JP2015514061A5 - - Google Patents

Download PDF

Info

Publication number
JP2015514061A5
JP2015514061A5 JP2015500603A JP2015500603A JP2015514061A5 JP 2015514061 A5 JP2015514061 A5 JP 2015514061A5 JP 2015500603 A JP2015500603 A JP 2015500603A JP 2015500603 A JP2015500603 A JP 2015500603A JP 2015514061 A5 JP2015514061 A5 JP 2015514061A5
Authority
JP
Japan
Prior art keywords
alkyl
nrc
haloalkyl
halogen
nrso
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015500603A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015514061A (ja
JP6114815B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/031250 external-priority patent/WO2013138568A1/en
Publication of JP2015514061A publication Critical patent/JP2015514061A/ja
Publication of JP2015514061A5 publication Critical patent/JP2015514061A5/ja
Application granted granted Critical
Publication of JP6114815B2 publication Critical patent/JP6114815B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015500603A 2012-03-16 2013-03-14 肝臓ｘレセプターモジュレーター Expired - Fee Related JP6114815B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261612063P 2012-03-16 2012-03-16
US61/612,063 2012-03-16
PCT/US2013/031250 WO2013138568A1 (en) 2012-03-16 2013-03-14 Liver x reception modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017048433A Division JP2017128589A (ja) 2012-03-16 2017-03-14 肝臓ｘレセプターモジュレーター

Publications (3)

Publication Number Publication Date
JP2015514061A JP2015514061A (ja) 2015-05-18
JP2015514061A5 true JP2015514061A5 (enExample) 2016-04-28
JP6114815B2 JP6114815B2 (ja) 2017-04-12

Family

ID=47997958

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015500603A Expired - Fee Related JP6114815B2 (ja) 2012-03-16 2013-03-14 肝臓ｘレセプターモジュレーター
JP2017048433A Pending JP2017128589A (ja) 2012-03-16 2017-03-14 肝臓ｘレセプターモジュレーター
JP2018172261A Pending JP2019006813A (ja) 2012-03-16 2018-09-14 肝臓ｘレセプターモジュレーター

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017048433A Pending JP2017128589A (ja) 2012-03-16 2017-03-14 肝臓ｘレセプターモジュレーター
JP2018172261A Pending JP2019006813A (ja) 2012-03-16 2018-09-14 肝臓ｘレセプターモジュレーター

Country Status (27)

Country Link
US (5) US9073931B2 (enExample)
EP (1) EP2825542B1 (enExample)
JP (3) JP6114815B2 (enExample)
KR (1) KR102069913B1 (enExample)
CN (1) CN104203950B (enExample)
AU (1) AU2013232069B2 (enExample)
BR (1) BR112014022780A8 (enExample)
CA (1) CA2865639C (enExample)
CY (1) CY1118323T1 (enExample)
DK (1) DK2825542T3 (enExample)
EA (1) EA026431B1 (enExample)
ES (1) ES2607113T3 (enExample)
HR (1) HRP20161690T1 (enExample)
HU (1) HUE030785T2 (enExample)
IL (2) IL234301A (enExample)
LT (1) LT2825542T (enExample)
ME (1) ME02660B (enExample)
MX (1) MX354820B (enExample)
NZ (1) NZ629189A (enExample)
PL (1) PL2825542T3 (enExample)
PT (1) PT2825542T (enExample)
RS (1) RS55532B1 (enExample)
SG (1) SG11201405323YA (enExample)
SI (1) SI2825542T1 (enExample)
SM (2) SMT201700009T1 (enExample)
WO (1) WO2013138568A1 (enExample)
ZA (1) ZA201406390B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013138568A1 (en) 2012-03-16 2013-09-19 Vitae Pharmaceuticals, Inc. Liver x reception modulators
WO2013138565A1 (en) 2012-03-16 2013-09-19 Vitae Pharmaceuticals, Inc. Liver x receptor modulators
EP3091970B1 (en) 2014-01-10 2020-10-28 Rgenix, Inc. Lxr agonists and uses thereof
WO2015195922A1 (en) * 2014-06-19 2015-12-23 Vitae Pharmaceuticals, Inc. Compounds for use in treating acute coronary syndrome and related conditions
JP6605583B2 (ja) * 2014-08-07 2019-11-13 ヴァイティー ファーマシューティカルズ，エルエルシー 肝臓ｘ受容体モジュレーターとしてのピペラジン誘導体
US10239849B2 (en) 2015-11-12 2019-03-26 Merck Sharp & Dohme Corp. Cyanopyridine derivatives as liver X receptor beta agonists, compositions, and their use
JP7025022B2 (ja) 2016-01-11 2022-02-24 ザ ロックフェラー ユニバーシティー 骨髄系由来抑制細胞関連障害の治療のための方法
WO2018019911A1 (en) 2016-07-27 2018-02-01 Hartis-Pharma Sarl Therapeutic combinations to treat red blood cell disorders
EP3713575A4 (en) 2017-11-21 2021-08-25 Rgenix, Inc. POLYMORPHS AND THEIR USES
AU2019271122A1 (en) 2018-05-15 2020-11-12 Alkahest, Inc. Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase
WO2020176846A2 (en) * 2019-02-28 2020-09-03 The Rockefeller University Apoe genotyping in cancer prognostics and treatment
US20220257596A1 (en) 2019-07-15 2022-08-18 Novartis Ag Methods for treating meibomian gland dysfunction with liver x receptor agonists
PL4073025T3 (pl) 2019-12-13 2024-09-16 Inspirna, Inc. Sole metali i ich zastosowania

