JP2018516853A5 - - Google Patents
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- JP2018516853A5 JP2018516853A5 JP2017551294A JP2017551294A JP2018516853A5 JP 2018516853 A5 JP2018516853 A5 JP 2018516853A5 JP 2017551294 A JP2017551294 A JP 2017551294A JP 2017551294 A JP2017551294 A JP 2017551294A JP 2018516853 A5 JP2018516853 A5 JP 2018516853A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding fragment
- seq
- antibody
- isolated antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 59
- 239000000427 antigen Substances 0.000 claims 51
- 102000036639 antigens Human genes 0.000 claims 51
- 108091007433 antigens Proteins 0.000 claims 51
- 230000004968 inflammatory condition Effects 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 235000018417 cysteine Nutrition 0.000 claims 7
- 125000000151 cysteine group Chemical class N[C@@H](CS)C(=O)* 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 6
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 102000005622 Receptor for Advanced Glycation End Products Human genes 0.000 claims 3
- 108010045108 Receptor for Advanced Glycation End Products Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000016396 cytokine production Effects 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 1
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 1
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 1
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 1
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 1
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 1
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 1
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 150000005829 chemical entities Chemical class 0.000 claims 1
- 230000009260 cross reactivity Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- -1 cysteine amino acids Chemical class 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562140913P | 2015-03-31 | 2015-03-31 | |
| US62/140,913 | 2015-03-31 | ||
| PCT/EP2016/056973 WO2016156440A1 (en) | 2015-03-31 | 2016-03-30 | A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020178437A Division JP2021038226A (ja) | 2015-03-31 | 2020-10-23 | 新規ｉｌ３３型、変異型のｉｌ３３、抗体、アッセイ及びそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516853A JP2018516853A (ja) | 2018-06-28 |
| JP2018516853A5 true JP2018516853A5 (enExample) | 2019-05-16 |
| JP6862351B2 JP6862351B2 (ja) | 2021-04-21 |
Family
ID=55640748
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551294A Active JP6862351B2 (ja) | 2015-03-31 | 2016-03-30 | 新規ｉｌ３３型、変異型のｉｌ３３、抗体、アッセイ及びそれらの使用方法 |
| JP2020178437A Pending JP2021038226A (ja) | 2015-03-31 | 2020-10-23 | 新規ｉｌ３３型、変異型のｉｌ３３、抗体、アッセイ及びそれらの使用方法 |
| JP2023173336A Pending JP2024001166A (ja) | 2015-03-31 | 2023-10-05 | 新規ｉｌ３３型、変異型のｉｌ３３、抗体、アッセイ及びそれらの使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020178437A Pending JP2021038226A (ja) | 2015-03-31 | 2020-10-23 | 新規ｉｌ３３型、変異型のｉｌ３３、抗体、アッセイ及びそれらの使用方法 |
| JP2023173336A Pending JP2024001166A (ja) | 2015-03-31 | 2023-10-05 | 新規ｉｌ３３型、変異型のｉｌ３３、抗体、アッセイ及びそれらの使用方法 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10668150B2 (enExample) |
| EP (3) | EP3733701A1 (enExample) |
| JP (3) | JP6862351B2 (enExample) |
| KR (1) | KR102261618B1 (enExample) |
| CN (1) | CN108064236B (enExample) |
