BRPI0807918A2 - composições e método para preservação de tecido - Google Patents

composições e método para preservação de tecido

Info

Publication number
BRPI0807918A2
BRPI0807918A2 BRPI0807918A BRPI0807918A BRPI0807918A2 BR PI0807918 A2 BRPI0807918 A2 BR PI0807918A2 BR PI0807918 A BRPI0807918 A BR PI0807918A BR PI0807918 A BRPI0807918 A BR PI0807918A BR PI0807918 A2 BRPI0807918 A2 BR PI0807918A2
Authority
BR
Brazil
Prior art keywords
compositions
preserving tissue
preserving
tissue
Prior art date
Application number
BRPI0807918A
Other languages
English (en)
Inventor
Thatte Hemant
Rousou Laki
Treanor Patrick
Khuri Shukri
Original Assignee
Harvard College
The Us Gov As Represented By Dept Of Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39401771&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0807918(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Harvard College, The Us Gov As Represented By Dept Of Veterans Affairs filed Critical Harvard College
Publication of BRPI0807918A2 publication Critical patent/BRPI0807918A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
BRPI0807918A 2007-02-17 2008-02-19 composições e método para preservação de tecido BRPI0807918A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90184407P 2007-02-17 2007-02-17
US90258707P 2007-02-20 2007-02-20
US96651107P 2007-08-27 2007-08-27
PCT/US2008/002170 WO2008100636A2 (en) 2007-02-17 2008-02-19 Compositions and method for tissue preservation

Publications (1)

Publication Number Publication Date
BRPI0807918A2 true BRPI0807918A2 (pt) 2017-05-16

Family

ID=39401771

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0807918A BRPI0807918A2 (pt) 2007-02-17 2008-02-19 composições e método para preservação de tecido

Country Status (7)

Country Link
US (4) US8211628B2 (pt)
EP (4) EP2543249B1 (pt)
CN (3) CN101790306A (pt)
AU (1) AU2008216612B2 (pt)
BR (1) BRPI0807918A2 (pt)
CA (1) CA2678486C (pt)
WO (1) WO2008100636A2 (pt)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
NZ600702A (en) 2004-10-07 2013-12-20 Transmedics Inc Systems and methods for ex-vivo organ care
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
EP2543249B1 (en) 2007-02-17 2018-05-23 President and Fellows of Harvard College Compositions and method for tissue preservation
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8420380B2 (en) 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
CN102088968A (zh) 2008-02-15 2011-06-08 哈佛学院董事会 血液替代溶液
US20120171716A1 (en) * 2009-08-11 2012-07-05 The Johns Hopkins University Measurement of Mitochondrial Membrane Potential to Assess Organ Dysfunction
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
CN103491976B (zh) * 2011-01-14 2015-04-01 卡思伯特·O·辛普金斯 用于处理与缺乏血液供给、休克和神经损伤相关的疾病的方法和组合物
EP2688541A4 (en) * 2011-03-23 2014-08-20 Vivoline Medical Ab DEVICE FOR MAINTAINING THE VITABILITY AND TRANSPORTABILITY OF REMOVED ORGANS
DK4032401T3 (da) 2011-04-14 2025-12-15 Transmedics Inc Fremgangsmåde til fremstilling af en organplejeopløsning til maskinperfusion ex-vivo af donorlunger
US9756848B2 (en) 2011-09-02 2017-09-12 Organ Assist B.V. Apparatus, system and method for conditioning and preserving an organ from a donor
ES2946695T3 (es) 2012-01-17 2023-07-24 Tevosol Inc Aparato para prueba, evaluación, y mantenimiento de corazones extraídos para trasplante
US9381247B2 (en) * 2012-04-16 2016-07-05 Biodel Inc. Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain
US9399065B2 (en) 2012-04-16 2016-07-26 Biodel Inc. Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin
CN103380769B (zh) * 2012-05-04 2016-04-13 西比曼生物科技（上海）有限公司 用于分离培养干细胞的脂肪组织的长时间保存液
CN104602682B (zh) 2012-05-08 2018-12-14 埃罗米克斯公司 用于治疗水通道蛋白介导的疾病的化合物
US10433538B2 (en) 2012-10-12 2019-10-08 University of Pittsburgh—of the Commonwealth System of Higher Education Compositions and methods for organ preservation
CA3153463A1 (en) 2012-10-29 2014-05-08 The University Of North Carolina At Chapel Hill Methods and compositions for treating mucosal tissue disorders
CN102986649B (zh) * 2012-12-18 2014-07-16 武汉大学 一种用于自体肝移植术的离体连续灌注装置
WO2014106091A1 (en) 2012-12-31 2014-07-03 Somahlution, Llc Solution for preserving vascular conduits
US20160081328A1 (en) * 2013-05-10 2016-03-24 President And Fellows Of Harvard College Solutions for Red Blood Cells
WO2015017500A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
EP3065729A4 (en) 2013-11-06 2017-05-31 Aeromics, Inc. Novel formulations
CA2923441C (en) 2013-11-22 2023-03-28 Somahlution, Llc Solutions for increasing the stability and shelf life of an organ and tissue preservation solution
ES3036002T3 (en) 2014-03-26 2025-09-11 Transmedics Inc Apparatus for maintenance of harvested hearts for transplanting
SMT201800476T1 (it) * 2014-05-23 2018-11-09 4I S R L Dispositivo sterile a circuito chiuso e metodo di raccolta, trasporto e processazione in totale filiera sterile
JP6292640B2 (ja) * 2014-05-30 2018-03-14 Ｓｂｉファーマ株式会社 臓器保存液
CN106659151B (zh) 2014-06-02 2021-06-08 特兰斯迈迪茨公司 离体器官护理系统
AU2015346076A1 (en) * 2014-11-13 2017-06-15 Aeromics, Inc. Novel methods
CA2970117A1 (en) 2014-12-12 2016-06-16 Darren FREED Apparatus and method for organ perfusion
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
JP7017415B2 (ja) * 2015-06-09 2022-02-08 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 血小板の長期貯蔵および保存の方法
HK1251947A1 (zh) * 2015-06-09 2019-05-03 哈佛学院董事会 在环境温度和亚常温下保存组织的组合物与方法
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CN107949419B (zh) 2015-09-09 2021-03-05 特兰斯迈迪茨公司 离体器官护理系统用的主动脉插管
US10674746B2 (en) 2015-10-27 2020-06-09 Cytozyme Animal Nutrition, Inc. Animal nutrition compositions and related methods
CN108473384A (zh) 2015-10-27 2018-08-31 细胞酶动物营养品公司 动物营养成分及相关方法
CN105746495A (zh) * 2016-04-29 2016-07-13 宋励修 果糖和二硫苏糖醇联合预处理在骨髓间充质干细胞冻存中的应用
CN114946834B (zh) 2016-05-30 2024-10-25 体沃索股份有限公司 利用变化的外部压力用于离体肺通气的装置和方法
ES2651717B1 (es) 2016-07-26 2018-11-16 Lara OLLER DUQUE Solución acuosa cristaloide isotónica
CN109497038A (zh) * 2017-09-14 2019-03-22 青岛瑞思德生物科技有限公司 一种脂肪保存液及其制备方法
CN108094410B (zh) * 2018-01-26 2021-08-31 山东大学齐鲁医院 一种皮肤深低温保护剂及皮肤保存方法
US11998001B2 (en) * 2018-02-09 2024-06-04 Yale University Perfusion device for normothermic, ex vivo preservation of a mammalian brain
CN110604127A (zh) * 2018-06-14 2019-12-24 宁波化奇工程技术有限公司 一种非甲醛环保生物标本保存液
CN109221081B (zh) * 2018-09-07 2021-02-12 银丰低温医学科技有限公司 一种多组织玻璃化原位保存装置
CN109511649B (zh) * 2018-11-21 2021-06-25 嘉兴莱普晟医疗科技有限公司 一种可以扩大供肝来源的常温机械灌注系统
WO2020122928A1 (en) * 2018-12-14 2020-06-18 National Taiwan University A stable cardioplegic solution for cardiac surgery
WO2020168191A1 (en) * 2019-02-14 2020-08-20 North Grove Investments, Inc. Compositions for maintaining the viability of living and static biological material, methods of making and the uses thereof
KR20250040760A (ko) * 2019-03-15 2025-03-24 가부시키가이샤 메가카리온 포유동물 세포의 보존액
EP4110050A1 (en) 2020-02-26 2023-01-04 Finless Food Inc. Systems and methods for live fish tissue preservation
CN112088875B (zh) * 2020-09-28 2023-07-25 四川大学华西医院 一种溶液氧化还原电位可调的器官保存装置及其实现方法
CN113025564B (zh) * 2021-03-17 2023-05-02 金华市人民医院 一种卵母细胞体外成熟培养液的制备方法
WO2023023309A1 (en) 2021-08-20 2023-02-23 Finless Foods Inc. Systems and methods for fish tissue preservation
CN114927044A (zh) * 2022-05-17 2022-08-19 付佩尧 一种离体动物胃保存液及使用其制备的胃部病变模拟装置
US12083204B2 (en) * 2022-06-02 2024-09-10 L'oreal Topical composition for homeostatic delivery of nitric oxide and uses thereof
US12667586B2 (en) 2023-03-07 2026-06-30 Glaukos Corporation Treatments for ocular surface disorders
CN116491500A (zh) * 2023-05-09 2023-07-28 博生吉安科细胞技术有限公司 一种nk细胞冻存液及其制备方法与应用
JP2026518142A (ja) * 2023-05-26 2026-06-04 アブレキサ ファーマスーティカルズ，インコーポレイテッド 臓器保存および臓器移植に使用するための化合物
AU2024347043A1 (en) * 2023-09-20 2026-04-09 Traferox Technologies, Inc. Systems, devices, and methods for preserving an organ for transplantation
GB2700353A (en) * 2024-05-09 2026-01-21 Softcell Medical Ltd Organ monitoring apparatus and method
WO2025257595A1 (en) * 2024-06-12 2025-12-18 Biocompatibility Innovation S.r.l. Preserving solution
CN118633593B (zh) * 2024-08-09 2024-11-05 北京百奥益康医药科技有限公司 一种用于单细胞测序的组织冻存液及其制备方法和应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256834A (en) 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
ATE11736T1 (de) 1980-12-23 1985-02-15 Dr. Franz Koehler Chemie Gmbh Protektive loesung fuer herz und niere und verfahren zu deren herstellung.
IT1214598B (it) * 1985-04-17 1990-01-18 Schiapparelli Farma Uso terapeutico della fosfocreatina.
US4879283A (en) 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4798824A (en) 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US5243044A (en) 1986-08-25 1993-09-07 International Therapeutics, Inc. Compounds of perfluoro[3,3,3]propellene and perfluoro hexamethylenetetramine
US5130230A (en) 1988-05-02 1992-07-14 Cryomedical Sciences, Inc. Blood substitute
US5075210A (en) 1989-12-21 1991-12-24 The Regents Of The University Of California Preservation of the heart for transplantation
AU9159891A (en) 1990-12-31 1992-08-17 University Of Florida Compositions and methods for achieving improved physiological response to exercice
US5200398A (en) 1991-09-12 1993-04-06 Mount Sinai Hospital Corporation Composition for the preservation of organs comprising glucuronic acid or a physiologically tolerated salt or ester thereof
US5279937A (en) 1992-04-30 1994-01-18 Detechnology Canada Use of macroglobulins to improve the signal-to-background ratio in affinity binding assays
US5945272A (en) 1993-06-04 1999-08-31 Biotime, Incorporated Plasma expanders and blood substitutes
US6680305B1 (en) 1993-06-04 2004-01-20 Biotime, Inc. Physiologically acceptable aqueous solutions and methods for their use
US5536751A (en) 1994-05-09 1996-07-16 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical alpha-keto carboxylic acid compositions method of making and use thereof
US5554497A (en) 1994-12-12 1996-09-10 Charlotte-Mecklenburg Hospital Authority Cardioplegic solution for arresting an organ
US5876916A (en) * 1996-03-18 1999-03-02 Case Western Reserve University Pyruvate compounds and methods for use thereof
US6028107A (en) * 1997-02-27 2000-02-22 Waugh; William Howard Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6100082A (en) 1997-09-23 2000-08-08 Hassanein; Waleed H. Perfusion apparatus and method including chemical compositions for maintaining an organ
US6153582A (en) * 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
FR2785501B1 (fr) 1998-11-10 2001-01-05 Centre Nat Rech Scient Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
US20040038192A1 (en) * 1999-04-14 2004-02-26 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
EP1207753A4 (en) 1999-06-17 2005-11-30 Univ California CONTINUOUS CARDIAL PERFUSION CONSERVATION WITH PEG-HB FOR IMPROVED HYPOTHERMAL STORAGE
CN100482278C (zh) 1999-10-26 2009-04-29 生物-水合研究室公司 微团簇液体以及制备和使用它们的方法
US6492103B1 (en) 2000-01-31 2002-12-10 Organ Recovery Systems, Inc. System for organ and tissue preservation and hypothermic blood substitution
US6569615B1 (en) 2000-04-10 2003-05-27 The United States Of America As Represented By The Department Of Veteran's Affairs Composition and methods for tissue preservation
EP1301226A4 (en) 2000-07-19 2004-07-14 Neuron Therapeutics Inc KITS AND COMPOSITIONS FOR INTRACRAMIAL PERFUSIONS
SE0002832D0 (sv) 2000-08-07 2000-08-07 Jostra Ab Cardioplegic solution
US20020132220A1 (en) * 2000-12-27 2002-09-19 Berens Kurt L. Use of selectin antagonists in organ preservation solutions
US6310094B1 (en) 2001-01-12 2001-10-30 Baxter International Inc. Ready-to-use esmolol solution
ITRM20010337A1 (it) * 2001-06-14 2002-12-16 Sigma Tau Ind Farmaceuti Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati.
US20030124503A1 (en) 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US7109169B2 (en) 2002-06-28 2006-09-19 Hobai Ion A Method for treating heart failure by inhibiting the sarcolemmal sodium/calcium exchange
MXPA05010042A (es) 2003-03-20 2006-05-25 Aquaphotonics Inc Composiciones de farmacos en micro-agregados, composiciones bioafectadoras, composiciones para el tratamiento corporal, medios de cultivo, alimentos y bebidas.
CN1791431A (zh) * 2003-03-20 2006-06-21 水光子学公司 微团粒组合物
EP1475434A1 (en) * 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
GB0311256D0 (en) 2003-05-16 2003-06-18 Bishop Gordon W Case with seat
US7087369B2 (en) 2003-12-17 2006-08-08 The Regents Of The University Of California Cornea preservation medium
WO2005103080A2 (en) 2004-04-21 2005-11-03 Albert Einstein College Of Medicine Of Yeshiva University Stable oxidation resistant powdered hemoglobin, methods of preparing same, and uses thereof
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
NZ600702A (en) * 2004-10-07 2013-12-20 Transmedics Inc Systems and methods for ex-vivo organ care
EP1830784A4 (en) 2004-12-13 2008-12-31 Aquaphotonics Inc PROCESS AND COMPOSITION AGAINST AGING
WO2006133273A2 (en) 2005-06-06 2006-12-14 Aquaphotonics, Inc. Device and method for mixing liquids and oils or particulate solids and mixtures generated therefrom
US7645742B2 (en) * 2005-06-22 2010-01-12 Advocare International, L.P. Composition for enhancing cellular energy
US7575856B2 (en) 2005-10-28 2009-08-18 The United States Of America As Represented By The Department Of Veterans Affairs Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant
US7763607B2 (en) 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
WO2008016937A2 (en) 2006-07-31 2008-02-07 Aquaphotonics, Inc. Device and method for combining oils with other fluids and mixtures generated therefrom
EP2543249B1 (en) 2007-02-17 2018-05-23 President and Fellows of Harvard College Compositions and method for tissue preservation

Also Published As

Publication number Publication date
CA2678486C (en) 2019-03-12
CA2678486A1 (en) 2008-08-21
US8945823B2 (en) 2015-02-03
EP2543249B1 (en) 2018-05-23
AU2008216612A1 (en) 2008-08-21
EP2543249A1 (en) 2013-01-09
CN105123670B (zh) 2018-12-14
US20100151435A1 (en) 2010-06-17
EP2543249A8 (en) 2013-08-14
CN105746492A (zh) 2016-07-13
US8211628B2 (en) 2012-07-03
EP3254560A1 (en) 2017-12-13
AU2008216612B2 (en) 2014-12-04
US20120282591A1 (en) 2012-11-08
US20190208768A1 (en) 2019-07-11
CN105123670A (zh) 2015-12-09
WO2008100636A3 (en) 2008-12-04
EP2124539A2 (en) 2009-12-02
AU2008216612A2 (en) 2013-01-10
US20120264103A1 (en) 2012-10-18
EP2543250A1 (en) 2013-01-09
WO2008100636A2 (en) 2008-08-21
CN101790306A (zh) 2010-07-28

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