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748247A (en) 1986-10-21 1988-05-31 American Home Products Corporation 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]alkyl]alkyl]pyrido- and pyrazino-indole-1,3-dione derivatives as histamine H1 antagonists
JPH05503518A (ja) 1990-01-22 1993-06-10 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 除草性スルホニル尿素
EP0572863A1 (de) 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag ZNS Pyrazinoindole
US5545636A (en) 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
WO1995017182A1 (en) 1993-12-23 1995-06-29 Eli Lilly And Company Protein kinase c inhibitors
AU3831495A (en) 1994-10-20 1996-05-15 American Home Products Corporation Indole derivatives useful as serotonergic agents
CA2258093A1 (en) 1996-06-28 1998-01-08 Mark E. Duggan Fibrinogen receptor antagonists
CA2257937A1 (en) 1996-06-28 1998-01-08 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5854245A (en) 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1998000401A1 (en) 1996-06-28 1998-01-08 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US6177440B1 (en) 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
FR2761070B1 (fr) 1997-03-20 1999-04-23 Synthelabo Derives de dihydropyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique
FR2761073B1 (fr) 1997-03-20 1999-04-23 Synthelabo Derives de pyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique
DE19802235A1 (de) 1998-01-22 1999-07-29 Bayer Ag Mit tricyclischen Indolen substituierte Oxazolidinone
IL129484A0 (en) 1998-04-17 2000-02-29 Lilly Co Eli Substituted tricyclics
JP2002544197A (ja) 1999-05-06 2002-12-24 ニューロゲン コーポレイション 置換４−オキソ−キノリン−３−カルボキサミド：ｇａｂａ脳受容体リガンド
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
IT1313593B1 (it) * 1999-08-03 2002-09-09 Novuspharma Spa Derivati di 1,2-diidro-1-oxo-pirazino 1,2-a indolo.
AU1189201A (en) 1999-10-22 2001-05-08 Eli Lilly And Company Therapeutic compositions including protein kinase c inhibitors
CA2396257A1 (en) 2000-01-06 2001-07-12 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Novel compounds and compositions as protease inhibitors
CN1277828C (zh) 2000-07-31 2006-10-04 霍夫曼-拉罗奇有限公司 哌嗪衍生物
JP2005506280A (ja) 2000-12-20 2005-03-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー アリールおよびアミノアリール置換セロトニン受容体アゴニストおよびアンタゴニストリガンド
GB0106177D0 (en) * 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
FR2829766A1 (fr) 2001-09-14 2003-03-21 Lipha Derives d'oxamates comportant un heterocycle azote diversement substitue
CN1617725A (zh) 2001-12-21 2005-05-18 王者制药研究发展有限公司 酪氨酰衍生物及其作为p2x7受体调节剂的用途
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
EP1714961B1 (en) 2004-02-12 2015-12-09 Mitsubishi Tanabe Pharma Corporation Indazole compound and pharmaceutical use thereof
BRPI0509754A (pt) 2004-04-08 2007-10-16 Novartis Ag inibidores de proteìna quinase c para o tratamento de doenças auto-imunes e de rejeição a transplante
RU2266906C1 (ru) 2004-04-29 2005-12-27 Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") Анелированные карбамоилазагетероциклы, способы их получения (варианты), фармацевтическая композиция, фокусированная библиотека
ITMI20040874A1 (it) 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici ed azaindolici con azione antitumorale
WO2005113526A2 (en) 2004-05-21 2005-12-01 Pfizer Products Inc. Metabolites of 4-(3,4-dichloro-phenyl)-2-[2-(4-methyl-piperazin-1-yl)-benzylidene]-thiomorpholin-3-one
MX2007006896A (es) 2004-12-15 2007-06-26 Hoffmann La Roche Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador 1 de glicina (glyt-1) para el tratamiento de la enfermedad de alzheimer.
WO2006072608A2 (en) 2005-01-03 2006-07-13 Universitá Degli Studi Di Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
US7790712B2 (en) 2005-03-17 2010-09-07 Boehringer Ingelheim Pharmaceutical, Inc. Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors
WO2006106423A2 (en) 2005-04-07 2006-10-12 Pfizer Inc. Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase
ES2317558T3 (es) 2005-07-14 2009-04-16 F. Hoffmann-La Roche Ag Derivados de indol-3-il-espiro-piperidina como antagonistas del receptr v1a.
WO2007035841A1 (en) 2005-09-21 2007-03-29 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
JP4882127B2 (ja) * 2005-11-16 2012-02-22 株式会社ジェイテクト 位置調整式ステアリング装置
JP2007137810A (ja) * 2005-11-17 2007-06-07 Sankyo Co Ltd インドール化合物を含有する医薬
DE602006010433D1 (de) 2005-12-09 2009-12-24 Hoffmann La Roche Für die behandlung von obesitas geeignete tricyclische amidderivate
US7351706B2 (en) 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
FR2897061B1 (fr) * 2006-02-03 2010-09-03 Sanofi Aventis Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique.
RU2318818C1 (ru) 2006-04-12 2008-03-10 Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты)
US8129527B2 (en) 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
CN101679220A (zh) 2007-04-09 2010-03-24 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
WO2009003003A2 (en) 2007-06-25 2008-12-31 Neurogen Corporation Piperazinyl oxoalkyl tetrahydro-beta-carbolines and related analogues
WO2009042092A1 (en) 2007-09-25 2009-04-02 Merck & Co., Inc. 2-aryl or heteroaryl indole derivatives
CN101456863B (zh) * 2007-12-14 2012-04-25 华北制药集团新药研究开发有限责任公司 Lxr激动剂及其制备方法和用途
BRPI0822239A2 (pt) * 2007-12-21 2015-06-30 Wyeth Llc Composto de pirazolo[1,5-a] pirimidina
KR20100130596A (ko) 2008-01-22 2010-12-13 다케다 야쿠힌 고교 가부시키가이샤 부신 피질 자극 호르몬 방출 인자 길항 작용을 갖는 3 환식 화합물 및 이를 함유하는 약학 조성물
US20090192147A1 (en) 2008-01-30 2009-07-30 Wyeth [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
US20100137320A1 (en) 2008-02-29 2010-06-03 Schering Corporation Gamma secretase modulators
US8207165B2 (en) 2008-03-28 2012-06-26 Nerviano Medical Sciences S.R.L. 3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
TW201031665A (en) 2009-02-04 2010-09-01 Gruenenthal Gmbh Substituted indole-compound
CA2764622A1 (en) 2009-06-08 2010-12-16 Stefan Schunk Substituted benzimidazoles, benzothiazoles and benzoxazoles
WO2011005295A1 (en) 2009-06-24 2011-01-13 Arena Pharmaceuticals, Inc. Modulators of the sphingosine-1-phosphate (s1p) receptor useful for the treatment of disorders related thereto
EP2475664A2 (en) 2009-09-11 2012-07-18 Sunovion Pharmaceuticals Inc. Histamine h3 inverse agonists and antagonists and methods of use thereof
JP5643332B2 (ja) 2009-12-07 2014-12-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピロロピリジンまたはベンゾイミダゾールコアを含有する複素環化合物
WO2011109237A2 (en) 2010-03-02 2011-09-09 Emory University Uses of noscapine and derivatives in subjects diagnosed with fap
KR101302474B1 (ko) * 2012-02-20 2013-09-02 주식회사 케이씨씨 내충격성 및 불연성이 우수한 진공단열재용 봉지부재
WO2013138565A1 (en) * 2012-03-16 2013-09-19 Vitae Pharmaceuticals, Inc. Liver x receptor modulators
WO2013138568A1 (en) * 2012-03-16 2013-09-19 Vitae Pharmaceuticals, Inc. Liver x reception modulators