| AU (3) | AU2016239331C1 (enExample) |
| CA (1) | CA2982400C (enExample) |
| CL (2) | CL2017002433A1 (enExample) |
| CO (1) | CO2017010753A2 (enExample) |
| CY (1) | CY1123925T1 (enExample) |
| DK (1) | DK3277717T3 (enExample) |
| ES (1) | ES2886114T3 (enExample) |
| HR (1) | HRP20210096T1 (enExample) |
| HU (1) | HUE053097T2 (enExample) |
| IL (2) | IL254551A0 (enExample) |
| LT (1) | LT3277717T (enExample) |
| MX (1) | MX387295B (enExample) |
| MY (1) | MY190209A (enExample) |
| NZ (1) | NZ736026A (enExample) |
| PL (1) | PL3277717T3 (enExample) |
| PT (1) | PT3277717T (enExample) |
| RS (1) | RS61438B1 (enExample) |
| RU (1) | RU2736299C2 (enExample) |
| SG (1) | SG11201707593UA (enExample) |
| SI (1) | SI3277717T1 (enExample) |
| SM (1) | SMT202100086T1 (enExample) |
| TW (1) | TWI721973B (enExample) |
| WO (1) | WO2016156440A1 (enExample) |
| ZA (1) | ZA201707355B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016013347B1 (pt) | 2013-12-26 | 2023-12-12 | Mitsubishi Tanabe Pharma Corporation | Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos |
| SG11201703767XA (en) | 2014-11-10 | 2017-06-29 | Genentech Inc | Anti-interleukin-33 antibodies and uses thereof |
| US11708608B2 (en) | 2014-11-10 | 2023-07-25 | Genentech, Inc. | Therapeutic and diagnostic methods for IL-33-mediated disorders |
| DK3277717T3 (da) * | 2015-03-31 | 2021-02-01 | Medimmune Ltd | En hidtil ukendt il33-form, muterede former af il33, antistoffer, assays og fremgangsmåder til anvendelse deraf |
| SG11201808693WA (en) | 2016-04-27 | 2018-11-29 | Pfizer | Anti-il-33 antibodies, compositions, methods and uses thereof |
| JOP20190093A1 (ar) | 2016-10-28 | 2019-04-25 | Lilly Co Eli | أجسام مضادة لـ il-33 واستخداماتها |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| UA126284C2 (uk) * | 2016-12-21 | 2022-09-14 | Сефалон, Інк. | Антитіла, які специфічно зв'язуються з людським il-15, та їхнє застосування |
| CA3059350A1 (en) | 2017-04-13 | 2018-10-18 | Regeneron Pharmaceuticals, Inc. | Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1 |
| WO2018231827A1 (en) | 2017-06-12 | 2018-12-20 | Bluefin Biomedicine, Inc. | Anti-il1rap antibodies and antibody drug conjugates |
| TWI850773B (zh) | 2017-08-31 | 2024-08-01 | 日商田邊三菱製藥股份有限公司 | 可溶性il-33受體的用途 |
| CN107973849B (zh) * | 2017-11-30 | 2020-07-28 | 畜科生物工程有限公司 | 一种用于增强猪疫苗免疫效果的蛋白质及其应用 |
| WO2019183375A1 (en) * | 2018-03-22 | 2019-09-26 | Eureka Therapeutics, Inc. | Antibody agents specifically recognizing monocarboxylate transporter 4 and uses thereof |
| IL307286B1 (en) | 2018-04-11 | 2025-11-01 | Regeneron Pharma | Methods and compositions for quantifying il-33 |
| JP7407723B2 (ja) * | 2018-09-14 | 2024-01-04 | 田辺三菱製薬株式会社 | ヒト抗ｉｌ－３３モノクローナル抗体含有医薬用組成物 |
| CN111434680B (zh) * | 2019-01-15 | 2021-11-23 | 南京赛新生物科技有限公司 | 一种与il33相关疾病的抗原表位肽及其应用 |
| CN111434687B (zh) * | 2019-01-15 | 2022-03-11 | 南京赛新生物科技有限公司 | 一种抗体及其应用 |
| CN112300265B (zh) * | 2019-07-29 | 2022-09-27 | 百奥赛图(北京)医药科技股份有限公司 | Il33基因人源化的非人动物的构建方法和应用 |
| CN110567861B (zh) * | 2019-09-09 | 2021-12-21 | 浙江普罗亭健康科技有限公司 | 基于质谱流式检测技术筛查具有免疫原性抗原肽的试剂盒及检测方法 |
| TW202134261A (zh) * | 2019-11-04 | 2021-09-16 | 英商梅迪繆思有限公司 | 使用il-33拮抗劑之方法 |
| JP2023501316A (ja) * | 2019-11-04 | 2023-01-18 | メドイミューン・リミテッド | 腎機能障害を治療するための抗ｉｌ－３３治療薬 |
