JP2010518847A5 - - Google Patents
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- JP2010518847A5 JP2010518847A5 JP2009550765A JP2009550765A JP2010518847A5 JP 2010518847 A5 JP2010518847 A5 JP 2010518847A5 JP 2009550765 A JP2009550765 A JP 2009550765A JP 2009550765 A JP2009550765 A JP 2009550765A JP 2010518847 A5 JP2010518847 A5 JP 2010518847A5
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- Prior art keywords
- cancer
- ogta076
- antibody
- lymphocytic leukemia
- fragments
- Prior art date
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- 108090001123 antibodies Proteins 0.000 claims 18
- 102000004965 antibodies Human genes 0.000 claims 18
- 239000003153 chemical reaction reagent Substances 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 7
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims 5
- 208000000429 Leukemia, Lymphocytic, Chronic, B-Cell Diseases 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 208000003747 Lymphoid Leukemia Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 201000011231 colorectal cancer Diseases 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 201000006439 lymphocytic leukemia Diseases 0.000 claims 4
- 201000002528 pancreatic cancer Diseases 0.000 claims 4
- 108010045030 monoclonal antibodies Proteins 0.000 claims 3
- 102000005614 monoclonal antibodies Human genes 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000001225 therapeutic Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 108010047814 Antigen-Antibody Complex Proteins 0.000 claims 1
- 210000003734 Kidney Anatomy 0.000 claims 1
- 206010024324 Leukaemias Diseases 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 230000000781 anti-lymphocytic Effects 0.000 claims 1
- 230000002946 anti-pancreatic Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 230000000295 complement Effects 0.000 claims 1
- 230000001472 cytotoxic Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000001809 detectable Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000003364 immunohistochemistry Methods 0.000 claims 1
- 230000007762 localization of cell Effects 0.000 claims 1
- 230000001926 lymphatic Effects 0.000 claims 1
- 230000003278 mimic Effects 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 210000004923 pancreatic tissues Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Claims (18)
- 結腸直腸癌、腎癌、肝癌、肺癌、リンパ性白血病(特に慢性リンパ球性白血病)、卵巣癌又は膵癌の治療又は予防における使用のための、OGTA076に特異的に結合することが可能な抗体若しくは他の親和性試薬又はそれらの断片、及び医薬として許容し得る希釈剤又は担体を含有する組成物。
- OGTA076又はその断片に特異的に結合することが可能な親和性試薬。
- 検出可能な標識若しくは治療的部分を含むか、又はこれらに複合体化された、請求項2記載の親和性試薬。
- 前記治療的部分が、細胞傷害性部分又は放射性アイソタイプである、請求項3記載の親和性試薬。
- 抗体である、請求項2〜4のいずれか1項記載の親和性試薬。
- 単離されたモノクローナル抗体、又はその抗原結合部分、ユニボディ、ドメイン抗体及びナノボディなどの抗体断片、又はアフィボディなどの抗体模倣物である、請求項5記載の抗体。
- 前記抗体が、IgG1、IgG2、IgG3若しくはIgG4アイソタイプの完全長抗体であるか、又は全抗体、抗体断片、ヒト化抗体、単鎖抗体、免疫複合体、脱フコシル化された抗体、及び二重特異性抗体からなる群から選択されたものである、請求項5記載の単離されたモノクローナル抗体。
- ヒト補体の存在下で、又はヒト免疫エフェクター細胞の存在下で、OGTA076抗原を発現している細胞に対する細胞傷害性を有する、請求項6記載のモノクローナル抗体。
- 治療又は予防、例えば、結腸直腸癌、腎癌、肝癌、肺癌、リンパ性白血病(特に慢性リンパ球性白血病)、卵巣癌若しくは膵癌などの癌の治療又は予防における使用のための、請求項2〜8のいずれか1項記載の親和性試薬又は抗体。
- 請求項2〜8のいずれか1項記載の親和性試薬若しくはそれらの断片又は抗体若しくはそれらの断片の治療有効量、及び医薬として許容し得る希釈剤又は担体を含有する、医薬組成物。
- 請求項2〜8のいずれか1項記載の1種以上の親和性試薬若しくは抗体、又は請求項10記載の組成物を含むキットであって、該親和性物質が治療及び/又は診断における使用に適したものである、前記キット。
