JP2015227351A5 - - Google Patents
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- JP2015227351A5 JP2015227351A5 JP2015140309A JP2015140309A JP2015227351A5 JP 2015227351 A5 JP2015227351 A5 JP 2015227351A5 JP 2015140309 A JP2015140309 A JP 2015140309A JP 2015140309 A JP2015140309 A JP 2015140309A JP 2015227351 A5 JP2015227351 A5 JP 2015227351A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- antimetabolite
- cancer
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000000340 anti-metabolite Effects 0.000 claims 3
- 239000002256 antimetabolite Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- CGXLVFZJJOXEDF-UHFFFAOYSA-N 1,8-naphthyridine-3-carboxylic acid Chemical compound N1=CC=CC2=CC(C(=O)O)=CN=C21 CGXLVFZJJOXEDF-UHFFFAOYSA-N 0.000 claims 1
- 229940100197 ANTIMETABOLITES Drugs 0.000 claims 1
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 1
- 206010024324 Leukaemias Diseases 0.000 claims 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 1
- 239000000317 Topoisomerase II Inhibitor Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000259 anti-tumor Effects 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- 229940079866 intestinal antibiotics Drugs 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
Claims (4)
- 有効成分として(＋)−1,4−ジヒドロ−7−[(3Ｓ,4Ｓ)−3−メトキシ−4−(メチルアミノ)−1−ピロリジニル]−4−オキソ−1−(2−チアゾリル)−1,8−ナフチリジン−3−カルボン酸を含む、患者のガンの治療用医薬組成物であって、抗腫瘍性抗生物質、抗代謝剤、プラチナ配位複合体、及びトポイソメラーゼＩＩ阻害剤から選択される薬剤と組み合わせて共投与される、医薬組成物。
- 前記薬剤が、抗代謝剤である、請求項１に記載の医薬組成物。
- 前記ガンが、白血病である、請求項１又は２に記載の医薬組成物。
- 前記抗代謝剤が静脈内に投与される、請求項１から３のいずれか１項に記載の医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55357804P | 2004-03-15 | 2004-03-15 | |
| US60/553,578 | 2004-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014091125A Division JP5856644B2 (ja) | 2004-03-15 | 2014-04-25 | Ｓｎｓ−５９５、及びその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016248041A Division JP2017095471A (ja) | 2004-03-15 | 2016-12-21 | Ｓｎｓ−５９５、及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015227351A JP2015227351A (ja) | 2015-12-17 |
| JP2015227351A5 true JP2015227351A5 (ja) | 2016-02-04 |
| JP6352863B2 JP6352863B2 (ja) | 2018-07-04 |
Family
ID=34993432
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503987A Expired - Fee Related JP5317472B2 (ja) | 2004-03-15 | 2005-03-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2007503972A Expired - Fee Related JP5096913B2 (ja) | 2004-03-15 | 2005-03-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2011135675A Pending JP2011225590A (ja) | 2004-03-15 | 2011-06-17 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2012036919A Pending JP2012140442A (ja) | 2004-03-15 | 2012-02-23 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2014091125A Expired - Fee Related JP5856644B2 (ja) | 2004-03-15 | 2014-04-25 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2014180862A Expired - Fee Related JP6261477B2 (ja) | 2004-03-15 | 2014-09-05 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2015140309A Expired - Fee Related JP6352863B2 (ja) | 2004-03-15 | 2015-07-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2016248041A Pending JP2017095471A (ja) | 2004-03-15 | 2016-12-21 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2018038834A Pending JP2018119977A (ja) | 2004-03-15 | 2018-03-05 | Ｓｎｓ−５９５、及びその使用方法 |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503987A Expired - Fee Related JP5317472B2 (ja) | 2004-03-15 | 2005-03-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2007503972A Expired - Fee