|
US4036945A
(en)
|
1976-05-03 |
1977-07-19 |
The Massachusetts General Hospital |
Composition and method for determining the size and location of myocardial infarcts
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4331647A
(en)
|
1980-03-03 |
1982-05-25 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US4957735A
(en)
|
1984-06-12 |
1990-09-18 |
The University Of Tennessee Research Corporation |
Target-sensitive immunoliposomes- preparation and characterization
|
|
US5019369A
(en)
|
1984-10-22 |
1991-05-28 |
Vestar, Inc. |
Method of targeting tumors in humans
|
|
US5079163A
(en)
|
1985-03-29 |
1992-01-07 |
Cetus Corporation |
Recombinant ricin toxin fragments
|
|
US4689401A
(en)
|
1986-03-06 |
1987-08-25 |
Cetus Corporation |
Method of recovering microbially produced recombinant ricin toxin a chain
|
|
US4902505A
(en)
|
1986-07-30 |
1990-02-20 |
Alkermes |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4892827A
(en)
|
1986-09-24 |
1990-01-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
CA1323293C
(en)
|
1987-12-11 |
1993-10-19 |
Keith C. Backman |
Assay using template-dependent nucleic acid probe reorganization
|
|
JP2955759B2
(ja)
|
1988-07-20 |
1999-10-04 |
セゲブ・ダイアグノスティックス・インコーポレイテッド |
核酸配列を増幅及び検出する方法
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5055303A
(en)
|
1989-01-31 |
1991-10-08 |
Kv Pharmaceutical Company |
Solid controlled release bioadherent emulsions
|
|
US5271961A
(en)
|
1989-11-06 |
1993-12-21 |
Alkermes Controlled Therapeutics, Inc. |
Method for producing protein microspheres
|
|
US5188837A
(en)
|
1989-11-13 |
1993-02-23 |
Nova Pharmaceutical Corporation |
Lipsopheres for controlled delivery of substances
|
|
US5427930A
(en)
|
1990-01-26 |
1995-06-27 |
Abbott Laboratories |
Amplification of target nucleic acids using gap filling ligase chain reaction
|
|
US5061620A
(en)
|
1990-03-30 |
1991-10-29 |
Systemix, Inc. |
Human hematopoietic stem cell
|
|
US5268164A
(en)
|
1990-04-23 |
1993-12-07 |
Alkermes, Inc. |
Increasing blood-brain barrier permeability with permeabilizer peptides
|
|
AU646673B2
(en)
|
1990-05-11 |
1994-03-03 |
United States of America, as represented by the Secretary, U.S. Department of Commerce, The |
Improved pseudomonas exotoxins of low animal toxicity and high cytocidal activity
|
|
US5608039A
(en)
|
1990-10-12 |
1997-03-04 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Single chain B3 antibody fusion proteins and their uses
|
|
US5254342A
(en)
|
1991-09-30 |
1993-10-19 |
University Of Southern California |
Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
ATE419355T1
(de)
|
1992-02-06 |
2009-01-15 |
Novartis Vaccines & Diagnostic |
Marker für krebs und biosynthetisches bindeprotein dafür
|
|
AU668384B2
(en)
|
1992-03-12 |
1996-05-02 |
Alkermes Controlled Therapeutics, Inc. |
Controlled release ACTH containing microspheres
|
|
ATE314475T1
(de)
|
1992-06-18 |
2006-01-15 |
Us Gov Health & Human Serv |
Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität
|
|
US5534496A
(en)
|
1992-07-07 |
1996-07-09 |
University Of Southern California |
Methods and compositions to enhance epithelial drug transport
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5514670A
(en)
|
1993-08-13 |
1996-05-07 |
Pharmos Corporation |
Submicron emulsions for delivery of peptides
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5648211A
(en)
|
1994-04-18 |
1997-07-15 |
Becton, Dickinson And Company |
Strand displacement amplification using thermophilic enzymes
|
|
WO1996002668A1
(en)
|
1994-07-15 |
1996-02-01 |
Azco Nobel N.V. |
Use of rna polymerase to improve nucleic acid amplification process
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
CA2218503C
(en)
|
1995-04-20 |
2001-07-24 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
AT402203B
(de)
|
1995-06-13 |
1997-03-25 |
Himmler Gottfried Dipl Ing Dr |
Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
EP0780386B1
(en)
|
1995-12-20 |
2002-10-02 |
F. Hoffmann-La Roche Ag |
Matrix metalloprotease inhibitors
|
|
PT885198E
(pt)
|
1996-03-05 |
2002-06-28 |
Astrazeneca Ab |
Derivados de 4-anilinoquinazolina
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
EP0912559B1
(en)
|
1996-07-13 |
2002-11-06 |
