EA024716B1 - Производные 5-(3-аминофенил)-5-алкил-5,6-дигидро-2h-[1,4]оксазин-3-амина - Google Patents
Производные 5-(3-аминофенил)-5-алкил-5,6-дигидро-2h-[1,4]оксазин-3-амина Download PDFInfo
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- EA024716B1 EA024716B1 EA201491102A EA201491102A EA024716B1 EA 024716 B1 EA024716 B1 EA 024716B1 EA 201491102 A EA201491102 A EA 201491102A EA 201491102 A EA201491102 A EA 201491102A EA 024716 B1 EA024716 B1 EA 024716B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- dementia
- fluoro
- mmol
- dihydro
- acid
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11192171 | 2011-12-06 | ||
| PCT/EP2012/074349 WO2013083556A1 (en) | 2011-12-06 | 2012-12-04 | 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201491102A1 EA201491102A1 (ru) | 2014-09-30 |
| EA024716B1 true EA024716B1 (ru) | 2016-10-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201491102A EA024716B1 (ru) | 2011-12-06 | 2012-12-04 | Производные 5-(3-аминофенил)-5-алкил-5,6-дигидро-2h-[1,4]оксазин-3-амина |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140364428A1 (enExample) |
| EP (1) | EP2788335B1 (enExample) |
| JP (1) | JP5989130B2 (enExample) |
| KR (1) | KR102002345B1 (enExample) |
| CN (1) | CN103974940B (enExample) |
| AU (1) | AU2012347396B2 (enExample) |
| CA (1) | CA2853891C (enExample) |
| EA (1) | EA024716B1 (enExample) |
| ES (1) | ES2582473T3 (enExample) |
| IL (1) | IL232917A (enExample) |
| MX (1) | MX357383B (enExample) |
| WO (1) | WO2013083556A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009258496B8 (en) | 2008-06-13 | 2014-06-26 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
| UA110467C2 (uk) | 2009-12-11 | 2016-01-12 | Шионогі Енд Ко., Лтд. | Похідні оксазину |
| PH12012502377A1 (en) | 2010-06-09 | 2014-10-14 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
| NZ610948A (en) | 2010-12-22 | 2014-06-27 | Janssen Pharmaceutica Nv | 5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives useful as inhibitors of beta-secretase (bace) |
| BR112013022917A2 (pt) | 2011-03-09 | 2016-12-06 | Janssen Pharmaceutica Nv | derivados 3,4-dihidro-pirrolo[1,2-a]pirazino-1-ilamina úteis como inibidores de beta-secretase (bace) |
| UA111749C2 (uk) * | 2011-12-05 | 2016-06-10 | Янссен Фармацевтика Нв | Похідні 6-дифторметил-5,6-дигідро-2h-[1,4]оксазин-3-аміну |
| EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
| JP6325092B2 (ja) | 2013-06-12 | 2018-05-16 | ヤンセン ファーマシューティカ エヌ．ベー． | βーセクレターゼ（ＢＡＣＥ）の阻害剤としての４−アミノ−６−フェニル−５，６−ジヒドロイミダゾ［１，５−Ａ］ピラジン誘導体 |
| KR102243133B1 (ko) | 2013-06-12 | 2021-04-22 | 얀센 파마슈티카 엔.브이. | 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-6,7-디하이드로[1,2,3]트리아졸로[1,5-a]피라진 유도체 |
| KR102243135B1 (ko) | 2013-06-12 | 2021-04-22 | 얀센 파마슈티카 엔.브이. | 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진-3(2h)-온 유도체 |
| EP3233834B1 (en) | 2014-12-18 | 2019-11-13 | Janssen Pharmaceutica NV | 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine derivatives useful as inhibitors of beta-secretase |
| US20190359609A1 (en) * | 2016-12-16 | 2019-11-28 | Janssen Pharmaceutica Nv | Bicyclic oga inhibitor compounds |
| WO2019025250A1 (en) | 2017-08-04 | 2019-02-07 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI |
| CN108440320A (zh) * | 2018-05-09 | 2018-08-24 | 上海凌凯医药科技有限公司 | 一种高手性选择性合成α-双取代α-氨基酸的方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011009943A1 (en) * | 2009-07-24 | 2011-01-27 | Novartis Ag | Oxazine derivatives and their use as bace inhibitors for the treatment of neurological disorders |
