JP2020522474A5 - - Google Patents
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- JP2020522474A5 JP2020522474A5 JP2019565011A JP2019565011A JP2020522474A5 JP 2020522474 A5 JP2020522474 A5 JP 2020522474A5 JP 2019565011 A JP2019565011 A JP 2019565011A JP 2019565011 A JP2019565011 A JP 2019565011A JP 2020522474 A5 JP2020522474 A5 JP 2020522474A5
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- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- sequence
- variable domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022211728A JP2023030174A (ja) | 2017-05-23 | 2022-12-28 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510168P | 2017-05-23 | 2017-05-23 | |
| US201762510169P | 2017-05-23 | 2017-05-23 | |
| US201762510167P | 2017-05-23 | 2017-05-23 | |
| US201762510137P | 2017-05-23 | 2017-05-23 | |
| US62/510,137 | 2017-05-23 | ||
| US62/510,167 | 2017-05-23 | ||
| US62/510,168 | 2017-05-23 | ||
| US62/510,169 | 2017-05-23 | ||
| US201762539425P | 2017-07-31 | 2017-07-31 | |
| US62/539,425 | 2017-07-31 | ||
| PCT/US2018/034221 WO2018217945A1 (en) | 2017-05-23 | 2018-05-23 | A protein binding nkg2d, cd16 and a tumor-associated antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022211728A Division JP2023030174A (ja) | 2017-05-23 | 2022-12-28 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020522474A JP2020522474A (ja) | 2020-07-30 |
| JP2020522474A5 true JP2020522474A5 (enExample) | 2021-07-26 |
Family
ID=64395873
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565011A Pending JP2020522474A (ja) | 2017-05-23 | 2018-05-23 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
| JP2022211728A Pending JP2023030174A (ja) | 2017-05-23 | 2022-12-28 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022211728A Pending JP2023030174A (ja) | 2017-05-23 | 2022-12-28 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200157226A1 (enExample) |
| EP (1) | EP3630181A4 (enExample) |
| JP (2) | JP2020522474A (enExample) |
| KR (1) | KR20200010429A (enExample) |
| CN (1) | CN111278460A (enExample) |
| AU (1) | AU2018273250A1 (enExample) |
| BR (1) | BR112019024620A2 (enExample) |
| CA (1) | CA3064567A1 (enExample) |
| IL (1) | IL270801A (enExample) |
| MX (1) | MX2019013995A (enExample) |
| WO (1) | WO2018217945A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4491234A3 (en) | 2017-02-08 | 2025-04-09 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| BR112019017197A2 (pt) | 2017-02-20 | 2020-04-14 | Dragonfly Therapeutics, Inc. | proteínas que se ligam a her2, nkg2d e cd16 |
| AU2019218125B2 (en) | 2018-02-08 | 2025-03-13 | Dragonfly Therapeutics, Inc. | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| PE20220278A1 (es) | 2018-02-08 | 2022-02-25 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d |
| TW201942134A (zh) | 2018-02-20 | 2019-11-01 | 美商蜻蜓醫療公司 | 結合cd33、nkg2d及cd16之多特異性結合蛋白及使用方法 |
| KR20250112921A (ko) | 2018-08-08 | 2025-07-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| EA202190468A1 (ru) | 2018-08-08 | 2021-07-06 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| WO2021209049A1 (zh) * | 2020-04-16 | 2021-10-21 | 南通壹宸生物医药科技有限公司 | 一种pd-1突变体多肽及其制备和用途 |
| EP4146271A4 (en) | 2020-05-06 | 2024-09-04 | Dragonfly Therapeutics, Inc. | PROTEINS THAT BIND NKG2D, CD16 AND CLEC12A |
| US12377144B2 (en) | 2021-03-03 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen |
| KR20240087855A (ko) * | 2021-09-29 | 2024-06-19 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 baff-r에 결합하는 단백질 |
