BR112019024620A2 - Ligante de proteína nkg2d, cd16 e antígeno associado a tumor - Google Patents

Ligante de proteína nkg2d, cd16 e antígeno associado a tumor Download PDF

Info

Publication number
BR112019024620A2
BR112019024620A2 BR112019024620-7A BR112019024620A BR112019024620A2 BR 112019024620 A2 BR112019024620 A2 BR 112019024620A2 BR 112019024620 A BR112019024620 A BR 112019024620A BR 112019024620 A2 BR112019024620 A2 BR 112019024620A2
Authority
BR
Brazil
Prior art keywords
seq
binding site
variable domain
chain variable
antigen
Prior art date
Application number
BR112019024620-7A
Other languages
English (en)
Portuguese (pt)
Inventor
P. Chang Gregory
Gregory P. Chang
F. Cheung Ann
Ann F. Cheung
Haney William
William Haney
M. Lunde Bradley
Bradley M. LUNDE
Prinz Bianka
Bianka Prinz
Original Assignee
Dragonfly Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dragonfly Therapeutics, Inc. filed Critical Dragonfly Therapeutics, Inc.
Publication of BR112019024620A2 publication Critical patent/BR112019024620A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056Lectin superfamily, e.g. CD23, CD72
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/524CH2 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR112019024620-7A 2017-05-23 2018-05-23 Ligante de proteína nkg2d, cd16 e antígeno associado a tumor BR112019024620A2 (pt)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762510168P 2017-05-23 2017-05-23
US201762510167P 2017-05-23 2017-05-23
US201762510169P 2017-05-23 2017-05-23
US201762510137P 2017-05-23 2017-05-23
US62/510,168 2017-05-23
US62/510,169 2017-05-23
US62/510,137 2017-05-23
US62/510,167 2017-05-23
US201762539425P 2017-07-31 2017-07-31
US62/539,425 2017-07-31
PCT/US2018/034221 WO2018217945A1 (en) 2017-05-23 2018-05-23 A protein binding nkg2d, cd16 and a tumor-associated antigen

Publications (1)

Publication Number Publication Date
BR112019024620A2 true BR112019024620A2 (pt) 2020-06-23

Family

ID=64395873

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019024620-7A BR112019024620A2 (pt) 2017-05-23 2018-05-23 Ligante de proteína nkg2d, cd16 e antígeno associado a tumor

Country Status (11)

Country Link
US (1) US20200157226A1 (enExample)
EP (1) EP3630181A4 (enExample)
JP (2) JP2020522474A (enExample)
KR (1) KR20200010429A (enExample)
CN (1) CN111278460A (enExample)
AU (1) AU2018273250A1 (enExample)
BR (1) BR112019024620A2 (enExample)
CA (1) CA3064567A1 (enExample)
IL (1) IL270801A (enExample)
MX (1) MX2019013995A (enExample)
WO (1) WO2018217945A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL268554B2 (en) 2017-02-08 2025-03-01 Dragonfly Therapeutics Inc Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
CA3235295C (en) 2017-02-20 2024-11-19 Dragonfly Therapeutics, Inc. Proteins binding her2, nkg2d and cd16
US12384847B2 (en) 2018-02-08 2025-08-12 Dragonfly Therapeutics, Inc. Cancer therapy involving an anti-PD1 antibody and a multi-specific binding protein that binds NKG2D, CD16, and a tumor-associated antigen
US11884733B2 (en) 2018-02-08 2024-01-30 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the NKG2D receptor
US12215157B2 (en) 2018-02-20 2025-02-04 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind CD33, NKG2D, and CD16, and methods of use
MA53284A (fr) 2018-08-08 2022-01-26 Dragonfly Therapeutics Inc Protéines de liaison à nkg2d, à cd16 et à un antigène associé à une tumeur
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
EP3833392A4 (en) 2018-08-08 2022-05-18 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use
US20230287081A1 (en) * 2020-04-16 2023-09-14 Nantong Yichen Biopharma. Co. Ltd. PD-1 mutant polypeptide and preparation and application thereof
TW202208428A (zh) 2020-05-06 2022-03-01 美商蜻蜓醫療公司 結合nkg2d、cd16及clec12a之蛋白質
EP4301774A4 (en) 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
CA3233377A1 (en) * 2021-09-29 2023-04-06 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and baff-r
US20230203202A1 (en) * 2021-12-08 2023-06-29 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and 5t4
WO2024026447A1 (en) 2022-07-29 2024-02-01 Alector Llc Anti-gpnmb antibodies and methods of use thereof
AU2023382738A1 (en) 2022-11-15 2025-05-29 Abbvie Inc. Anti-papp-a antibodies and methods of use thereof
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025166040A1 (en) 2024-01-31 2025-08-07 Alector Llc Multi-specific binding proteins that bind to gpnmb and a blood brain barrier target and methods of use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32808A (es) * 2009-07-29 2011-02-28 Abbott Lab Inmunoglobulinas como dominio variable dual y usos de las mismas
UY33707A (es) * 2010-11-04 2012-05-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
JP5972915B2 (ja) * 2011-03-16 2016-08-17 アムジエン・インコーポレーテツド Fc変異体
PT2900694T (pt) * 2012-09-27 2018-11-13 Merus Nv Anticorpos de igg biespecíficos como ativadores de células t
DE102013019352A1 (de) * 2013-11-13 2015-09-17 Elke Pogge Von Strandmann Tri-spezifische rekombinante Antikörperderivate zur Behandlung von malignen Erkrankungen durch Aktivierung einer NK-Zell-basierten Immunantwort
EP3126384B1 (en) * 2014-04-01 2020-12-02 Adimab, LLC Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use
TN2016000525A1 (en) * 2014-05-29 2018-04-04 Macrogenics Inc Tri-specific binding molecules and methods of use thereof
WO2016022939A1 (en) * 2014-08-08 2016-02-11 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Human monoclonal antibodies specific for 5t4 and methods of their use
US10941207B2 (en) * 2014-12-19 2021-03-09 Chiome Bioscience, Inc Fusion protein comprising three binding domains to 5T4 and CD3
TW201627322A (zh) * 2015-01-26 2016-08-01 宏觀基因股份有限公司 抗-dr5抗體和包括其dr5-結合結構域的分子
US10973914B2 (en) * 2015-02-20 2021-04-13 Ohio State Innovation Foundation Bivalent antibody directed against NKG2D and tumor associated antigens
WO2016207273A2 (en) * 2015-06-23 2016-12-29 Innate Pharma Multispecific antigen binding proteins
EP3374389A1 (en) * 2015-11-13 2018-09-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti- nkg2d single domain antibodies and uses thereof
US20200048347A1 (en) * 2016-09-01 2020-02-13 Immunomab, Inc. Bispecific antibodies
IL268554B2 (en) * 2017-02-08 2025-03-01 Dragonfly Therapeutics Inc Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer

Also Published As

Publication number Publication date
IL270801A (en) 2020-01-30
JP2020522474A (ja) 2020-07-30
CN111278460A (zh) 2020-06-12
EP3630181A4 (en) 2021-03-17
US20200157226A1 (en) 2020-05-21
RU2019142714A3 (enExample) 2021-10-22
JP2023030174A (ja) 2023-03-07
AU2018273250A1 (en) 2019-12-12
WO2018217945A1 (en) 2018-11-29
EP3630181A1 (en) 2020-04-08
CA3064567A1 (en) 2018-11-29
RU2019142714A (ru) 2021-06-23
KR20200010429A (ko) 2020-01-30
MX2019013995A (es) 2020-07-29

Similar Documents

Publication Publication Date Title
AU2018329937B2 (en) Proteins binding nkg2d, cd16 and nectin4
BR112019024620A2 (pt) Ligante de proteína nkg2d, cd16 e antígeno associado a tumor
AU2018220734B2 (en) Proteins binding CD33, NKG2D and CD16
BR112020005078A2 (pt) proteínas de ligação a nkg2d, cd16, e molécula 1 semelhante a lecitina de tipo c (cll-1)
BR112020003050A2 (pt) proteínas de ligação a nkg2d, cd16, e egfr, hla-e, ccr4 ou pd-l1
BR112021002278A2 (pt) proteínas que ligam nkg2d, cd16 e um antígeno associado a tumor
US20200157174A1 (en) Proteins binding nkg2d, cd16 and ror1 or ror2
BR112019017758A2 (pt) proteínas multispecíficas de ligação ao alvo caixa, ano1, mesotelina, trop2, cea ou claudin-18.2
BR112019016424A2 (pt) proteínas de ligação a bcma, nkg2d e cd16
BR112019017197A2 (pt) proteínas que se ligam a her2, nkg2d e cd16
BR112020001972A2 (pt) proteínas de ligação a nkg2d, cd16 e flt3
BR112021002213A2 (pt) proteínas de ligação multi-específicas que se ligam her2, nkg2d e cd16 e métodos de uso
BR112020023299A2 (pt) proteína de ligação nkg2d, cd16 e uma proteína de ativação de fibroblastos
BR112020003654A2 (pt) proteínas de ligação ao nkg2d, cd16 e a um antígeno associado a tumor
BR112019016553A2 (pt) Proteínas que se ligam ao psma, nkg2d e cd16
BR112021002276A2 (pt) proteínas de ligação a nkg2d, cd16 e um antígeno associado ao tumor
BR112019017256A2 (pt) proteínas de ligação gd2, nkg2d e cd16
BR112019017237A2 (pt) proteínas que se ligam a cd123, nkg2d e cd16
RU2816716C2 (ru) Белки, связывающие NKG2D, CD16 и опухолеассоциированный антиген
RU2788531C2 (ru) Белок, связывающийся с nkg2d, cd16 и с опухолеспецифическим антигеном
BR112020016190B1 (pt) Sítio de ligação ao antígeno que se liga a nkg2d, proteína, formulação compreendendo a mesma e seus usos
BR112020016190A2 (pt) Domínios variáveis de anticorpos direcionando o receptor nkg2d
BR112019016315A2 (pt) Proteínas de ligação multiespecíficas para ativação de células natural killer e usos terapêuticos destas para tratamento de câncer

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements