CN104602682B - 用于治疗水通道蛋白介导的疾病的化合物 - Google Patents

用于治疗水通道蛋白介导的疾病的化合物 Download PDF

Info

Publication number
CN104602682B
CN104602682B CN201380033198.7A CN201380033198A CN104602682B CN 104602682 B CN104602682 B CN 104602682B CN 201380033198 A CN201380033198 A CN 201380033198A CN 104602682 B CN104602682 B CN 104602682B
Authority
CN
China
Prior art keywords
edema
compound
controlled
brain
spinal cord
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380033198.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN104602682A (zh
Inventor
M·F·佩尔蒂埃
G·W·法尔
P·R·迈盖克
C·H·哈尔
W·F·博龙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeromics Inc
Original Assignee
Aeromics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeromics Inc filed Critical Aeromics Inc
Priority to CN201811415090.5A priority Critical patent/CN109512805B/zh
Publication of CN104602682A publication Critical patent/CN104602682A/zh
Application granted granted Critical
Publication of CN104602682B publication Critical patent/CN104602682B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201380033198.7A 2012-05-08 2013-05-08 用于治疗水通道蛋白介导的疾病的化合物 Active CN104602682B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811415090.5A CN109512805B (zh) 2012-05-08 2013-05-08 用于治疗水通道蛋白介导的疾病的化合物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261644268P 2012-05-08 2012-05-08
US61/644,268 2012-05-08
US201261651778P 2012-05-25 2012-05-25
US61/651,778 2012-05-25
US201361799606P 2013-03-15 2013-03-15
US61/799,606 2013-03-15
PCT/US2013/040194 WO2013169939A2 (en) 2012-05-08 2013-05-08 New methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811415090.5A Division CN109512805B (zh) 2012-05-08 2013-05-08 用于治疗水通道蛋白介导的疾病的化合物

Publications (2)

Publication Number Publication Date
CN104602682A CN104602682A (zh) 2015-05-06
CN104602682B true CN104602682B (zh) 2018-12-14

Family

ID=49551452

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201811415090.5A Active CN109512805B (zh) 2012-05-08 2013-05-08 用于治疗水通道蛋白介导的疾病的化合物
CN201380033198.7A Active CN104602682B (zh) 2012-05-08 2013-05-08 用于治疗水通道蛋白介导的疾病的化合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201811415090.5A Active CN109512805B (zh) 2012-05-08 2013-05-08 用于治疗水通道蛋白介导的疾病的化合物

Country Status (13)

