ATE277642T1 - Makromolekular träger auf basis von dextran fur arzneimittel und diagnosticum abgabe - Google Patents
Makromolekular träger auf basis von dextran fur arzneimittel und diagnosticum abgabeInfo
- Publication number
- ATE277642T1 ATE277642T1 AT00937555T AT00937555T ATE277642T1 AT E277642 T1 ATE277642 T1 AT E277642T1 AT 00937555 T AT00937555 T AT 00937555T AT 00937555 T AT00937555 T AT 00937555T AT E277642 T1 ATE277642 T1 AT E277642T1
- Authority
- AT
- Austria
- Prior art keywords
- dextran
- drug
- carrier based
- macromolecular carrier
- diagnostic delivery
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- 229920002307 Dextran Polymers 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
- A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
- A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pathology (AREA)
- Dentistry (AREA)
- Biomedical Technology (AREA)
- High Energy & Nuclear Physics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13432999P | 1999-05-14 | 1999-05-14 | |
| PCT/US2000/013300 WO2000069473A2 (en) | 1999-05-14 | 2000-05-12 | Macromolecular carrier for drug and diagnostic agent delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277642T1 true ATE277642T1 (de) | 2004-10-15 |
Family
ID=22462862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00937555T ATE277642T1 (de) | 1999-05-14 | 2000-05-12 | Makromolekular träger auf basis von dextran fur arzneimittel und diagnosticum abgabe |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6409990B1 (de) |
| EP (1) | EP1178838B1 (de) |
| JP (2) | JP4056701B2 (de) |
| AT (1) | ATE277642T1 (de) |
| AU (1) | AU5270500A (de) |
| DE (1) | DE60014359T2 (de) |
| ES (1) | ES2228536T3 (de) |
| FR (1) | FR15C0033I2 (de) |
| NL (1) | NL300736I2 (de) |
| WO (1) | WO2000069473A2 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| JP4163381B2 (ja) | 1997-11-17 | 2008-10-08 | カリフォルニア・インスティテュート・オブ・テクノロジー | 生理学的薬剤の検出のための磁気共鳴造影剤 |
| JP4056701B2 (ja) * | 1999-05-14 | 2008-03-05 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬剤および診断薬の送達のための高分子担体 |
| US6673333B1 (en) * | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| US20040146463A1 (en) * | 2000-05-04 | 2004-07-29 | Meade Thomas J. | Functional MRI agents for cancer imaging |
| EP1355672A2 (de) | 2000-12-01 | 2003-10-29 | Cell Works Inc. | "konjugate von glykosylierten/galaktosylierten peptiden, bifunktionellen linkern und nukleotid?monomeren/polymeren, damit zusammenhängende zusammensetzungen, sowie verfahren zu ihrer verwendung" |
| US20030004236A1 (en) * | 2001-04-20 | 2003-01-02 | Meade Thomas J. | Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances |
| WO2002087632A1 (en) * | 2001-05-02 | 2002-11-07 | Metaprobe, Inc. | High throughput screening methods using magnetic resonance imaging agents |
| WO2003057715A2 (en) * | 2001-12-28 | 2003-07-17 | The Regents Of The University Of California | Novel ligand involved in the transmigration of leukocytes . |
| US20030198597A1 (en) * | 2002-04-22 | 2003-10-23 | Meade Thomas J. | Novel macrocyclic activatible magnetic resonance imaging contrast agents |
| US7651689B2 (en) * | 2002-11-15 | 2010-01-26 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of applying ionization radiation for therapy of infections |
| US20040191843A1 (en) * | 2003-02-03 | 2004-09-30 | Palo Alto Institute Of Molecular Medicine | Cell-killing molecules and methods of use thereof |
| US7727969B2 (en) * | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| US20050171424A1 (en) * | 2004-01-13 | 2005-08-04 | The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services | Methods for imaging the lymphatic system using dendrimer-based contrast agents |
| US20050186642A1 (en) | 2004-02-24 | 2005-08-25 | Biocare Medical, Inc. | Immunoassay reagents and methods of use thereof |
| JPWO2005117995A1 (ja) * | 2004-06-03 | 2008-04-03 | 丈二 北山 | ヒアルロン酸のセンチネルリンパ節同定への応用 |
| US7381400B2 (en) * | 2004-07-13 | 2008-06-03 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Injection of a radioactive dye for sentinel lymph node identification |
