JP2015514061A5 - - Google Patents
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- Publication number
- JP2015514061A5 JP2015514061A5 JP2015500603A JP2015500603A JP2015514061A5 JP 2015514061 A5 JP2015514061 A5 JP 2015514061A5 JP 2015500603 A JP2015500603 A JP 2015500603A JP 2015500603 A JP2015500603 A JP 2015500603A JP 2015514061 A5 JP2015514061 A5 JP 2015514061A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- nrc
- haloalkyl
- halogen
- nrso
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *[C@](c1cc(cc(*)c(S(*)(=O)=O)c2)c2[n]1CC1)N1c1nc(*)c(*)cn1 Chemical compound *[C@](c1cc(cc(*)c(S(*)(=O)=O)c2)c2[n]1CC1)N1c1nc(*)c(*)cn1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261612063P | 2012-03-16 | 2012-03-16 | |
| US61/612,063 | 2012-03-16 | ||
| PCT/US2013/031250 WO2013138568A1 (en) | 2012-03-16 | 2013-03-14 | Liver x reception modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017048433A Division JP2017128589A (ja) | 2012-03-16 | 2017-03-14 | 肝臓ｘレセプターモジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514061A JP2015514061A (ja) | 2015-05-18 |
| JP2015514061A5 true JP2015514061A5 (enExample) | 2016-04-28 |
| JP6114815B2 JP6114815B2 (ja) | 2017-04-12 |
Family
ID=47997958
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500603A Expired - Fee Related JP6114815B2 (ja) | 2012-03-16 | 2013-03-14 | 肝臓ｘレセプターモジュレーター |
| JP2017048433A Pending JP2017128589A (ja) | 2012-03-16 | 2017-03-14 | 肝臓ｘレセプターモジュレーター |
| JP2018172261A Pending JP2019006813A (ja) | 2012-03-16 | 2018-09-14 | 肝臓ｘレセプターモジュレーター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017048433A Pending JP2017128589A (ja) | 2012-03-16 | 2017-03-14 | 肝臓ｘレセプターモジュレーター |
| JP2018172261A Pending JP2019006813A (ja) | 2012-03-16 | 2018-09-14 | 肝臓ｘレセプターモジュレーター |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US9073931B2 (enExample) |
| EP (1) | EP2825542B1 (enExample) |
| JP (3) | JP6114815B2 (enExample) |
| KR (1) | KR102069913B1 (enExample) |
| CN (1) | CN104203950B (enExample) |
| AU (1) | AU2013232069B2 (enExample) |
| BR (1) | BR112014022780A8 (enExample) |
| CA (1) | CA2865639C (enExample) |
| CY (1) | CY1118323T1 (enExample) |
| DK (1) | DK2825542T3 (enExample) |
| EA (1) | EA026431B1 (enExample) |
| ES (1) | ES2607113T3 (enExample) |
| HR (1) | HRP20161690T1 (enExample) |
| HU (1) | HUE030785T2 (enExample) |
| IL (2) | IL234301A (enExample) |
| LT (1) | LT2825542T (enExample) |
| ME (1) | ME02660B (enExample) |
| MX (1) | MX354820B (enExample) |
| NZ (1) | NZ629189A (enExample) |
| PL (1) | PL2825542T3 (enExample) |
| PT (1) | PT2825542T (enExample) |
| RS (1) | RS55532B1 (enExample) |
| SG (1) | SG11201405323YA (enExample) |
| SI (1) | SI2825542T1 (enExample) |
| SM (2) | SMT201700009T1 (enExample) |
| WO (1) | WO2013138568A1 (enExample) |
| ZA (1) | ZA201406390B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2607113T3 (es) * | 2012-03-16 | 2017-03-29 | Vitae Pharmaceuticals, Inc. | Moduladores de los receptores X del hígado |
| SG11201405328SA (en) | 2012-03-16 | 2014-11-27 | Vitae Pharmaceuticals Inc | Liver x receptor modulators |
| AU2015204572B2 (en) | 2014-01-10 | 2020-07-30 | Inspirna, Inc. | LXR agonists and uses thereof |
| US20170231992A1 (en) * | 2014-06-19 | 2017-08-17 | Vitae Pharmaceuticals, Inc. | Compounds for use in treating acute coronary syndrome and related conditions |
| BR112017002260A2 (pt) * | 2014-08-07 | 2017-11-21 | Vitae Pharmaceuticals Inc | derivados de piperazina como moduladores do receptor x do fígado |
| US10239849B2 (en) | 2015-11-12 | 2019-03-26 | Merck Sharp & Dohme Corp. | Cyanopyridine derivatives as liver X receptor beta agonists, compositions, and their use |
| AU2017207291B2 (en) | 2016-01-11 | 2023-06-15 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
