CN104203950B - 肝x受体调节剂 - Google Patents
肝x受体调节剂 Download PDFInfo
- Publication number
- CN104203950B CN104203950B CN201380014301.3A CN201380014301A CN104203950B CN 104203950 B CN104203950 B CN 104203950B CN 201380014301 A CN201380014301 A CN 201380014301A CN 104203950 B CN104203950 B CN 104203950B
- Authority
- CN
- China
- Prior art keywords
- isopropyl
- methylsulfonyl
- disease
- mixture
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 CC(C)[C@@](c1cc(cc(CO)c(S(C)(=O)=O)c2)c2[n]1CC1)N1c(nc1)nc(C(F)(F)F)c1C(**)=O Chemical compound CC(C)[C@@](c1cc(cc(CO)c(S(C)(=O)=O)c2)c2[n]1CC1)N1c(nc1)nc(C(F)(F)F)c1C(**)=O 0.000 description 9
- FCCWMBKRZXINDB-FQEVSTJZSA-N CC(C)[C@@H](c([n](CC1)c2c3)cc2cc(CO)c3S(C)(=O)=O)N1c(nc1)nc(C(F)(F)F)c1C(C)=O Chemical compound CC(C)[C@@H](c([n](CC1)c2c3)cc2cc(CO)c3S(C)(=O)=O)N1c(nc1)nc(C(F)(F)F)c1C(C)=O FCCWMBKRZXINDB-FQEVSTJZSA-N 0.000 description 1
- JFJWQTWGAGTYDB-QGZVFWFLSA-N CC(C)[C@H](C(N(CC1)c(cc(c(C(OC)=O)c2)S(C)(=O)=O)c2N)=O)N1C(OC(C)(C)C)=O Chemical compound CC(C)[C@H](C(N(CC1)c(cc(c(C(OC)=O)c2)S(C)(=O)=O)c2N)=O)N1C(OC(C)(C)C)=O JFJWQTWGAGTYDB-QGZVFWFLSA-N 0.000 description 1
- SDRWUUREIQCDDC-SECBINFHSA-N CC(C)[C@H](C(NCC1)=O)N1C(OC(C)(C)C)=O Chemical compound CC(C)[C@H](C(NCC1)=O)N1C(OC(C)(C)C)=O SDRWUUREIQCDDC-SECBINFHSA-N 0.000 description 1
- LVVZIICHFJJLNA-CQSZACIVSA-N CC(C)[C@H](C(NCc1ccccc1)=O)NC(OC(C)(C)C)=O Chemical compound CC(C)[C@H](C(NCc1ccccc1)=O)NC(OC(C)(C)C)=O LVVZIICHFJJLNA-CQSZACIVSA-N 0.000 description 1
- WNUZZCLXNSKBJU-GOSISDBHSA-N CC(C)[C@H](c1cc(cc(CO)c(SC)c2)c2[n]1CC1)N1c(nc1)nc(C(F)(F)F)c1C(N)=O Chemical compound CC(C)[C@H](c1cc(cc(CO)c(SC)c2)c2[n]1CC1)N1c(nc1)nc(C(F)(F)F)c1C(N)=O WNUZZCLXNSKBJU-GOSISDBHSA-N 0.000 description 1
- KSUUZTVQFBVBED-HXUWFJFHSA-N CC(C)[C@H](c1cc(cc(CO)c(SC)c2)c2[n]1CC1)N1c(nc1)nc(C)c1C(N)=O Chemical compound CC(C)[C@H](c1cc(cc(CO)c(SC)c2)c2[n]1CC1)N1c(nc1)nc(C)c1C(N)=O KSUUZTVQFBVBED-HXUWFJFHSA-N 0.000 description 1
- NJQFXUZMDAIDHD-MRXNPFEDSA-N CC(C)[C@H](c1nc(cc(CO)c(C)c2)c2[nH]1)Nc(nc1)nc(C(F)(F)F)c1C(N(C)C)=O Chemical compound CC(C)[C@H](c1nc(cc(CO)c(C)c2)c2[nH]1)Nc(nc1)nc(C(F)(F)F)c1C(N(C)C)=O NJQFXUZMDAIDHD-MRXNPFEDSA-N 0.000 description 1
- ZWGZCSXCYWYFTL-QGZVFWFLSA-N CC(C)[C@H](c1nc(cc(CO)c(S(C)(=O)=O)c2)c2[n]1CC1)N1c(nc1)nc(C(F)(F)F)c1C(OC)=O Chemical compound CC(C)[C@H](c1nc(cc(CO)c(S(C)(=O)=O)c2)c2[n]1CC1)N1c(nc1)nc(C(F)(F)F)c1C(OC)=O ZWGZCSXCYWYFTL-QGZVFWFLSA-N 0.000 description 1
- XGGSOUTYVGCEJO-UHFFFAOYSA-N CCOC(c1c(C(F)(F)F)nc(N2C(C(C)C)c3cc(cc(CO)c(S(C)(=O)=O)c4)c4[n]3CC2)nc1)=O Chemical compound CCOC(c1c(C(F)(F)F)nc(N2C(C(C)C)c3cc(cc(CO)c(S(C)(=O)=O)c4)c4[n]3CC2)nc1)=O XGGSOUTYVGCEJO-UHFFFAOYSA-N 0.000 description 1
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261612063P | 2012-03-16 | 2012-03-16 | |
| US61/612,063 | 2012-03-16 | ||
| PCT/US2013/031250 WO2013138568A1 (en) | 2012-03-16 | 2013-03-14 | Liver x reception modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104203950A CN104203950A (zh) | 2014-12-10 |
| CN104203950B true CN104203950B (zh) | 2016-08-24 |
Family
ID=47997958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380014301.3A Expired - Fee Related CN104203950B (zh) | 2012-03-16 | 2013-03-14 | 肝x受体调节剂 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US9073931B2 (enExample) |
| EP (1) | EP2825542B1 (enExample) |
| JP (3) | JP6114815B2 (enExample) |
| KR (1) | KR102069913B1 (enExample) |
| CN (1) | CN104203950B (enExample) |
| AU (1) | AU2013232069B2 (enExample) |
| BR (1) | BR112014022780A8 (enExample) |
| CA (1) | CA2865639C (enExample) |
| CY (1) | CY1118323T1 (enExample) |
| DK (1) | DK2825542T3 (enExample) |
| EA (1) | EA026431B1 (enExample) |
| ES (1) | ES2607113T3 (enExample) |
| HR (1) | HRP20161690T1 (enExample) |
| HU (1) | HUE030785T2 (enExample) |
| IL (2) | IL234301A (enExample) |
| LT (1) | LT2825542T (enExample) |
| ME (1) | ME02660B (enExample) |
| MX (1) | MX354820B (enExample) |
| NZ (1) | NZ629189A (enExample) |
| PL (1) | PL2825542T3 (enExample) |
| PT (1) | PT2825542T (enExample) |
| RS (1) | RS55532B1 (enExample) |
| SG (1) | SG11201405323YA (enExample) |
| SI (1) | SI2825542T1 (enExample) |
| SM (2) | SMT201700009T1 (enExample) |
| WO (1) | WO2013138568A1 (enExample) |
| ZA (1) | ZA201406390B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2607113T3 (es) * | 2012-03-16 | 2017-03-29 | Vitae Pharmaceuticals, Inc. | Moduladores de los receptores X del hígado |
| SG11201405328SA (en) | 2012-03-16 | 2014-11-27 | Vitae Pharmaceuticals Inc | Liver x receptor modulators |
| AU2015204572B2 (en) | 2014-01-10 | 2020-07-30 | Inspirna, Inc. | LXR agonists and uses thereof |
| US20170231992A1 (en) * | 2014-06-19 | 2017-08-17 | Vitae Pharmaceuticals, Inc. | Compounds for use in treating acute coronary syndrome and related conditions |
| BR112017002260A2 (pt) * | 2014-08-07 | 2017-11-21 | Vitae Pharmaceuticals Inc | derivados de piperazina como moduladores do receptor x do fígado |
| US10239849B2 (en) | 2015-11-12 | 2019-03-26 | Merck Sharp & Dohme Corp. | Cyanopyridine derivatives as liver X receptor beta agonists, compositions, and their use |
| AU2017207291B2 (en) | 2016-01-11 | 2023-06-15 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
| EP3490579B1 (en) | 2016-07-27 | 2025-09-10 | Hartis-Pharma SA | Therapeutic combinations to treat red blood cell disorders |
| EP3713575A4 (en) | 2017-11-21 | 2021-08-25 | Rgenix, Inc. | POLYMORPHS AND THEIR USES |
| US11426399B2 (en) | 2018-05-15 | 2022-08-30 | Alkahest, Inc. | Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase |
| WO2020176846A2 (en) * | 2019-02-28 | 2020-09-03 | The Rockefeller University | Apoe genotyping in cancer prognostics and treatment |
| WO2021009664A1 (en) | 2019-07-15 | 2021-01-21 | Novartis Ag | Methods for treating meibomian gland dysfunction with liver x receptor agonists |
| JP7689964B2 (ja) | 2019-12-13 | 2025-06-09 | インスピルナ，インコーポレーテッド | 金属塩及びその使用 |
| US12575690B2 (en) * | 2023-07-26 | 2026-03-17 | Brumate, Inc. | Keyed straw |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101456863A (zh) * | 2007-12-14 | 2009-06-17 | 华北制药集团新药研究开发有限责任公司 | 新的lxr激动剂及其制备方法和用途 |
| WO2009086129A1 (en) * | 2007-12-21 | 2009-07-09 | Wyeth | Pyrazolo [1,5-a] pyrimidine compounds |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4748247A (en) | 1986-10-21 | 1988-05-31 | American Home Products Corporation | 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]alkyl]alkyl]pyrido- and pyrazino-indole-1,3-dione derivatives as histamine H1 antagonists |
| AU7165591A (en) | 1990-01-22 | 1991-08-05 | E.I. Du Pont De Nemours And Company | Herbicidal sulfonylureas |
| EP0572863A1 (de) | 1992-06-05 | 1993-12-08 | F. Hoffmann-La Roche Ag | ZNS Pyrazinoindole |
| US5545636A (en) | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| EP1449529B1 (en) | 1993-12-23 | 2010-01-27 | Eli Lilly And Company | Protein Kinase C Inhibitors |
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