- 被験体における結腸直腸癌、腎癌、肝癌、肺癌、リンパ性白血病(特に慢性リンパ球性白血病)、卵巣癌若しくは膵癌の検出、診断及び/又はスクリーニング、又は進行のモニタリングの方法、或いは抗結腸直腸癌、抗腎癌、抗肝癌、抗肺癌、抗リンパ性白血病(特に慢性リンパ球性白血病)、抗卵巣癌若しくは抗膵癌の薬物又は療法の作用のモニタリングの方法であって、前記被験体におけるOGTA076若しくはそれらの1種以上の断片の存在若しくはレベル、又はOGTA076をコードしている核酸の存在若しくはレベル、又はOGTA076の活性の存在若しくはレベルを検出することを含むか、或いはそれらのレベルの変化を検出することを含む、前記方法。
- OGTA076若しくはその1種以上の断片の存在、又はOGTA076をコードしている核酸の存在、又はOGTA076の活性の存在が、前記被験体から得られた生物学的試料の分析により検出され、該試料が結腸直腸、腎臓、肝臓、肺、リンパ系、卵巣又は膵臓の組織の試料である、請求項12記載の方法。
- OGTA076若しくはその1種以上の断片の存在、又はOGTA076をコードしている核酸の存在、又はOGTA076の活性の存在が、定量的に検出される、請求項12又は13記載の方法。
- OGTA076若しくはその1種以上の断片の存在、又はOGTA076をコードしている核酸の存在、又はOGTA076の活性の存在が、画像技術の使用が関与する手段により定量的に検出される、請求項12記載の方法。
- OGTA076若しくはその1種以上の断片の存在、又はOGTA076をコードしている核酸の存在、又はOGTA076の活性の存在を測定し、これによって結腸直腸癌、腎癌、肝癌、肺癌、リンパ性白血病(特に慢性リンパ球性白血病)、卵巣癌又は膵癌の細胞の局在を決定するための組織切片に対する免疫組織化学の使用が関与している、請求項12〜14のいずれか1項記載の方法。
- 前記OGTA076若しくはその1種以上の断片の存在が、OGTA076若しくはその1種以上の断片に特異的に結合することが可能な親和性試薬を使用して検出される、請求項12記載の方法。
- 前記親和性試薬が、抗体である、請求項16記載の方法。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90350907P | 2007-02-26 | 2007-02-26 | |
| US90351007P | 2007-02-26 | 2007-02-26 | |
| US60/903,509 | 2007-02-26 | ||
| US60/903,510 | 2007-02-26 | ||
| PCT/GB2008/050124 WO2008104803A2 (en) | 2007-02-26 | 2008-02-25 | Proteins |
| GBPCT/GB2008/050124 | 2008-02-25 | ||
| PCT/GB2008/050127 WO2008104806A2 (en) | 2007-02-26 | 2008-02-26 | Protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207923A Division JP2015091797A (ja) | 2007-02-26 | 2014-10-09 | タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518847A JP2010518847A (ja) | 2010-06-03 |
| JP2010518847A5 true JP2010518847A5 (ja) | 2011-04-21 |
| JP5945381B2 JP5945381B2 (ja) | 2016-07-05 |
Family
ID=39486447
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009550765A Active JP5945381B2 (ja) | 2007-02-26 | 2008-02-26 | タンパク質 |
| JP2014207923A Withdrawn JP2015091797A (ja) | 2007-02-26 | 2014-10-09 | タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207923A Withdrawn JP2015091797A (ja) | 2007-02-26 | 2014-10-09 | タンパク質 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20100098627A1 (ja) |
| EP (3) | EP3118220B1 (ja) |
| JP (2) | JP5945381B2 (ja) |
| CY (2) | CY1118169T1 (ja) |
| DK (3) | DK2441775T3 (ja) |
| ES (2) | ES2745014T3 (ja) |
| HR (2) | HRP20161338T1 (ja) |
| HU (2) | HUE030894T2 (ja) |
| LT (2) | LT3118220T (ja) |
| PL (2) | PL3118220T3 (ja) |
| PT (2) | PT3118220T (ja) |
| SI (2) | SI3118220T1 (ja) |
| WO (3) | WO2008104803A2 (ja) |
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| EP2364444A4 (en) | 2008-10-21 | 2012-08-08 | Astute Medical Inc | METHOD AND COMPOSITIONS FOR THE DIAGNOSIS AND FORECASTING KIDNEY INJURY AND KIDNEY FAILURES |
| MX336869B (es) | 2008-11-03 | 2016-02-04 | Alethia Biotherapeutics Inc | Anticuerpos que bloquean espicificamente la actividad biologica de un antigeno de tumor. |
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| US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| SG175734A1 (en) * | 2009-04-20 | 2011-12-29 | Oxford Biotherapeutics Ltd | Antibodies specific to cadherin-17 |
| KR20120061863A (ko) | 2009-08-07 | 2012-06-13 | 아스튜트 메디컬 인코포레이티드 | 신장 손상 및 신부전증의 진단과 예후를 위한 방법 및 조성물 |
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