| US20060204443A1 (en) * | 2005-03-11 | 2006-09-14 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for tumor treatment using dendrimer conjugates |
| DE102005018330B4 (de) | 2005-04-20 | 2007-04-19 | Siemens Ag | System zur Erzeugung von CT-Bilddatensätzen und zur Bestrahlung eines Tumor-Patienten |
| JP4934802B2 (ja) * | 2005-05-30 | 2012-05-23 | 国立大学法人信州大学 | リンパ系の細胞接着物質、リンパ系薬物輸送材およびそれを含有する薬剤 |
| US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
| US20070031512A1 (en) * | 2005-08-03 | 2007-02-08 | Amcol International Corporation | Virus-interacting layered phyllosilicates and methods of inactivating viruses |
| US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
| JP5563299B2 (ja) * | 2006-08-17 | 2014-07-30 | エピックス ファーマシューティカルズ,インコーポレイテッド | リンパ系撮像方法 |
| US20100196272A1 (en) * | 2009-01-30 | 2010-08-05 | Neoprobe Corporation | Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran |
| US11077212B2 (en) | 2010-08-24 | 2021-08-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Molecular imaging of cancer cells in vivo |
| WO2012154983A2 (en) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systems and methods for anti-pax8 antibodies |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| EP2900265B1 (de) | 2012-09-27 | 2018-05-30 | Biocare Medical, LLC | Anti-uroplakin-ii-antikörper, systeme und verfahren |
| US10429390B2 (en) | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| ES2720483T3 (es) | 2013-02-28 | 2019-07-22 | Biocare Medical Llc | Sistemas y procedimientos de anticuerpos anti p40 |
| JP6163698B2 (ja) * | 2013-03-21 | 2017-07-19 | 国立大学法人 千葉大学 | マクロファージマンノース受容体を認識する新規多糖金属錯体化合物、及び、その医薬組成物 |
| WO2015013341A1 (en) * | 2013-07-22 | 2015-01-29 | Navidea Biopharmaceuticals, Inc. | Compositions, methods and kits for diagnosing and treating cd206 expressing cell-related disorders |
| CN104511030A (zh) * | 2013-09-29 | 2015-04-15 | 复旦大学 | 基于葡聚糖的双模态纳米影像药物-Dex-Rho-99mTc |
| US9816997B2 (en) | 2013-10-03 | 2017-11-14 | Biocare Medical, Llc | Anti-SOX10 antibody systems and methods |
| WO2015189477A1 (en) | 2014-06-13 | 2015-12-17 | Tenboron Oy | Conjugates comprising an anti-egfr1 antibody |
| JP6722663B2 (ja) * | 2014-07-17 | 2020-07-15 | オハイオ ステート イノベーション ファウンデーション | マクロファージおよび他のマンノース結合c型レクチン受容体高発現細胞を標的化するための化合物および組成物、ならびにそれらを使用して治療するおよび診断する方法 |
| US10806803B2 (en) * | 2014-07-17 | 2020-10-20 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis |
| CA2955441C (en) * | 2014-07-17 | 2023-03-14 | Ohio State Innovation Foundation | Dextran conjugates for targeting macrophages and other cd296-expressing cells |
| US20180015187A1 (en) * | 2015-01-21 | 2018-01-18 | Cardinal Health 414, Llc | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same |
| CN106317237B (zh) * | 2015-07-03 | 2019-07-19 | 华中科技大学 | 一种用于spect成像的当归多糖衍生物及其合成方法 |
| KR20180083304A (ko) * | 2015-09-25 | 2018-07-20 | 세린, 엘엘씨 | sn-117m 라벨된 만노스 결합 덱스트란 아민 |
| US20190076557A1 (en) | 2015-10-05 | 2019-03-14 | Serene, Llc | Hyaluronan sn-117m colloid for radiosynoviorthesis and symptomatic therapy related applications |
| EP3522938A4 (de) * | 2016-10-04 | 2020-06-24 | Cardinal Health 414, LLC | Zusammensetzungen und verfahren zur diagnose und behandlung von makrophagenbedingten störungen unter verwendung eines kohlenhydratbasierten makromolekularen trägers |
| MX2019004029A (es) * | 2016-10-07 | 2019-09-27 | Navidea Biopharmaceuticals Inc | Compuestos y metodos para diagnosis y tratamiento de infecciones virales. |
| JP6329302B2 (ja) * | 2017-05-10 | 2018-05-23 | 国立大学法人千葉大学 | マクロファージマンノース受容体を認識する新規多糖金属錯体化合物、及び、その医薬組成物 |
| CA3151519A1 (en) * | 2019-08-19 | 2021-02-25 | Navidea Biopharmaceuticals, Inc. | Compositions and related methods for the ablation of m2 macrophages and myeloid derived suppressor cells |
| CA3155675A1 (en) * | 2019-09-30 | 2021-04-08 | Navidea Biopharmaceuticals, Inc. | Compositions and related methods for blocking off-target localization of mannosylated dextrans and other cd206 ligands |
| US11497763B1 (en) | 2020-07-01 | 2022-11-15 | Physis International LLC | Compounds and methods for treating and diagnosing RNA virus infections |