Glaxo Group Limited |
Fused heterocyclic compounds as protein tyrosine kinase inhibitors
|
|
DE69718472T2
(de)
|
1996-07-13 |
2003-11-06 |
Glaxo Group Ltd., Greenford |
Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren
|
|
KR20000067904A
(ko)
|
1996-07-18 |
2000-11-25 |
디. 제이. 우드, 스피겔 알렌 제이 |
매트릭스 메탈로프로테아제의 포스피네이트계 억제제
|
|
BR9711223A
(pt)
|
1996-08-23 |
1999-08-17 |
Pfizer |
Derivados de cido arilsulfonilamino-hidrox mico
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
EP0950059B1
(en)
|
1997-01-06 |
2004-08-04 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
IL131042A0
(en)
|
1997-02-03 |
2001-01-28 |
Pfizer Prod Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
BR9807824A
(pt)
|
1997-02-07 |
2000-03-08 |
Pfizer |
Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz
|
|
KR20000070923A
(ko)
|
1997-02-11 |
2000-11-25 |
디. 제이. 우드, 스피겔 알렌 제이 |
아릴설포닐 하이드록삼산 유도체
|
|
WO1998050356A1
(en)
|
1997-05-07 |
1998-11-12 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
AU734009B2
(en)
|
1997-05-30 |
2001-05-31 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
DE69822839T2
(de)
|
1997-08-08 |
2004-08-19 |
Pfizer Products Inc., Groton |
Derivate von aryloxyarylsulfonylamino hydroxyaminsäuren
|
|
AU8816298A
(en)
|
1997-08-22 |
1999-03-16 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
|
EP1017682A4
(en)
|
1997-09-26 |
2000-11-08 |
Merck & Co Inc |
NEW ANGIOGENESIS INHIBITORS
|
|
HUP0100287A3
(en)
|
1997-11-11 |
2003-04-28 |
Pfizer Prod Inc |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
US6809184B1
(en)
|
1997-12-01 |
2004-10-26 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9800569D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
JP4462654B2
(ja)
|
1998-03-26 |
2010-05-12 |
ソニー株式会社 |
映像素材選択装置及び映像素材選択方法
|
|
US6296843B1
(en)
|
1998-04-03 |
2001-10-02 |
The Penn State Research Foundation |
Mutagenized IL 13-based chimeric molecules
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
CA2314156C
(en)
|
1998-05-29 |
2010-05-25 |
Sugen, Inc. |
Pyrrole substituted 2-indolinone protein kinase inhibitors
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
ES2213985T3
(es)
|
1998-11-05 |
2004-09-01 |
Pfizer Products Inc. |
Derivados de hidroxiamida de acido 5-oxo-pirrolidin-2-carboxilico.
|
|
CA2374398C
(en)
|
1999-05-27 |
2011-03-15 |
Ira Pastan |
Immunoconjugates having high binding affinity
|
|
US7252821B2
(en)
|
1999-10-08 |
2007-08-07 |
Arius Research Inc. |
Cancerous disease modifying antibodies
|
|
US20040001789A1
(en)
*
|
1999-10-08 |
2004-01-01 |
Young David S. F. |
Cytotoxicity mediation of cells evidencing surface expression of gp96 or precursors thereof
|
|
AU2003291527A1
(en)
*
|
2002-12-31 |
2004-07-29 |
Nektar Therapeutics |
Antibody-containing particles and compositions
|
|
US20050008649A1
(en)
*
|
2003-06-02 |
2005-01-13 |
University Of Miami |
Chimeric molecules and methods of use
|
|
HRP20110320T1
(hr)
*
|
2004-05-27 |
2011-05-31 |
Crucell Holland B.V. |
Molekule za vezanje koje mogu neutralizirati virus bjesnoće i njihova uporaba
|
|
ATE500276T1
(de)
|
2004-12-30 |
2011-03-15 |
Us Gov Health & Human Serv |
Humanisierte col-1-antikörper mit substituierten resten am gerüst, und deren anwendung
|
|
WO2006120230A2
(en)
*
|
2005-05-12 |
2006-11-16 |
Crucell Holland B.V. |
Host cell specific binding molecules capable of neutralizing viruses and uses thereof
|
|
KR101661770B1
(ko)
*
|
2007-09-21 |
2016-10-04 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
표적화된 인터페론이 강력한 아폽토시스 및 항-종양 활성을 발휘함
|
|
WO2009113074A1
(en)
*
|
2008-03-13 |
2009-09-17 |
Compugen Ltd. |
Novel gp96 derived peptides
|
|
ES2611479T3
(es)
*
|
2010-06-16 |
2017-05-09 |
University Of Pittsburgh- Of The Commonwealth System Of Higher Education |
Anticuerpos contra endoplasmina y su uso
|
|
EP2646054A4
(en)
|
2010-12-02 |
2015-03-04 |
Univ Pittsburgh |
METHOD FOR THE TREATMENT OF A TUMOR WITH THE HELP OF AN ANTIBODY FOR SPECIFIC BINDING TO GRP94
|
|
US9672526B2
(en)
|
2012-03-13 |
2017-06-06 |
American Express Travel Related Services Company, Inc. |
Systems and methods for tailoring marketing
|
|
US10884952B2
(en)
|
2016-09-30 |
2021-01-05 |
Intel Corporation |
Enforcing memory operand types using protection keys
|