JP2020522473A5 - - Google Patents
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- JP2020522473A5 JP2020522473A5 JP2019564917A JP2019564917A JP2020522473A5 JP 2020522473 A5 JP2020522473 A5 JP 2020522473A5 JP 2019564917 A JP2019564917 A JP 2019564917A JP 2019564917 A JP2019564917 A JP 2019564917A JP 2020522473 A5 JP2020522473 A5 JP 2020522473A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- variable domain
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023172090A JP2024012297A (ja) | 2017-05-23 | 2023-10-03 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510173P | 2017-05-23 | 2017-05-23 | |
| US62/510,173 | 2017-05-23 | ||
| US201762539416P | 2017-07-31 | 2017-07-31 | |
| US201762539396P | 2017-07-31 | 2017-07-31 | |
| US201762539419P | 2017-07-31 | 2017-07-31 | |
| US62/539,416 | 2017-07-31 | ||
| US62/539,419 | 2017-07-31 | ||
| US62/539,396 | 2017-07-31 | ||
| US201762546296P | 2017-08-16 | 2017-08-16 | |
| US201762546292P | 2017-08-16 | 2017-08-16 | |
| US62/546,292 | 2017-08-16 | ||
| US62/546,296 | 2017-08-16 | ||
| US201762552146P | 2017-08-30 | 2017-08-30 | |
| US62/552,146 | 2017-08-30 | ||
| PCT/US2018/034223 WO2018217947A1 (en) | 2017-05-23 | 2018-05-23 | A protein binding nkg2d, cd16 and a tumor-associated antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023172090A Division JP2024012297A (ja) | 2017-05-23 | 2023-10-03 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020522473A JP2020522473A (ja) | 2020-07-30 |
| JP2020522473A5 true JP2020522473A5 (enExample) | 2021-07-26 |
Family
ID=64395887
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564917A Withdrawn JP2020522473A (ja) | 2017-05-23 | 2018-05-23 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
| JP2023172090A Pending JP2024012297A (ja) | 2017-05-23 | 2023-10-03 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023172090A Pending JP2024012297A (ja) | 2017-05-23 | 2023-10-03 | Ｎｋｇ２ｄ、ｃｄ１６、および腫瘍関連抗原に結合するタンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200157227A1 (enExample) |
| EP (1) | EP3630169A4 (enExample) |
| JP (2) | JP2020522473A (enExample) |
| KR (1) | KR20200010430A (enExample) |
| CN (1) | CN111278455A (enExample) |
| AU (1) | AU2018271930B2 (enExample) |
| BR (1) | BR112019024632A2 (enExample) |
| CA (1) | CA3064714A1 (enExample) |
| IL (1) | IL270803B1 (enExample) |
| MX (1) | MX2019014000A (enExample) |
| WO (1) | WO2018217947A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3579848T3 (da) | 2017-02-08 | 2025-01-20 | Dragonfly Therapeutics Inc | Multispecifikke bindende proteiner til aktivering af naturlige dræberceller og terapeutiske anvendelser heraf til behandling af kræft |
| KR20240060739A (ko) | 2017-02-20 | 2024-05-08 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
| SG11202007482WA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Antibody variable domains targeting the nkg2d receptor |
| SG11202007579TA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| JP7353576B2 (ja) | 2018-02-20 | 2023-10-02 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| EP3833385A4 (en) | 2018-08-08 | 2021-12-22 | Dragonfly Therapeutics, Inc. | PROTEINS THAT BINDING NKG2D, CD16 AND A TUMOR-ASSOCIATED ANTIGEN |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE |
| WO2021068971A1 (en) * | 2019-10-12 | 2021-04-15 | Bio-Thera Solutions, Ltd. | Anti-cd20 antibody formulation and use of anti-cd20 antibody for treatment of cd20 positive diseases |
| CN115836088A (zh) | 2020-05-06 | 2023-03-21 | 蜻蜓疗法股份有限公司 | 结合nkg2d、cd16和clec12a的蛋白质 |
| CN114057875B (zh) * | 2020-07-31 | 2023-05-05 | 北京市神经外科研究所 | 抗cd133的单链抗体及其在制备治疗肿瘤的药物中的用途 |
| CN116368154A (zh) * | 2020-10-08 | 2023-06-30 | 阿菲姆德股份有限公司 | 三特异性结合剂 |
| PL244438B1 (pl) * | 2020-12-28 | 2024-01-29 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Peptyd do stosowania w leczeniu lub zapobieganiu COVID-19 |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| US20240343811A1 (en) * | 2021-06-29 | 2024-10-17 | Shandong Simcere Biopharmacutical Co., Ltd. | Cd16 antibody and use thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001071005A2 (en) * | 2000-03-24 | 2001-09-27 | Micromet Ag | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
