CY1119309T1 - Συνδυασμενη χρηση toy (+)-1,4-διϋδρο-7-[(3s,4s)-3-meθoξy-4-(μεθυλαμινο)-1-πυρρολιδινυλ]-4-οξο-1(2-θειαζολυλ)-1,8-ναφθυριδιν-3-καρβοξυλικου οξεος και της κυταραβινης (ara-c) για την αγωγη της λευχαιμιας - Google Patents
Συνδυασμενη χρηση toy (+)-1,4-διϋδρο-7-[(3s,4s)-3-meθoξy-4-(μεθυλαμινο)-1-πυρρολιδινυλ]-4-οξο-1(2-θειαζολυλ)-1,8-ναφθυριδιν-3-καρβοξυλικου οξεος και της κυταραβινης (ara-c) για την αγωγη της λευχαιμιαςInfo
- Publication number
- CY1119309T1 CY1119309T1 CY20151101147T CY151101147T CY1119309T1 CY 1119309 T1 CY1119309 T1 CY 1119309T1 CY 20151101147 T CY20151101147 T CY 20151101147T CY 151101147 T CY151101147 T CY 151101147T CY 1119309 T1 CY1119309 T1 CY 1119309T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- ara
- leukemia
- naphthyridine
- cytochrome
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Μέθοδοι αγωγής, πρόληψης ή αντιμετώπισης αιματολογικών διαταραχών, όπως είναι η λευχαιμία αποκαλύπτονται. Οι μέθοδοι εμπερικλείουν την χορήγηση του SNS-595. Επίσης παρέχονται και μέθοδοι αγωγής χρησιμοποιώντας αυτήν την ένωση με χημειοθεραπεία, θεραπεία ακτινοβολίας, ορμονική θεραπεία, βιολογική θεραπεία ή ανοσοθεραπεία. Σε ορισμένες ενσωματώσεις, η μέθοδος αγωγής περιλαμβάνει χορήγηση του SNS-595 σε συνδυασμός Ara-C. Φαρμακευτικές συνθέσεις και μονές μορφές δοσολογίας μονάδας κατάλληλες για χρήση στις μεθόδους αποκαλύπτονται επίσης.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83523906P | 2006-08-02 | 2006-08-02 | |
US87376006P | 2006-12-08 | 2006-12-08 | |
PCT/US2007/017344 WO2008016702A2 (en) | 2006-08-02 | 2007-08-02 | Combined use of (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1(2-thiazolyl)-1,8-naphthyridine-3-carboxylic |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119309T1 true CY1119309T1 (el) | 2018-02-14 |
Family
ID=38859094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151101147T CY1119309T1 (el) | 2006-08-02 | 2015-12-15 | Συνδυασμενη χρηση toy (+)-1,4-διϋδρο-7-[(3s,4s)-3-meθoξy-4-(μεθυλαμινο)-1-πυρρολιδινυλ]-4-οξο-1(2-θειαζολυλ)-1,8-ναφθυριδιν-3-καρβοξυλικου οξεος και της κυταραβινης (ara-c) για την αγωγη της λευχαιμιας |
Country Status (12)
Country | Link |
---|---|
US (3) | US20080063642A1 (el) |
EP (2) | EP2049109B1 (el) |
JP (4) | JP2009545601A (el) |
CA (1) | CA2659861A1 (el) |
CY (1) | CY1119309T1 (el) |
DK (1) | DK2049109T3 (el) |
ES (1) | ES2556677T3 (el) |
HU (1) | HUE026693T2 (el) |
MX (1) | MX344865B (el) |
PL (1) | PL2049109T3 (el) |
SI (1) | SI2049109T1 (el) |
WO (1) | WO2008016702A2 (el) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2005089757A1 (en) | 2004-03-15 | 2005-09-29 | Sunesis Pharmaceuticals, Inc. | Sns-595 and methods of using the same |
US8580814B2 (en) | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
EP2043645A2 (en) | 2006-06-12 | 2009-04-08 | Sunesis Pharmaceuticals, Inc. | Compounds and compositions for treatment of cancer |
WO2008016678A2 (en) * | 2006-08-01 | 2008-02-07 | Sunesis Pharmaceuticals, Inc. | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
EP3141250A1 (en) | 2007-10-22 | 2017-03-15 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
AU2008335772B2 (en) * | 2007-12-10 | 2014-11-27 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3- methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1- (2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
MX2011006974A (es) | 2008-12-31 | 2011-11-18 | Sunesis Pharmaceuticals Inc | Metodo para preparar acido (+)-1,4-dihidro-7-[(3s,4s)-3-metoxi-4-( metilamino)-1-pirrolidinil]-4-oxo-1-) (2-tiazolil)-1, 8-naftiridin-3-carboxilico. |
UA110465C2 (en) | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
US8470817B2 (en) * | 2009-10-26 | 2013-06-25 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
LT2506840T (lt) | 2009-12-04 | 2021-06-25 | OncoC4, Inc. | Hipoksija sukeliančio faktoriaus inhibitorių naudojimas |
RU2550663C2 (ru) * | 2013-02-13 | 2015-05-10 | Владимир Владимирович Савостьянов | Способ гормонально-лучевой подготовки больных хроническим лимфолейкозом к последующей химиотерапии |
US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