| EP3490579B1 (en) | 2016-07-27 | 2025-09-10 | Hartis-Pharma SA | Therapeutic combinations to treat red blood cell disorders |
| EP3713575A4 (en) | 2017-11-21 | 2021-08-25 | Rgenix, Inc. | POLYMORPHS AND THEIR USES |
| US11426399B2 (en) | 2018-05-15 | 2022-08-30 | Alkahest, Inc. | Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase |
| WO2020176846A2 (en) * | 2019-02-28 | 2020-09-03 | The Rockefeller University | Apoe genotyping in cancer prognostics and treatment |
| WO2021009664A1 (en) | 2019-07-15 | 2021-01-21 | Novartis Ag | Methods for treating meibomian gland dysfunction with liver x receptor agonists |
| JP7689964B2 (ja) | 2019-12-13 | 2025-06-09 | インスピルナ，インコーポレーテッド | 金属塩及びその使用 |
| US12575690B2 (en) * | 2023-07-26 | 2026-03-17 | Brumate, Inc. | Keyed straw |
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| US4748247A (en) | 1986-10-21 | 1988-05-31 | American Home Products Corporation | 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]alkyl]alkyl]pyrido- and pyrazino-indole-1,3-dione derivatives as histamine H1 antagonists |
| AU7165591A (en) | 1990-01-22 | 1991-08-05 | E.I. Du Pont De Nemours And Company | Herbicidal sulfonylureas |
| EP0572863A1 (de) | 1992-06-05 | 1993-12-08 | F. Hoffmann-La Roche Ag | ZNS Pyrazinoindole |
| US5545636A (en) | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| EP1449529B1 (en) | 1993-12-23 | 2010-01-27 | Eli Lilly And Company | Protein Kinase C Inhibitors |
| AU3831495A (en) | 1994-10-20 | 1996-05-15 | American Home Products Corporation | Indole derivatives useful as serotonergic agents |
| CA2257937A1 (en) | 1996-06-28 | 1998-01-08 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
| JP2000514061A (ja) | 1996-06-28 | 2000-10-24 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲン受容体拮抗物質 |
| JP2000513375A (ja) | 1996-06-28 | 2000-10-10 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲンレセプター拮抗薬プロドラッグ |
| US5854245A (en) | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US6177440B1 (en) | 1996-10-30 | 2001-01-23 | Eli Lilly And Company | Substituted tricyclics |
| FR2761070B1 (fr) | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de dihydropyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique |
| FR2761073B1 (fr) | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de pyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique |
| DE19802235A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Mit tricyclischen Indolen substituierte Oxazolidinone |
| IL129484A0 (en) | 1998-04-17 | 2000-02-29 | Lilly Co Eli | Substituted tricyclics |
| MXPA01011173A (es) | 1999-05-06 | 2002-04-24 | Neurogen Corp | 4-0x0-quinolin-3-carboxamidas sustituidas: ligandos del receptor cerebro de gaba. |
| US7037916B2 (en) | 1999-07-15 | 2006-05-02 | Pharmacopeia Drug Discovery, Inc. | Pyrimidine derivatives as IL-8 receptor antagonists |
| IT1313593B1 (it) * | 1999-08-03 | 2002-09-09 | Novuspharma Spa | Derivati di 1,2-diidro-1-oxo-pirazino 1,2-a indolo. |
| AU1189201A (en) | 1999-10-22 | 2001-05-08 | Eli Lilly And Company | Therapeutic compositions including protein kinase c inhibitors |
| DE60132975T2 (de) | 2000-01-06 | 2009-02-26 | Merck Frosst Canada Inc., Kirkland | Neue substanzen und verbindungen als protease-inhibitoren |
| WO2002010169A1 (en) | 2000-07-31 | 2002-02-07 | F. Hoffmann-La Roche Ag | Piperazine derivatives |
| HUP0303316A2 (hu) | 2000-12-20 | 2004-01-28 | Bristol-Myers Squibb Pharma Company | Aril- és amino-aril-szubsztituált szerotoninreceptor agonista és antagonista ligandumok és ezeket tartalmazó gyógyszerkészítmények |
| GB0106177D0 (en) * | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| FR2829766A1 (fr) | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