Related JP5096913B2 (ja) | 2004-03-15 | 2005-03-14 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2011135675A Pending JP2011225590A (ja) | 2004-03-15 | 2011-06-17 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2012036919A Pending JP2012140442A (ja) | 2004-03-15 | 2012-02-23 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2014091125A Expired - Fee Related JP5856644B2 (ja) | 2004-03-15 | 2014-04-25 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2014180862A Expired - Fee Related JP6261477B2 (ja) | 2004-03-15 | 2014-09-05 | Ｓｎｓ−５９５、及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016248041A Pending JP2017095471A (ja) | 2004-03-15 | 2016-12-21 | Ｓｎｓ−５９５、及びその使用方法 |
| JP2018038834A Pending JP2018119977A (ja) | 2004-03-15 | 2018-03-05 | Ｓｎｓ−５９５、及びその使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (12) | US7968565B2 (ja) |
| EP (4) | EP1729770B1 (ja) |
| JP (9) | JP5317472B2 (ja) |
| KR (1) | KR101169825B1 (ja) |
| CN (5) | CN103251589B (ja) |
| AT (2) | ATE493982T1 (ja) |
| AU (3) | AU2005222622B2 (ja) |
| BR (1) | BRPI0508700A (ja) |
| CA (3) | CA2559652C (ja) |
| CY (2) | CY1109741T1 (ja) |
| DE (2) | DE602005018333D1 (ja) |
| DK (3) | DK2295056T5 (ja) |
| ES (3) | ES2334802T3 (ja) |
| HK (1) | HK1097196A1 (ja) |
| HU (1) | HUE027266T2 (ja) |
| IL (2) | IL177946A (ja) |
| MX (2) | MXPA06010382A (ja) |
| NO (3) | NO338058B1 (ja) |
| NZ (2) | NZ549557A (ja) |
| PL (3) | PL2295056T3 (ja) |
| PT (2) | PT1725233E (ja) |
| SI (2) | SI1725233T1 (ja) |
| WO (2) | WO2005089756A1 (ja) |
| ZA (1) | ZA200607248B (ja) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2559652C (en) | 2004-03-15 | 2017-02-14 | Sunesis Pharmaceuticals, Inc. | Methods of using sns-595 in treating cancer |
| KR100989029B1 (ko) | 2004-09-17 | 2010-10-25 | 사일린 파마슈티칼스, 인크 | 세포 증식 억제제로서의 퀴놀론 동족체 |
| US7652134B2 (en) | 2004-09-17 | 2010-01-26 | Cylene Pharmaceuticals, Inc. | Methods for converting quinolone esters into quinolone amides |
| EP1926372A2 (en) * | 2005-08-19 | 2008-06-04 | Cylene Pharmaceuticals, Inc. | HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF |
| US8580814B2 (en) * | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| CA2620915C (en) * | 2005-09-02 | 2014-03-25 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| AU2006287149B2 (en) * | 2005-09-02 | 2013-05-23 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| EP2043645A2 (en) | 2006-06-12 | 2009-04-08 | Sunesis Pharmaceuticals, Inc. | Compounds and compositions for treatment of cancer |
| US20100048609A1 (en) * | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| DK2049109T3 (en) * | 2006-08-02 | 2016-01-11 | Sunesis Pharmaceuticals Inc | Combined use of (+) - 1,4-dihydro-7 - [(3S, 4S) -3-methoxy-4- (methylamino) -1-pyrrolidinyl] -4-oxo-1- (2-thiazolyl) -1,8-naphthyridine-3-carboxylic acid and cytarabine (Ara-C) for the treatment of leukemia |
| EP2209380A4 (en) * | 2007-10-09 | 2011-09-14 | Mark T Hamann | METHOD OF USE OF COMPOSITIONS WITH ANTIDEPRESSIVE EFFICACY, MOOD EFFICACY AND OTHER NEUROLOGICAL EFFECTIVENESS AND COMPOSITIONS THEREOF |
| JP6029808B2 (ja) * | 2007-10-22 | 2016-11-24 | サネシス ファーマシューティカルズ， インコーポレイテッド | 併用療法における（＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の使用方法 |
| AU2014277779B2 (en) * | 2007-10-22 | 2016-05-19 | Sunesis Pharmaceuticals, Inc. | METHODS OF USING (+)-1,4-DIHYDRO-7-[(3s,4s)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION THERAPY |
