|
CN101098854B
(zh)
|
2004-07-23 |
2012-12-05 |
恩多塞特公司 |
二价连接体及其轭合物
|
|
CN104127878A
(zh)
|
2007-03-14 |
2014-11-05 |
恩多塞特公司 |
结合配体连接的微管溶素递药缀合物
|
|
US9877965B2
(en)
|
2007-06-25 |
2018-01-30 |
Endocyte, Inc. |
Vitamin receptor drug delivery conjugates for treating inflammation
|
|
BRPI0812970A2
(pt)
|
2007-06-25 |
2019-09-24 |
Endocyte Inc |
conjugados contendo espaçadores hidrofílicos
|
|
WO2013126797A1
(en)
|
2012-02-24 |
2013-08-29 |
Purdue Research Foundation |
Cholecystokinin b receptor targeting for imaging and therapy
|
|
US20140080175A1
(en)
|
2012-03-29 |
2014-03-20 |
Endocyte, Inc. |
Processes for preparing tubulysin derivatives and conjugates thereof
|
|
US20140079636A1
(en)
|
2012-04-16 |
2014-03-20 |
Dinesh U. Chimmanamada |
Targeted therapeutics
|
|
CN104640572B
(zh)
|
2012-05-15 |
2018-04-27 |
索伦托医疗有限公司 |
药物偶联物,偶联方法,及其用途
|
|
EA201590622A1
(ru)
|
2012-10-16 |
2015-10-30 |
Эндосайт, Инк. |
Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения
|
|
KR20210132742A
(ko)
|
2012-12-21 |
2021-11-04 |
알트루바이오 인코퍼레이티드 |
친수성 자기-희생 링커 및 그것의 포합체
|
|
HK1220626A1
(zh)
|
2013-03-15 |
2017-05-12 |
The Centre For Drug Research And Development |
具细胞毒性和抗有丝分裂的化合物以及其使用方法
|
|
WO2014197991A1
(en)
|
2013-06-12 |
2014-12-18 |
Muhammad Yousaf |
Compounds for promoting liposomal and cellular adhesion and compositions and methods of use thereof
|
|
EP3738594A1
(en)
|
2013-09-10 |
2020-11-18 |
Madrigal Pharmaceuticals, Inc. |
Targeted therapeutics having an hsp90 ligand as binding moiety
|
|
AU2014337317A1
(en)
|
2013-10-15 |
2016-09-15 |
Sorrento Therapeutics Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
PT3057585T
(pt)
|
2013-10-15 |
2020-10-21 |
Seagen Inc |
Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando
|
|
WO2015066053A2
(en)
|
2013-10-28 |
2015-05-07 |
Synta Pharmaceuticals Corp. |
Targeted therapeutics
|
|
MX2016008448A
(es)
*
|
2013-12-27 |
2017-01-09 |
Zymeworks Inc |
Conjugados de var2csa-farmaco.