| EP1487449A4 (en) | 2001-12-21 | 2006-08-23 | King Pharmaceuticals Res & Dev | TYROSYL DERIVATIVES AND THEIR USE AS P2X7 RECEPTOR MODULATORS |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| DE10320780A1 (de) | 2003-05-09 | 2005-01-20 | Bayer Healthcare Ag | Heterocyclyl-substituierte Dihydrochinazoline |
| ES2564804T3 (es) | 2004-02-12 | 2016-03-29 | Mitsubishi Tanabe Pharma Corporation | Compuesto de indazol y uso farmacéutico del mismo |
| US20070232658A1 (en) | 2004-04-08 | 2007-10-04 | Jurgen Wagner | Protein Kinase C Inhibitors for the Treatment of Autoimmune Diseases and of Transplant Rejiction |
| RU2266906C1 (ru) | 2004-04-29 | 2005-12-27 | Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") | Анелированные карбамоилазагетероциклы, способы их получения (варианты), фармацевтическая композиция, фокусированная библиотека |
| ITMI20040874A1 (it) | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici ed azaindolici con azione antitumorale |
| WO2005113526A2 (en) | 2004-05-21 | 2005-12-01 | Pfizer Products Inc. | Metabolites of 4-(3,4-dichloro-phenyl)-2-[2-(4-methyl-piperazin-1-yl)-benzylidene]-thiomorpholin-3-one |
| MX2007006896A (es) | 2004-12-15 | 2007-06-26 | Hoffmann La Roche | Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador 1 de glicina (glyt-1) para el tratamiento de la enfermedad de alzheimer. |
| NZ555491A (en) | 2005-01-03 | 2010-01-29 | Univ Siena | Aryl piperazine derivatives for the treatment of neuropsychiatric disorders |
| US7790712B2 (en) | 2005-03-17 | 2010-09-07 | Boehringer Ingelheim Pharmaceutical, Inc. | Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors |
| WO2006106423A2 (en) | 2005-04-07 | 2006-10-12 | Pfizer Inc. | Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase |
| AU2006268724B2 (en) | 2005-07-14 | 2011-06-02 | F. Hoffmann-La Roche Ag | Indol-3-carbonyl-spiro-piperidine derivatives as V1A receptor antagonists |
| WO2007035841A1 (en) | 2005-09-21 | 2007-03-29 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| EP1779848A1 (en) | 2005-10-28 | 2007-05-02 | Nikem Research S.R.L. | V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases |
| JP4882127B2 (ja) * | 2005-11-16 | 2012-02-22 | 株式会社ジェイテクト | 位置調整式ステアリング装置 |
| JP2007137810A (ja) * | 2005-11-17 | 2007-06-07 | Sankyo Co Ltd | インドール化合物を含有する医薬 |
| ES2333672T3 (es) | 2005-12-09 | 2010-02-25 | F. Hoffmann-La Roche Ag | Derivados de amida triciclica para tratamiento de obesidad. |
| US7351706B2 (en) | 2006-01-05 | 2008-04-01 | Hoffmann-La Roche Inc. | Indol-3-yl-carbonyl-spiro-piperidine derivatives |
| FR2897061B1 (fr) * | 2006-02-03 | 2010-09-03 | Sanofi Aventis | Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique. |
| RU2318818C1 (ru) | 2006-04-12 | 2008-03-10 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты) |
| US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| CN101679220A (zh) | 2007-04-09 | 2010-03-24 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
| US20110002855A1 (en) | 2007-06-25 | 2011-01-06 | Neurogen Corporation | Piperazinyl oxoalkyl tetrahydro-beta-carbolines and related analogues |
| EP2205085A1 (en) | 2007-09-25 | 2010-07-14 | Merck Sharp & Dohme Corp. | 2-aryl or heteroaryl indole derivatives |
| CN101456863B (zh) | 2007-12-14 | 2012-04-25 | 华北制药集团新药研究开发有限责任公司 | Lxr激动剂及其制备方法和用途 |
| EP2235020A1 (en) * | 2007-12-21 | 2010-10-06 | Wyeth LLC | Pyrazolo [1,5-a] pyrimidine compounds |
| EP2240485B1 (en) | 2008-01-22 | 2014-10-15 | Takeda Pharmaceutical Company Limited | Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them |
| US20090192147A1 (en) | 2008-01-30 | 2009-07-30 | Wyeth | [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES |
| US20100137320A1 (en) | 2008-02-29 | 2010-06-03 | Schering Corporation | Gamma secretase modulators |