Similar Documents

Publication Publication Date Title
JP2015514061A5 (enExample)
JP2015510892A5 (enExample)
ME02660B (me) Modulator! jetrenog x receptora
HRP20161196T1 (hr) Modulatori jetrenog receptora x
JP2020519654A5 (enExample)
RU2017121588A (ru) Конденсированные бициклические соединения для лечения заболевания
ME01982B (me) 2-anilinobenzimidazol-6-karboksamidi kao anti-inflamatorni agensi
HRP20230052T1 (hr) Spojevi derivata 1,3,4-oksadiazol sulfonamida kao inhibitori histonske deacetilaze 6, i farmaceutski pripravak koji ih sadrži
WO2014174524A8 (en) A novel composition for nonalcoholic fatty liver disease (nafld)
JP2017531688A5 (enExample)
JP2013542261A5 (enExample)
JP2014507455A5 (enExample)
HRP20181048T1 (hr) Neuroaktivni 19-alkoksi-17-supstituirani steroidi, korisni u postupcima liječenja
JP2015517579A5 (enExample)
AR084824A1 (es) Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas
JP2017522277A5 (enExample)
JP2014506907A5 (enExample)
JP2013522367A5 (enExample)
RU2021100040A (ru) Конденсированные бициклические соединения для лечения заболевания
JP2017537937A5 (enExample)
JP2014516033A5 (enExample)
ME02685B (me) Kristalni oblik pemirolasta
WO2012116176A3 (en) Asymmetric ureas and medical uses thereof
JP2016540749A5 (enExample)
JP2015514781A5 (enExample)