| DE10261223A1 (de) * | 2002-12-20 | 2004-07-08 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Steigerung der Immunantwort durch Substanzen, welche die Funktion von Natürlichen Killerzellen beeinflussen |
| DOP2006000029A (es) * | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
| DK2222706T4 (en) * | 2007-12-14 | 2016-11-21 | Novo Nordisk As | Antibodies that bind to NKG2D and its use |
| TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| EP2569337A1 (en) * | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
| EP2603526A1 (en) * | 2010-08-13 | 2013-06-19 | Medimmune Limited | Monomeric polypeptides comprising variant fc regions and methods of use |
| US20120263722A1 (en) * | 2010-11-04 | 2012-10-18 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| PL2635607T3 (pl) * | 2010-11-05 | 2020-05-18 | Zymeworks Inc. | Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC |
| PL2773671T3 (pl) * | 2011-11-04 | 2022-01-24 | Zymeworks Inc. | Projekt stabilnego przeciwciała heterodimerycznego z mutacjami w domenie fc |
| JP6441079B2 (ja) * | 2011-12-19 | 2018-12-19 | シンイミューン ゲーエムベーハー | 二重特異性抗体分子 |
| US20140154253A1 (en) * | 2012-07-13 | 2014-06-05 | Zymeworks Inc. | Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs |
| PL2900694T3 (pl) * | 2012-09-27 | 2018-12-31 | Merus N.V. | Dwuswoiste przeciwciała igg jako aktywatory komórek t |
| CN111925437A (zh) * | 2013-03-14 | 2020-11-13 | 宏观基因有限公司 | 与表达激活受体的免疫效应细胞具有免疫反应性的双特异性分子 |
| JP6693872B2 (ja) * | 2013-07-25 | 2020-05-13 | シトムクス セラピューティクス，インコーポレイティド | 多重特異性抗体、多重特異性活性化可能抗体、及びそれらの使用方法 |
| US20160326249A1 (en) * | 2014-01-15 | 2016-11-10 | Zymeworks Inc. | Bi-specific cd3 and cd19 antigen-binding constructs |
| DK3126384T3 (da) * | 2014-04-01 | 2021-01-18 | Adimab Llc | Multispecifikke antistofanaloger omfattende en fælles letkæde, og fremgangsmåder til deres fremstilling og anvendelse |
| SG10201913680PA (en) * | 2014-05-29 | 2020-03-30 | Macrogenics Inc | Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof |
| DK3160994T3 (da) * | 2014-06-27 | 2025-05-05 | Innate Pharma | Multispecifikke antigenbindende proteiner |
| AR100680A1 (es) * | 2015-01-26 | 2016-10-26 | Macrogenics Inc | Anticuerpos anti-dr5 y moléculas que comprenden dominios de unión de dr5 de los mismos |
| WO2016146702A1 (en) * | 2015-03-16 | 2016-09-22 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Trispecific binding molecules for treating hbv infection and associated conditions |
| EP3313876B1 (en) * | 2015-06-23 | 2025-01-22 | Innate Pharma | Multispecific antigen binding proteins |
| CA2991799A1 (en) * | 2015-07-15 | 2017-01-19 | Zymeworks Inc. | Drug-conjugated bi-specific antigen-binding constructs |
| EP3374389A1 (en) * | 2015-11-13 | 2018-09-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti- nkg2d single domain antibodies and uses thereof |
| DK3579848T3 (da) * | 2017-02-08 | 2025-01-20 | Dragonfly Therapeutics Inc | Multispecifikke bindende proteiner til aktivering af naturlige dræberceller og terapeutiske anvendelser heraf til behandling af kræft |
-
2018
- 2018-05-23 WO PCT/US2018/034223 patent/WO2018217947A1/en not_active Ceased
- 2018-05-23 US US16/615,261 patent/US20200157227A1/en active Pending
- 2018-05-23 CN CN201880051763.5A patent/CN111278455A/zh active Pending
- 2018-05-23 BR BR112019024632-0A patent/BR112019024632A2/pt unknown
- 2018-05-23 JP JP2019564917A patent/JP2020522473A/ja not_active Withdrawn
- 2018-05-23 MX MX2019014000A patent/MX2019014000A/es unknown
- 2018-05-23 AU AU2018271930A patent/AU2018271930B2/en active Active
- 2018-05-23 IL IL270803A patent/IL270803B1/en unknown
- 2018-05-23 KR KR1020197037754A patent/KR20200010430A/ko not_active Ceased
- 2018-05-23 CA CA3064714A patent/CA3064714A1/en active Pending
- 2018-05-23 EP EP18806934.8A patent/EP3630169A4/en active Pending
-
2023
- 2023-10-03 JP JP2023172090A patent/JP2024012297A/ja active Pending
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