| EP2254886B1 (en) | 2008-03-28 | 2016-05-25 | Nerviano Medical Sciences S.r.l. | 3,4-dihydro-2h-pyrazino[1,2-a]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| TW201031665A (en) | 2009-02-04 | 2010-09-01 | Gruenenthal Gmbh | Substituted indole-compound |
| EP2440542B1 (en) | 2009-06-08 | 2013-12-18 | Grünenthal GmbH | Substituted benzimidazoles, benzonthiazoles and benzoxazoles |
| WO2011005295A1 (en) | 2009-06-24 | 2011-01-13 | Arena Pharmaceuticals, Inc. | Modulators of the sphingosine-1-phosphate (s1p) receptor useful for the treatment of disorders related thereto |
| JP2013504580A (ja) | 2009-09-11 | 2013-02-07 | スノヴィオン ファーマシューティカルズ インコーポレイテッド | ヒスタミンｈ３インバースアゴニストおよびアンタゴニストとその使用方法 |
| WO2011071725A1 (en) | 2009-12-07 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core |
| WO2011109237A2 (en) | 2010-03-02 | 2011-09-09 | Emory University | Uses of noscapine and derivatives in subjects diagnosed with fap |
| KR101302474B1 (ko) | 2012-02-20 | 2013-09-02 | 주식회사 케이씨씨 | 내충격성 및 불연성이 우수한 진공단열재용 봉지부재 |
| SG11201405328SA (en) * | 2012-03-16 | 2014-11-27 | Vitae Pharmaceuticals Inc | Liver x receptor modulators |
| ES2607113T3 (es) | 2012-03-16 | 2017-03-29 | Vitae Pharmaceuticals, Inc. | Moduladores de los receptores X del hígado |
-
2013
- 2013-03-14 ES ES13712103.4T patent/ES2607113T3/es active Active
- 2013-03-14 HR HRP20161690TT patent/HRP20161690T1/hr unknown
- 2013-03-14 US US14/385,671 patent/US9073931B2/en active Active
- 2013-03-14 AU AU2013232069A patent/AU2013232069B2/en not_active Ceased
- 2013-03-14 SI SI201330426A patent/SI2825542T1/sl unknown
- 2013-03-14 BR BR112014022780A patent/BR112014022780A8/pt not_active Application Discontinuation
- 2013-03-14 RS RS20161114A patent/RS55532B1/sr unknown
- 2013-03-14 SM SM20170009T patent/SMT201700009T1/it unknown
- 2013-03-14 PT PT137121034T patent/PT2825542T/pt unknown
- 2013-03-14 DK DK13712103.4T patent/DK2825542T3/en active
- 2013-03-14 HU HUE13712103A patent/HUE030785T2/en unknown
- 2013-03-14 CA CA2865639A patent/CA2865639C/en not_active Expired - Fee Related
- 2013-03-14 JP JP2015500603A patent/JP6114815B2/ja not_active Expired - Fee Related
- 2013-03-14 KR KR1020147028756A patent/KR102069913B1/ko not_active Expired - Fee Related
- 2013-03-14 EA EA201491610A patent/EA026431B1/ru unknown
- 2013-03-14 EP EP13712103.4A patent/EP2825542B1/en active Active
- 2013-03-14 MX MX2014011104A patent/MX354820B/es active IP Right Grant
- 2013-03-14 SG SG11201405323YA patent/SG11201405323YA/en unknown
- 2013-03-14 LT LTEP13712103.4T patent/LT2825542T/lt unknown
- 2013-03-14 PL PL13712103T patent/PL2825542T3/pl unknown
- 2013-03-14 NZ NZ629189A patent/NZ629189A/en not_active IP Right Cessation
- 2013-03-14 CN CN201380014301.3A patent/CN104203950B/zh not_active Expired - Fee Related
- 2013-03-14 ME MEP-2016-289A patent/ME02660B/me unknown
- 2013-03-14 WO PCT/US2013/031250 patent/WO2013138568A1/en not_active Ceased
-
2014
- 2014-08-26 IL IL234301A patent/IL234301A/en active IP Right Grant
- 2014-08-29 ZA ZA201406390A patent/ZA201406390B/en unknown
-
2015
- 2015-05-26 US US14/721,262 patent/US9416135B2/en active Active
-
2016
- 2016-07-07 US US15/204,422 patent/US9707232B2/en active Active
- 2016-12-12 CY CY20161101280T patent/CY1118323T1/el unknown
-
2017
- 2017-01-10 SM SM201700009T patent/SMT201700009B/it unknown
- 2017-03-14 JP JP2017048433A patent/JP2017128589A/ja active Pending
- 2017-04-25 IL IL251897A patent/IL251897A0/en unknown
- 2017-06-09 US US15/618,297 patent/US20180117041A1/en not_active Abandoned
-
2018
- 2018-09-14 JP JP2018172261A patent/JP2019006813A/ja active Pending
-
2019
- 2019-05-21 US US16/418,339 patent/US20200138812A1/en not_active Abandoned
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