JP2015520151A5 - - Google Patents
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- JP2015520151A5 JP2015520151A5 JP2015511669A JP2015511669A JP2015520151A5 JP 2015520151 A5 JP2015520151 A5 JP 2015520151A5 JP 2015511669 A JP2015511669 A JP 2015511669A JP 2015511669 A JP2015511669 A JP 2015511669A JP 2015520151 A5 JP2015520151 A5 JP 2015520151A5
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- Prior art keywords
- edema
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- disease
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 30
- 208000006752 brain edema Diseases 0.000 claims 15
- 206010048962 Brain oedema Diseases 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 11
- 206010021143 Hypoxia Diseases 0.000 claims 8
- 230000007954 hypoxia Effects 0.000 claims 8
- 206010030113 Oedema Diseases 0.000 claims 7
- 102000010637 Aquaporins Human genes 0.000 claims 6
- 108010063290 Aquaporins Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010019280 Heart failures Diseases 0.000 claims 4
- 208000006011 Stroke Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 150000003839 salts Chemical group 0.000 claims 4
- 208000009447 Cardiac Edema Diseases 0.000 claims 3
- 206010021036 Hyponatraemia Diseases 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 208000031225 myocardial ischemia Diseases 0.000 claims 3
- 230000001629 suppression Effects 0.000 claims 3
- 230000008733 trauma Effects 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 206010019196 Head injury Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000003435 Optic Neuritis Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000005486 microgravity Effects 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 230000002107 myocardial effect Effects 0.000 claims 2
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 2
- 208000032253 retinal ischemia Diseases 0.000 claims 2
- 210000000278 spinal cord Anatomy 0.000 claims 2
- 208000001380 Diabetic Ketoacidosis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010019663 Hepatic failure Diseases 0.000 claims 1
- 206010053198 Inappropriate antidiuretic hormone secretion Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 206010025130 Lupus encephalitis Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 208000034388 Mountain sickness acute Diseases 0.000 claims 1
- 201000010183 Papilledema Diseases 0.000 claims 1
- 206010033712 Papilloedema Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010038886 Retinal oedema Diseases 0.000 claims 1
- 206010041549 Spinal cord compression Diseases 0.000 claims 1
- 206010063036 Spinal cord oedema Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 102000002852 Vasopressins Human genes 0.000 claims 1
- 108010004977 Vasopressins Proteins 0.000 claims 1
- 208000005735 Water intoxication Diseases 0.000 claims 1
- 206010000269 abscess Diseases 0.000 claims 1
- 208000018315 acute mountain sickness Diseases 0.000 claims 1
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 230000008081 blood perfusion Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000002296 eclampsia Diseases 0.000 claims 1
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 1
- 201000008284 inappropriate ADH syndrome Diseases 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 201000011195 retinal edema Diseases 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 229960003726 vasopressin Drugs 0.000 claims 1
