CN104379168B - 药物偶联物，偶联方法，及其用途 - Google Patents

药物偶联物，偶联方法，及其用途 Download PDF

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CN104379168B
CN104379168B CN201380025774.3A CN201380025774A CN104379168B CN 104379168 B CN104379168 B CN 104379168B CN 201380025774 A CN201380025774 A CN 201380025774A CN 104379168 B CN104379168 B CN 104379168B
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pab
compound
antibody
group
drug
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CN104379168A (zh
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苗振伟
洪予丰
朱同
A·W·楚佐罗斯基
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Lian Ning (suzhou) Biopharmaceutical Co Ltd
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Sorrento Therapeutics Inc
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    • A—HUMAN NECESSITIES
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Emergency Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201380025774.3A 2012-05-15 2013-05-14 药物偶联物，偶联方法，及其用途 Active CN104379168B (zh)

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US201261647300P 2012-05-15 2012-05-15
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US201261648532P 2012-05-17 2012-05-17
US201261648406P 2012-05-17 2012-05-17
US61/648,532 2012-05-17
US61/648,406 2012-05-17
US201261652512P 2012-05-29 2012-05-29
US61/652,512 2012-05-29
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