| EP2649997B1 (en) * | 2007-12-10 | 2019-01-23 | Sunesis Pharmaceuticals, Inc. | (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for use in the treatment of myelodyspastic syndrome |
| ES2646093T3 (es) | 2008-12-31 | 2017-12-12 | Sunesis Pharmaceuticals, Inc. | Método de preparación del ácido (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil)-1,8-naftiridina-3-carboxílico |
| JP5936862B2 (ja) * | 2009-02-27 | 2016-06-22 | サネシス ファーマシューティカルズ， インコーポレイテッド | Ｂｒｃａ２活性が低下した癌対象の治療のためのｓｎｓ−５９５の使用方法 |
| UA110465C2 (en) * | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
| WO2011056566A2 (en) * | 2009-10-26 | 2011-05-12 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
| WO2013128232A1 (en) | 2012-02-27 | 2013-09-06 | Labs & Technological Holding Solea, S.L. | Monitoring and control of soil conditions |
| LT3459942T (lt) | 2012-04-24 | 2021-05-10 | Vertex Pharmaceuticals Incorporated | Dnr-pk inhibitoriai |
| AU2014244555B2 (en) | 2013-03-12 | 2018-06-28 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
| WO2014169067A1 (en) * | 2013-04-09 | 2014-10-16 | Merrimack Pharmaceuticals, Inc. | Compositions for improving outcomes of liposomal chemotherapy |
| WO2015000034A1 (en) * | 2013-07-02 | 2015-01-08 | Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro) | Method for preventing and/or treating chronic traumatic encephalopathy-iii |
| JP6408569B2 (ja) | 2013-10-17 | 2018-10-17 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｄｎａ−ｐｋ阻害剤としての（ｓ）−ｎ−メチル−８−（１−（（２’−メチル−［４，５’−ビピリミジン］−６−イル）アミノ）プロパン−２−イル）キノリン−４−カルボキサミドおよびその重水素化誘導体の共結晶 |
| KR101775356B1 (ko) * | 2015-07-06 | 2017-09-06 | 재단법인 아산사회복지재단 | Parp 및 탄키라제 동시 저해제에 대한 감수성 결정 방법 |
| JP2019529475A (ja) | 2016-09-27 | 2019-10-17 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｄｎａ損傷剤とｄｎａ−ｐｋ阻害剤との組合せ物を使用する、がんを処置するための方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US216316A (en) * | 1879-06-10 | Improvement in latches | ||
| US3021A (en) * | 1843-03-30 | Stove with elevated ovejst | ||
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| US5078996A (en) | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
| CZ292631B6 (cs) * | 1994-06-14 | 2003-11-12 | Dainippon Pharmaceutical Co., Ltd. | Deriváty pyridonkarboxylové kyseliny, protinádorové a farmakologické prostředky je obsahující |
| JP4323574B2 (ja) | 1995-12-13 | 2009-09-02 | 大日本住友製薬株式会社 | 抗腫瘍剤 |
| ATE237136T1 (de) * | 1997-01-13 | 2003-04-15 | Kudos Pharm Ltd | Assay, verbindungen, therapie und nachweisverfahren um zelluläre dns-reparatur- aktivität zu modulieren |
| US20020032216A1 (en) * | 1997-03-21 | 2002-03-14 | Lg Chemical Ltd. | Salt of naphthyridine carboxylic acid derivative |
| JP2001523977A (ja) | 1997-06-05 | 2001-11-27 | ザ ユニバーシティ オブ テキサス システム ボード オブ リージェンツ | Ａｐａｆ−１、ｃｅｄ−４ヒト相同体、カスパーゼ−３の活性化因子 |
| US6171857B1 (en) * | 1997-10-17 | 2001-01-09 | Brown University Research Foundatiion | Leucine zipper protein, KARP-1 and methods of regulating DNA dependent protein kinase activity |
| US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
| IL124015A0 (en) * | 1998-04-08 | 1999-01-26 | Yeda Res & Dev | Pharmaceutical compositions comprising a protein |
| JP4294121B2 (ja) | 1998-06-05 | 2009-07-08 | 大日本住友製薬株式会社 | ピリドンカルボン酸誘導体の製造方法およびその中間体 |
| WO2000000644A1 (en) * | 1998-06-30 | 2000-01-06 | Sloan-Kettering Institute For Cancer Research | Uses of dna-pk |
| JP2002540769A (ja) * | 1999-02-26 | 2002-12-03 | ザ ジョンズ ホプキンス ユニヴァーシティ | プログラム細胞死の新規抑制剤 |
| US6670144B1 (en) | 1999-02-26 | 2003-12-30 | Cyclacel, Ltd. | Compositions and methods for monitoring the phosphorylation of natural binding partners |