- 0 CC(C)(C(C1)=CC(*C(C=C(CCC(*)=*)OI(*)(*)=O)=O)=CC1C(F)(F)F)F Chemical compound CC(C)(C(C1)=CC(*C(C=C(CCC(*)=*)OI(*)(*)=O)=O)=CC1C(F)(F)F)F 0.000 description 2
- UQRLOIYSRFRJKL-UHFFFAOYSA-N OC(c(cc(cc1)Cl)c1OCC(C1O)(C1O)O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 Chemical compound OC(c(cc(cc1)Cl)c1OCC(C1O)(C1O)O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 UQRLOIYSRFRJKL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261644268P | 2012-05-08 | 2012-05-08 | |
| US61/644,268 | 2012-05-08 | ||
| US201261651778P | 2012-05-25 | 2012-05-25 | |
| US61/651,778 | 2012-05-25 | ||
| US201361799606P | 2013-03-15 | 2013-03-15 | |
| US61/799,606 | 2013-03-15 | ||
| PCT/US2013/040194 WO2013169939A2 (en) | 2012-05-08 | 2013-05-08 | New methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017210529A Division JP6570597B2 (ja) | 2012-05-08 | 2017-10-31 | 新規方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520151A JP2015520151A (ja) | 2015-07-16 |
| JP2015520151A5 true JP2015520151A5 (enExample) | 2016-06-23 |
| JP6238969B2 JP6238969B2 (ja) | 2017-11-29 |
Family
ID=49551452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511669A Active JP6238969B2 (ja) | 2012-05-08 | 2013-05-08 | 新規方法 |
| JP2017210529A Active JP6570597B2 (ja) | 2012-05-08 | 2017-10-31 | 新規方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017210529A Active JP6570597B2 (ja) | 2012-05-08 | 2017-10-31 | 新規方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9994514B2 (enExample) |
| EP (1) | EP2846787B1 (enExample) |
| JP (2) | JP6238969B2 (enExample) |
| KR (1) | KR102200176B1 (enExample) |
| CN (2) | CN104602682B (enExample) |
| AU (2) | AU2013259526B2 (enExample) |
| BR (1) | BR112014027983B1 (enExample) |
| CA (1) | CA2872012C (enExample) |
| ES (1) | ES2699646T3 (enExample) |
| IL (1) | IL235512B (enExample) |
| MX (1) | MX363473B (enExample) |
| RU (1) | RU2671495C2 (enExample) |
| WO (1) | WO2013169939A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102200176B1 (ko) | 2012-05-08 | 2021-01-11 | 에어로믹스, 인코포레이티드 | 신규 방법 |
| CN106163506A (zh) * | 2013-11-06 | 2016-11-23 | 埃罗米克斯公司 | 新配方 |
| CA2966950A1 (en) * | 2014-11-13 | 2016-05-19 | Aeromics, Inc. | Novel methods |
| CN107205971A (zh) | 2014-11-18 | 2017-09-26 | 罗格斯，新泽西州立大学 | 用于治疗代谢疾病和癌症的新的线粒体解偶联剂 |
| CZ305738B6 (cs) * | 2014-12-16 | 2016-02-24 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Substituovaný derivát kyslíkatých kyselin fosforu, jeho použití a farmaceutický přípravek ho obsahující |
| US10246733B2 (en) | 2015-06-04 | 2019-04-02 | Case Western University | Assay and method for quantitating carbonic anhydrase activity and assessing red blood hemolysis |
| CN105030747B (zh) * | 2015-07-03 | 2017-11-17 | 厦门大学 | 氯硝柳胺在制备防治近视药物中的应用 |
| US10292951B2 (en) | 2015-09-01 | 2019-05-21 | First Wave Bio, Inc. | Methods and compositions for treating conditions associated with an abnormal inflammatory responses |
| US11117909B2 (en) * | 2016-05-13 | 2021-09-14 | Aeromics, Inc. | Crystals |
| CA3024610A1 (en) | 2016-05-18 | 2017-11-23 | David J. Augeri | Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer |
| WO2018053807A1 (zh) * | 2016-09-23 | 2018-03-29 | 深圳市中医院 | 氯硝柳胺乙醇胺盐在制备1型糖尿病药物中的应用 |
| TWI631944B (zh) * | 2016-10-14 | 2018-08-11 | 長庚大學 | 氯硝柳胺及其衍生物的用途 |
| US11439869B2 (en) | 2017-05-19 | 2022-09-13 | Trudell Medical International | Positive expiratory pressure device |
| JP6895165B2 (ja) * | 2017-06-06 | 2021-06-30 | 知和 松浦 | α１−アンチキモトリプシンを含むバイオマーカー |
| US10945995B2 (en) * | 2017-09-26 | 2021-03-16 | Deha, Llc | Compositions and methods for channelopathy disorders-targeting fluid movement across membranes |
| CN108203719A (zh) * | 2017-12-26 | 2018-06-26 | 吉林医药学院 | 用于治疗视神经脊髓炎的小分子化合物及其高通量筛选方法 |
| USD874064S1 (en) | 2018-05-18 | 2020-01-28 | Trudell Medical International | Mask |
| USD903097S1 (en) | 2018-05-18 | 2020-11-24 | Trudell Medical International | Mask |
| US12285182B2 (en) | 2018-10-10 | 2025-04-29 | Innova Vascular, Inc. | Devices and methods for removing an embolus |
| USD893806S1 (en) | 2018-11-09 | 2020-08-18 | Trudell Medical Internationl | Mask and shroud |
| USD902947S1 (en) * | 2019-03-25 | 2020-11-24 | Apple Inc. | Electronic device with graphical user interface |
| CN112107568B (zh) * | 2019-06-19 | 2022-03-25 | 北京龙嘉博创医药科技有限公司 | 二芳基酰胺类化合物及其应用 |
| CN110790787B (zh) * | 2019-11-12 | 2022-06-14 | 广东药科大学 | 一类水溶性前药、其制备方法及其作为药物的用途 |
| US10980756B1 (en) | 2020-03-16 | 2021-04-20 | First Wave Bio, Inc. | Methods of treatment |
| KR20230137284A (ko) * | 2020-08-05 | 2023-10-04 | 장쑤 심시어 파마슈티컬 컴퍼니 리미티드 | 아쿠아포린 억제제의 약학 조성물 및 이의 제조 방법 |
| CN116139116A (zh) * | 2023-03-30 | 2023-05-23 | 中南大学湘雅医院 | 氯硝柳胺在抑制急性肝衰竭中的应用 |
| WO2025075479A1 (ko) * | 2023-10-04 | 2025-04-10 | 이화여자대학교 산학협력단 | 아쿠아포린 4 억제제의 심방세동 치료 용도 |
| EP4559520A1 (en) | 2023-11-21 | 2025-05-28 | Origenis GmbH | Novel aqp4 inhibitors |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE615511A (enExample) | 1961-03-25 | |||
| NL292958A (enExample) | 1962-05-29 | 1900-01-01 | ||
| GB8809205D0 (en) | 1988-04-19 | 1988-05-25 | Nye P C G | Treatment of oedema |
| US5137871A (en) * | 1989-07-28 | 1992-08-11 | Regents Of The University Of California | Treatment to reduce edema for brain and musculature injuries |
| DE4010536A1 (de) | 1990-04-02 | 1991-10-10 | Boehringer Mannheim Gmbh | Pharmazeutische waessrige loesung von 4-(2-(benzolsulfonylamino)-ethyl)-phenoxyessigsaeure |
| US5137817A (en) | 1990-10-05 | 1992-08-11 | Amoco Corporation | Apparatus and method for electroporation |
| DE4113820A1 (de) | 1991-04-27 | 1992-10-29 | Boehringer Mannheim Gmbh | Verwendung von torasemid zur behandlung von hirnoedemen |
| US5486530A (en) | 1991-04-27 | 1996-01-23 | Boehringer Mannheim Gmbh | Use of torasemide for the treatment of brain oedemas |
| US5858702A (en) | 1991-12-13 | 1999-01-12 | The Johns Hopkins University | Isolation, cloning and expression of transmembrane water channel Aquaporin 5 (AQP5) |
| US5741671A (en) | 1991-12-12 | 1998-04-21 | The Johns Hopkins University | Isolation cloning and expression of transmembrane water channel aquaporin 1(AQP1) |
| US5519035A (en) * | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
| US20060167110A1 (en) * | 1995-01-13 | 2006-07-27 | Blume Cherly D | Methods for treating cerebrovascular disease by administering desmethylselegiline |
| EP0886471A4 (en) | 1996-11-18 | 2002-07-17 | Emisphere Tech Inc | METHODS AND COMPOSITIONS FOR INDUCING ORAL TOLERANCE IN MUZZLES |
| CA2298824A1 (en) | 1997-08-06 | 1999-02-18 | Smithkline Beecham Corporation | Macrophage scavenger receptor antagonists for use in the treatment of cardiovascular diseases |
| US5905090A (en) | 1998-04-29 | 1999-05-18 | Italfarmaco S.P.A. | Analogues of the active metabolite of leflunomide |
| CO5180581A1 (es) | 1999-09-30 | 2002-07-30 | Pfizer Prod Inc | Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia |
| US6500809B1 (en) * | 1999-11-12 | 2002-12-31 | Neuron Therapeutics, Inc. | Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith |
| ATE257479T1 (de) * | 1999-12-10 | 2004-01-15 | Pfizer | 5-ring heteroarylsubstituierte 1,4- dihydropyridine als bradykinin antagonisten |
| US8263657B2 (en) | 2000-12-18 | 2012-09-11 | Institute Of Medicinal Molecular Design, Inc. | Inhibitors against the production and release of inflammatory cytokines |
| WO2003079987A2 (en) | 2002-03-20 | 2003-10-02 | University Of Maryland Baltimore | A non-selective cation channel in neural cells and methods for treating brain swelling |
| US7872048B2 (en) | 2004-09-18 | 2011-01-18 | University Of Maryland, Baltimore | Methods for treating spinal cord injury with a compound that inhibits a NCCa-ATP channel |
| US8980952B2 (en) | 2002-03-20 | 2015-03-17 | University Of Maryland, Baltimore | Methods for treating brain swelling with a compound that blocks a non-selective cation channel |
| CA2487900A1 (en) | 2002-06-05 | 2003-12-18 | Institute Of Medicinal Molecular Design, Inc. | Immunity-related protein kinase inhibitors |
| US20060100257A1 (en) | 2002-06-05 | 2006-05-11 | Susumu Muto | Inhibitors against the activation of ap-1 and nfat |
| EP1510207A4 (en) | 2002-06-05 | 2008-12-31 | Inst Med Molecular Design Inc | THERAPEUTIC MEDICAMENT AGAINST DIABETES |
| KR101054562B1 (ko) | 2002-06-06 | 2011-08-04 | 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 | 항알레르기약 |
| WO2003103656A1 (ja) * | 2002-06-06 | 2003-12-18 | 株式会社医薬分子設計研究所 | Ｏ−置換ヒドロキシアリール誘導体 |
| JPWO2003103654A1 (ja) * | 2002-06-10 | 2005-10-06 | 株式会社医薬分子設計研究所 | ＮＦ−κＢ活性化阻害剤 |
| EP1535610A4 (en) | 2002-06-10 | 2008-12-31 | Inst Med Molecular Design Inc | THERAPEUTIC CANCER |
| EA011707B1 (ru) * | 2002-06-11 | 2009-04-28 | Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. | Лекарственное средство для лечения нейродегенеративных заболеваний |
| KR20050019739A (ko) * | 2002-06-11 | 2005-03-03 | 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 | 신경변성질환 치료제 |
| CA2492593A1 (en) | 2002-07-15 | 2004-01-22 | Myriad Genetics, Inc. | Compounds, compositions, and methods employing same |
| EP1590458B1 (en) | 2003-02-06 | 2012-10-31 | Queen's University Of Belfast | Bradykinin b2 receptor antagonist peptide from amphibian skin |
| EP1617834B1 (en) * | 2003-05-01 | 2006-09-27 | Innogene Kalbiotech Pte. Ltd. | Use of a pharmaceutical composition containing lactic acid or lactate and potassium for treating brain edema or brain injury |
| WO2005007151A1 (ja) | 2003-07-16 | 2005-01-27 | Institute Of Medicinal Molecular Design. Inc. | 皮膚色素沈着の治療剤 |
| WO2005035514A2 (en) | 2003-10-08 | 2005-04-21 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters containing cycloalkyl or pyranyl groups |
| US8467876B2 (en) * | 2003-10-15 | 2013-06-18 | Rmx, Llc | Breathing disorder detection and therapy delivery device and method |
| JPWO2005039556A1 (ja) | 2003-10-29 | 2007-02-15 | 紘一 首藤 | 血行再建術後の再狭窄又は再閉塞の治療及び／又は予防のための医薬 |
| EP1691817A2 (en) | 2003-12-02 | 2006-08-23 | Corgentech, Inc. | NF-kB OLIGONUCLEOTIDE DECOY MOLECULES |
| CN101043891A (zh) | 2004-09-18 | 2007-09-26 | 巴尔的摩马里兰大学 | 靶向NCCa－ATP通道的治疗剂及其使用方法 |
| US7601745B2 (en) * | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
| EP1835909A2 (en) | 2005-01-04 | 2007-09-26 | Novartis AG | Biomarkers for identifying efficacy of tegaserod in patients with chronic constipation |
| TWI462745B (zh) | 2005-04-28 | 2014-12-01 | Takeda Pharmaceutical | 安定的乳化組成物 |
| WO2007084464A2 (en) | 2006-01-17 | 2007-07-26 | The University Of North Carolina At Chapel Hill | Water channel blockers and methods of use thereof |
