JP2017524343A5 - - Google Patents

Info

Publication number

JP2017524343A5

JP2017524343A5 JP2016570831A JP2016570831A JP2017524343A5 JP 2017524343 A5 JP2017524343 A5 JP 2017524343A5 JP 2016570831 A JP2016570831 A JP 2016570831A JP 2016570831 A JP2016570831 A JP 2016570831A JP 2017524343 A5 JP2017524343 A5 JP 2017524343A5

Authority

JP

Japan

Prior art keywords

seq

residues

antibody

group

functional fragment

Prior art date

2015-06-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000012634 fragment Substances 0.000 claims description 50
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 40
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 24
• 108091033319 polynucleotide Proteins 0.000 claims description 20
• 102000040430 polynucleotide Human genes 0.000 claims description 20
• 239000002157 polynucleotide Substances 0.000 claims description 20
• 206010028980 Neoplasm Diseases 0.000 claims description 14
• 239000008194 pharmaceutical composition Substances 0.000 claims description 10
• 206010006187 Breast cancer Diseases 0.000 claims description 6
• 208000026310 Breast neoplasm Diseases 0.000 claims description 6
• 201000011510 cancer Diseases 0.000 claims description 6
• 239000003814 drug Substances 0.000 claims description 6
• 229940124597 therapeutic agent Drugs 0.000 claims description 6
• 201000010099 disease Diseases 0.000 claims description 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 4
• 239000003795 chemical substances by application Substances 0.000 claims description 4
• 150000007523 nucleic acids Chemical group 0.000 claims description 4
• 206010003571 Astrocytoma Diseases 0.000 claims description 2
• 208000032612 Glial tumor Diseases 0.000 claims description 2
• 206010018338 Glioma Diseases 0.000 claims description 2
• 208000000172 Medulloblastoma Diseases 0.000 claims description 2
• 206010029260 Neuroblastoma Diseases 0.000 claims description 2
• 206010039491 Sarcoma Diseases 0.000 claims description 2
• 206010041067 Small cell lung cancer Diseases 0.000 claims description 2
• 239000002246 antineoplastic agent Substances 0.000 claims description 2
• 230000036952 cancer formation Effects 0.000 claims description 2
• 210000004027 cell Anatomy 0.000 claims description 2
• 229940127089 cytotoxic agent Drugs 0.000 claims description 2
• 238000001514 detection method Methods 0.000 claims description 2
• 239000000032 diagnostic agent Substances 0.000 claims description 2
• 229940039227 diagnostic agent Drugs 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 239000002955 immunomodulating agent Substances 0.000 claims description 2
• 201000001441 melanoma Diseases 0.000 claims description 2
• 201000008968 osteosarcoma Diseases 0.000 claims description 2
• 208000000587 small cell lung carcinoma Diseases 0.000 claims description 2
• 210000000130 stem cell Anatomy 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 1
• 230000005740 tumor formation Effects 0.000 claims 1
• 238000000034 method Methods 0.000 description 7
• 208000005623 Carcinogenesis Diseases 0.000 description 1
• 231100000504 carcinogenesis Toxicity 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1