JP2015500257A5 - - Google Patents
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- Publication number
- JP2015500257A5 JP2015500257A5 JP2014545204A JP2014545204A JP2015500257A5 JP 2015500257 A5 JP2015500257 A5 JP 2015500257A5 JP 2014545204 A JP2014545204 A JP 2014545204A JP 2014545204 A JP2014545204 A JP 2014545204A JP 2015500257 A5 JP2015500257 A5 JP 2015500257A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- phenyl
- dementia
- alkyloxy
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003545 alkoxy group Chemical group 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 206010012289 Dementia Diseases 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 18
- 125000001153 fluoro group Chemical group F* 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 125000001072 heteroaryl group Chemical group 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 208000024827 Alzheimer disease Diseases 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 6
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 6
- 125000005843 halogen group Chemical group 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims description 4
- 201000010374 Down Syndrome Diseases 0.000 claims description 4
- 208000009829 Lewy Body Disease Diseases 0.000 claims description 4
- 201000002832 Lewy body dementia Diseases 0.000 claims description 4
- 208000018737 Parkinson disease Diseases 0.000 claims description 4
- 208000006011 Stroke Diseases 0.000 claims description 4
- 206010044688 Trisomy 21 Diseases 0.000 claims description 4
- 230000032683 aging Effects 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 208000010877 cognitive disease Diseases 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 208000027061 mild cognitive impairment Diseases 0.000 claims description 4
- 125000004076 pyridyl group Chemical group 0.000 claims description 4
- 206010061216 Infarction Diseases 0.000 claims description 3
- 230000007574 infarction Effects 0.000 claims description 3
- OUUZRPQDOFAPGM-GOSISDBHSA-N (5r)-6-(difluoromethylidene)-5-[2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl]-5-methyl-2h-1,4-oxazin-3-amine Chemical compound COC1=CC=CN=C1NC1=CC=C(F)C([C@]2(C)C(OCC(N)=N2)=C(F)F)=C1 OUUZRPQDOFAPGM-GOSISDBHSA-N 0.000 claims description 2
- PCZXVLXHPWLNDS-UKRRQHHQSA-N (5r,6r)-5-[2-fluoro-5-(pyrimidin-2-ylamino)phenyl]-5-methyl-6-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-amine Chemical compound C=1C(NC=2N=CC=CN=2)=CC=C(F)C=1[C@@]1(C)N=C(N)CO[C@H]1C(F)(F)F PCZXVLXHPWLNDS-UKRRQHHQSA-N 0.000 claims description 2
- VJQVDJKEAGOIJY-HZPDHXFCSA-N (5r,6r)-5-[2-fluoro-5-[(3-methoxypyrazin-2-yl)amino]phenyl]-5-methyl-6-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-amine Chemical compound COC1=NC=CN=C1NC1=CC=C(F)C([C@]2(C)[C@@H](OCC(N)=N2)C(F)(F)F)=C1 VJQVDJKEAGOIJY-HZPDHXFCSA-N 0.000 claims description 2
- AZTLHEQHXVOHHJ-DZGCQCFKSA-N (5r,6r)-6-fluoro-5-[2-fluoro-5-(pyrimidin-2-ylamino)phenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine Chemical compound C=1C(NC=2N=CC=CN=2)=CC=C(F)C=1[C@@]1(C)N=C(N)CO[C@@H]1F AZTLHEQHXVOHHJ-DZGCQCFKSA-N 0.000 claims description 2
- QZDGAPNXFGXMQG-JKSUJKDBSA-N (5r,6r)-6-fluoro-5-[2-fluoro-5-[(3-methoxypyrazin-2-yl)amino]phenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine Chemical compound COC1=NC=CN=C1NC1=CC=C(F)C([C@]2(C)[C@H](OCC(N)=N2)F)=C1 QZDGAPNXFGXMQG-JKSUJKDBSA-N 0.000 claims description 2