| JP4273235B2 (ja) | 2006-06-01 | 2009-06-03 | 国立大学法人 新潟大学 | アクアポリン４阻害薬 |
| SG175615A1 (en) | 2006-06-06 | 2011-11-28 | Genentech Inc | Anti-dll4 antibodies and methods using same |
| JP2009539870A (ja) | 2006-06-06 | 2009-11-19 | ジェネンテック・インコーポレーテッド | 血管発生の調節ための組成物および方法 |
| US7671058B2 (en) | 2006-06-21 | 2010-03-02 | Institute Of Medicinal Molecular Design, Inc. | N-(3,4-disubstituted phenyl) salicylamide derivatives |
| US10004703B2 (en) | 2006-10-12 | 2018-06-26 | Biogen Chesapeake Llc | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective CA++ activated ATP-sensitive cation channels regulated by SUR1 channels |
| WO2008046014A1 (en) | 2006-10-12 | 2008-04-17 | Remedy Pharmaceuticals, Inc. | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective ca++- activated atp-sensitive cation channels regulated by sur1 receptors |
| EP2086329B1 (en) * | 2006-10-26 | 2014-07-23 | The Arizona Board of Regents on behalf of the University of Arizona | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance |
| WO2008067196A2 (en) | 2006-11-16 | 2008-06-05 | The Regents Of The University Of California | Methods for identifying inhibitors of solute transporters |
| WO2008067373A2 (en) | 2006-11-28 | 2008-06-05 | Alcon Research, Ltd. | RNAi-MEDIATED INHIBITION OF AQUAPORIN 1 FOR TREATMENT OF IOP-RELATED CONDITIONS |
| WO2008067382A2 (en) | 2006-11-28 | 2008-06-05 | Alcon Research, Ltd. | Rnai-mediated inhibition of aquaporin 4 for treatment of iop-related conditions |
| EP2111224B1 (en) | 2007-01-12 | 2016-07-13 | University of Maryland, Baltimore | Targeting ncca-atp channel for organ protection following ischemic episode |
| TR201802359T4 (tr) * | 2007-01-16 | 2018-03-21 | Ipintl Llc | Metabolik sendromun tedavi edilmesine yönelik yeni bileşim. |
| US20120183600A1 (en) | 2007-01-16 | 2012-07-19 | Chien-Hung Chen | Novel composition for treating metabolic syndrome and other conditions |
| WO2008098160A1 (en) | 2007-02-09 | 2008-08-14 | University Of Maryland, Baltimore | Antagonists of a non-selective cation channel in neural cells |
| BRPI0807918A2 (pt) | 2007-02-17 | 2017-05-16 | Harvard College | composições e método para preservação de tecido |
| TW200848063A (en) | 2007-04-23 | 2008-12-16 | Combinatorx Inc | Methods and compositions for the treatment of neurodegenerative disorders |
| WO2009002832A2 (en) | 2007-06-22 | 2008-12-31 | University Of Maryland, Baltimore | Inhibitors of ncca-atp channels for therapy |
| JP2010532385A (ja) | 2007-07-02 | 2010-10-07 | ユ，ミン | 複合的癌治療の方法、組成物および標的 |
| EP2201946A4 (en) | 2007-10-23 | 2012-01-25 | Inst Med Molecular Design Inc | HAMMER OF PAI-1 PRODUCTION |
| US20090239868A1 (en) | 2007-10-23 | 2009-09-24 | Institute Of Medical Molecular Design, Inc. | Inhibitor of pai-1 production |
| CA3240562A1 (en) | 2007-12-04 | 2009-06-11 | Remedy Pharmaceuticals, Inc. | Improved formulations and methods for lyophilization and lyophilates provided thereby |
| GB0724340D0 (en) | 2007-12-13 | 2008-01-30 | Univ Dundee | Novel Therapeutic Agents |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009097443A2 (en) | 2008-01-29 | 2009-08-06 | Remedy Pharmaceuticals, Inc. | Liquid formulations of compounds active at sulfonylurea receptors |
| US8211882B2 (en) * | 2008-03-08 | 2012-07-03 | Richard Delarey Wood | Glutamate receptor modulators and therapeutic agents |
| US20090286799A1 (en) * | 2008-05-16 | 2009-11-19 | Zhi-Gang Jiang | Methods for the treatment of brain edema |
| US20110263478A1 (en) | 2008-09-16 | 2011-10-27 | Simard J Marc | Sur1 inhibitors for therapy |
| US20120010178A1 (en) | 2008-10-21 | 2012-01-12 | President And Fellows Of Harvard College | Methods and compounds for treatment of neurodegenerative disorders |
| GB0823366D0 (en) | 2008-12-22 | 2009-01-28 | Uni I Oslo | Synthesis |
| JP5778583B2 (ja) * | 2009-01-12 | 2015-09-16 | バギ リサーチ リミテッド | 炎症を治療するためおよび免疫応答を調節するための化合物ならびにそれらの使用 |
| US20120039805A1 (en) | 2009-02-20 | 2012-02-16 | Pangea Biosciences, Inc. | Therapeutics And Methods For Treating Neoplastic Diseases Comprising Determining The Level Of Caveolin-1 And/Or Caveolin-2 In A Stromal Cell Sample |
| EP2544706B1 (en) | 2010-03-10 | 2015-06-17 | The University Of Melbourne | Modulating aquaporins with relaxin |
| JP6188021B2 (ja) | 2010-07-19 | 2017-08-30 | バイオジェン チェサピーク エルエルシー | グリブリドおよび他の薬剤の静脈内投与方法 |
| EP2598145A1 (en) | 2010-07-28 | 2013-06-05 | Boehringer Ingelheim International GmbH | Pharmaceutical composition for treatment of respiratory and inflammatory diseases |
| US20110052678A1 (en) * | 2010-11-05 | 2011-03-03 | Shantha Totada R | Method for treating age related macular degeneration |
| WO2012125749A2 (en) | 2011-03-14 | 2012-09-20 | Io Therapeutics, Inc. | INFLAMMATION AND AUTOIMMUNE DISORDER TREATMENT USING RARα SELECTIVE AGONISTS |
| EP2717883B1 (en) | 2011-05-02 | 2017-03-22 | Stichting VUmc | Protection against endothelial barrier dysfunction through inhibition of the tyrosine kinase abl-related gene (arg) |
| RU2461375C1 (ru) | 2011-05-19 | 2012-09-20 | Учреждение Российской академии медицинских наук Научно-исследовательский институт онкологии Сибирского отделения Российской академии медицинских наук (НИИ онкологии СО РАМН) | Способ комбинированного лечения больных местно-распространенным раком желудка |
| US20140336159A1 (en) | 2011-10-07 | 2014-11-13 | Pulmatrix, Inc. | Methods for treating and diagnosing respiratory tract infections |
| WO2013152313A1 (en) | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Compositions and methods for treating cancer and diseases and conditions responsive to growth factor inhibition |
| ES2929283T3 (es) | 2012-05-04 | 2022-11-28 | Us Health | Moduladores del receptor de relaxina 1 |
| KR102200176B1 (ko) | 2012-05-08 | 2021-01-11 | 에어로믹스, 인코포레이티드 | 신규 방법 |
| JP6083770B2 (ja) | 2013-09-13 | 2017-02-22 | 昭子 板井 | 水溶液製剤及びその製造方法 |
| CN106163506A (zh) | 2013-11-06 | 2016-11-23 | 埃罗米克斯公司 | 新配方 |
| LT3080134T (lt) | 2013-12-13 | 2018-11-12 | Vertex Pharmaceuticals Incorporated | Piridono amidų provaistai, naudotini kaip natrio kanalų moduliatoriai |
| CA2966950A1 (en) | 2014-11-13 | 2016-05-19 | Aeromics, Inc. | Novel methods |
| EA038398B1 (ru) | 2015-05-29 | 2021-08-23 | Юниверсити Оф Мэрилэнд, Балтимор | Способы уменьшения или предотвращения повреждения интимы, вызванного механической стимуляцией эндотелиальных клеток |
| EA201890893A1 (ru) | 2015-10-07 | 2018-09-28 | БАЙОДЖЕН ЧЕСАПИК ЭлЭлСи | Способы лечения повреждений или состояний, относящихся к отеку цнс |
| US11117909B2 (en) | 2016-05-13 | 2021-09-14 | Aeromics, Inc. | Crystals |
| EP4299127A3 (en) | 2016-07-29 | 2024-05-15 | Remedy Pharmaceuticals, Inc. | Methods of medical treatment with sur1-trpm4 channel inhibitors |
| KR20230137284A (ko) | 2020-08-05 | 2023-10-04 | 장쑤 심시어 파마슈티컬 컴퍼니 리미티드 | 아쿠아포린 억제제의 약학 조성물 및 이의 제조 방법 |
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