JP2020519654A5 - - Google Patents
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- Publication number
- JP2020519654A5 JP2020519654A5 JP2019562655A JP2019562655A JP2020519654A5 JP 2020519654 A5 JP2020519654 A5 JP 2020519654A5 JP 2019562655 A JP2019562655 A JP 2019562655A JP 2019562655 A JP2019562655 A JP 2019562655A JP 2020519654 A5 JP2020519654 A5 JP 2020519654A5
- Authority
- JP
- Japan
- Prior art keywords
- solid form
- disease
- berberine
- liver
- ursodeoxycholic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023020228A JP7728295B2 (ja) | 2017-05-12 | 2023-02-13 | ベルベリンウルソデオキシコール酸の固体形態ならびにその組成物および方法 |
| JP2025134447A JP2025183212A (ja) | 2017-05-12 | 2025-08-12 | ベルベリンウルソデオキシコール酸の固体形態ならびにその組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710335467.5 | 2017-05-12 | ||
| CN201710335467.5A CN108864077B (zh) | 2017-05-12 | 2017-05-12 | 小檗碱有机酸盐的固体形式及其制备方法 |
| PCT/CN2018/086461 WO2018205987A1 (en) | 2017-05-12 | 2018-05-11 | Solid forms of berberine ursodeoxycholate and compositions and methods thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023020228A Division JP7728295B2 (ja) | 2017-05-12 | 2023-02-13 | ベルベリンウルソデオキシコール酸の固体形態ならびにその組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519654A JP2020519654A (ja) | 2020-07-02 |
| JP2020519654A5 true JP2020519654A5 (enExample) | 2021-07-26 |
| JP7685314B2 JP7685314B2 (ja) | 2025-05-29 |
Family
ID=64105207
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019562655A Active JP7685314B2 (ja) | 2017-05-12 | 2018-05-11 | ベルベリンウルソデオキシコール酸の固体形態ならびにその組成物および方法 |
| JP2023020228A Active JP7728295B2 (ja) | 2017-05-12 | 2023-02-13 | ベルベリンウルソデオキシコール酸の固体形態ならびにその組成物および方法 |
| JP2025134447A Pending JP2025183212A (ja) | 2017-05-12 | 2025-08-12 | ベルベリンウルソデオキシコール酸の固体形態ならびにその組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023020228A Active JP7728295B2 (ja) | 2017-05-12 | 2023-02-13 | ベルベリンウルソデオキシコール酸の固体形態ならびにその組成物および方法 |
| JP2025134447A Pending JP2025183212A (ja) | 2017-05-12 | 2025-08-12 | ベルベリンウルソデオキシコール酸の固体形態ならびにその組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10959999B2 (enExample) |
| EP (2) | EP3625229B9 (enExample) |
| JP (3) | JP7685314B2 (enExample) |
| KR (2) | KR102761338B1 (enExample) |
| CN (1) | CN108864077B (enExample) |
| AU (2) | AU2018264384B2 (enExample) |
| CA (1) | CA3062833A1 (enExample) |
| EA (1) | EA201992607A1 (enExample) |
| ES (1) | ES2988672T3 (enExample) |
| WO (1) | WO2018205987A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108864077B (zh) * | 2017-05-12 | 2020-05-22 | 深圳君圣泰生物技术有限公司 | 小檗碱有机酸盐的固体形式及其制备方法 |
| CN110954645B (zh) * | 2019-09-09 | 2020-09-29 | 山东琪康生物技术有限公司 | 一种高质量四黄止痢颗粒的检测方法 |
| CN112851660B (zh) * | 2019-11-12 | 2022-03-18 | 广东药科大学 | 含有小檗碱的酸-碱加成盐、其制备方法及其作为药物的用途 |
| CN111920777A (zh) * | 2020-09-18 | 2020-11-13 | 四川迪菲特药业有限公司 | 一种盐酸小檗碱片及其制备方法 |
| KR102636847B1 (ko) * | 2020-09-18 | 2024-02-19 | 경북대학교 산학협력단 | 티아민 유도체를 포함하는 이식편대숙주질환 예방 또는 치료용 약학적 조성물 |
| EP4232045A4 (en) * | 2020-10-23 | 2024-09-04 | Shenzhen Hightide Biopharmaceutical Ltd. | BERBERINE URSODEOXYCHOLATE COMPOSITIONS AND RELATED METHODS FOR THE TREATMENT OF FATTY LIVER, DIABETES AND HYPERLIPIDEMIA |
| US20230112845A1 (en) * | 2020-10-23 | 2023-04-13 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating fatty liver disease, diabetes and hyperlipidemia |
| US20230346803A1 (en) * | 2021-01-28 | 2023-11-02 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating primary sclerosing cholangitis |
| WO2022161468A1 (en) * | 2021-01-28 | 2022-08-04 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating primary sclerosing cholangitis |
| WO2023088463A1 (en) * | 2021-11-22 | 2023-05-25 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions and methods of berberine ursodeoxycholate for modulating gut microbiome compositions |
| CN114716498B (zh) * | 2022-01-20 | 2024-01-23 | 成都贝诺科成生物科技有限公司 | 一种高稳定性的失碳熊去氧胆酸小檗碱盐晶型及其制备方法 |
| CN115477647A (zh) * | 2022-10-26 | 2022-12-16 | 山西医科大学 | 小檗碱富马酸盐晶型及其制备方法和其组合物与应用 |
| WO2024120452A1 (en) * | 2022-12-07 | 2024-06-13 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions and methods for prophylaxis and treatment of covid-19 |
| TW202432104A (zh) * | 2022-12-30 | 2024-08-16 | 大陸商深圳君聖泰生物技術有限公司 | 藥物組合、藥物組合物及其應用 |
| EP4665727A1 (en) * | 2023-02-15 | 2025-12-24 | Shenzhen Hightide Biopharmaceutical Ltd. | Berberine tauroursodeoxycholate compositions and methods thereof |
| WO2024179570A1 (en) * | 2023-03-01 | 2024-09-06 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions and methods for treating severe hypertriglyceridemia |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070116643A1 (en) | 2005-07-01 | 2007-05-24 | Concert Pharmaceuticals Inc. | Novel aryloxypropanamines |
| US20070032555A1 (en) | 2005-07-01 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel aryloxyphenyl-propanamines |
| WO2007016431A2 (en) | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel benzo [d] [1,3]-dioxol derivatives |
| WO2007016361A2 (en) | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| CN102229636A (zh) * | 2011-04-21 | 2011-11-02 | 东北林业大学 | 小檗碱9位酯键偶合胆酸的新衍生物及其制备方法 |
| US9597337B2 (en) * | 2014-04-04 | 2017-03-21 | North American Biomedical Research Center Usa, Inc. | Berberine-ursodeoxycholic acid conjugate for treating the liver |
| BR112017001623B1 (pt) | 2014-07-29 | 2022-11-29 | Shenzhen Hightide Biopharmaceutical, Ltd | Sal de adição ácido-base em uma forma substancialmente pura, composição farmacêutica compreendendo uma quantidade do referido sal e seus usos |
| CN105693805A (zh) * | 2016-03-15 | 2016-06-22 | 合肥华方医药科技有限公司 | 一种胆酸类小檗碱偶合物的制备及医药用途 |
| CN108864077B (zh) * | 2017-05-12 | 2020-05-22 | 深圳君圣泰生物技术有限公司 | 小檗碱有机酸盐的固体形式及其制备方法 |
-
2017
- 2017-05-12 CN CN201710335467.5A patent/CN108864077B/zh active Active
-
2018
- 2018-05-11 EA EA201992607A patent/EA201992607A1/ru unknown
- 2018-05-11 AU AU2018264384A patent/AU2018264384B2/en active Active
- 2018-05-11 US US16/608,457 patent/US10959999B2/en active Active
- 2018-05-11 EP EP18798004.0A patent/EP3625229B9/en active Active
- 2018-05-11 KR KR1020197036227A patent/KR102761338B1/ko active Active
- 2018-05-11 KR KR1020257002617A patent/KR20250017765A/ko active Pending
- 2018-05-11 JP JP2019562655A patent/JP7685314B2/ja active Active
- 2018-05-11 EP EP23167629.7A patent/EP4234568A3/en active Pending
- 2018-05-11 CA CA3062833A patent/CA3062833A1/en active Pending
- 2018-05-11 ES ES18798004T patent/ES2988672T3/es active Active
- 2018-05-11 WO PCT/CN2018/086461 patent/WO2018205987A1/en not_active Ceased
-
2021
- 2021-02-23 US US17/182,715 patent/US12138258B2/en active Active
-
2022
- 2022-07-18 AU AU2022206685A patent/AU2022206685B2/en active Active
-
2023
- 2023-02-13 JP JP2023020228A patent/JP7728295B2/ja active Active
-
2024
- 2024-10-02 US US18/904,564 patent/US20250099456A1/en active Pending
-
2025
- 2025-08-12 JP JP2025134447A patent/JP2025183212A/ja active Pending
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