|
|
KR102384740B1
(ko)
*
|
2013-12-27 |
2022-04-07 |
자임워크스 인코포레이티드 |
약물 접합체를 위한 설폰아마이드-함유 연결 시스템
|
|
WO2015113760A1
(en)
*
|
2014-01-28 |
2015-08-06 |
Tube Pharmaceuticals Gmbh |
Cytotoxic tubulysin compounds for conjugation
|
|
EP3099332A4
(en)
|
2014-01-29 |
2017-06-21 |
Madrigal Pharmaceuticals, Inc. |
Targeted therapeutics
|
|
GB201402006D0
(en)
*
|
2014-02-06 |
2014-03-26 |
Oncomatryx Biopharma S L |
Antibody-drug conjugates and immunotoxins
|
|
JP6576942B6
(ja)
|
2014-03-03 |
2019-11-27 |
マドリガル ファーマシューティカルズ インコーポレイテッド |
標的治療薬
|
|
MA39483A
(fr)
|
2014-03-18 |
2015-09-24 |
Synta Pharmaceuticals Corp |
Agents thérapeutiques cibles
|
|
RU2747989C2
(ru)
*
|
2014-05-28 |
2021-05-18 |
Эдженсис, Инк. |
Производные пептидов долапроин-долаизолейина
|
|
KR20170020868A
(ko)
|
2014-06-20 |
2017-02-24 |
바이오얼라이언스 씨.브이. |
항-폴레이트 수용체 알파 (fra) 항체-약물 컨쥬게이트 및 그것의 사용 방법
|
|
DK3169706T3
(da)
|
2014-07-11 |
2020-03-09 |
Genmab As |
Antistoffer, der binder axl
|
|
HRP20241124T1
(hr)
*
|
2014-09-11 |
2024-11-22 |
Seagen Inc. |
Ciljana isporuka lijekovitih tvari koje sadrže tercijarni amin
|
|
ES2905569T3
(es)
*
|
2014-09-17 |
2022-04-11 |
Zymeworks Inc |
Compuestos citotóxicos y antimitóticos y métodos para utilizarlos
|
|
ES2885854T3
(es)
|
2014-10-14 |
2021-12-15 |
Polytherics Ltd |
Proceso para la conjugación de un péptido o proteína con un reactivo que comprende un grupo saliente que incluye una porción de PEG
|
|
US10077287B2
(en)
|
2014-11-10 |
2018-09-18 |
Bristol-Myers Squibb Company |
Tubulysin analogs and methods of making and use
|
|
US20170281796A1
(en)
*
|
2014-12-08 |
2017-10-05 |
Sorrento Therapeutics, Inc. |
c-Met Antibody Drug Conjugate
|
|
US9968683B2
(en)
|
2014-12-17 |
2018-05-15 |
Organolinx Corp. |
Method for conjugating molecules
|
|
JP6871858B2
(ja)
*
|
2015-01-28 |
2021-05-19 |
ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. |
抗体薬物コンジュゲート
|
|
US20170224835A1
(en)
*
|
2015-02-06 |
2017-08-10 |
Sorrento Therapeutics, Inc. |
Antibody Drug Conjugates
|
|
CN111150851A
(zh)
*
|
2015-02-15 |
2020-05-15 |
江苏恒瑞医药股份有限公司 |
配体-细胞毒性药物偶联物、其制备方法及其应用
|
|
CN106279352B
(zh)
*
|
2015-05-29 |
2020-05-22 |
上海新理念生物医药科技有限公司 |
海兔毒素10的衍生物及其应用
|
|
EP3308801A4
(en)
|
2015-06-09 |
2019-02-27 |
XDCExplorer (Shanghai) Co., Ltd. |
ANTIBODY-ACTIVE CONJUGATE, INTERMEDIATE PRODUCT, METHOD OF MANUFACTURE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
|
|
CA2991805A1
(en)
|
2015-07-10 |
2017-01-19 |
Genmab A/S |
Axl-specific antibody-drug conjugates for cancer treatment
|
|
CA2991973C
(en)
|
2015-07-12 |
2021-12-07 |
Suzhou M-Conj Biotech Co., Ltd. |
Bridge linkers for conjugation of a cell-binding molecule
|
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
