JP2008532523A5 - - Google Patents
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- JP2008532523A5 JP2008532523A5 JP2008500966A JP2008500966A JP2008532523A5 JP 2008532523 A5 JP2008532523 A5 JP 2008532523A5 JP 2008500966 A JP2008500966 A JP 2008500966A JP 2008500966 A JP2008500966 A JP 2008500966A JP 2008532523 A5 JP2008532523 A5 JP 2008532523A5
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- Prior art keywords
- antibody
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- acid sequence
- cell
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 21
- 102000003735 Mesothelin Human genes 0.000 claims 11
- 108090000015 Mesothelin Proteins 0.000 claims 11
- 108091033319 polynucleotide Proteins 0.000 claims 11
- 102000040430 polynucleotide Human genes 0.000 claims 11
- 239000002157 polynucleotide Substances 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 229940127089 cytotoxic agent Drugs 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 4
- 239000012642 immune effector Substances 0.000 claims 4
- 229940121354 immunomodulator Drugs 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000003966 growth inhibitor Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66017705P | 2005-03-10 | 2005-03-10 | |
| US60/660,177 | 2005-03-10 | ||
| PCT/US2006/008598 WO2006099141A2 (en) | 2005-03-10 | 2006-03-09 | Anti-mesothelin antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290449A Division JP5378497B2 (ja) | 2005-03-10 | 2011-12-29 | 抗メソテリン抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008532523A JP2008532523A (ja) | 2008-08-21 |
| JP2008532523A5 true JP2008532523A5 (enExample) | 2009-07-30 |
| JP4949373B2 JP4949373B2 (ja) | 2012-06-06 |
Family
ID=36992268
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500966A Expired - Lifetime JP4949373B2 (ja) | 2005-03-10 | 2006-03-09 | 抗メソテリン抗体 |
| JP2011290449A Expired - Lifetime JP5378497B2 (ja) | 2005-03-10 | 2011-12-29 | 抗メソテリン抗体 |
| JP2013168325A Expired - Lifetime JP5788443B2 (ja) | 2005-03-10 | 2013-08-13 | 抗メソテリン抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290449A Expired - Lifetime JP5378497B2 (ja) | 2005-03-10 | 2011-12-29 | 抗メソテリン抗体 |
| JP2013168325A Expired - Lifetime JP5788443B2 (ja) | 2005-03-10 | 2013-08-13 | 抗メソテリン抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7592426B2 (enExample) |
| EP (2) | EP2322560B1 (enExample) |
| JP (3) | JP4949373B2 (enExample) |
| AU (2) | AU2006223301B2 (enExample) |
| CA (1) | CA2600505C (enExample) |
| ES (2) | ES2386367T3 (enExample) |
| WO (1) | WO2006099141A2 (enExample) |
Families Citing this family (86)
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| IL324632A (en) | 2016-12-01 | 2026-01-01 | Regeneron Pharma | Radiolabeled anti-PD-L1 antibodies for immuno-PET imaging |
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| AU2002258518A1 (en) | 2001-03-14 | 2002-09-24 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
| EP1258255A1 (en) | 2001-05-18 | 2002-11-20 | Boehringer Ingelheim International GmbH | Conjugates of an antibody to CD44 and a maytansinoid |
| PL365735A1 (en) | 2001-05-18 | 2005-01-10 | Boehringer Ingelheim International Gmbh | Antibodies specific for cd44v6 |
| US20060127894A1 (en) | 2001-08-08 | 2006-06-15 | Incyte Corporation | Protein associated with cell growth, differentiation, and death |
| JP4527531B2 (ja) | 2002-07-19 | 2010-08-18 | モーフオテク・インコーポレーテツド | 改良された増殖の特徴を伴う高められた抗体産生細胞株の生成方法 |
| WO2005014652A1 (en) * | 2003-08-05 | 2005-02-17 | Morphotek, Inc. | A variant cell surface molecule associated with cancer |
| EP2322560B1 (en) | 2005-03-10 | 2013-09-04 | Morphotek, Inc. | Anti-mesothelin antibodies |
| JP2009521206A (ja) * | 2005-04-22 | 2009-06-04 | モルフォテック、インク． | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
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2006
- 2006-03-09 EP EP10180413.6A patent/EP2322560B1/en not_active Expired - Lifetime
- 2006-03-09 JP JP2008500966A patent/JP4949373B2/ja not_active Expired - Lifetime
- 2006-03-09 CA CA2600505A patent/CA2600505C/en not_active Expired - Lifetime
- 2006-03-09 ES ES06737748T patent/ES2386367T3/es not_active Expired - Lifetime
- 2006-03-09 US US11/373,546 patent/US7592426B2/en active Active
- 2006-03-09 ES ES10180413T patent/ES2429340T3/es not_active Expired - Lifetime
- 2006-03-09 EP EP06737748A patent/EP1861425B1/en not_active Expired - Lifetime
- 2006-03-09 WO PCT/US2006/008598 patent/WO2006099141A2/en not_active Ceased
- 2006-03-09 AU AU2006223301A patent/AU2006223301B2/en not_active Expired
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2009
- 2009-08-21 US US12/545,369 patent/US8206710B2/en active Active
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2011
- 2011-01-24 AU AU2011200251A patent/AU2011200251B2/en not_active Expired
- 2011-12-29 JP JP2011290449A patent/JP5378497B2/ja not_active Expired - Lifetime
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2012
- 2012-05-21 US US13/476,656 patent/US8481703B2/en not_active Expired - Lifetime
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2013
- 2013-03-13 US US13/799,766 patent/US8658173B2/en not_active Expired - Lifetime
- 2013-08-13 JP JP2013168325A patent/JP5788443B2/ja not_active Expired - Lifetime
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2014
- 2014-01-06 US US14/148,011 patent/US9115197B2/en not_active Expired - Lifetime
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