| US12070504B1 (en) | 2020-07-01 | 2024-08-27 | Physis International LLC | Compounds and methods for altering cyto-states of cells that express c-type lectin receptors |
| JP2023533405A (ja) * | 2020-07-08 | 2023-08-03 | ナビディア、バイオファーマスーティカルズ、インコーポレイテッド | 均一に定められた分子量のマンノシル化デキストランおよびその誘導体の合成 |
| EP4199936A4 (de) * | 2020-08-21 | 2025-05-07 | Resolute Science, Inc. | Zusammensetzungen und verfahren zum targeting von tumorassoziierten makrophagen |
| US11833170B2 (en) * | 2022-02-04 | 2023-12-05 | Navidea Biopharmaceuticals, Inc. | Altering net charge on mannosylated dextrans to maximize target tissue uptake and off target competitive blocking |
| US20230302041A1 (en) * | 2022-03-25 | 2023-09-28 | Navidea Biopharmaceuticals, Inc. | Competitive Self-Blocking with Unlabeled Manocept Imaging Agents |
| EP4598583A2 (de) | 2022-10-03 | 2025-08-13 | Navidea Biopharmaceuticals, Inc. | Amidbindungen von zuckerresten an aminterminierte leinen, die an kohlenhydratpolymeren gebunden sind |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE286598C (de) | ||||
| US4707440A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
| US5175269A (en) * | 1984-01-30 | 1992-12-29 | Enzo Diagnostics, Inc. | Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group |
| SE465907B (sv) | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
| US5336762A (en) * | 1985-11-18 | 1994-08-09 | Access Pharmaceuticals, Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
| US5490991A (en) * | 1986-07-03 | 1996-02-13 | Advanced Magnetics, Inc. | Directed delivery of radioprotectants using a receptor specific carrier |
| US4822594A (en) | 1987-01-27 | 1989-04-18 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
| CS263561B1 (en) * | 1987-09-18 | 1989-04-14 | Kery Vladimir | Process for preparing water soluble allylderivatives of oligo and polysaccharides |
| DD286598A5 (de) * | 1989-06-29 | 1991-01-31 | Adw Der Ddr,Zi F. Mulekularbiologie,De | Verfahren zur einfuehrung von primaeren aminogruppen in wasserloesliche polymere |
| US5789578A (en) * | 1996-01-11 | 1998-08-04 | Massey University | Methods for the preparation of resins with ligands attached thereto through a linking group comprising sulfide, sulfoxide or sulfone functionality |
| WO1998018497A2 (en) * | 1996-10-28 | 1998-05-07 | Nycomed Imaging As | Contrast agents |
| AU5135698A (en) * | 1996-11-28 | 1998-06-22 | Nihon Schering K.K. | Contrast compound, contrast medium for mri, and method for mri |
| JP4056701B2 (ja) * | 1999-05-14 | 2008-03-05 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬剤および診断薬の送達のための高分子担体 |
-
2000
- 2000-05-12 JP JP2000617933A patent/JP4056701B2/ja not_active Expired - Lifetime
- 2000-05-12 AU AU52705/00A patent/AU5270500A/en not_active Abandoned
- 2000-05-12 DE DE60014359T patent/DE60014359T2/de not_active Expired - Lifetime
- 2000-05-12 US US09/569,466 patent/US6409990B1/en not_active Expired - Lifetime
- 2000-05-12 ES ES00937555T patent/ES2228536T3/es not_active Expired - Lifetime
- 2000-05-12 WO PCT/US2000/013300 patent/WO2000069473A2/en not_active Ceased
- 2000-05-12 EP EP00937555A patent/EP1178838B1/de not_active Expired - Lifetime
- 2000-05-12 AT AT00937555T patent/ATE277642T1/de not_active IP Right Cessation
-
2007
- 2007-07-04 JP JP2007175770A patent/JP2007332380A/ja active Pending
-
2015
- 2015-04-23 FR FR15C0033C patent/FR15C0033I2/fr active Active
- 2015-04-29 NL NL300736C patent/NL300736I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL300736I1 (de) | 2016-01-26 |
| JP2007332380A (ja) | 2007-12-27 |
| EP1178838A2 (de) | 2002-02-13 |
| DE60014359T2 (de) | 2006-02-23 |
| EP1178838B1 (de) | 2004-09-29 |
| US6409990B1 (en) | 2002-06-25 |
| DE60014359D1 (de) | 2004-11-04 |
| NL300736I2 (de) | 2016-01-26 |
| FR15C0033I2 (fr) | 2016-09-09 |
| ES2228536T3 (es) | 2005-04-16 |
| FR15C0033I1 (de) | 2015-06-26 |
| JP2002544243A (ja) | 2002-12-24 |
| WO2000069473A2 (en) | 2000-11-23 |
| AU5270500A (en) | 2000-12-05 |
| JP4056701B2 (ja) | 2008-03-05 |
| WO2000069473A3 (en) | 2001-08-16 |
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