|
WO2017054080A1
(en)
*
|
2015-09-29 |
2017-04-06 |
Zymeworks Inc. |
Cytotoxic and anti-mitotic compounds, and methods of using the same
|
|
WO2017058808A1
(en)
*
|
2015-10-02 |
2017-04-06 |
Sirenas Llc |
Anti-cancer compounds and conjugates thereof
|
|
TWI660741B
(zh)
|
2015-11-03 |
2019-06-01 |
財團法人工業技術研究院 |
抗體藥物複合物及其製造方法
|
|
CN106729743B
(zh)
|
2015-11-23 |
2021-09-21 |
四川科伦博泰生物医药股份有限公司 |
抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用
|
|
US11229708B2
(en)
|
2015-12-04 |
2022-01-25 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
US11793880B2
(en)
|
2015-12-04 |
2023-10-24 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
WO2017120534A1
(en)
|
2016-01-08 |
2017-07-13 |
Bioalliance C.V. |
Tetravalent anti-psgl-1 antibodies and uses thereof
|
|
CN107029244B
(zh)
*
|
2016-02-04 |
2021-04-27 |
浙江昭华生物医药有限公司 |
抗her2抗体-药物偶联物及其应用
|
|
MY199595A
(en)
|
2016-03-02 |
2023-11-08 |
Eisai R&D Man Co Ltd |
Eribulin-based antibody-drug conjugates and methods of use
|
|
EP3433278A4
(en)
|
2016-03-25 |
2019-11-06 |
Seattle Genetics, Inc. |
METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF
|
|
WO2017172907A1
(en)
*
|
2016-03-29 |
2017-10-05 |
Sorrento Therapeutics, Inc. |
Calicheamicin antibody drug conjugates linking an amidoacetyl group to a sugar moiety on calicheamicin
|
|
ES2948846T3
(es)
|
2016-03-29 |
2023-09-20 |
Toray Industries |
Derivado peptídico y uso del mismo
|
|
KR102775461B1
(ko)
|
2016-04-01 |
2025-02-28 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩타이드 조성물 및 이의 용도
|
|
US11013816B2
(en)
*
|
2016-05-31 |
2021-05-25 |
Sorrento Therapeutics, Inc. |
Antibody drug conjugates having derivatives of amatoxin as the drug
|
|
US10111966B2
(en)
|
2016-06-17 |
2018-10-30 |
Magenta Therapeutics, Inc. |
Methods for the depletion of CD117+ cells
|
|
WO2018036438A1
(zh)
*
|
2016-08-23 |
2018-03-01 |
四川科伦博泰生物医药股份有限公司 |
一种抗体-药物偶联物及其制备方法和应用
|
|
US10517958B2
(en)
|
2016-10-04 |
2019-12-31 |
Zymeworks Inc. |
Compositions and methods for the treatment of platinum-drug resistant cancer
|
|
CN108101825B
(zh)
*
|
2016-11-25 |
2022-02-22 |
迈威(上海)生物科技股份有限公司 |
用于抗体-药物偶联的双取代马来酰胺类连接子及其制备方法和用途
|
|
CN109810039B
(zh)
*
|
2017-11-22 |
2021-11-12 |
迈威(上海)生物科技股份有限公司 |
一种用于抗体-药物偶联的双取代马来酰胺类连接子及其制备方法和用途
|
|
EP3546448B1
(en)
*
|
2016-11-25 |
2022-04-06 |
Mabwell (Shanghai) Bioscience Co., Ltd. |
Di-substituted maleic amide linker for antibody-drug conjugating and preparation method and use thereof
|
|
US10864279B2
(en)
|
2016-12-16 |
2020-12-15 |
Industrial Technology Research Institute |
Linker-drug and antibody-drug conjugate (ADC) employing the same
|
|
KR20240172236A
(ko)
|
2017-01-06 |
2024-12-09 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩티드 조성물 및 엑손 스키핑을 유도하는 방법
