JP2016533721A5 - - Google Patents

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Publication number

JP2016533721A5

JP2016533721A5 JP2016521982A JP2016521982A JP2016533721A5 JP 2016533721 A5 JP2016533721 A5 JP 2016533721A5 JP 2016521982 A JP2016521982 A JP 2016521982A JP 2016521982 A JP2016521982 A JP 2016521982A JP 2016533721 A5 JP2016533721 A5 JP 2016533721A5

Authority

JP

Japan

Prior art keywords

seq

antibody

antigen

binding fragment

cdr2

Prior art date

2014-10-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 239000012634 fragment Substances 0.000 claims description 55
• 239000000427 antigen Substances 0.000 claims description 53
• 102000036639 antigens Human genes 0.000 claims description 53
• 108091007433 antigens Proteins 0.000 claims description 53
• 210000004027 cell Anatomy 0.000 claims description 49
• 206010028980 Neoplasm Diseases 0.000 claims description 22
• 238000000034 method Methods 0.000 claims description 21
• 150000001413 amino acids Chemical class 0.000 claims description 20
• 239000000611 antibody drug conjugate Substances 0.000 claims description 19
• 229940049595 antibody-drug conjugate Drugs 0.000 claims description 19
• 108020004707 nucleic acids Proteins 0.000 claims description 17
• 150000007523 nucleic acids Chemical class 0.000 claims description 17
• 102000039446 nucleic acids Human genes 0.000 claims description 17
• 102100031323 Anthrax toxin receptor 1 Human genes 0.000 claims description 15
• 101000796095 Homo sapiens Anthrax toxin receptor 1 Proteins 0.000 claims description 15
• 210000002889 endothelial cell Anatomy 0.000 claims description 13
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
• 239000003550 marker Substances 0.000 claims description 12
• 239000003053 toxin Substances 0.000 claims description 12
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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
• 241000193738 Bacillus anthracis Species 0.000 claims description 7
• 101710194807 Protective antigen Proteins 0.000 claims description 7
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• 239000012636 effector Substances 0.000 claims description 6
• MFRNYXJJRJQHNW-DEMKXPNLSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 claims description 4
• 208000034038 Pathologic Neovascularization Diseases 0.000 claims description 4
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims description 4
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• 108010044540 auristatin Proteins 0.000 claims description 4
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• 108010093470 monomethyl auristatin E Proteins 0.000 claims description 4
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• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 2
• 108091007741 Chimeric antigen receptor T cells Proteins 0.000 claims description 2
• 206010009944 Colon cancer Diseases 0.000 claims description 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
• 108090000790 Enzymes Proteins 0.000 claims description 2
• 102000004190 Enzymes Human genes 0.000 claims description 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
• 206010060862 Prostate cancer Diseases 0.000 claims description 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
• 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
• 239000012472 biological sample Substances 0.000 claims description 2
• 238000001514 detection method Methods 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 201000010536 head and neck cancer Diseases 0.000 claims description 2
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• 229910052717 sulfur Inorganic materials 0.000 claims description 2
• 125000004434 sulfur atom Chemical group 0.000 claims description 2
• 210000004881 tumor cell Anatomy 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 12
• 102000005600 Cathepsins Human genes 0.000 claims 1
• 108010084457 Cathepsins Proteins 0.000 claims 1
• 238000001727 in vivo Methods 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
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