Country Link
US (4) US9994514B2 (enExample)
EP (1) EP2846787B1 (enExample)
JP (2) JP6238969B2 (enExample)
KR (1) KR102200176B1 (enExample)
CN (2) CN109512805B (enExample)
AU (2) AU2013259526B2 (enExample)
BR (1) BR112014027983B1 (enExample)
CA (1) CA2872012C (enExample)
ES (1) ES2699646T3 (enExample)
IL (1) IL235512B (enExample)
MX (1) MX363473B (enExample)
RU (1) RU2671495C2 (enExample)
WO (1) WO2013169939A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102200176B1 (ko) 2012-05-08 2021-01-11 에어로믹스, 인코포레이티드 신규 방법
RU2691951C2 (ru) * 2013-11-06 2019-06-19 Аэромикс, Инк. Новые составы
CN107207417A (zh) * 2014-11-13 2017-09-26 埃罗米克斯公司 新方法
HK1243636A1 (zh) 2014-11-18 2018-07-20 Rutgers, The State University Of New Jersey 用於治疗代谢疾病和癌症的新的线粒体解偶联剂
CZ2014915A3 (cs) * 2014-12-16 2016-02-24 Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Substituovaný derivát kyslíkatých kyselin fosforu, jeho použití a farmaceutický přípravek ho obsahující
US10246733B2 (en) 2015-06-04 2019-04-02 Case Western University Assay and method for quantitating carbonic anhydrase activity and assessing red blood hemolysis
CN105030747B (zh) * 2015-07-03 2017-11-17 厦门大学 氯硝柳胺在制备防治近视药物中的应用
AU2016315852B2 (en) 2015-09-01 2023-06-15 First Wave Bio, Inc. Methods and compositions for treating conditions associated with an abnormal inflammatory responses
KR20190005991A (ko) 2016-05-13 2019-01-16 에어로믹스, 인코포레이티드 결정
CA3024610A1 (en) 2016-05-18 2017-11-23 David J. Augeri Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer
WO2018053807A1 (zh) * 2016-09-23 2018-03-29 深圳市中医院 氯硝柳胺乙醇胺盐在制备1型糖尿病药物中的应用
TWI631944B (zh) * 2016-10-14 2018-08-11 長庚大學 氯硝柳胺及其衍生物的用途
US11439869B2 (en) 2017-05-19 2022-09-13 Trudell Medical International Positive expiratory pressure device
JP6895165B2 (ja) * 2017-06-06 2021-06-30 知和 松浦 α１−アンチキモトリプシンを含むバイオマーカー
US10945995B2 (en) * 2017-09-26 2021-03-16 Deha, Llc Compositions and methods for channelopathy disorders-targeting fluid movement across membranes
CN108203719A (zh) * 2017-12-26 2018-06-26 吉林医药学院 用于治疗视神经脊髓炎的小分子化合物及其高通量筛选方法
USD903097S1 (en) 2018-05-18 2020-11-24 Trudell Medical International Mask
USD874064S1 (en) 2018-05-18 2020-01-28 Trudell Medical International Mask
US12285182B2 (en) 2018-10-10 2025-04-29 Innova Vascular, Inc. Devices and methods for removing an embolus
USD893806S1 (en) 2018-11-09 2020-08-18 Trudell Medical Internationl Mask and shroud
USD902947S1 (en) * 2019-03-25 2020-11-24 Apple Inc. Electronic device with graphical user interface
CN112107568B (zh) * 2019-06-19 2022-03-25 北京龙嘉博创医药科技有限公司 二芳基酰胺类化合物及其应用
CN110790787B (zh) * 2019-11-12 2022-06-14 广东药科大学 一类水溶性前药、其制备方法及其作为药物的用途
US10980756B1 (en) 2020-03-16 2021-04-20 First Wave Bio, Inc. Methods of treatment
US20230293556A1 (en) * 2020-08-05 2023-09-21 Jiangsu Simcere Pharmaceutical Co., Ltd. Pharmaceutical composition of aquaporin inhibitor and preparation method thereof
CN116139116A (zh) * 2023-03-30 2023-05-23 中南大学湘雅医院 氯硝柳胺在抑制急性肝衰竭中的应用
WO2025075479A1 (ko) * 2023-10-04 2025-04-10 이화여자대학교 산학협력단 아쿠아포린 4 억제제의 심방세동 치료 용도
EP4559520A1 (en) 2023-11-21 2025-05-28 Origenis GmbH Novel aqp4 inhibitors

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE615511A (enExample) 1961-03-25
NL292958A (enExample) 1962-05-29 1900-01-01
GB8809205D0 (en) 1988-04-19 1988-05-25 Nye P C G Treatment of oedema
US5137871A (en) * 1989-07-28 1992-08-11 Regents Of The University Of California Treatment to reduce edema for brain and musculature injuries
DE4010536A1 (de) 1990-04-02 1991-10-10 Boehringer Mannheim Gmbh Pharmazeutische waessrige loesung von 4-(2-(benzolsulfonylamino)-ethyl)-phenoxyessigsaeure
US5137817A (en) 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
DE4113820A1 (de) 1991-04-27 1992-10-29 Boehringer Mannheim Gmbh Verwendung von torasemid zur behandlung von hirnoedemen
US5486530A (en) 1991-04-27 1996-01-23 Boehringer Mannheim Gmbh Use of torasemide for the treatment of brain oedemas
US5741671A (en) 1991-12-12 1998-04-21 The Johns Hopkins University Isolation cloning and expression of transmembrane water channel aquaporin 1(AQP1)
US5858702A (en) 1991-12-13 1999-01-12 The Johns Hopkins University Isolation, cloning and expression of transmembrane water channel Aquaporin 5 (AQP5)
US5519035A (en) * 1993-07-02 1996-05-21 Cornell Research Foundation, Inc. Treatment of stroke or in anticipation of the occurrence of brain ischemia
US20060167110A1 (en) * 1995-01-13 2006-07-27 Blume Cherly D Methods for treating cerebrovascular disease by administering desmethylselegiline
WO1998021951A1 (en) 1996-11-18 1998-05-28 Emisphere Technologies, Inc. Methods and compositions for inducing oral tolerance in mammals
US6255298B1 (en) 1997-08-06 2001-07-03 Smithkline Beecham Corporation Macrophage scavenger receptor antagonists for use in the treatment of cardiovascular diseases
US5905090A (en) * 1998-04-29 1999-05-18 Italfarmaco S.P.A. Analogues of the active metabolite of leflunomide
CO5180581A1 (es) 1999-09-30 2002-07-30 Pfizer Prod Inc Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia
US6500809B1 (en) * 1999-11-12 2002-12-31 Neuron Therapeutics, Inc. Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith
PT1106614E (pt) * 1999-12-10 2004-04-30 Pfizer Compostos de 1,4-dihidropiridina substituidos com heteroarilos de 5 membros como antagonistas de bradiquinina
CN100370975C (zh) 2000-12-18 2008-02-27 株式会社医药分子设计研究所 炎症性细胞因子产生游离抑制剂
US8980952B2 (en) 2002-03-20 2015-03-17 University Of Maryland, Baltimore Methods for treating brain swelling with a compound that blocks a non-selective cation channel
SI2438913T1 (sl) 2002-03-20 2020-10-30 University Of Maryland, Baltimore Neselektivni kationski kanal v nevralnih celicah in spojine, ki blokirajo kanal, za uporabo pri zdravljenju otekanja možganov
AU2003242131A1 (en) 2002-06-05 2003-12-22 Institute Of Medicinal Molecular Design, Inc. Immunity-related protein kinase inhibitors
CN1658849A (zh) 2002-06-05 2005-08-24 株式会社医药分子设计研究所 Ap－1和nfat活化抑制剂
CA2488342A1 (en) 2002-06-05 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Therapeutic drug for diabetes
WO2003103665A1 (ja) 2002-06-06 2003-12-18 株式会社医薬分子設計研究所 抗アレルギー薬
US7626042B2 (en) 2002-06-06 2009-12-01 Institute Of Medicinal Molecular Design, Inc. O-substituted hydroxyaryl derivatives
WO2003103655A1 (ja) 2002-06-10 2003-12-18 株式会社医薬分子設計研究所 癌治療剤
EA010470B1 (ru) * 2002-06-10 2008-08-29 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. ИНГИБИТОРЫ АКТИВАЦИИ NF-kB
AU2003242124A1 (en) 2002-06-11 2003-12-22 Institute Of Medicinal Molecular Design, Inc. Medicament for treatment of neurodegenerative diseases
KR20050019739A (ko) * 2002-06-11 2005-03-03 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 신경변성질환 치료제
KR20050029209A (ko) 2002-07-15 2005-03-24 미리어드 제네틱스, 인크. 화합물, 조성물 및 이의 사용방법
WO2004068928A2 (en) 2003-02-06 2004-08-19 Uutech Limited Bradykinin b2 receptor antagonist peptide from amphibian skin
AR043670A1 (es) * 2003-05-01 2005-08-03 Innogene Kalbiotech Pte Ltd Composicion farmaceutica que contiene lactato y usos de la misma
KR20060054308A (ko) 2003-07-16 2006-05-22 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 피부 색소침착의 치료제
CA2540978A1 (en) 2003-10-08 2005-04-21 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters containing cycloalkyl or pyranyl groups
US8467876B2 (en) * 2003-10-15 2013-06-18 Rmx, Llc Breathing disorder detection and therapy delivery device and method
US20070254956A1 (en) 2003-10-29 2007-11-01 Koichi Shudo Medicament for Therapeutic and/or Preventive Treatment of Restenosis or Reocclusion After Vascular Recanalization Operation
US7378509B2 (en) 2003-12-02 2008-05-27 Anesiva, Inc. NF-kappaB oligonucleotide decoy molecules
AU2005290238A1 (en) 2004-09-18 2006-04-06 Department Of Veterans Affairs Therapeutic agents trageting the NCCa-ATP channel and methods of use thereof
AU2005287090A1 (en) 2004-09-18 2006-03-30 Department Of Veterans Affairs Therapeutic agents targeting the NCca-ATP channel and methods of use thereof
US7601745B2 (en) * 2004-09-27 2009-10-13 4Sc Ag Heterocyclic NF-kB inhibitors
CN101132791A (zh) 2005-01-04 2008-02-27 诺瓦提斯公司 用于鉴定替加色罗在慢性便秘患者中的功效的生物标记
MY147790A (en) 2005-04-28 2013-01-31 Takeda Pharmaceutical Stable emulsion composition
WO2007084464A2 (en) 2006-01-17 2007-07-26 The University Of North Carolina At Chapel Hill Water channel blockers and methods of use thereof
JP4273235B2 (ja) 2006-06-01 2009-06-03 国立大学法人 新潟大学 アクアポリン４阻害薬
CA2654304A1 (en) 2006-06-06 2007-12-13 Genentech, Inc. Compositions and methods for modulating vascular development
CL2007001623A1 (es) 2006-06-06 2008-01-18 Genentech Inc Anticuerpo anti-dll4; polinucleotido que lo codifica; vector y celula huesped que comprenden dicho polinucleotido; metodo para elaborar el anticuerpo e inmunojugado; metodo de deteccion de dll4 y metodo diagnostico de un trastorno asociado a dll4; composicion que comprende al anticuerpo.
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
WO2008046014A1 (en) 2006-10-12 2008-04-17 Remedy Pharmaceuticals, Inc. Treatment of alzheimer's disease using compounds that reduce the activity of non-selective ca++- activated atp-sensitive cation channels regulated by sur1 receptors
US10004703B2 (en) 2006-10-12 2018-06-26 Biogen Chesapeake Llc Treatment of alzheimer's disease using compounds that reduce the activity of non-selective CA++ activated ATP-sensitive cation channels regulated by SUR1 channels
US7906555B2 (en) * 2006-10-26 2011-03-15 Arizona Board Of Regents On Behalf Of The University Of Arizona Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance
US9316633B2 (en) 2006-11-16 2016-04-19 The Regents Of The University Of California Methods for identifying inhibitors of solute transporters
US20080214486A1 (en) 2006-11-28 2008-09-04 Alcon Manufacturing, Ltd. RNAi-MEDIATED INHIBITION OF AQUAPORIN 4 FOR TREATMENT OF IOP-RELATED CONDITIONS
WO2008067373A2 (en) 2006-11-28 2008-06-05 Alcon Research, Ltd. RNAi-MEDIATED INHIBITION OF AQUAPORIN 1 FOR TREATMENT OF IOP-RELATED CONDITIONS
US9511075B2 (en) 2007-01-12 2016-12-06 The University Of Maryland, Baltimore Targeting NCCA-ATP channel for organ protection following ischemic episode
EP2118279B1 (en) * 2007-01-16 2017-11-22 Ipintl, Llc Novel composition for treating metabolic syndrome
US20120183600A1 (en) 2007-01-16 2012-07-19 Chien-Hung Chen Novel composition for treating metabolic syndrome and other conditions
CA2618099C (en) 2007-02-09 2016-09-20 University Of Maryland, Baltimore Antagonists of a non-selective cation channel in neural cells
CN105746492A (zh) 2007-02-17 2016-07-13 哈佛学院董事会 用于进行组织保存的组合物以及方法
TW200848063A (en) 2007-04-23 2008-12-16 Combinatorx Inc Methods and compositions for the treatment of neurodegenerative disorders
CA3065983C (en) 2007-06-22 2022-07-26 The United States Of America As Represented By The Department Of Veterans Affairs Inhibitors of ncca-atp channels for therapy
CN101842095B (zh) 2007-07-02 2015-06-24 于明 肿瘤治疗的配方,方法和靶目标
US20090239868A1 (en) 2007-10-23 2009-09-24 Institute Of Medical Molecular Design, Inc. Inhibitor of pai-1 production
WO2009054439A1 (ja) 2007-10-23 2009-04-30 Institute Of Medicinal Molecular Design, Inc. Pai-1産生抑制剤
LT2868315T (lt) 2007-12-04 2017-09-25 Biogen Chesapeake Llc Patobulintos kompozicijos ir liofilizacijos būdai bei gauti liofilizatai
GB0724340D0 (en) 2007-12-13 2008-01-30 Univ Dundee Novel Therapeutic Agents
JP2011507910A (ja) 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
US20110034560A1 (en) 2008-01-29 2011-02-10 Sven Jacobson Liquid formulations of compounds active at sulfonylurea receptors
US8211882B2 (en) * 2008-03-08 2012-07-03 Richard Delarey Wood Glutamate receptor modulators and therapeutic agents
WO2009139925A1 (en) * 2008-05-16 2009-11-19 Panacea Pharmaceuticals, Inc. Methods for the treatment of brain edema
US20110263478A1 (en) 2008-09-16 2011-10-27 Simard J Marc Sur1 inhibitors for therapy
WO2010048273A2 (en) 2008-10-21 2010-04-29 President And Fellows Of Harvard College Methods and compounds for treatment of neurodegenerative disorders
GB0823366D0 (en) 2008-12-22 2009-01-28 Uni I Oslo Synthesis
EP2385935A4 (en) * 2009-01-12 2014-11-05 Purapharm Company Ltd COMPOUNDS AND APPLICATIONS THEREFOR FOR TREATING INFLAMMATION AND FOR MODULATING IMMUNE REACTIONS
US20120039805A1 (en) * 2009-02-20 2012-02-16 Pangea Biosciences, Inc. Therapeutics And Methods For Treating Neoplastic Diseases Comprising Determining The Level Of Caveolin-1 And/Or Caveolin-2 In A Stromal Cell Sample
JP5970380B2 (ja) * 2010-03-10 2016-08-17 ザ ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド リラキシンによるアクアポリンの調節
KR20190031592A (ko) 2010-07-19 2019-03-26 바이오젠 체사피크 엘엘씨 글리부리드 및 다른 약물의 정맥내 투여를 위한 방법
EP2598145A1 (en) 2010-07-28 2013-06-05 Boehringer Ingelheim International GmbH Pharmaceutical composition for treatment of respiratory and inflammatory diseases
US20110052678A1 (en) * 2010-11-05 2011-03-03 Shantha Totada R Method for treating age related macular degeneration
US20120238623A1 (en) 2011-03-14 2012-09-20 Chandraratna Roshantha A Inflammation and Autoimmune Disorder Treatment using RARa Selective Agonists
HRP20170553T1 (hr) 2011-05-02 2017-06-02 Stichting Vumc Zaštita protiv disfunkcije endotelne barijere putem inhibicije gena povezanog s tirozin kinazom abl (arg)
RU2461375C1 (ru) 2011-05-19 2012-09-20 Учреждение Российской академии медицинских наук Научно-исследовательский институт онкологии Сибирского отделения Российской академии медицинских наук (НИИ онкологии СО РАМН) Способ комбинированного лечения больных местно-распространенным раком желудка
WO2013052844A1 (en) 2011-10-07 2013-04-11 Pulmatrix, Inc. Methods for treating and diagnosing respiratory tract infections
WO2013152313A1 (en) 2012-04-05 2013-10-10 The Regents Of The University Of California Compositions and methods for treating cancer and diseases and conditions responsive to growth factor inhibition
EP2844345B1 (en) 2012-05-04 2022-08-03 The United States of America, as Represented by The Secretary, Department of Health and Human Services Modulators of the relaxin receptor 1
KR102200176B1 (ko) 2012-05-08 2021-01-11 에어로믹스, 인코포레이티드 신규 방법
US9974860B2 (en) 2013-09-13 2018-05-22 Akiko Itai Aqueous solution formulation and method for manufacturing same
RU2691951C2 (ru) 2013-11-06 2019-06-19 Аэромикс, Инк. Новые составы
US9163042B2 (en) 2013-12-13 2015-10-20 Vertex Pharmaceuticals Incorporated Prodrugs of pyridone amides useful as modulators of sodium channels
CN107207417A (zh) 2014-11-13 2017-09-26 埃罗米克斯公司 新方法
JP6973752B2 (ja) 2015-05-29 2021-12-01 ユニバーシティー オブ メリーランド，ボルティモア 内皮細胞の機械的刺激によって引き起こされる内膜損傷を減少させるまたは予防する方法
HK1257542A1 (zh) 2015-10-07 2019-10-25 生物切萨皮克有限责任公司 治療與cns水腫相關的損傷或狀況的方法
KR20190005991A (ko) 2016-05-13 2019-01-16 에어로믹스, 인코포레이티드 결정
AU2017301735B2 (en) 2016-07-29 2023-12-14 Remedy Pharmaceuticals, Inc. Methods of medical treatment with SUR1-TRPM4 channel inhibitors
US20230293556A1 (en) 2020-08-05 2023-09-21 Jiangsu Simcere Pharmaceutical Co., Ltd. Pharmaceutical composition of aquaporin inhibitor and preparation method thereof

Also Published As

Publication number Publication date
KR20150035566A (ko) 2015-04-06
IL235512A0 (en) 2015-01-29
JP2018016647A (ja) 2018-02-01
MX363473B (es) 2019-03-25
KR102200176B1 (ko) 2021-01-11
US9573885B2 (en) 2017-02-21
RU2671495C2 (ru) 2018-11-01
CA2872012A1 (en) 2013-11-14
BR112014027983B1 (pt) 2022-05-24
US11084778B2 (en) 2021-08-10
JP6238969B2 (ja) 2017-11-29
EP2846787A2 (en) 2015-03-18
AU2013259526B2 (en) 2018-02-15
BR112014027983A2 (pt) 2017-06-27
AU2013259526A1 (en) 2014-12-18
JP6570597B2 (ja) 2019-09-04
AU2018203357A1 (en) 2018-05-31
CN109512805A (zh) 2019-03-26
US20180334424A1 (en) 2018-11-22
JP2015520151A (ja) 2015-07-16
US20220081391A1 (en) 2022-03-17
US20150133405A1 (en) 2015-05-14
CN104602682A (zh) 2015-05-06
US20150342967A1 (en) 2015-12-03
CA2872012C (en) 2017-06-20
US11873266B2 (en) 2024-01-16
CN109512805B (zh) 2021-12-31
RU2014148984A (ru) 2016-06-27
HK1208363A1 (en) 2016-03-04
US9994514B2 (en) 2018-06-12
MX2014013639A (es) 2015-08-20
WO2013169939A3 (en) 2014-02-13
WO2013169939A2 (en) 2013-11-14
EP2846787B1 (en) 2018-08-29
ES2699646T3 (es) 2019-02-12
IL235512B (en) 2018-06-28
US20240360077A1 (en) 2024-10-31
EP2846787A4 (en) 2015-11-11
AU2018203357C1 (en) 2020-06-25
AU2018203357B2 (en) 2020-01-30

Similar Documents

Publication Publication Date Title
CN104602682B (zh) 用于治疗水通道蛋白介导的疾病的化合物
US9949991B2 (en) Methods of treating aquaporin-mediated conditions
JP2023516284A (ja) カンナビジオールの組成物および治療的使用
US20240366566A1 (en) Use of carbamate compound for prevention, alleviation or treatment of status epilepticus
US12503425B2 (en) Methods of treating or controlling cytotoxic cerebral edema
HK1208363B (en) Compounds for use in the treatment of aquaporin-mediated diseases
JPWO2006059423A1 (ja) 過興奮性の細胞傷害によって生じる疾患を治療するための薬剤および方法
BR112016010338B1 (pt) Composição farmacêutica compreendendo um composto de diidrogenfosfato de 2-{[3,5-bis(trifluormetil)fenil]carbamoil}-4-clorofenila e uma ou mais bases de bronsted, kit compreendendo o dito composto e uso dos mesmos para tratar ou controlar edema
JP2009067738A (ja) 虚血関連眼疾患予防乃至治療剤

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: ohio

Applicant after: Errol Meeks

Address before: ohio

Applicant before: AEROMICS, LLC

COR Change of bibliographic data
GR01 Patent grant
GR01 Patent grant