|
|
SG11201906319XA
(en)
|
2017-01-20 |
2019-08-27 |
Magenta Therapeutics Inc |
Compositions and methods for the depletion of cd137+ cells
|
|
JP7527787B2
(ja)
|
2017-03-24 |
2024-08-05 |
シージェン インコーポレイテッド |
グルクロニド薬物-リンカーの調製のためのプロセスおよびその中間体
|
|
KR20210125094A
(ko)
*
|
2017-04-06 |
2021-10-15 |
항저우 디에이씨 바이오테크 씨오, 엘티디 |
비스-링키지를 사용한 세포독성 약물의 접합
|
|
EP3617221A4
(en)
|
2017-04-19 |
2021-04-14 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
CYTOTOXIN AND CONJUGATE, USES THEREOF AND MANUFACTURING PROCESSES THEREFORE
|
|
US11491145B2
(en)
|
2017-06-20 |
2022-11-08 |
Madrigal Pharmaceuticals, Inc. |
Combination therapies comprising targeted therapeutics
|
|
US11377447B2
(en)
|
2017-06-20 |
2022-07-05 |
Madrigal Pharmaceuticals, Inc. |
Targeted therapeutics
|
|
JP7359700B2
(ja)
*
|
2017-06-20 |
2023-10-11 |
ソレント・セラピューティクス・インコーポレイテッド |
Cd38抗体薬物コンジュゲート
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
CN111201030B
(zh)
|
2017-07-25 |
2024-11-01 |
真和制药有限公司 |
通过阻断tim-3和其配体的相互作用治疗癌症
|
|
US10799598B2
(en)
|
2017-08-01 |
2020-10-13 |
Sorrento Therapeutics, Inc. |
Disulfide bridging conjugates
|
|
CN111051329B
(zh)
|
2017-08-10 |
2024-07-30 |
住友制药株式会社 |
哈米特林衍生物及它们的抗体药物复合物
|
|
MA50124A
(fr)
|
2017-09-08 |
2020-07-15 |
Seattle Genetics Inc |
Procédé de préparation de tubulysines et d'intermédiaires de celles-ci
|
|
SG11202002517RA
(en)
|
2017-09-22 |
2020-04-29 |
Avidity Biosciences Inc |
Nucleic acid-polypeptide compositions and methods of inducing exon skipping
|
|
SG11202003126VA
(en)
|
2017-10-04 |
2020-05-28 |
Avidity Biosciences Inc |
Nucleic acid-polypeptide compositions and uses thereof
|
|
AU2018375412B2
(en)
*
|
2017-11-30 |
2025-01-02 |
Seagen Inc. |
Process for the preparation of drug linker compounds
|
|
CN118638787A
(zh)
|
2017-12-06 |
2024-09-13 |
艾维迪提生物科学公司 |
治疗肌萎缩和强直性肌营养不良的组合物和方法
|
|
CN119219654A
(zh)
|
2017-12-15 |
2024-12-31 |
四川科伦博泰生物医药股份有限公司 |
生物活性物偶联物及其制备方法和用途
|
|
CN111447939B
(zh)
*
|
2018-01-30 |
2024-07-12 |
四川科伦博泰生物医药股份有限公司 |
制备偶联物的方法
|
|
MX2020008267A
(es)
*
|
2018-02-20 |
2020-09-21 |
Seattle Genetics Inc |
Compuestos de auristatina f hidrofoba y conjugados de los mismos.
|
|
IL278740B2
(en)
|
2018-06-01 |
2024-01-01 |
Eisai R&D Man Co Ltd |
Methods for using splicing modulators
|
|
CN119405833A
(zh)
|
2018-06-01 |
2025-02-11 |
卫材R&D管理有限公司 |
剪接调节抗体-药物缀合物及其使用方法
|
|
WO2019246445A1
(en)
|
2018-06-20 |
2019-12-26 |
The Research Foundation For The State University Of New York |
Triazamacrocycle-derived chelator compositions for coordination of imaging and therapy metal ions and methods of using same
|
|
US20230010108A1
(en)
*
|
2018-10-12 |
2023-01-12 |
Hangzhou Dac Biotech Co., Ltd. |
