JP2016500655A5 - - Google Patents
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- JP2016500655A5 JP2016500655A5 JP2015534544A JP2015534544A JP2016500655A5 JP 2016500655 A5 JP2016500655 A5 JP 2016500655A5 JP 2015534544 A JP2015534544 A JP 2015534544A JP 2015534544 A JP2015534544 A JP 2015534544A JP 2016500655 A5 JP2016500655 A5 JP 2016500655A5
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- Prior art keywords
- monoclonal antibody
- antibody
- isolated
- cancer
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims description 21
- 229940127121 immunoconjugate Drugs 0.000 claims description 19
- 201000011510 cancer Diseases 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- 108020001507 fusion proteins Proteins 0.000 claims description 13
- 102000037865 fusion proteins Human genes 0.000 claims description 13
- 239000000523 sample Substances 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 10
- 108020004707 nucleic acids Proteins 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 10
- 102000003735 Mesothelin Human genes 0.000 claims description 9
- 108090000015 Mesothelin Proteins 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 125000000539 amino acid group Chemical group 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 206010027476 Metastases Diseases 0.000 claims description 4
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims description 4
- 239000013068 control sample Substances 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 4
- 239000012636 effector Substances 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 230000009401 metastasis Effects 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000003053 toxin Substances 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- 206010004593 Bile duct cancer Diseases 0.000 claims description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 101000576802 Homo sapiens Mesothelin Proteins 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010027406 Mesothelioma Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims description 2
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000007850 fluorescent dye Substances 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 230000012010 growth Effects 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims description 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 8
- 230000004614 tumor growth Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261706396P | 2012-09-27 | 2012-09-27 | |
| US61/706,396 | 2012-09-27 | ||
| PCT/US2013/059883 WO2014052064A1 (en) | 2012-09-27 | 2013-09-16 | Mesothelin antibodies and methods for eliciting potent antitumor activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016500655A JP2016500655A (ja) | 2016-01-14 |
| JP2016500655A5 true JP2016500655A5 (enExample) | 2016-09-15 |
| JP6307085B2 JP6307085B2 (ja) | 2018-04-04 |
Family
ID=49237710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534544A Active JP6307085B2 (ja) | 2012-09-27 | 2013-09-16 | メソテリン抗体および強力な抗腫瘍活性を惹起するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9416190B2 (enExample) |
| EP (1) | EP2900695B1 (enExample) |
| JP (1) | JP6307085B2 (enExample) |
| CN (1) | CN104955845B (enExample) |
| AU (1) | AU2013324049B2 (enExample) |
| CA (1) | CA2885761C (enExample) |
| ES (1) | ES2666131T3 (enExample) |
| WO (1) | WO2014052064A1 (enExample) |
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| WO2014031476A1 (en) | 2012-08-21 | 2014-02-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mesothelin domain-specific monoclonal antibodies and use thereof |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
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-
2013
- 2013-09-16 ES ES13766859.6T patent/ES2666131T3/es active Active
- 2013-09-16 JP JP2015534544A patent/JP6307085B2/ja active Active
- 2013-09-16 CN CN201380060415.1A patent/CN104955845B/zh active Active
- 2013-09-16 CA CA2885761A patent/CA2885761C/en active Active
- 2013-09-16 WO PCT/US2013/059883 patent/WO2014052064A1/en not_active Ceased
- 2013-09-16 EP EP13766859.6A patent/EP2900695B1/en active Active
- 2013-09-16 AU AU2013324049A patent/AU2013324049B2/en active Active
- 2013-09-16 US US14/428,771 patent/US9416190B2/en active Active
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