MX2014011104A - Moduladores del receptor x del higado. - Google Patents

Moduladores del receptor x del higado.

Info

Publication number
MX2014011104A
MX2014011104A MX2014011104A MX2014011104A MX2014011104A MX 2014011104 A MX2014011104 A MX 2014011104A MX 2014011104 A MX2014011104 A MX 2014011104A MX 2014011104 A MX2014011104 A MX 2014011104A MX 2014011104 A MX2014011104 A MX 2014011104A
Authority
MX
Mexico
Prior art keywords
liver
compounds
modulators
reception
reception modulators
Prior art date
Application number
MX2014011104A
Other languages
English (en)
Other versions
MX354820B (es
Inventor
Katerina Leftheris
Colin Tice
Wei Zhao
Suresh B Singh
Linghang Zhuang
Yajun Zheng
Chengguo Dong
Yi Fan
Stephen Lotesta
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of MX2014011104A publication Critical patent/MX2014011104A/es
Publication of MX354820B publication Critical patent/MX354820B/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
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  • Neurology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
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  • Transplantation (AREA)

Abstract

Se proveen aquí compuestos novedosos y sales farmacéuticamente aceptables de los mismos que son moduladores del receptor X del hígado; también se proveen composiciones que comprenden los compuestos de la invención y un vehículo; adicionalmente se describe el uso de estos compuestos y métodos de tratamiento de una enfermedad o trastorno asociado con el receptor X del hígado.
MX2014011104A 2012-03-16 2013-03-14 Moduladores del receptor x del higado. MX354820B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261612063P 2012-03-16 2012-03-16
PCT/US2013/031250 WO2013138568A1 (en) 2012-03-16 2013-03-14 Liver x reception modulators

Publications (2)

Publication Number Publication Date
MX2014011104A true MX2014011104A (es) 2014-12-05
MX354820B MX354820B (es) 2018-03-21

Family

ID=47997958

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014011104A MX354820B (es) 2012-03-16 2013-03-14 Moduladores del receptor x del higado.

Country Status (28)

Country Link
US (5) US9073931B2 (es)
EP (1) EP2825542B1 (es)
JP (3) JP6114815B2 (es)
KR (1) KR102069913B1 (es)
CN (1) CN104203950B (es)
AU (1) AU2013232069B2 (es)
BR (1) BR112014022780A8 (es)
CA (1) CA2865639C (es)
CY (1) CY1118323T1 (es)
DK (1) DK2825542T3 (es)
EA (1) EA026431B1 (es)
ES (1) ES2607113T3 (es)
HK (1) HK1206332A1 (es)
HR (1) HRP20161690T1 (es)
HU (1) HUE030785T2 (es)
IL (2) IL234301A (es)
LT (1) LT2825542T (es)
ME (1) ME02660B (es)
MX (1) MX354820B (es)
NZ (1) NZ629189A (es)
PL (1) PL2825542T3 (es)
PT (1) PT2825542T (es)
RS (1) RS55532B1 (es)
SG (1) SG11201405323YA (es)
SI (1) SI2825542T1 (es)
SM (1) SMT201700009B (es)
WO (1) WO2013138568A1 (es)
ZA (1) ZA201406390B (es)

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