- ACDYYEYWVRIDEJ-DLBZAZTESA-N (5r,6r)-6-fluoro-5-[2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine Chemical compound COC1=CC=CN=C1NC1=CC=C(F)C([C@]2(C)[C@H](OCC(N)=N2)F)=C1 ACDYYEYWVRIDEJ-DLBZAZTESA-N 0.000 claims description 2
- VSZGDYZXYYMQJO-RTBURBONSA-N (5r,6s)-5-cyclopropyl-6-fluoro-5-[3-[(3-methoxypyridin-2-yl)amino]phenyl]-6-(trifluoromethyl)-2h-1,4-oxazin-3-amine Chemical compound COC1=CC=CN=C1NC1=CC=CC([C@@]2([C@](OCC(N)=N2)(F)C(F)(F)F)C2CC2)=C1 VSZGDYZXYYMQJO-RTBURBONSA-N 0.000 claims description 2
- TUOYAPTYJOOGCK-UHFFFAOYSA-N 2h-1,4-oxazin-3-amine Chemical compound NC1=NC=COC1 TUOYAPTYJOOGCK-UHFFFAOYSA-N 0.000 claims description 2
- -1 3-methoxypyridin-2-yl Chemical group 0.000 claims description 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims description 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims description 2
- 125000002541 furyl group Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 125000002883 imidazolyl group Chemical group 0.000 claims description 2
- 125000001786 isothiazolyl group Chemical group 0.000 claims description 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims description 2
- 125000002971 oxazolyl group Chemical group 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
- 125000005412 pyrazyl group Chemical group 0.000 claims description 2
- 125000005495 pyridazyl group Chemical group 0.000 claims description 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims description 2
- 125000000335 thiazolyl group Chemical group 0.000 claims description 2
- 125000001544 thienyl group Chemical group 0.000 claims description 2
- 125000001425 triazolyl group Chemical group 0.000 claims description 2
- 208000005314 Multi-Infarct Dementia Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11192171 | 2011-12-06 | ||
| EP11192171.4 | 2011-12-06 | ||
| PCT/EP2012/074349 WO2013083556A1 (en) | 2011-12-06 | 2012-12-04 | 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500257A JP2015500257A (ja) | 2015-01-05 |
| JP2015500257A5 true JP2015500257A5 (enExample) | 2015-12-17 |
| JP5989130B2 JP5989130B2 (ja) | 2016-09-07 |
Family
ID=47278316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014545204A Expired - Fee Related JP5989130B2 (ja) | 2011-12-06 | 2012-12-04 | ５−（３−アミノフェニル）−５−アルキル−５，６−ジヒドロ−２ｈ−［１，４］オキサジン−３−アミン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140364428A1 (enExample) |
| EP (1) | EP2788335B1 (enExample) |
| JP (1) | JP5989130B2 (enExample) |
| KR (1) | KR102002345B1 (enExample) |
| CN (1) | CN103974940B (enExample) |
| AU (1) | AU2012347396B2 (enExample) |
| CA (1) | CA2853891C (enExample) |
| EA (1) | EA024716B1 (enExample) |
| ES (1) | ES2582473T3 (enExample) |
| IL (1) | IL232917A (enExample) |
| MX (1) | MX357383B (enExample) |
| WO (1) | WO2013083556A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009258496B8 (en) | 2008-06-13 | 2014-06-26 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
| UA110467C2 (uk) | 2009-12-11 | 2016-01-12 | Шионогі Енд Ко., Лтд. | Похідні оксазину |
| PH12012502377A1 (en) | 2010-06-09 | 2014-10-14 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
| NZ610948A (en) | 2010-12-22 | 2014-06-27 | Janssen Pharmaceutica Nv | 5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives useful as inhibitors of beta-secretase (bace) |