| US7163801B2 (en) * | 1999-09-01 | 2007-01-16 | The Burnham Institute | Methods for determining the prognosis for cancer patients using tucan |
| US6479541B1 (en) * | 2000-03-30 | 2002-11-12 | Baxter International | Amiodarone-containing parenteral administration |
| JP2004500849A (ja) * | 2000-05-20 | 2004-01-15 | キャンサー・リサーチ・テクノロジー・リミテッド | 薬剤スクリーニングシステム及びアッセイ |
| US7179912B2 (en) * | 2000-09-01 | 2007-02-20 | Icos Corporation | Materials and methods to potentiate cancer treatment |
| WO2002028387A1 (en) | 2000-10-03 | 2002-04-11 | Oncopharmaceutical, Inc. | Inhibitors of angiogenesis and tumor growth for local and systemic administration |
| EP1337275A4 (en) | 2000-11-02 | 2007-05-09 | Sloan Kettering Inst Cancer | METHOD FOR ENHANCING THE EFFICACY OF CYTOTOXIC AGENTS USING HSP 90 INHIBITORS |
| WO2003089573A2 (en) * | 2002-04-05 | 2003-10-30 | Fishel Richard A | Methods of identifying compounds that modulate a dna repair pathway and/or retroviral infectivity, the compounds, and uses thereof |
| JP2006523681A (ja) * | 2003-03-24 | 2006-10-19 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | Ｄｎａ−ｐｋ阻害剤としてのキサントン、チオキサントンおよびアクリジノン |
| CA2559652C (en) * | 2004-03-15 | 2017-02-14 | Sunesis Pharmaceuticals, Inc. | Methods of using sns-595 in treating cancer |
| AU2006287149B2 (en) | 2005-09-02 | 2013-05-23 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| US8580814B2 (en) | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| EP2043645A2 (en) | 2006-06-12 | 2009-04-08 | Sunesis Pharmaceuticals, Inc. | Compounds and compositions for treatment of cancer |
| US20100048609A1 (en) | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| DK2049109T3 (en) | 2006-08-02 | 2016-01-11 | Sunesis Pharmaceuticals Inc | Combined use of (+) - 1,4-dihydro-7 - [(3S, 4S) -3-methoxy-4- (methylamino) -1-pyrrolidinyl] -4-oxo-1- (2-thiazolyl) -1,8-naphthyridine-3-carboxylic acid and cytarabine (Ara-C) for the treatment of leukemia |
| JP6029808B2 (ja) | 2007-10-22 | 2016-11-24 | サネシス ファーマシューティカルズ， インコーポレイテッド | 併用療法における（＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の使用方法 |
| EP2649997B1 (en) | 2007-12-10 | 2019-01-23 | Sunesis Pharmaceuticals, Inc. | (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for use in the treatment of myelodyspastic syndrome |
| ES2646093T3 (es) | 2008-12-31 | 2017-12-12 | Sunesis Pharmaceuticals, Inc. | Método de preparación del ácido (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil)-1,8-naftiridina-3-carboxílico |
| JP5936862B2 (ja) | 2009-02-27 | 2016-06-22 | サネシス ファーマシューティカルズ， インコーポレイテッド | Ｂｒｃａ２活性が低下した癌対象の治療のためのｓｎｓ−５９５の使用方法 |
| CN101631081B (zh) | 2009-08-12 | 2011-06-08 | 华为技术有限公司 | 一种多级交换网 |
| UA110465C2 (en) | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
| WO2011056566A2 (en) | 2009-10-26 | 2011-05-12 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
-
2005
- 2005-03-14 CA CA2559652A patent/CA2559652C/en not_active Expired - Fee Related
- 2005-03-14 PT PT05731600T patent/PT1725233E/pt unknown
- 2005-03-14 JP JP2007503987A patent/JP5317472B2/ja not_active Expired - Fee Related
- 2005-03-14 CN CN201210307785.8A patent/CN103251589B/zh not_active Expired - Fee Related
- 2005-03-14 MX MXPA06010382A patent/MXPA06010382A/es active IP Right Grant
- 2005-03-14 DK DK10177951.0T patent/DK2295056T5/en active
- 2005-03-14 PL PL10177951T patent/PL2295056T3/pl unknown
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