CN115461373A - 密蛋白18.2的抗体及其用途 - Google Patents

密蛋白18.2的抗体及其用途 Download PDF

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CN115461373A
CN115461373A CN202180013588.2A CN202180013588A CN115461373A CN 115461373 A CN115461373 A CN 115461373A CN 202180013588 A CN202180013588 A CN 202180013588A CN 115461373 A CN115461373 A CN 115461373A
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antibody
seq
chain variable
variable region
light chain
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CN115461373B (zh
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周清
许传营
粘伟红
何向宇
郑欣桐
张新敏
何峰
肖婧
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Shanghai Shijian Biotechnology Co ltd
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/16Animal cells
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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Abstract

本发明涉及一种密蛋白18.2(CLDN18.2)的抗体,及其在治疗癌症,例如胃癌、胰腺癌、食管癌中的用途。

Description

PCT国内申请,说明书已公开。

Claims (27)

  1. PCT国内申请,权利要求书已公开。
CN202180013588.2A 2020-02-10 2021-02-10 密蛋白18.2的抗体及其用途 Active CN115461373B (zh)

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CN2020100865168 2020-02-10
CN202010086516 2020-02-10
PCT/CN2021/076482 WO2021160155A1 (zh) 2020-02-10 2021-02-10 密蛋白18.2的抗体及其用途

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CN115461373A true CN115461373A (zh) 2022-12-09
CN115461373B CN115461373B (zh) 2024-03-29

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EP (1) EP4105238A4 (zh)
JP (1) JP2023513401A (zh)
KR (1) KR20220140786A (zh)
CN (1) CN115461373B (zh)
AU (1) AU2021218927A1 (zh)
CA (1) CA3167349A1 (zh)
WO (1) WO2021160155A1 (zh)

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WO2023045997A1 (zh) * 2021-09-24 2023-03-30 盛禾(中国)生物制药有限公司 一种抗Claudin18.2抗体及其应用

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WO2019173420A1 (en) * 2018-03-08 2019-09-12 Phanes Therapeutics, Inc. Anti-claudin 18.2 antibodies and uses thereof
WO2019219089A1 (en) * 2018-05-18 2019-11-21 Bridge Health Bio-Tech Co., Ltd Anti-claudin 18.2 antibodies and uses thereof

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AU2021218927A1 (en) 2022-09-22
US20230096452A1 (en) 2023-03-30
CA3167349A1 (en) 2021-08-19
EP4105238A4 (en) 2024-03-27
WO2021160155A1 (zh) 2021-08-19
EP4105238A1 (en) 2022-12-21
JP2023513401A (ja) 2023-03-30
CN115461373B (zh) 2024-03-29
KR20220140786A (ko) 2022-10-18

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