| BR112013022917A2 (pt) | 2011-03-09 | 2016-12-06 | Janssen Pharmaceutica Nv | derivados 3,4-dihidro-pirrolo[1,2-a]pirazino-1-ilamina úteis como inibidores de beta-secretase (bace) |
| UA111749C2 (uk) * | 2011-12-05 | 2016-06-10 | Янссен Фармацевтика Нв | Похідні 6-дифторметил-5,6-дигідро-2h-[1,4]оксазин-3-аміну |
| EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
| JP6325092B2 (ja) | 2013-06-12 | 2018-05-16 | ヤンセン ファーマシューティカ エヌ．ベー． | βーセクレターゼ（ＢＡＣＥ）の阻害剤としての４−アミノ−６−フェニル−５，６−ジヒドロイミダゾ［１，５−Ａ］ピラジン誘導体 |
| KR102243133B1 (ko) | 2013-06-12 | 2021-04-22 | 얀센 파마슈티카 엔.브이. | 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-6,7-디하이드로[1,2,3]트리아졸로[1,5-a]피라진 유도체 |
| KR102243135B1 (ko) | 2013-06-12 | 2021-04-22 | 얀센 파마슈티카 엔.브이. | 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진-3(2h)-온 유도체 |
| EP3233834B1 (en) | 2014-12-18 | 2019-11-13 | Janssen Pharmaceutica NV | 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine derivatives useful as inhibitors of beta-secretase |
| US20190359609A1 (en) * | 2016-12-16 | 2019-11-28 | Janssen Pharmaceutica Nv | Bicyclic oga inhibitor compounds |
| WO2019025250A1 (en) | 2017-08-04 | 2019-02-07 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI |
| CN108440320A (zh) * | 2018-05-09 | 2018-08-24 | 上海凌凯医药科技有限公司 | 一种高手性选择性合成α-双取代α-氨基酸的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2476605T3 (es) * | 2007-04-24 | 2014-07-15 | Shionogi & Co., Ltd. | Derivados de aminohidrotiazina sustituidos con grupos cíclicos |
| JP5383483B2 (ja) * | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
| UY32799A (es) * | 2009-07-24 | 2011-02-28 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos |
| US8188079B2 (en) * | 2009-08-19 | 2012-05-29 | Hoffman-La Roche Inc. | 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
| US20120238557A1 (en) * | 2009-11-13 | 2012-09-20 | Shionogi & Co., Ltd. | Aminothiazine or aminooxazine derivative having amino linker |
| UA110467C2 (uk) * | 2009-12-11 | 2016-01-12 | Шионогі Енд Ко., Лтд. | Похідні оксазину |
| PH12012502377A1 (en) * | 2010-06-09 | 2014-10-14 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
| US9242943B2 (en) * | 2011-01-18 | 2016-01-26 | Siena Biotech S.P.A. | 1,4 oxazines as BACE1 and/or BACE2 inhibitors |
| IN2014DN03206A (enExample) * | 2011-10-13 | 2015-05-22 | Novartis Ag | |
| UA111749C2 (uk) * | 2011-12-05 | 2016-06-10 | Янссен Фармацевтика Нв | Похідні 6-дифторметил-5,6-дигідро-2h-[1,4]оксазин-3-аміну |
-
2012
- 2012-12-04 JP JP2014545204A patent/JP5989130B2/ja not_active Expired - Fee Related
- 2012-12-04 AU AU2012347396A patent/AU2012347396B2/en not_active Ceased
- 2012-12-04 ES ES12794730.7T patent/ES2582473T3/es active Active
- 2012-12-04 WO PCT/EP2012/074349 patent/WO2013083556A1/en not_active Ceased
- 2012-12-04 EP EP12794730.7A patent/EP2788335B1/en active Active
- 2012-12-04 KR KR1020147015002A patent/KR102002345B1/ko not_active Expired - Fee Related
- 2012-12-04 US US14/362,662 patent/US20140364428A1/en not_active Abandoned
- 2012-12-04 MX MX2014006752A patent/MX357383B/es active IP Right Grant
- 2012-12-04 CA CA2853891A patent/CA2853891C/en active Active
- 2012-12-04 CN CN201280060009.0A patent/CN103974940B/zh not_active Expired - Fee Related
- 2012-12-04 EA EA201491102A patent/EA024716B1/ru not_active IP Right Cessation
-
2014
- 2014-06-02 IL IL232917A patent/IL232917A/en active IP Right Grant
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