JP2018513141A5 - - Google Patents
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- Publication number
- JP2018513141A5 JP2018513141A5 JP2017551169A JP2017551169A JP2018513141A5 JP 2018513141 A5 JP2018513141 A5 JP 2018513141A5 JP 2017551169 A JP2017551169 A JP 2017551169A JP 2017551169 A JP2017551169 A JP 2017551169A JP 2018513141 A5 JP2018513141 A5 JP 2018513141A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- cdr
- seq
- residues
- epitope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 21
- 201000011510 cancer Diseases 0.000 claims 21
- 108010056045 K cadherin Proteins 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 18
- 108010018828 cadherin 5 Proteins 0.000 claims 18
- 101710196881 Cadherin-17 Proteins 0.000 claims 17
- 102100024152 Cadherin-17 Human genes 0.000 claims 17
- 101710196906 Cadherin-20 Proteins 0.000 claims 17
- 102100022480 Cadherin-20 Human genes 0.000 claims 17
- 102100029761 Cadherin-5 Human genes 0.000 claims 17
- 102100029756 Cadherin-6 Human genes 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 8
- 239000003550 marker Substances 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 101000762247 Homo sapiens Cadherin-17 Proteins 0.000 claims 6
- 101000899459 Homo sapiens Cadherin-20 Proteins 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 102000051456 human CDH17 Human genes 0.000 claims 6
- 102000043623 human CDH20 Human genes 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 101000794587 Homo sapiens Cadherin-5 Proteins 0.000 claims 5
- 101000794604 Homo sapiens Cadherin-6 Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 208000017897 Carcinoma of esophagus Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 201000005619 esophageal carcinoma Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 4
- 201000002528 pancreatic cancer Diseases 0.000 claims 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 3
- 201000011549 stomach cancer Diseases 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 241000282836 Camelus dromedarius Species 0.000 claims 1
- 108010069514 Cyclic Peptides Proteins 0.000 claims 1
- 102000001189 Cyclic Peptides Human genes 0.000 claims 1
- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 claims 1
- 108010079855 Peptide Aptamers Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000010749 gastric carcinoma Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 108091008104 nucleic acid aptamers Proteins 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 201000000498 stomach carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2015/058527 WO2016169581A1 (en) | 2015-04-20 | 2015-04-20 | Agents binding specifically to human cadherin-17, human cadherin-5, human cadherin-6 and human cadherin-20 rgd motif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018513141A JP2018513141A (ja) | 2018-05-24 |
| JP2018513141A5 true JP2018513141A5 (enExample) | 2018-07-05 |
Family
ID=52875715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551169A Pending JP2018513141A (ja) | 2015-04-20 | 2015-04-20 | ヒトカドヘリン−１７、ヒトカドヘリン−５、ヒトカドヘリン−６およびヒトカドヘリン−２０のｒｇｄモチーフに特異的に結合する薬剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10829560B2 (enExample) |
| EP (1) | EP3286218B1 (enExample) |
| JP (1) | JP2018513141A (enExample) |
| AU (1) | AU2015392603B2 (enExample) |
| ES (1) | ES2939013T3 (enExample) |
| WO (1) | WO2016169581A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2703949C1 (ru) * | 2018-04-27 | 2019-10-22 | Открытое акционерное общество "Всероссийский научный Центр молекулярной диагностики и лечения" (ОАО ВНЦМДЛ) | Вариабельные домены лёгкой и тяжёлой цепи мышиного моноклонального антитела против кадгерина-17 человека, антигенсвязывающий фрагмент (Fab) против кадгерина-17 человека, содержащий указанные домены |
| WO2019222557A1 (en) * | 2018-05-16 | 2019-11-21 | Arbele Limited | Compositions and methods for diagnosis and treatment of cancer |
| CN111349157B (zh) * | 2018-12-21 | 2023-06-23 | 艾比玛特医药科技（上海）有限公司 | 钙粘附蛋白6的单克隆抗体及其应用 |
| JP7249579B2 (ja) * | 2019-02-20 | 2023-03-31 | 日本電信電話株式会社 | 細胞接着基板及びその製造方法 |
| AU2022406708A1 (en) * | 2021-12-10 | 2024-06-27 | Multitude Therapeutics Inc. | Anti-cdh6 antibodies and antibody-drug conjugates thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003038096A1 (fr) | 2001-10-30 | 2003-05-08 | Shunichiro Kubota | Recepteur pour inhibiteur de l'angiogenese et procede de criblage dudit inhibiteur |
| WO2005110039A2 (en) | 2004-05-07 | 2005-11-24 | Applera Corporation | Genetic polymorphisms associated with vascular diseases, methods of detection and uses thereof |
| DE102004023187A1 (de) * | 2004-05-11 | 2005-12-01 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
| MA33276B1 (fr) * | 2009-04-20 | 2012-05-02 | Oxford Biotherapeutics Ltd | Anticorps spécifiques à la cadhérine-17 |
| US8617829B2 (en) | 2009-09-24 | 2013-12-31 | Gene Techno Science Co., Ltd. | Humanized antibodies specific for amino acid sequence RGD of an extracellular matrix protein and the uses thereof |
| KR101398079B1 (ko) | 2011-10-10 | 2014-05-27 | 재단법인 의약바이오컨버젼스연구단 | 글리실-티알엔에이 합성효소 및 캐드헤린을 이용한 암 예방 또는 치료제의 스크리닝 방법 |
| AU2014243704A1 (en) * | 2013-03-13 | 2015-09-10 | Creatics Llc | Methods and compositions for detecting pancreatic cancer |
-
2015
- 2015-04-20 AU AU2015392603A patent/AU2015392603B2/en active Active
- 2015-04-20 WO PCT/EP2015/058527 patent/WO2016169581A1/en not_active Ceased
- 2015-04-20 JP JP2017551169A patent/JP2018513141A/ja active Pending
- 2015-04-20 ES ES15716831T patent/ES2939013T3/es active Active
- 2015-04-20 US US15/565,937 patent/US10829560B2/en active Active
- 2015-04-20 EP EP15716831.1A patent/EP3286218B1/en active Active
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