A conjugation linker containing 2,3-diaminosuccinyl group
|
|
WO2020081493A1
(en)
|
2018-10-16 |
2020-04-23 |
Molecular Templates, Inc. |
Pd-l1 binding proteins
|
|
CN113302207B
(zh)
|
2018-11-16 |
2025-05-13 |
维尔托索宾科公司 |
Cd38和icam1抗体及其用途
|
|
CN120189526A
(zh)
|
2018-12-13 |
2025-06-24 |
卫材R&D管理有限公司 |
荷伯希二烯抗体-药物缀合物及使用方法
|
|
AU2019403552A1
(en)
*
|
2018-12-21 |
2021-06-17 |
Seagen Inc. |
ADCs with thiol multiplex linkers
|
|
IL312067B2
(en)
|
2018-12-21 |
2025-08-01 |
Avidity Biosciences Inc |
Anti-transferrin receptor antibodies and uses thereof
|
|
KR20210124308A
(ko)
|
2019-01-30 |
2021-10-14 |
트루바인딩 아이엔씨. |
항-gal3 항체 및 이의 용도
|
|
CN113412271B
(zh)
|
2019-02-13 |
2024-10-22 |
住友制药株式会社 |
具有半胱氨酸残基的哈米特林衍生物
|
|
US12178879B2
(en)
|
2019-02-13 |
2024-12-31 |
Sumitomo Pharma Co., Ltd. |
Hemiasterlin derivative and antibody-drug conjugate thereof
|
|
CN109824759A
(zh)
*
|
2019-03-08 |
2019-05-31 |
联宁(苏州)生物制药有限公司 |
一种用于抗体药物偶联物的药物-连接子mc-mmaf的制备方法及其中间体
|
|
WO2020219820A1
(en)
|
2019-04-25 |
2020-10-29 |
Avidity Biosciences, Inc. |
Nucleic acid compositions and methods of multi-exon skipping
|
|
JP7581252B2
(ja)
|
2019-06-06 |
2024-11-12 |
アビディティー バイオサイエンシーズ,インク. |
Unaアミダイトおよびその使用
|
|
WO2020247782A1
(en)
|
2019-06-06 |
2020-12-10 |
Avidity Biosciences, Inc. |
Nucleic acid-polypeptide compositions and uses thereof
|
|
WO2021055816A1
(en)
|
2019-09-18 |
2021-03-25 |
Molecular Templates, Inc. |
Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
|
|
CN115279789A
(zh)
|
2019-12-06 |
2022-11-01 |
真和制药有限公司 |
破坏gal3和胰岛素受体或整联蛋白的相互作用的抗体及其使用方法
|
|
WO2021144314A1
(en)
|
2020-01-13 |
2021-07-22 |
Synaffix B.V. |
Via cycloaddition bilaterally functionalized antibodies
|
|
CN115768483A
(zh)
|
2020-01-13 |
2023-03-07 |
西纳福克斯股份有限公司 |
抗体与免疫细胞衔接器的缀合物
|
|
JP7807376B2
(ja)
|
2020-01-13 |
2026-01-27 |
シンアフィックス ビー.ブイ. |
付加環化を介して両側官能化された抗体
|
|
WO2021173612A1
(en)
|
2020-02-26 |
2021-09-02 |
Sorrento Therapeutics, Inc. |
Activatable antigen binding proteins with universal masking moieties
|
|
FR3107648B1
(fr)
*
|
2020-02-27 |
2022-03-18 |
Mc Saf |
conjugués anticorps-médicament anti-CD56 et leur utilisation en thérapie
|
|
BR112022018002A2
(pt)
*
|
2020-03-09 |
2022-11-08 |
Sigma Aldrich Co Llc |
Preparação eficiente de análogos de dolastatina e auristatina por meio de um intermediário comum
|
|
TW202144572A
(zh)
|
2020-03-19 |
2021-12-01 |
美商亞維代堤生物科學公司 |
治療臉肩胛肱骨肌肉失養症之組合物及方法
|
|
KR102927945B1
(ko)
|
2020-03-27 |
2026-02-23 |
어비디티 바이오사이언시스 인크. |
근이영양증의 치료용 조성물 및 방법
|
|
US10987487B1
(en)
|
2020-04-29 |
2021-04-27 |
Cure Medical Llc |
Gripper sleeve for urinary catheter
|
|
MX2022014786A
(es)
|
2020-05-26 |
2023-01-16 |
Truebinding Inc |
Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3.