| EP4118114A1 (en) | 2020-03-13 | 2023-01-18 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| EP4118236A1 (en) | 2020-03-13 | 2023-01-18 | MedImmune Limited | Therapeutic methods for the treatment of subjects with risk alelles in il33 |
| JP2023521061A (ja) * | 2020-04-06 | 2023-05-23 | メドイミューン・リミテッド | Ｉｌ－３３軸結合アンタゴニストによる急性呼吸窮迫症候群の治療 |
| BR112022022620A2 (pt) * | 2020-05-11 | 2022-12-20 | Medimmune Ltd | Formulações de anticorpos anti-il-33 |
| EP4151654A4 (en) * | 2020-05-12 | 2024-11-27 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | St2 antigen binding protein |
| CN111378037B (zh) * | 2020-06-01 | 2020-09-01 | 南京诺艾新生物技术有限公司 | 一种抗hIL-33人源化单抗及其应用 |
| WO2022175217A1 (en) | 2021-02-18 | 2022-08-25 | F. Hoffmann-La Roche Ag | Method for resolving complex, multistep antibody interactions |
| CN113234157B (zh) * | 2021-07-09 | 2021-09-21 | 上海普铭生物科技有限公司 | 亲和力成熟的人源化抗人il-33单克隆抗体及其应用 |
| ES2991847T3 (es) | 2021-08-27 | 2024-12-05 | Medimmune Ltd | Tratamiento de enfermedad pulmonar obstructiva crónica con un anticuerpo anti-interleucina-33 |
| EP4430072A1 (en) * | 2021-11-10 | 2024-09-18 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| TW202402790A (zh) | 2022-03-25 | 2024-01-16 | 英商梅迪繆思有限公司 | 減少呼吸系統感染之方法 |
| CN119923406A (zh) | 2022-08-19 | 2025-05-02 | 免疫医疗有限公司 | 选择患者以用il-33轴拮抗剂进行治疗的方法 |
| IL319071A (en) | 2022-08-19 | 2025-04-01 | Medimmune Ltd | Treatment of acute respiratory failure |
| CN119894926A (zh) | 2022-08-19 | 2025-04-25 | 免疫医疗有限公司 | 用于检测il-33的测定 |
| TW202423972A (zh) | 2022-08-26 | 2024-06-16 | 英商梅迪繆思有限公司 | 使用抗介白素－３３抗體的氣喘治療 |
| KR20250168673A (ko) | 2023-04-12 | 2025-12-02 | 아스트라제네카 아베 | Steap2-표적화 화합물 및 이의 용도 |
| TW202540170A (zh) * | 2023-11-27 | 2025-10-16 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | 抗原結合蛋白 |
| WO2025120567A1 (en) | 2023-12-07 | 2025-06-12 | Medimmune Limited | Method of treatment of asthma |
| TW202540173A (zh) | 2024-04-04 | 2025-10-16 | 英商梅迪繆思有限公司 | 治療及選擇對象之方法 |
| WO2025242619A1 (en) | 2024-05-20 | 2025-11-27 | Medimmune Limited | Treatment for mucus plugging |
| WO2025242618A1 (en) | 2024-05-20 | 2025-11-27 | Medimmune Limited | Bronchiectasis treatment |
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| DK3277717T3 (da) * | 2015-03-31 | 2021-02-01 | Medimmune Ltd | En hidtil ukendt il33-form, muterede former af il33, antistoffer, assays og fremgangsmåder til anvendelse deraf |
-
2016
- 2016-03-30 DK DK16712353.8T patent/DK3277717T3/da active
- 2016-03-30 EP EP20169253.0A patent/EP3733701A1/en not_active Ceased
- 2016-03-30 NZ NZ736026A patent/NZ736026A/en unknown
- 2016-03-30 CN CN201680019480.3A patent/CN108064236B/zh active Active
- 2016-03-30 HU HUE16712353A patent/HUE053097T2/hu unknown
- 2016-03-30 JP JP2017551294A patent/JP6862351B2/ja active Active
- 2016-03-30 AU AU2016239331A patent/AU2016239331C1/en active Active
- 2016-03-30 PT PT167123538T patent/PT3277717T/pt unknown
- 2016-03-30 KR KR1020177030936A patent/KR102261618B1/ko active Active
- 2016-03-30 ES ES16712353T patent/ES2886114T3/es active Active
- 2016-03-30 EP EP16712353.8A patent/EP3277717B1/en active Active
- 2016-03-30 PL PL16712353T patent/PL3277717T3/pl unknown
- 2016-03-30 SM SM20210086T patent/SMT202100086T1/it unknown
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