (en) 1997-07-08 2007-03-27 Human Genome Sciences, Inc. Secreted protein HHTLF25
CA2303165C (en) 1997-09-22 2006-07-11 Chiron Corporation Buffers for stabilizing antigens
US7294459B1 (en) 1997-10-15 2007-11-13 President And Fellows Of Harvard College Cell regulatory genes, encoded products, and uses related thereto
US6277968B1 (en) * 1997-11-13 2001-08-21 New York University Human uroplakin II gene and methods for detecting and classifying bladder cancer via human uroplakin genes
US6476206B1 (en) 1998-03-27 2002-11-05 The Johns Hopkins University p40 protein acts as an oncogene
JP3524401B2 (ja) 1998-09-16 2004-05-10 株式会社ニチレイ 酵素抗体複合体およびその製造方法
WO2000069473A2 (en) 1999-05-14 2000-11-23 The Regents Of The University Of California Macromolecular carrier for drug and diagnostic agent delivery
US6723506B2 (en) 2000-01-20 2004-04-20 Brigham And Women's Hospital Method of identifying PAX8-PPAR gamma-nucleic acid molecules
US20030017491A1 (en) 2000-09-14 2003-01-23 Zuo-Rong Shi Chromogenic in situ hybridization methods, kits, and compositions
DE10063179A1 (de) 2000-12-18 2002-06-20 Bayer Ag Verfahren zur spezifischen Detektion von Tumorzellen und ihren Vorstufen in Gebärmutterhalsabstrichen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US20020173053A1 (en) 2001-04-27 2002-11-21 Bassam Damaj Multiple simultaneous antigen detection by immunohistochemistry
US20040076955A1 (en) 2001-07-03 2004-04-22 Eos Biotechnology, Inc. Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer
US6580056B1 (en) 2001-09-21 2003-06-17 Biocare Medical Biological specimen heating device and quality control method for immunohistochemistry heat retrieval procedures
EP1480520A4 (en) * 2002-02-12 2006-02-15 Raven Biotechnologies Inc EPITHELIAL CELLS FROM THE HUMAN FOLDS BUBBLE
CN102659946A (zh) 2002-03-13 2012-09-12 拜奥根Idec马萨诸塞公司 抗αvβ6抗体
US7850912B2 (en) 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
KR20110094361A (ko) 2003-04-11 2011-08-23 메디뮨 엘엘씨 재조합 ｉｌ­９ 항체 및 그의 용도
WO2005007809A2 (en) 2003-05-30 2005-01-27 Alexion Pharmaceuticals, Inc. Antibodies and fusion proteins that include engineered constant regions
JP2005122810A (ja) 2003-10-16 2005-05-12 Hitachi Ltd 光ディスク装置
CA2544577C (en) 2003-12-01 2013-01-08 Dako Denmark A/S Methods and compositions for immuno-histochemical detection
WO2005076005A2 (en) 2004-01-30 2005-08-18 Medizinische Universität Wien A method for classifying a tumor cell sample based upon differential expression of at least two genes
US20050186642A1 (en) 2004-02-24 2005-08-25 Biocare Medical, Inc. Immunoassay reagents and methods of use thereof
US7502666B2 (en) 2004-05-14 2009-03-10 Mts Medication Technologies, Inc. Systems and methods for storing and dispensing medication
JP4576168B2 (ja) * 2004-06-29 2010-11-04 Ｔｓｓバイオテック株式会社 膀胱尿管逆流症または間質性膀胱炎の検査方法
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
ES2351057T3 (es) 2005-07-08 2011-01-31 Pfizer Limited Anticuerpos contra madcam.
US8114588B2 (en) * 2005-07-15 2012-02-14 Tss Biotech Inc. Method for detecting vesicoureteral reflux or interstitial cystitis
JP4736037B2 (ja) 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
BRPI0619249A2 (pt) 2005-11-30 2011-09-20 Abbott Lab anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
HUE043255T2 (hu) 2006-06-07 2019-08-28 Bioalliance Cv Antitestek, amelyek felismernek ráksejteken expresszált CD43-on és CEA-n jelenlévõ, szénhidrátot tartalmazó epitópot, és eljárások alkalmazásukra
US20100092457A1 (en) 2006-08-14 2010-04-15 Forerunner Pharma Research Co., Ltd. Diagnosis and Treatment of Cancer Using Anti-Desmoglein-3 Antibodies
CN101855241B (zh) 2006-12-08 2013-11-06 莱克康制药公司 针对angptl3的单克隆抗体
WO2008127642A1 (en) 2007-04-11 2008-10-23 Enteron Limited Partnership Myelin specific ige unencumbered by corresponding blocking antibodies as a causative factor in multiple sclerosis
JP5117765B2 (ja) 2007-05-28 2013-01-16 国立大学法人 東京大学 抗ｒｏｂｏ１抗体を含むｐｅｔ用腫瘍診断剤
MX2010003325A (es) 2007-09-26 2010-04-09 Genentech Inc Anticuepos novedosos.
RU2540146C2 (ru) * 2008-08-29 2015-02-10 Симфоген А/С Композиции рекомбинантных антител против рецептора эпидермального фактора роста
EP2342229A1 (en) 2008-09-12 2011-07-13 ISIS Innovation Limited Pd-1 specific antibodies and uses thereof
US7846762B2 (en) 2008-09-22 2010-12-07 Applied Materials, Inc. Integrated emitter formation and passivation
CA2760569C (en) 2009-05-01 2018-01-02 Dako Denmark A/S New antibody cocktail
CN102666584A (zh) 2009-05-12 2012-09-12 辉瑞公司 封闭性抗dkk-1抗体及其用途
US20120245051A1 (en) 2009-10-13 2012-09-27 Rimm David L Objective, quantitative method to predict histological subtype in non-small cell lung cancer
US20120321557A1 (en) 2010-02-26 2012-12-20 Forerunner Pharma Research Co., Ltd. Anti-icam3 antibody and use thereof
EP2402370A1 (en) 2010-06-29 2012-01-04 Pierre Fabre Médicament Novel antibody for the diagnosis and/or prognosis of cancer
NZ608814A (en) * 2010-09-03 2015-06-26 Stem Centrx Inc Novel modulators and methods of use
CA2851101C (en) 2010-10-06 2017-02-14 Biocare Medical, Llc Methods and systems for efficient processing of biological samples
US20120154983A1 (en) 2010-10-08 2012-06-21 The Regents Of The University Of California Method of Fabrication of Carbon Nanofibers on Nickel Foam
WO2012154983A2 (en) 2011-05-10 2012-11-15 Biocare Medical, Llc Systems and methods for anti-pax8 antibodies
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
DK2900265T3 (en) 2012-09-27 2018-08-20 Biocare Medical Llc Anti-Uroplakin II Antibodies, Systems and Methods
US10429390B2 (en) 2012-12-18 2019-10-01 Biocare Medical, Llc Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer
DK2962113T3 (da) 2013-02-28 2019-07-01 Biocare Medical Llc Systemer og fremgangsmåder med anti-p40-antistoffer
WO2015051320A2 (en) 2013-10-03 2015-04-09 Biocare Medical, Llc Anti-sox10 antibody systems and methods