|
|
EP4161966A1
(en)
|
2020-06-05 |
2023-04-12 |
Eisai R&D Management Co., Ltd. |
Anti-bcma antibody-drug conjugates and methods of use
|
|
WO2021260232A1
(en)
|
2020-06-26 |
2021-12-30 |
Synaffix B.V. |
Methods for the preparation of linker payload constructs
|
|
NL2026400B1
(en)
|
2020-09-02 |
2022-05-04 |
Synaffix Bv |
Methods for the preparation of bioconjugates
|
|
KR20230060509A
(ko)
|
2020-09-04 |
2023-05-04 |
노바록 바이오테라퓨틱스 리미티드 |
넥틴-4 항체 및 이의 용도
|
|
JP7904824B2
(ja)
|
2020-09-15 |
2026-08-13 |
シンアフィックス ビー.ブイ. |
抗体-エクサテカンコンジュゲート
|
|
NL2026947B1
(en)
|
2020-11-20 |
2022-07-01 |
Synaffix Bv |
Tyrosine-based antibody conjugates
|
|
AR124475A1
(es)
|
2020-12-23 |
2023-03-29 |
Univ Muenchen Ludwig Maximilians |
Conjugados anticuerpo-droga mejorados dirigidos contra cd30 y usos de los mismos
|
|
EP4284804A1
(en)
|
2021-01-26 |
2023-12-06 |
Schrödinger, Inc. |
Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders
|
|
CN115209922A
(zh)
*
|
2021-01-28 |
2022-10-18 |
南京桦冠生物技术有限公司 |
缀合物及其用途
|
|
JP2024506022A
(ja)
|
2021-02-08 |
2024-02-08 |
シンアフィックス ビー.ブイ. |
多機能性抗体
|
|
WO2022184082A1
(en)
|
2021-03-03 |
2022-09-09 |
Sorrento Therapeutics, Inc. |
Antibody-drug conjugates comprising an anti-bcma antibody
|
|
US20220306700A1
(en)
|
2021-03-17 |
2022-09-29 |
Molecular Templates, Inc. |
Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens
|
|
WO2022204947A1
(zh)
*
|
2021-03-30 |
2022-10-06 |
上海复旦张江生物医药股份有限公司 |
一种连接基药物偶联物的制备方法及其中间体
|
|
US20240252665A1
(en)
*
|
2021-06-02 |
2024-08-01 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Chemical coupling linker and use thereof
|
|
JP2024526764A
(ja)
|
2021-07-13 |
2024-07-19 |
トゥルーバインディング,インコーポレイテッド |
タンパク質凝集を防止する方法
|
|
EP4401792A4
(en)
|
2021-09-16 |
2025-12-03 |
Avidity Biosciences Inc |
COMPOSITIONS AND METHODS OF TREATMENT OF FACIO-SCAPULO-HUMERAL MUSCULAR DYSTROPHY
|
|
AU2022380909A1
(en)
*
|
2021-11-03 |
2024-06-06 |
Adcentrx Therapeutics Inc. |
Drug conjugates and methods of preparing and using the same
|
|
US20230279120A1
(en)
|
2021-11-09 |
2023-09-07 |
Truebinding, Inc. |
Methods of treating or inhibiting cardiovascular diseases
|
|
KR20240125036A
(ko)
|
2021-12-23 |
2024-08-19 |
마이레큘, 인크. |
폴리뉴클레오타이드의 전달을 위한 조성물
|
|
JP2025509286A
(ja)
|
2022-03-10 |
2025-04-11 |
ビバソル, インコーポレイテッド |
抗体-薬物コンジュゲートおよびその使用
|
|
US12071621B2
(en)
|
2022-04-05 |
2024-08-27 |
Avidity Biosciences, Inc. |
Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
|
|
CN120659627A
(zh)
|
2022-07-29 |
2025-09-16 |
瑞泽恩制药公司 |
用于转铁蛋白受体(tfr)介导的脑和肌肉递送的组合物和方法
|
|
EP4572798A1
(en)
|
2022-08-15 |
2025-06-25 |
Synaffix B.V. |
Anthracyclins and conjugates thereof
|
|
JP2025537044A
(ja)
|
2022-09-30 |
2025-11-13 |
シャンハイ ドーァ ノボ ファーマテック カンパニー,リミティド |
ベンザゼピン誘導体、それを含む複合体およびその応用
|
|
AU2023379457A1
(en)
|
2022-11-14 |
2025-05-15 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
|
EP4389152A1
(en)
|
2022-12-23 |
2024-06-26 |
Synaffix B.V. |
Conjugates of pbd prodrugs
|
|
CN116621927B
(zh)
*
|
2023-01-09 |
2024-03-26 |
联宁(苏州)生物制药有限公司 |
带有伊喜替康和C-lock定点偶联基团的抗体偶联中间体、偶联方法及抗体偶联药物
|
|
EP4410313A1
(en)
|
2023-01-31 |
2024-08-07 |
Synaffix B.V. |
Homogeneous antibody-conjugates with high payload loading
|
|
KR20250153767A
(ko)
|
2023-02-28 |
2025-10-27 |
쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 |
화학적 접합 링커 및 이의 용도
|
|
WO2024211234A1
(en)
|
2023-04-05 |
2024-10-10 |
Sorrento Therapeutics, Inc. |
Antibody-drug conjugates and uses thereof
|
|
WO2024211236A2
(en)
|
2023-04-05 |
2024-10-10 |
Sorrento Therapeutics, Inc. |
Antibody-drug conjugates and uses thereof
|
|
CN121985963A
(zh)
|
2023-04-05 |
2026-05-05 |
维硕公司 |
抗体偶联药物及其用途
|
|
EP4450093A1
(en)
|
2023-04-17 |
2024-10-23 |
Synaffix B.V. |
Cleavable immune cell engagers
|
|
WO2024218162A1
(en)
|
2023-04-17 |
2024-10-24 |
Synaffix B.V. |
Cleavable immune cell engagers
|
|
US12491257B2
(en)
|
2023-06-27 |
2025-12-09 |
Avidity Biosciences, Inc. |
Compositions and methods of using PRKAG2-targeting antibody-oligonucleotide conjugates
|
|
AU2024308906A1
(en)
|
2023-06-30 |
2026-02-05 |
Atrium Therapeutics, Inc. |
Compositions and methods of using pln-targeting antibody-oligonucleotide conjugates
|
|
WO2025027529A1
(en)
|
2023-07-31 |
2025-02-06 |
Advesya |
Anti-il-1rap antibody drug conjugates and methods of use thereof
|
|
WO2025076006A2
(en)
|
2023-10-02 |
2025-04-10 |
Avidity Biosciences, Inc. |
Antibody-oligonucleotide conjugate compositions and methods of inducing dmd exon 45 skipping
|
|
TW202530255A
(zh)
|
2023-12-15 |
2025-08-01 |
法商亞維西亞有限公司 |
抗il-1rap結合結構域及其抗體-藥物偶聯物
|
|
CN117964682A
(zh)
*
|
2024-01-12 |
2024-05-03 |
杭州爱科瑞思生物医药有限公司 |
Dolastatin衍生物及其制备方法和应用
|
|
WO2025238253A1
(en)
|
2024-05-16 |
2025-11-20 |
Synaffix B.V. |
Antibody-oligonucleotide conjugates
|
|
WO2026008881A1
(en)
|
2024-07-05 |
2026-01-08 |
Synaffix B.V. |
Extracellular vesicles comprising biomolecule-conjugates
|
|
US20260078179A1
(en)
|
2024-07-18 |
2026-03-19 |
Novarock Biotherapeutics, Ltd. |
Cdh17 antibodies and uses thereof
|