JP2020522473A5 - - Google Patents
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- JP2020522473A5 JP2020522473A5 JP2019564917A JP2019564917A JP2020522473A5 JP 2020522473 A5 JP2020522473 A5 JP 2020522473A5 JP 2019564917 A JP2019564917 A JP 2019564917A JP 2019564917 A JP2019564917 A JP 2019564917A JP 2020522473 A5 JP2020522473 A5 JP 2020522473A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 213
- 239000000427 antigen Substances 0.000 claims description 143
- 102000036639 antigens Human genes 0.000 claims description 143
- 108091007433 antigens Proteins 0.000 claims description 143
- 230000027455 binding Effects 0.000 claims description 143
- 102000004169 proteins and genes Human genes 0.000 claims description 108
- 108090000623 proteins and genes Proteins 0.000 claims description 108
- 206010028980 Neoplasm Diseases 0.000 claims description 39
- 201000011510 cancer Diseases 0.000 claims description 25
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 18
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 15
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 15
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 15
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 12
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 12
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 12
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 12
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 12
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims description 11
- 102100040120 Prominin-1 Human genes 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 10
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 10
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims description 10
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims description 10
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 9
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 9
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 9
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 9
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 9
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 9
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 9
- 201000003444 follicular lymphoma Diseases 0.000 claims description 9
- 201000009277 hairy cell leukemia Diseases 0.000 claims description 9
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims description 8
- 108010065524 CD52 Antigen Proteins 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 230000036210 malignancy Effects 0.000 claims description 7
- 208000017604 Hodgkin disease Diseases 0.000 claims description 6
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims description 6
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 6
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 6
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims description 6
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims description 6
- 208000027190 Peripheral T-cell lymphomas Diseases 0.000 claims description 6
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 6
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims description 6
- 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 claims description 6
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims description 6
- 208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 claims description 6
- 201000005962 mycosis fungoides Diseases 0.000 claims description 6
- 229920001184 polypeptide Polymers 0.000 claims description 6
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 claims description 5
- 206010001413 Adult T-cell lymphoma/leukaemia Diseases 0.000 claims description 5
- 201000009030 Carcinoma Diseases 0.000 claims description 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 4
- 201000006845 reticulosarcoma Diseases 0.000 claims description 4
- 208000029922 reticulum cell sarcoma Diseases 0.000 claims description 4
- 210000004881 tumor cell Anatomy 0.000 claims description 4
- 208000003200 Adenoma Diseases 0.000 claims description 3
- 206010001233 Adenoma benign Diseases 0.000 claims description 3
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 208000032612 Glial tumor Diseases 0.000 claims description 3
- 206010018338 Glioma Diseases 0.000 claims description 3
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 208000034578 Multiple myelomas Diseases 0.000 claims description 3
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
- 201000000331 Testicular germ cell cancer Diseases 0.000 claims description 3
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 3
- 208000029742 colonic neoplasm Diseases 0.000 claims description 3
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 3
- 230000001605 fetal effect Effects 0.000 claims description 3