| WO2011020806A1 (en) * | 2009-08-19 | 2011-02-24 | F. Hoffmann-La Roche Ag | 3-amino-5-phenyl-5,6-dihydro-2h-[1,4]oxazine derivatives |
| WO2011071135A1 (ja) * | 2009-12-11 | 2011-06-16 | 塩野義製薬株式会社 | オキサジン誘導体 |
| WO2011154431A1 (en) * | 2010-06-09 | 2011-12-15 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2476605T3 (es) * | 2007-04-24 | 2014-07-15 | Shionogi & Co., Ltd. | Derivados de aminohidrotiazina sustituidos con grupos cíclicos |
| JP5383483B2 (ja) * | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
| US20120238557A1 (en) * | 2009-11-13 | 2012-09-20 | Shionogi & Co., Ltd. | Aminothiazine or aminooxazine derivative having amino linker |
| US9242943B2 (en) * | 2011-01-18 | 2016-01-26 | Siena Biotech S.P.A. | 1,4 oxazines as BACE1 and/or BACE2 inhibitors |
| IN2014DN03206A (enExample) * | 2011-10-13 | 2015-05-22 | Novartis Ag | |
| UA111749C2 (uk) * | 2011-12-05 | 2016-06-10 | Янссен Фармацевтика Нв | Похідні 6-дифторметил-5,6-дигідро-2h-[1,4]оксазин-3-аміну |
-
2012
- 2012-12-04 JP JP2014545204A patent/JP5989130B2/ja not_active Expired - Fee Related
- 2012-12-04 AU AU2012347396A patent/AU2012347396B2/en not_active Ceased
- 2012-12-04 ES ES12794730.7T patent/ES2582473T3/es active Active
- 2012-12-04 WO PCT/EP2012/074349 patent/WO2013083556A1/en not_active Ceased
- 2012-12-04 EP EP12794730.7A patent/EP2788335B1/en active Active
- 2012-12-04 KR KR1020147015002A patent/KR102002345B1/ko not_active Expired - Fee Related
- 2012-12-04 US US14/362,662 patent/US20140364428A1/en not_active Abandoned
- 2012-12-04 MX MX2014006752A patent/MX357383B/es active IP Right Grant
- 2012-12-04 CA CA2853891A patent/CA2853891C/en active Active
- 2012-12-04 CN CN201280060009.0A patent/CN103974940B/zh not_active Expired - Fee Related
- 2012-12-04 EA EA201491102A patent/EA024716B1/ru not_active IP Right Cessation
-
2014
- 2014-06-02 IL IL232917A patent/IL232917A/en active IP Right Grant
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011009943A1 (en) * | 2009-07-24 | 2011-01-27 | Novartis Ag | Oxazine derivatives and their use as bace inhibitors for the treatment of neurological disorders |
| WO2011020806A1 (en) * | 2009-08-19 | 2011-02-24 | F. Hoffmann-La Roche Ag | 3-amino-5-phenyl-5,6-dihydro-2h-[1,4]oxazine derivatives |
| WO2011071135A1 (ja) * | 2009-12-11 | 2011-06-16 | 塩野義製薬株式会社 | オキサジン誘導体 |
| WO2011154431A1 (en) * | 2010-06-09 | 2011-12-15 | Janssen Pharmaceutica Nv | 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace) |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140106541A (ko) | 2014-09-03 |
| NZ623858A (en) | 2015-05-29 |
| HK1198535A1 (en) | 2015-05-15 |
| CA2853891C (en) | 2020-03-10 |
| CA2853891A1 (en) | 2013-06-13 |
| EP2788335A1 (en) | 2014-10-15 |
| MX2014006752A (es) | 2014-07-14 |
| IL232917A (en) | 2016-07-31 |
| MX357383B (es) | 2018-07-06 |
| ES2582473T3 (es) | 2016-09-13 |
| IL232917A0 (en) | 2014-08-03 |
| US20140364428A1 (en) | 2014-12-11 |
| CN103974940B (zh) | 2016-08-24 |
| AU2012347396A1 (en) | 2014-05-08 |
| CN103974940A (zh) | 2014-08-06 |
| AU2012347396B2 (en) | 2017-02-16 |
| KR102002345B1 (ko) | 2019-07-22 |
| JP5989130B2 (ja) | 2016-09-07 |
| WO2013083556A1 (en) | 2013-06-13 |
| EP2788335B1 (en) | 2016-04-13 |
| EA201491102A1 (ru) | 2014-09-30 |
| JP2015500257A (ja) | 2015-01-05 |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |