DK1487493T3 - Konjugater af cytotoksiske midler og biologisk aktive peptider - Google Patents
Konjugater af cytotoksiske midler og biologisk aktive peptiderInfo
- Publication number
- DK1487493T3 DK1487493T3 DK03716299.7T DK03716299T DK1487493T3 DK 1487493 T3 DK1487493 T3 DK 1487493T3 DK 03716299 T DK03716299 T DK 03716299T DK 1487493 T3 DK1487493 T3 DK 1487493T3
- Authority
- DK
- Denmark
- Prior art keywords
- biologically active
- conjugates
- cytotoxic agents
- active peptides
- peptides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36083102P | 2002-03-01 | 2002-03-01 | |
PCT/US2003/006657 WO2003074551A2 (en) | 2002-03-01 | 2003-03-03 | Conjugates of therapeutic or cytotoxic agents and biologically active peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1487493T3 true DK1487493T3 (da) | 2010-05-25 |
Family
ID=27789031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03716299.7T DK1487493T3 (da) | 2002-03-01 | 2003-03-03 | Konjugater af cytotoksiske midler og biologisk aktive peptider |
Country Status (21)
Country | Link |
---|---|
US (2) | US7771727B2 (da) |
EP (1) | EP1487493B1 (da) |
JP (1) | JP4477881B2 (da) |
KR (1) | KR101003622B1 (da) |
CN (2) | CN102133407A (da) |
AT (1) | ATE455561T1 (da) |
AU (1) | AU2003220011B2 (da) |
BR (1) | BR0308090A (da) |
CA (1) | CA2476182A1 (da) |
CO (1) | CO5611160A2 (da) |
DE (1) | DE60331049D1 (da) |
DK (1) | DK1487493T3 (da) |
ES (1) | ES2339934T3 (da) |
IL (1) | IL163573A0 (da) |
IS (1) | IS7431A (da) |
MX (1) | MXPA04008419A (da) |
NO (1) | NO20044039L (da) |
NZ (1) | NZ534719A (da) |
PL (1) | PL373567A1 (da) |
WO (1) | WO2003074551A2 (da) |
ZA (1) | ZA200406614B (da) |
Families Citing this family (66)
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HUE027549T2 (hu) | 2002-07-31 | 2016-10-28 | Seattle Genetics Inc | Hatóanyagot tartalmazó konjugátumok és alkalmazásuk rák, autoimmun betegség vagy fertõzéses betegség kezelésére |
ATE483476T1 (de) * | 2003-03-20 | 2010-10-15 | Nippon Kayaku Kk | Micellen-zubereitung mit schwer wasserlöslichem anti-krebsmittel und neuem blockcopolymer |
WO2004083432A1 (en) | 2003-03-21 | 2004-09-30 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
KR20070108953A (ko) * | 2003-04-22 | 2007-11-13 | 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. | 펩타이드 벡터 |
US20060281897A1 (en) * | 2003-08-22 | 2006-12-14 | Andre Trouet | Potentialization of the activation of high molecular weight prodrugs |
CA2542834C (en) | 2003-10-21 | 2012-04-24 | Igf Oncology, Llc | Conjugates or co-administration of igf-1 receptor ligands with anti-cancer chemotherapeutic agents |
US9011880B2 (en) | 2003-10-21 | 2015-04-21 | Igf Oncology, Llc | Compounds and methods for treating cancer |
CA2581125C (en) | 2004-09-22 | 2013-04-23 | Nippon Kayaku Kabushiki Kaisha | Modified poly(ethylene oxide-amino acid) copolymer, micelle preparation, and anticancer agent containing the same |
WO2006047214A2 (en) | 2004-10-21 | 2006-05-04 | Igf Oncology, Llc | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
KR100897915B1 (ko) * | 2004-11-03 | 2009-05-18 | 포휴먼텍(주) | 경피전달을 위한 약제 조성물 |
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DK2203173T3 (da) | 2007-10-26 | 2016-02-29 | Academisch Ziekenhuis Leiden | Midler og fremgangsmåder til modvirkning af muskellidelser |
USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
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KR20040047846A (ko) | 2001-09-21 | 2004-06-05 | 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 | 진단 또는 치료용 소마토스타틴 또는 봄베신 유사체콘쥬게이트 및 이들의 용도 |
-
2003
- 2003-03-03 PL PL03373567A patent/PL373567A1/xx not_active Application Discontinuation
- 2003-03-03 EP EP03716299A patent/EP1487493B1/en not_active Expired - Lifetime
- 2003-03-03 CN CN2010106215969A patent/CN102133407A/zh active Pending
- 2003-03-03 JP JP2003573017A patent/JP4477881B2/ja not_active Expired - Lifetime
- 2003-03-03 DE DE60331049T patent/DE60331049D1/de not_active Expired - Lifetime
- 2003-03-03 DK DK03716299.7T patent/DK1487493T3/da active
- 2003-03-03 AU AU2003220011A patent/AU2003220011B2/en not_active Ceased
- 2003-03-03 CN CNA038099276A patent/CN1649625A/zh active Pending
- 2003-03-03 AT AT03716299T patent/ATE455561T1/de active
- 2003-03-03 IL IL16357303A patent/IL163573A0/xx unknown
- 2003-03-03 ES ES03716299T patent/ES2339934T3/es not_active Expired - Lifetime
- 2003-03-03 MX MXPA04008419A patent/MXPA04008419A/es active IP Right Grant
- 2003-03-03 BR BRPI0308090-0A patent/BR0308090A/pt not_active IP Right Cessation
- 2003-03-03 KR KR1020047013597A patent/KR101003622B1/ko not_active IP Right Cessation
- 2003-03-03 CA CA002476182A patent/CA2476182A1/en not_active Abandoned
- 2003-03-03 US US10/506,223 patent/US7771727B2/en not_active Expired - Fee Related
- 2003-03-03 WO PCT/US2003/006657 patent/WO2003074551A2/en active Application Filing
- 2003-03-03 NZ NZ534719A patent/NZ534719A/en not_active IP Right Cessation
-
2004
- 2004-08-19 ZA ZA200406614A patent/ZA200406614B/en unknown
- 2004-08-31 IS IS7431A patent/IS7431A/is unknown
- 2004-09-24 NO NO20044039A patent/NO20044039L/no not_active Application Discontinuation
- 2004-09-29 CO CO04097209A patent/CO5611160A2/es not_active Application Discontinuation
-
2009
- 2009-08-25 US US12/547,096 patent/US20090324620A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2003220011A1 (en) | 2003-09-16 |
EP1487493A2 (en) | 2004-12-22 |
ES2339934T3 (es) | 2010-05-27 |
PL373567A1 (en) | 2005-09-05 |
WO2003074551A3 (en) | 2004-03-25 |
IS7431A (is) | 2004-08-31 |
EP1487493B1 (en) | 2010-01-20 |
JP2006510571A (ja) | 2006-03-30 |
KR101003622B1 (ko) | 2010-12-24 |
WO2003074551A2 (en) | 2003-09-12 |
MXPA04008419A (es) | 2004-11-26 |
CN102133407A (zh) | 2011-07-27 |
CO5611160A2 (es) | 2006-02-28 |
ZA200406614B (en) | 2006-06-28 |
CA2476182A1 (en) | 2003-09-12 |
IL163573A0 (en) | 2005-12-18 |
CN1649625A (zh) | 2005-08-03 |
BR0308090A (pt) | 2006-04-11 |
AU2003220011B2 (en) | 2008-05-29 |
EP1487493A4 (en) | 2006-08-30 |
US7771727B2 (en) | 2010-08-10 |
US20060009622A1 (en) | 2006-01-12 |
DE60331049D1 (de) | 2010-03-11 |
JP4477881B2 (ja) | 2010-06-09 |
KR20040088568A (ko) | 2004-10-16 |
NO20044039L (no) | 2004-09-29 |
NZ534719A (en) | 2008-02-29 |
US20090324620A1 (en) | 2009-12-31 |
ATE455561T1 (de) | 2010-02-15 |
WO2003074551A8 (en) | 2005-11-03 |
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