Also Published As

Publication number Publication date
JP2016500659A (ja) 2016-01-14
US9823251B2 (en) 2017-11-21
EP2900265B1 (en) 2018-05-30
US20150247861A1 (en) 2015-09-03
DK2900265T3 (en) 2018-08-20
US9429577B2 (en) 2016-08-30
WO2014052672A1 (en) 2014-04-03
EP2900265A4 (en) 2016-05-25
EP2900265A1 (en) 2015-08-05
ES2682345T3 (es) 2018-09-20
US20160334407A1 (en) 2016-11-17

Similar Documents

Publication Publication Date Title
JP6324970B2 (ja) 抗ウロプラキンｉｉ抗体システムおよび方法
US20160370370A1 (en) Systems and Methods for Anti-PAX8 Antibodies
JP5941615B2 (ja) ヒトｃｘｃｌ１タンパク質の免疫学的測定方法
JP6445467B2 (ja) 抗ｐ４０抗体システムおよび方法
JP6506267B2 (ja) 抗ｓｏｘ１０抗体のシステムおよび方法
JP2016500659A5 (enExample)
US20050214301A1 (en) Antibodies specific for BCR-ABL fusion protein and uses thereof
JPWO2009044561A1 (ja) 抗ｐｒｏＮＴ／ＮＭＮモノクローナル抗体
US10316103B1 (en) Systems and methods for anti-Uroplakin III antibodies
JP6793514B2 (ja) 新規甲状腺癌関連抗原に結合する抗体および甲状腺癌診断剤
KR102688094B1 (ko) Cobll1 단백질 특이 항체 또는 이의 항원 결합 단편, 및 이의 용도
US9127054B2 (en) Immunoassay of cofilin 1 protein
WO2024251260A1 (zh) 结合Nectin-4的抗体及其用途
WO2025218662A1 (zh) 抗成纤维细胞生长因子受体2b的抗体及其用途
CN119569876A (zh) 抗igf2单克隆抗体及其作为肾上腺肿瘤诊断剂中的应用
JP2598893C (enExample)
JPWO2003052102A1 (ja) ブラディオン検出用特異的抗体

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20150423

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150526

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160926

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160926

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20170726

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170802

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171026

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171227

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180320

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180411

R150 Certificate of patent or registration of utility model

Ref document number: 6324970

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250