EA035979B1 (ru) | 2014-09-09 | 2020-09-08 | Янссен Байотек, Инк. | Варианты комбинированной терапии анти-cd38 антителами |
CN107406506A (zh) * | 2014-12-04 | 2017-11-28 | 詹森生物科技公司 | 用于治疗急性髓系白血病的抗cd38抗体 |
US10751318B2 (en) | 2015-05-18 | 2020-08-25 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal and use thereof |
CA2986594A1 (en) | 2015-05-20 | 2016-11-24 | Tufts Medical Center, Inc. | Anti-cd38 antibodies for treatment of light chain amyloidosis and other cd38-positive hematological malignancies |
KR20180014834A (ko) | 2015-06-19 | 2018-02-09 | 신-낫 프로덕츠 엔터프라이즈 엘엘씨 | 카보플라틴을 함유하는 조성물 및 용도 |
BR112017027285A2 (pt) | 2015-06-19 | 2018-09-11 | Syn Nat Products Entpr Llc | ?cocristal, composição farmacêutica e método para o tratamento de uma doença? |
CN107708734B (zh) | 2015-06-22 | 2022-01-11 | 詹森生物科技公司 | 用抗cd38抗体和生存素抑制剂联合治疗血红素恶性肿瘤 |
US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
CA2989001A1 (en) | 2015-06-25 | 2016-12-29 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal composition and use thereof |
KR20180067693A (ko) | 2015-11-03 | 2018-06-20 | 얀센 바이오테크 인코포레이티드 | 항-cd38 항체의 피하 제제 및 이의 용도 |
US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
KR20200079293A (ko) | 2017-10-31 | 2020-07-02 | 얀센 바이오테크 인코포레이티드 | 고위험 다발성 골수종을 치료하는 방법 |
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US7163801B2 (en) * | 1999-09-01 | 2007-01-16 | The Burnham Institute | Methods for determining the prognosis for cancer patients using tucan |
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WO2005089757A1 (en) * | 2004-03-15 | 2005-09-29 | Sunesis Pharmaceuticals, Inc. | Sns-595 and methods of using the same |
US20050222267A1 (en) * | 2004-04-01 | 2005-10-06 | Truong Van H | Solution based methacholine formulations |
WO2007028171A1 (en) | 2005-09-02 | 2007-03-08 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
US8580814B2 (en) * | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
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2007
- 2007-08-02 EP EP07811049.1A patent/EP2049109B1/en not_active Revoked
- 2007-08-02 PL PL07811049T patent/PL2049109T3/pl unknown
- 2007-08-02 HU HUE07811049A patent/HUE026693T2/hu unknown
- 2007-08-02 WO PCT/US2007/017344 patent/WO2008016702A2/en active Application Filing
- 2007-08-02 CA CA002659861A patent/CA2659861A1/en not_active Abandoned
- 2007-08-02 DK DK07811049.1T patent/DK2049109T3/en active
- 2007-08-02 EP EP15189348.4A patent/EP3025712A1/en not_active Withdrawn
- 2007-08-02 JP JP2009522883A patent/JP2009545601A/ja active Pending
- 2007-08-02 ES ES07811049.1T patent/ES2556677T3/es active Active
- 2007-08-02 MX MX2009001130A patent/MX344865B/es active IP Right Grant
- 2007-08-02 US US11/890,196 patent/US20080063642A1/en not_active Abandoned
- 2007-08-02 SI SI200731723T patent/SI2049109T1/sl unknown
-
2013
- 2013-09-25 JP JP2013198807A patent/JP2014040437A/ja active Pending
-
2014
- 2014-08-15 US US14/461,271 patent/US20150190380A1/en not_active Abandoned
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2015
- 2015-11-09 JP JP2015219880A patent/JP6189911B2/ja not_active Expired - Fee Related
- 2015-12-15 CY CY20151101147T patent/CY1119309T1/el unknown
-
2016
- 2016-06-03 US US15/173,506 patent/US20170119745A1/en not_active Abandoned
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2017
- 2017-08-03 JP JP2017150849A patent/JP2017226683A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP2049109A2 (en) | 2009-04-22 |
CA2659861A1 (en) | 2008-02-07 |
JP2009545601A (ja) | 2009-12-24 |
WO2008016702A3 (en) | 2008-03-20 |
JP2017226683A (ja) | 2017-12-28 |
ES2556677T3 (es) | 2016-01-19 |
MX344865B (es) | 2016-12-19 |
MX2009001130A (es) | 2009-05-13 |
JP2014040437A (ja) | 2014-03-06 |
DK2049109T3 (en) | 2016-01-11 |
SI2049109T1 (sl) | 2016-04-29 |
PL2049109T3 (pl) | 2016-05-31 |
JP2016053070A (ja) | 2016-04-14 |
US20080063642A1 (en) | 2008-03-13 |
EP3025712A1 (en) | 2016-06-01 |
WO2008016702A2 (en) | 2008-02-07 |
HUE026693T2 (hu) | 2016-07-28 |
US20150190380A1 (en) | 2015-07-09 |
EP2049109B1 (en) | 2015-11-18 |
US20170119745A1 (en) | 2017-05-04 |
JP6189911B2 (ja) | 2017-08-30 |
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