- 208000005017 glioblastoma Diseases 0.000 claims description 3
- 208000032839 leukemia Diseases 0.000 claims description 3
- 201000007270 liver cancer Diseases 0.000 claims description 3
- 208000014018 liver neoplasm Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 208000020816 lung neoplasm Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 230000009826 neoplastic cell growth Effects 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 210000000115 thoracic cavity Anatomy 0.000 claims description 3
- 206010046766 uterine cancer Diseases 0.000 claims description 3
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 230000030833 cell death Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 210000000822 natural killer cell Anatomy 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 239000001608 potassium adipate Substances 0.000 claims description 2
- 239000001601 sodium adipate Substances 0.000 claims description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 81
- 239000000203 mixture Substances 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 description 7
- 108091008324 binding proteins Proteins 0.000 description 7
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- 208000033766 Prolymphocytic Leukemia Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 102000044042 human KLRK1 Human genes 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000026037 malignant tumor of neck Diseases 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023172090A JP2024012297A (ja) | 2017-05-23 | 2023-10-03 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510173P | 2017-05-23 | 2017-05-23 | |
| US62/510,173 | 2017-05-23 | ||
| US201762539419P | 2017-07-31 | 2017-07-31 | |
| US201762539396P | 2017-07-31 | 2017-07-31 | |
| US201762539416P | 2017-07-31 | 2017-07-31 | |
| US62/539,419 | 2017-07-31 | ||
| US62/539,396 | 2017-07-31 | ||
| US62/539,416 | 2017-07-31 | ||
| US201762546296P | 2017-08-16 | 2017-08-16 | |
| US201762546292P | 2017-08-16 | 2017-08-16 | |
| US62/546,296 | 2017-08-16 | ||
| US62/546,292 | 2017-08-16 | ||
| US201762552146P | 2017-08-30 | 2017-08-30 | |
| US62/552,146 | 2017-08-30 | ||
| PCT/US2018/034223 WO2018217947A1 (en) | 2017-05-23 | 2018-05-23 | A protein binding nkg2d, cd16 and a tumor-associated antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023172090A Division JP2024012297A (ja) | 2017-05-23 | 2023-10-03 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020522473A JP2020522473A (ja) | 2020-07-30 |
| JP2020522473A5 true JP2020522473A5 (enExample) | 2021-07-26 |
Family
ID=64395887
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564917A Withdrawn JP2020522473A (ja) | 2017-05-23 | 2018-05-23 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
| JP2023172090A Pending JP2024012297A (ja) | 2017-05-23 | 2023-10-03 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023172090A Pending JP2024012297A (ja) | 2017-05-23 | 2023-10-03 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200157227A1 (enExample) |
| EP (1) | EP3630169A4 (enExample) |
| JP (2) | JP2020522473A (enExample) |
| KR (1) | KR20200010430A (enExample) |
| CN (1) | CN111278455A (enExample) |
| AU (1) | AU2018271930B2 (enExample) |
| BR (1) | BR112019024632A2 (enExample) |
| CA (1) | CA3064714A1 (enExample) |
| IL (1) | IL270803A (enExample) |
| MX (1) | MX2019014000A (enExample) |
| WO (1) | WO2018217947A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020506971A (ja) | 2017-02-08 | 2020-03-05 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ナチュラルキラー細胞の活性化のための多重特異性結合タンパク質およびがんを処置するためのその治療的使用 |
| SG11201907646YA (en) | 2017-02-20 | 2019-09-27 | Dragonfly Therapeutics Inc | Proteins binding her2, nkg2d and cd16 |
| FI3749346T3 (fi) | 2018-02-08 | 2024-09-04 | Dragonfly Therapeutics Inc | Nkg2d-reseptoriin kohdistuvat vasta-aineen vaihtelevan domeenin yhdistelmät |
| PE20210375A1 (es) | 2018-02-08 | 2021-03-02 | Dragonfly Therapeutics Inc | Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales |
| MX2020008684A (es) | 2018-02-20 | 2020-12-07 | Dragonfly Therapeutics Inc | Proteinas de union multiespecificas que se unen a cd33, nkg2d y cd16 y metodos de uso. |
| US12384851B2 (en) | 2018-08-08 | 2025-08-12 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use |
| JP7482363B2 (ja) | 2018-08-08 | 2024-05-14 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６及び腫瘍関連抗原に結合するタンパク質 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| EP4025250A4 (en) * | 2019-10-12 | 2024-01-17 | Bio-Thera Solutions, Ltd. | FORMULATION OF ANTI-CD20 ANTIBODIES AND USE OF ANTI-CD20 ANTIBODIES FOR THE TREATMENT OF CD20-POSITIVE DISEASES |
| TW202208428A (zh) | 2020-05-06 | 2022-03-01 | 美商蜻蜓醫療公司 | 結合ｎｋｇ２ｄ、ｃｄ１６及ｃｌｅｃ１２ａ之蛋白質 |
| CN114057875B (zh) * | 2020-07-31 | 2023-05-05 | 北京市神经外科研究所 | 抗cd133的单链抗体及其在制备治疗肿瘤的药物中的用途 |
| JP2023545099A (ja) * | 2020-10-08 | 2023-10-26 | アフィメド ゲーエムベーハー | 三重特異性バインダー |
| PL244438B1 (pl) * | 2020-12-28 | 2024-01-29 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Peptyd do stosowania w leczeniu lub zapobieganiu COVID-19 |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
| WO2023274183A1 (zh) * | 2021-06-29 | 2023-01-05 | 江苏先声药业有限公司 | Cd16抗体及其应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1423700A (zh) * | 2000-03-24 | 2003-06-11 | 麦克美特股份公司 | 含有针对nkg2d受体复合物的表位的结合位点的多功能多肽 |
| DE10261223A1 (de) * | 2002-12-20 | 2004-07-08 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Steigerung der Immunantwort durch Substanzen, welche die Funktion von Natürlichen Killerzellen beeinflussen |
| DOP2006000029A (es) * | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
| PL2222706T5 (pl) * | 2007-12-14 | 2017-09-29 | Novo Nordisk As | Przeciwciała przeciwko ludzkiemu NKG2D i ich zastosowania |
| TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| US9527926B2 (en) * | 2010-05-14 | 2016-12-27 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
| EP2603526A1 (en) * | 2010-08-13 | 2013-06-19 | Medimmune Limited | Monomeric polypeptides comprising variant fc regions and methods of use |
| AR083705A1 (es) * | 2010-11-04 | 2013-03-13 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| RS59589B1 (sr) * | 2010-11-05 | 2019-12-31 | Zymeworks Inc | Dizajniranje stabilnog heterodimernog antitela sa mutacijama u fc domenu |
| WO2013063702A1 (en) * | 2011-11-04 | 2013-05-10 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the fc domain |
| BR112014015018A2 (pt) * | 2011-12-19 | 2020-10-27 | Synimmune Gmbh | moléculas de anticorpo biespecífico e seu método de produção, bem como composição farmacêutica e molécula de ácido nucleico |
| AU2013289883B2 (en) * | 2012-07-13 | 2018-11-01 | Zymeworks Bc Inc. | Bispecific asymmetric heterodimers comprising anti-CD3 constructs |
| LT2900694T (lt) * | 2012-09-27 | 2018-11-12 | Merus N.V. | Bispecifiniai igg antikūnai kaip t ląstelių aktyvatoriai |
| PL2968520T3 (pl) * | 2013-03-14 | 2022-01-03 | Macrogenics, Inc. | Dwuspecyficzne cząsteczki, które są immunoreaktywne wobec immunologicznych komórek efektorowych wykazujących ekspresję receptora aktywującego |
| RU2727836C2 (ru) * | 2013-07-25 | 2020-07-24 | Сайтомкс Терапьютикс, Инк. | Мультспецифические антитела, мультспецифические активируемые антитела и способы их применения |
| BR112016016114A2 (pt) * | 2014-01-15 | 2018-05-22 | Zymeworks Inc | Construtos de ligação a antígeno cd19 e cd3 bi- específico. |
| EP3126384B1 (en) * | 2014-04-01 | 2020-12-02 | Adimab, LLC | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
| EP3152235B1 (en) * | 2014-05-29 | 2021-08-25 | MacroGenics, Inc. | Tri-specific binding molecules and methods of use thereof |
| WO2015197598A2 (en) * | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
| AR100680A1 (es) * | 2015-01-26 | 2016-10-26 | Macrogenics Inc | Anticuerpos anti-dr5 y moléculas que comprenden dominios de unión de dr5 de los mismos |
| RU2733496C2 (ru) * | 2015-03-16 | 2020-10-02 | Гельмгольц Центрум Мюнхен - Дойчес Форшунгсцентрум Фюр Гезундхайт Унд Умвельт (Гмбх) | Триспецифические связывающие молекулы для лечения вирусной инфекции гепатита в и связанных состояний |
| AU2016284866B2 (en) * | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific antigen binding proteins |
| WO2017008169A1 (en) * | 2015-07-15 | 2017-01-19 | Zymeworks Inc. | Drug-conjugated bi-specific antigen-binding constructs |
| US20180327499A1 (en) * | 2015-11-13 | 2018-11-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti- nkg2d single domain antibodies and uses thereof |
| JP2020506971A (ja) * | 2017-02-08 | 2020-03-05 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ナチュラルキラー細胞の活性化のための多重特異性結合タンパク質およびがんを処置するためのその治療的使用 |
-
2018
- 2018-05-23 CN CN201880051763.5A patent/CN111278455A/zh active Pending
- 2018-05-23 US US16/615,261 patent/US20200157227A1/en active Pending
- 2018-05-23 KR KR1020197037754A patent/KR20200010430A/ko not_active Ceased
- 2018-05-23 BR BR112019024632-0A patent/BR112019024632A2/pt unknown
- 2018-05-23 MX MX2019014000A patent/MX2019014000A/es unknown
- 2018-05-23 EP EP18806934.8A patent/EP3630169A4/en active Pending
- 2018-05-23 AU AU2018271930A patent/AU2018271930B2/en active Active
- 2018-05-23 WO PCT/US2018/034223 patent/WO2018217947A1/en not_active Ceased
- 2018-05-23 JP JP2019564917A patent/JP2020522473A/ja not_active Withdrawn
- 2018-05-23 CA CA3064714A patent/CA3064714A1/en active Pending
-
2019
- 2019-11-20 IL IL270803A patent/IL270803A/en unknown
-
2023
- 2023-10-03 JP JP2023172090A patent/JP2024012297A/ja active Pending
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