JP2012505659A5 - - Google Patents
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- JP2012505659A5 JP2012505659A5 JP2011532263A JP2011532263A JP2012505659A5 JP 2012505659 A5 JP2012505659 A5 JP 2012505659A5 JP 2011532263 A JP2011532263 A JP 2011532263A JP 2011532263 A JP2011532263 A JP 2011532263A JP 2012505659 A5 JP2012505659 A5 JP 2012505659A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- isolated
- human monoclonal
- monoclonal antibody
- functional fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims description 53
- 150000001413 amino acids Chemical class 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 23
- 201000011510 cancer Diseases 0.000 claims description 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 239000000523 sample Substances 0.000 claims description 16
- 108020004707 nucleic acids Proteins 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 12
- 150000007523 nucleic acids Chemical class 0.000 claims description 12
- 102100028757 Chondroitin sulfate proteoglycan 4 Human genes 0.000 claims description 9
- 101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 claims description 9
- 229940127121 immunoconjugate Drugs 0.000 claims description 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 239000013068 control sample Substances 0.000 claims description 6
- 238000003745 diagnosis Methods 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 208000032612 Glial tumor Diseases 0.000 claims description 4
- 206010018338 Glioma Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims description 4
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 201000001441 melanoma Diseases 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 230000036039 immunity Effects 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 206010027476 Metastases Diseases 0.000 claims description 2
- 206010036790 Productive cough Diseases 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 2
- 239000007850 fluorescent dye Substances 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000001394 metastastic effect Effects 0.000 claims description 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000003802 sputum Anatomy 0.000 claims description 2
- 208000024794 sputum Diseases 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 239000000816 peptidomimetic Substances 0.000 description 3
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10605508P | 2008-10-16 | 2008-10-16 | |
| US61/106,055 | 2008-10-16 | ||
| PCT/US2009/060903 WO2010045495A2 (en) | 2008-10-16 | 2009-10-15 | Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505659A JP2012505659A (ja) | 2012-03-08 |
| JP2012505659A5 true JP2012505659A5 (enExample) | 2012-11-29 |
| JP5836125B2 JP5836125B2 (ja) | 2015-12-24 |
Family
ID=42107249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532263A Active JP5836125B2 (ja) | 2008-10-16 | 2009-10-15 | 高分子量メラノーマ関連抗原に対する完全ヒト抗体およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8476410B2 (enExample) |
| EP (1) | EP2334701A4 (enExample) |
| JP (1) | JP5836125B2 (enExample) |
| CA (1) | CA2737597C (enExample) |
| WO (1) | WO2010045495A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011009090A1 (en) | 2009-07-16 | 2011-01-20 | Xoma Technology Ltd. | Antibodies to high molecular weight melanoma associated antigen |
| EP2613857B1 (en) * | 2010-07-30 | 2018-05-30 | MedImmune, LLC | Method for purifying immunoconjugates |
| EP2646054A4 (en) * | 2010-12-02 | 2015-03-04 | Univ Pittsburgh | METHOD FOR THE TREATMENT OF A TUMOR WITH THE HELP OF AN ANTIBODY FOR SPECIFIC BINDING TO GRP94 |
| WO2013050725A1 (en) | 2011-10-04 | 2013-04-11 | King's College London | Ige anti -hmw-maa antibody |
| ES2686692T3 (es) | 2013-09-24 | 2018-10-19 | Oncoinvent As | Anticuerpo monoclonal anti CD146 |
| US20160376375A1 (en) | 2013-11-27 | 2016-12-29 | Baylor College Of Medicine | CSGP4 - Specific Chimeric Antigen Receptor for Cancer |
| JP6779873B2 (ja) | 2014-11-12 | 2020-11-04 | メモリアル スローン ケタリング キャンサー センター | 抗コンドロイチン硫酸プロテオグリカン４抗体およびその使用 |
| WO2016164408A1 (en) * | 2015-04-06 | 2016-10-13 | The General Hospital Corporation | Anti-cspg4 reagents and methods of treating cancer |
| GB201517528D0 (en) * | 2015-10-02 | 2015-11-18 | Julius Maximillians Universitãt Würzburg | GDF-15 as a diagnosis marker for melanoma |
| EP4548927A3 (en) | 2017-06-21 | 2025-07-23 | The University of North Carolina at Chapel Hill | Methods and compositions for chimeric antigen receptor targeting cancer cells |
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| US7091323B2 (en) * | 2001-04-24 | 2006-08-15 | Bayer Corporation | Human TIMP-1 antibodies |
| US20080095785A2 (en) | 2001-11-30 | 2008-04-24 | Soldano Ferrone | Monoclonal antibodies to human high molecular weight-melanoma associated antigen |
| ATE500276T1 (de) | 2004-12-30 | 2011-03-15 | Us Gov Health & Human Serv | Humanisierte col-1-antikörper mit substituierten resten am gerüst, und deren anwendung |
| BRPI0608468A2 (pt) | 2005-03-25 | 2010-01-05 | Glycart Biotechnology Ag | moléculas de ligação a antìgeno direcionadas a mcsp e tendo afinidade de ligação a receptor de fc e função efetora aumentadas |
| PT2977456T (pt) | 2006-08-15 | 2018-02-05 | Univ Pennsylvania | Composições compreendendo hmw-maa e seus fragmentos para tratamento do cancro |
| US9672526B2 (en) | 2012-03-13 | 2017-06-06 | American Express Travel Related Services Company, Inc. | Systems and methods for tailoring marketing |
| US10884952B2 (en) | 2016-09-30 | 2021-01-05 | Intel Corporation | Enforcing memory operand types using protection keys |
-
2009
- 2009-10-15 CA CA2737597A patent/CA2737597C/en active Active
- 2009-10-15 EP EP09821279.8A patent/EP2334701A4/en not_active Withdrawn
- 2009-10-15 WO PCT/US2009/060903 patent/WO2010045495A2/en not_active Ceased
- 2009-10-15 JP JP2011532263A patent/JP5836125B2/ja active Active
- 2009-10-15 US US13/123,489 patent/US8476410B2/en not_active Expired - Fee Related
-
2013
- 2013-06-07 US US13/912,429 patent/US9193796B2/en active Active
-
2015
- 2015-10-20 US US14/887,700 patent/US9694061B2/en not_active Expired - Fee Related
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