MX354820B - Moduladores del receptor x del higado. - Google Patents
Moduladores del receptor x del higado.Info
- Publication number
- MX354820B MX354820B MX2014011104A MX2014011104A MX354820B MX 354820 B MX354820 B MX 354820B MX 2014011104 A MX2014011104 A MX 2014011104A MX 2014011104 A MX2014011104 A MX 2014011104A MX 354820 B MX354820 B MX 354820B
- Authority
- MX
- Mexico
- Prior art keywords
- liver
- compounds
- modulators
- reception
- reception modulators
- Prior art date
Links
- 210000004185 liver Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000004311 liver X receptors Human genes 0.000 abstract 2
- 108090000865 liver X receptors Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
Abstract
Se proveen aquí compuestos novedosos y sales farmacéuticamente aceptables de los mismos que son moduladores del receptor X del hígado; también se proveen composiciones que comprenden los compuestos de la invención y un vehículo; adicionalmente se describe el uso de estos compuestos y métodos de tratamiento de una enfermedad o trastorno asociado con el receptor X del hígado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261612063P | 2012-03-16 | 2012-03-16 | |
PCT/US2013/031250 WO2013138568A1 (en) | 2012-03-16 | 2013-03-14 | Liver x reception modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014011104A MX2014011104A (es) | 2014-12-05 |
MX354820B true MX354820B (es) | 2018-03-21 |
Family
ID=47997958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014011104A MX354820B (es) | 2012-03-16 | 2013-03-14 | Moduladores del receptor x del higado. |
Country Status (28)
Country | Link |
---|---|
US (5) | US9073931B2 (es) |
EP (1) | EP2825542B1 (es) |
JP (3) | JP6114815B2 (es) |
KR (1) | KR102069913B1 (es) |
CN (1) | CN104203950B (es) |
AU (1) | AU2013232069B2 (es) |
BR (1) | BR112014022780A8 (es) |
CA (1) | CA2865639C (es) |
CY (1) | CY1118323T1 (es) |
DK (1) | DK2825542T3 (es) |
EA (1) | EA026431B1 (es) |
ES (1) | ES2607113T3 (es) |
HK (1) | HK1206332A1 (es) |
HR (1) | HRP20161690T1 (es) |
HU (1) | HUE030785T2 (es) |
IL (2) | IL234301A (es) |
LT (1) | LT2825542T (es) |
ME (1) | ME02660B (es) |
MX (1) | MX354820B (es) |
NZ (1) | NZ629189A (es) |
PL (1) | PL2825542T3 (es) |
PT (1) | PT2825542T (es) |
RS (1) | RS55532B1 (es) |
SG (1) | SG11201405323YA (es) |
SI (1) | SI2825542T1 (es) |
SM (1) | SMT201700009B (es) |
WO (1) | WO2013138568A1 (es) |
ZA (1) | ZA201406390B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2825542T (pt) | 2012-03-16 | 2016-12-20 | Vitae Pharmaceuticals Inc | Modeladores do recetor x do fígado |
US9006244B2 (en) | 2012-03-16 | 2015-04-14 | Vitae Pharmaceuticals, Inc. | Liver X receptor modulators |
EP3091970B1 (en) | 2014-01-10 | 2020-10-28 | Rgenix, Inc. | Lxr agonists and uses thereof |
US20170231992A1 (en) * | 2014-06-19 | 2017-08-17 | Vitae Pharmaceuticals, Inc. | Compounds for use in treating acute coronary syndrome and related conditions |
SG11201700655WA (en) * | 2014-08-07 | 2017-02-27 | Vitae Pharmaceuticals Inc | Piperazine derivatives as liver x receptor modulators |
WO2017083216A1 (en) * | 2015-11-12 | 2017-05-18 | Merck Sharp & Dohme Corp. | Cyanopyridine derivatives as liver x receptor beta agonists, compositions, and their use |
CA3010883A1 (en) | 2016-01-11 | 2017-07-20 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
WO2018019911A1 (en) | 2016-07-27 | 2018-02-01 | Hartis-Pharma Sarl | Therapeutic combinations to treat red blood cell disorders |
US11214536B2 (en) | 2017-11-21 | 2022-01-04 | Inspirna, Inc. | Polymorphs and uses thereof |
BR112020023001A2 (pt) | 2018-05-15 | 2021-02-02 | Alkahest, Inc. | tratamento de doença associada ao envelhecimento com moduladores da leucotrieno a4 hidrolase |
JP2022523773A (ja) * | 2019-02-28 | 2022-04-26 | ザ ロックフェラー ユニバーシティー | がんの予後及び治療におけるapoe遺伝子型決定 |
CN114126618A (zh) | 2019-07-15 | 2022-03-01 | 诺华股份有限公司 | 用肝脏x受体激动剂治疗睑板腺功能障碍的方法 |
JP2023509845A (ja) | 2019-12-13 | 2023-03-10 | インスピルナ,インコーポレーテッド | 金属塩及びその使用 |
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