| US20230203202A1 (en) * | 2021-12-08 | 2023-06-29 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and 5t4 |
| EP4561703A1 (en) | 2022-07-29 | 2025-06-04 | Alector LLC | Anti-gpnmb antibodies and methods of use thereof |
| CN120641121A (zh) | 2022-11-15 | 2025-09-12 | 卡里科生命科学有限责任公司 | 抗papp-a抗体及其使用方法 |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025166040A1 (en) | 2024-01-31 | 2025-08-07 | Alector Llc | Multi-specific binding proteins that bind to gpnmb and a blood brain barrier target and methods of use thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32808A (es) * | 2009-07-29 | 2011-02-28 | Abbott Lab | Inmunoglobulinas como dominio variable dual y usos de las mismas |
| WO2012061558A2 (en) * | 2010-11-04 | 2012-05-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| ES2668895T3 (es) * | 2011-03-16 | 2018-05-23 | Amgen Inc. | Variantes de Fc |
| HRP20181717T1 (hr) * | 2012-09-27 | 2018-12-28 | Merus N.V. | Bispecifična igg protutijela kao aktivatori t stanice |
| DE102013019352A1 (de) * | 2013-11-13 | 2015-09-17 | Elke Pogge Von Strandmann | Tri-spezifische rekombinante Antikörperderivate zur Behandlung von malignen Erkrankungen durch Aktivierung einer NK-Zell-basierten Immunantwort |
| DK3126384T3 (da) * | 2014-04-01 | 2021-01-18 | Adimab Llc | Multispecifikke antistofanaloger omfattende en fælles letkæde, og fremgangsmåder til deres fremstilling og anvendelse |
| TWI742423B (zh) * | 2014-05-29 | 2021-10-11 | 美商宏觀基因股份有限公司 | 特異性結合多種癌症抗原的三特異性結合分子和其使用方法 |
| WO2016022939A1 (en) * | 2014-08-08 | 2016-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Human monoclonal antibodies specific for 5t4 and methods of their use |
| US10941207B2 (en) * | 2014-12-19 | 2021-03-09 | Chiome Bioscience, Inc | Fusion protein comprising three binding domains to 5T4 and CD3 |
| AR100680A1 (es) * | 2015-01-26 | 2016-10-26 | Macrogenics Inc | Anticuerpos anti-dr5 y moléculas que comprenden dominios de unión de dr5 de los mismos |
| KR102606190B1 (ko) * | 2015-02-20 | 2023-11-23 | 오하이오 스테이트 이노베이션 파운데이션 | Nkg2d 및 종양 연관 항원에 대해 유도된 이가 항체 |
| AU2016284866B2 (en) * | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific antigen binding proteins |
| EP3374389A1 (en) * | 2015-11-13 | 2018-09-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti- nkg2d single domain antibodies and uses thereof |
| WO2018045090A1 (en) * | 2016-09-01 | 2018-03-08 | Immunomab, Inc. | Bispecific antibodies |
| EP4491234A3 (en) * | 2017-02-08 | 2025-04-09 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
-
2018
- 2018-05-23 EP EP18805878.8A patent/EP3630181A4/en not_active Withdrawn
- 2018-05-23 CN CN201880051761.6A patent/CN111278460A/zh active Pending
- 2018-05-23 MX MX2019013995A patent/MX2019013995A/es unknown
- 2018-05-23 WO PCT/US2018/034221 patent/WO2018217945A1/en not_active Ceased
- 2018-05-23 KR KR1020197037753A patent/KR20200010429A/ko not_active Ceased
- 2018-05-23 US US16/615,231 patent/US20200157226A1/en not_active Abandoned
- 2018-05-23 AU AU2018273250A patent/AU2018273250A1/en not_active Abandoned
- 2018-05-23 JP JP2019565011A patent/JP2020522474A/ja active Pending
- 2018-05-23 CA CA3064567A patent/CA3064567A1/en active Pending
- 2018-05-23 BR BR112019024620-7A patent/BR112019024620A2/pt not_active Application Discontinuation
-
2019
- 2019-11-20 IL IL270801A patent/IL270801A/en unknown
-
2022
- 2022-12-28 JP JP2022211728A patent/JP2023030174A/ja active Pending